ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1741221
Target Type SINGLE PROTEIN
Preferred Name Cysteine protease ATG4B
Synonyms APG4B | ATG4B | AUT-like 1 cysteine endopeptidase | AUTL1 | Autophagin-1 | Autophagy-related cysteine endopeptidase 1 | Autophagy-related protein 4 homolog B | Cysteine protease ATG4B | KIAA0943 | hAPG4B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Cysteine protease ATG4B SINGLE PROTEIN Q9Y4P1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168397
Ensembl ENSG00000168397
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0004175 (endopeptidase activity)
GO:0004197 (cysteine-type endopeptidase activity)
GO:0005515 (protein binding)
GO:0008233 (peptidase activity)
GO:0008234 (cysteine-type peptidase activity)
GO:0016787 (hydrolase activity)
GO Biological Process GO:0000045 (autophagosome assembly)
GO:0000422 (mitophagy)
GO:0006501 (C-terminal protein lipidation)
GO:0006508 (proteolysis)
GO:0006612 (protein targeting to membrane)
GO:0006914 (autophagy)
GO:0015031 (protein transport)
GO:0016236 (macroautophagy)
GO:0044804 (nucleophagy)
GO:0045732 (positive regulation of protein catabolic process)
GO:0051697 (protein delipidation)
Wikipedia ATG4B

Target Cross References - Protein

Human Protein Atlas ENSG00000168397
IntAct Q9Y4P1
Open Targets ENSG00000168397
PharmGKB PA134898340
Reactome R-HSA-1632852 (Macroautophagy.)
UniProt B7WNK2 Q53NU4 Q6ZUV8 Q8WYM9 Q96K07 Q96K96 Q96SZ1 Q9Y2F2 Q9Y4P1

Target Cross References - Domain

InterPro IPR005078 (Peptidase_C54.)
IPR032916 (ATG4B_met.)
Pfam PF03416 (Peptidase_C54)

Target Cross References - Structure

PDBe 2CY7 2D1I 2Z0D 2Z0E 2ZZP 5LXH 5LXI
CREDO 2CY7 2D1I 2Z0D 2Z0E 2ZZP 5LXH 5LXI
spacer
spacer