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Target Report Card

Target Name and Classification

Target ID CHEMBL1293267
Target Type SINGLE PROTEIN
Preferred Name G-protein coupled receptor 35
Synonyms G-protein coupled receptor 35 | GPR35 | KYNA receptor | Kynurenic acid receptor
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > carboxylic acid receptor > kynurenic acid receptor

Target Components

Component Description Relationship Accession
G-protein coupled receptor 35 SINGLE PROTEIN Q9HC97

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000178623
Ensembl ENSG00000178623
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0016494 (C-X-C chemokine receptor activity)
GO Biological Process GO:0007010 (cytoskeleton organization)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0070098 (chemokine-mediated signaling pathway)
GO:1901386 (negative regulation of voltage-gated calcium channel activity)
GO:1904456 (negative regulation of neuronal action potential)
Wikipedia GPR35

Target Cross References - Protein

Human Protein Atlas ENSG00000178623
Guide to Pharmacology 102
Open Targets ENSG00000178623
PharmGKB PA28880
Pharos Q9HC97 (Tchem)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
UniProt J3KR30 O43495 Q17R58 Q4VBN5 Q4ZFV2 Q6FHI8 Q86UH4 Q9HC97

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)
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