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Target Report Card

Target Name and Classification

Target ID CHEMBL1293277
Preferred Name Niemann-Pick C1 protein
Synonyms NPC intracellular cholesterol transporter 1 | NPC1 | Niemann-Pick C1 protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter

Target Components

Component Description Relationship Accession
NPC intracellular cholesterol transporter 1 SINGLE PROTEIN O15118

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141458
Ensembl ENSG00000141458
GO Cellular Component GO:0005576 (extracellular region)
GO:0005635 (nuclear envelope)
GO:0005764 (lysosome)
GO:0005765 (lysosomal membrane)
GO:0005768 (endosome)
GO:0005783 (endoplasmic reticulum)
GO:0005794 (Golgi apparatus)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031902 (late endosome membrane)
GO:0031982 (vesicle)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0001618 (virus receptor activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005319 (lipid transporter activity)
GO:0005515 (protein binding)
GO:0015248 (sterol transporter activity)
GO:0015485 (cholesterol binding)
GO:0038023 (signaling receptor activity)
GO Biological Process GO:0006486 (protein glycosylation)
GO:0006629 (lipid metabolic process)
GO:0006897 (endocytosis)
GO:0006914 (autophagy)
GO:0007041 (lysosomal transport)
GO:0007165 (signal transduction)
GO:0007628 (adult walking behavior)
GO:0008202 (steroid metabolic process)
GO:0008203 (cholesterol metabolic process)
GO:0008206 (bile acid metabolic process)
GO:0016032 (viral process)
GO:0016242 (negative regulation of macroautophagy)
GO:0030301 (cholesterol transport)
GO:0031579 (membrane raft organization)
GO:0033344 (cholesterol efflux)
GO:0034383 (low-density lipoprotein particle clearance)
GO:0042493 (response to drug)
GO:0042632 (cholesterol homeostasis)
GO:0046686 (response to cadmium ion)
GO:0046718 (viral entry into host cell)
GO:0060548 (negative regulation of cell death)
GO:0071383 (cellular response to steroid hormone stimulus)
GO:0071404 (cellular response to low-density lipoprotein particle stimulus)
GO:0090150 (establishment of protein localization to membrane)
Wikipedia NPC1

Target Cross References - Protein

CGD Niemann-Pick disease, type C1; Niemann-Pick disease, type D
Human Protein Atlas ENSG00000141458
IntAct O15118
Open Targets ENSG00000141458
PharmGKB PA31698
Reactome R-HSA-8964038 (LDL clearance.)
UniProt B4DET3 O15118 Q9P130

Target Cross References - Domain

InterPro IPR000731 (SSD.)
IPR003392 (Ptc/Disp.)
IPR004765 (NP_C_type.)
IPR032190 (NPC1_N.)
Pfam PF02460 (Patched)
PF12349 (Sterol-sensing)
PF16414 (NPC1_N)

Target Cross References - Structure

PDBe 3GKH 3GKI 3GKJ 5F18 5F1B 5HNS 5KWY 5U73 5U74
CREDO 3GKH 3GKI 3GKJ 5F18 5F1B 5HNS 5KWY 5U73 5U74