ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL1741179
Target Type SINGLE PROTEIN
Preferred Name Probable DNA dC->dU-editing enzyme APOBEC-3A
Synonyms A3A | APOBEC3A | DNA dC->dU-editing enzyme APOBEC-3A | Phorbolin-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
DNA dC->dU-editing enzyme APOBEC-3A SINGLE PROTEIN P31941

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000128383 ENSG00000262156
Ensembl ENSG00000128383 ENSG00000262156
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004126 (cytidine deaminase activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016787 (hydrolase activity)
GO:0016814 (hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines)
GO:0046872 (metal ion binding)
GO:0047844 (deoxycytidine deaminase activity)
GO Biological Process GO:0002376 (immune system process)
GO:0009972 (cytidine deamination)
GO:0010529 (negative regulation of transposition)
GO:0044356 (clearance of foreign intracellular DNA by conversion of DNA cytidine to uridine)
GO:0045071 (negative regulation of viral genome replication)
GO:0045087 (innate immune response)
GO:0051607 (defense response to virus)
GO:0070383 (DNA cytosine deamination)
GO:0071466 (cellular response to xenobiotic stimulus)
GO:0080111 (DNA demethylation)
Wikipedia APOBEC3A

Target Cross References - Protein

Human Protein Atlas ENSG00000128383 ENSG00000262156
IntAct P31941
Open Targets ENSG00000128383 ENSG00000262156
PharmGKB PA24891
Reactome R-HSA-72200 (mRNA Editing: C to U Conversion.)
R-HSA-75094 (Formation of the Editosome.)
UniProt A0AVM1 P31941 Q12807 Q5JZ93 Q9UH18

Target Cross References - Domain

InterPro IPR002125 (CMP_dCMP_dom.)
IPR013158 (APOBEC_N.)
IPR016192 (APOBEC/CMP_deaminase_Zn-bd.)
IPR016193 (Cytidine_deaminase-like.)
Pfam PF08210 (APOBEC_N)

Target Cross References - Structure

PDBe 4XXO 5KEG 5SWW
CREDO 4XXO 5KEG 5SWW
spacer
spacer