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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293255
Target Type SINGLE PROTEIN
Preferred Name 15-hydroxyprostaglandin dehydrogenase [NAD+]
Synonyms 15-PGDH | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | HPGD | PGDH1 | Prostaglandin dehydrogenase 1 | SDR36C1 | Short chain dehydrogenase/reductase family 36C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
15-hydroxyprostaglandin dehydrogenase [NAD(+)] SINGLE PROTEIN P15428

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000164120
Ensembl ENSG00000164120
GO Cellular Component GO:0005615 (extracellular space)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016323 (basolateral plasma membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0003824 (catalytic activity)
GO:0004957 (prostaglandin E receptor activity)
GO:0016404 (15-hydroxyprostaglandin dehydrogenase (NAD+) activity)
GO:0016491 (oxidoreductase activity)
GO:0042803 (protein homodimerization activity)
GO:0051287 (NAD binding)
GO:0070403 (NAD+ binding)
GO Biological Process GO:0001822 (kidney development)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006693 (prostaglandin metabolic process)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007565 (female pregnancy)
GO:0007567 (parturition)
GO:0019372 (lipoxygenase pathway)
GO:0030728 (ovulation)
GO:0032355 (response to estradiol)
GO:0032496 (response to lipopolysaccharide)
GO:0043065 (positive regulation of apoptotic process)
GO:0045471 (response to ethanol)
GO:0045786 (negative regulation of cell cycle)
GO:0055114 (oxidation-reduction process)
GO:0070493 (thrombin receptor signaling pathway)
GO:0097070 (ductus arteriosus closure)
GO:1904707 (positive regulation of vascular smooth muscle cell proliferation)
GO:2001301 (lipoxin biosynthetic process)
Wikipedia HPGD

Target Cross References - Protein

CGD Hypertrophic osteoarthropathy, primary, autosomal recessive 1; Cranioosteoarthropathy; Digital clubbing, isolated congenital
Human Protein Atlas ENSG00000164120
Guide to Pharmacology 1384
Open Targets ENSG00000164120
PharmGKB PA29424
Reactome R-HSA-2142700 (Synthesis of Lipoxins (LX).)
R-HSA-2162123 (Synthesis of Prostaglandins (PG) and Thromboxanes (TX).)
UniProt B4DTA4 B4DU74 B4DV57 D3DP43 E7EV11 O00749 P15428 Q06F08 Q12998

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR036291 (NAD(P)-bd_dom_sf.)
Pfam PF00106 (adh_short)

Target Cross References - Structure

PDBe 2GDZ
CREDO 2GDZ
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