ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1741176
Preferred Name X-box-binding protein 1
Synonyms Synonyms=TREB5 | TREB-5 | Tax-responsive element-binding protein 5 | X-box-binding protein 1 | X-box-binding protein 1, cytoplasmic form | X-box-binding protein 1, luminal form | XBP-1 | XBP1 | XBP2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
X-box-binding protein 1 SINGLE PROTEIN P17861

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100219
Ensembl ENSG00000100219
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030176 (integral component of endoplasmic reticulum membrane)
GO Molecular Function GO:0000977 (RNA polymerase II regulatory region sequence-specific DNA binding)
GO:0000981 (RNA polymerase II transcription factor activity, sequence-specific DNA binding)
GO:0001047 (core promoter binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001158 (enhancer sequence-specific DNA binding)
GO:0002020 (protease binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO:0030331 (estrogen receptor binding)
GO:0031490 (chromatin DNA binding)
GO:0031625 (ubiquitin protein ligase binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001525 (angiogenesis)
GO:0001889 (liver development)
GO:0001934 (positive regulation of protein phosphorylation)
GO:0001935 (endothelial cell proliferation)
GO:0002070 (epithelial cell maturation)
GO:0002639 (positive regulation of immunoglobulin production)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006511 (ubiquitin-dependent protein catabolic process)
GO:0006629 (lipid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006914 (autophagy)
GO:0006915 (apoptotic process)
GO:0006955 (immune response)
GO:0006986 (response to unfolded protein)
GO:0006990 (positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response)
GO:0006996 (organelle organization)
GO:0007275 (multicellular organism development)
GO:0007517 (muscle organ development)
GO:0008284 (positive regulation of cell proliferation)
GO:0010506 (regulation of autophagy)
GO:0010508 (positive regulation of autophagy)
GO:0010832 (negative regulation of myotube differentiation)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0015031 (protein transport)
GO:0016049 (cell growth)
GO:0030154 (cell differentiation)
GO:0030335 (positive regulation of cell migration)
GO:0030512 (negative regulation of transforming growth factor beta receptor signaling pathway)
GO:0030968 (endoplasmic reticulum unfolded protein response)
GO:0031017 (exocrine pancreas development)
GO:0031062 (positive regulation of histone methylation)
GO:0031647 (regulation of protein stability)
GO:0031648 (protein destabilization)
GO:0031670 (cellular response to nutrient)
GO:0032008 (positive regulation of TOR signaling)
GO:0032869 (cellular response to insulin stimulus)
GO:0034599 (cellular response to oxidative stress)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035356 (cellular triglyceride homeostasis)
GO:0035470 (positive regulation of vascular wound healing)
GO:0035924 (cellular response to vascular endothelial growth factor stimulus)
GO:0036498 (IRE1-mediated unfolded protein response)
GO:0036500 (ATF6-mediated unfolded protein response)
GO:0042149 (cellular response to glucose starvation)
GO:0042593 (glucose homeostasis)
GO:0042632 (cholesterol homeostasis)
GO:0043066 (negative regulation of apoptotic process)
GO:0045348 (positive regulation of MHC class II biosynthetic process)
GO:0045579 (positive regulation of B cell differentiation)
GO:0045582 (positive regulation of T cell differentiation)
GO:0045600 (positive regulation of fat cell differentiation)
GO:0045766 (positive regulation of angiogenesis)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048666 (neuron development)
GO:0051024 (positive regulation of immunoglobulin secretion)
GO:0051897 (positive regulation of protein kinase B signaling)
GO:0055089 (fatty acid homeostasis)
GO:0055092 (sterol homeostasis)
GO:0060394 (negative regulation of pathway-restricted SMAD protein phosphorylation)
GO:0060612 (adipose tissue development)
GO:0060691 (epithelial cell maturation involved in salivary gland development)
GO:0070059 (intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071332 (cellular response to fructose stimulus)
GO:0071333 (cellular response to glucose stimulus)
GO:0071353 (cellular response to interleukin-4)
GO:0071375 (cellular response to peptide hormone stimulus)
GO:0071498 (cellular response to fluid shear stress)
GO:0071499 (cellular response to laminar fluid shear stress)
GO:1900100 (positive regulation of plasma cell differentiation)
GO:1900102 (negative regulation of endoplasmic reticulum unfolded protein response)
GO:1900103 (positive regulation of endoplasmic reticulum unfolded protein response)
GO:1900413 (positive regulation of phospholipid biosynthetic process by positive regulation of transcription from RNA polymerase II promoter)
GO:1901800 (positive regulation of proteasomal protein catabolic process)
GO:1901985 (positive regulation of protein acetylation)
GO:1902236 (negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1903071 (positive regulation of ER-associated ubiquitin-dependent protein catabolic process)
GO:1903489 (positive regulation of lactation)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:1904754 (positive regulation of vascular associated smooth muscle cell migration)
GO:1990418 (response to insulin-like growth factor stimulus)
GO:1990440 (positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress)
GO:1990830 (cellular response to leukemia inhibitory factor)
GO:2000347 (positive regulation of hepatocyte proliferation)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
GO:2000778 (positive regulation of interleukin-6 secretion)
Wikipedia XBP1

Target Cross References - Protein

Human Protein Atlas ENSG00000100219
IntAct P17861
Open Targets ENSG00000100219
PharmGKB PA37400
Reactome R-HSA-381038 (XBP1(S) activates chaperone genes.)
R-HSA-381070 (IRE1alpha activates chaperones.)
R-HSA-381183 (ATF6 (ATF6-alpha) activates chaperone genes.)
UniProt P17861 Q8WYK6 Q969P1 Q96BD7

Target Cross References - Domain

InterPro IPR004827 (bZIP.)
Pfam PF07716 (bZIP_2)