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Target Report Card

Target Name and Classification

Target ID CHEMBL1293231
Preferred Name Nuclear receptor ROR-gamma
Synonyms Nr1f3 | Nuclear receptor ROR-gamma | Nuclear receptor RZR-gamma | Nuclear receptor subfamily 1 group F member 3 | RAR-related orphan receptor C | Retinoid-related orphan receptor-gamma | Rorc | Rorg | TOR | Thor | Thymus orphan receptor
Organism Mus musculus
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 1 > nuclear hormone receptor subfamily 1 group f > nuclear hormone receptor subfamily 1 group f member 3

Target Components

Component Description Relationship Accession
Nuclear receptor ROR-gamma SINGLE PROTEIN P51450

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0009897 (external side of plasma membrane)
GO:0016604 (nuclear body)
GO Molecular Function GO:0000978 (RNA polymerase II core promoter proximal region sequence-specific DNA binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001223 (transcription coactivator binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0004879 (RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008142 (oxysterol binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0098531 (transcription factor activity, direct ligand regulated sequence-specific DNA binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006805 (xenobiotic metabolic process)
GO:0007275 (multicellular organism development)
GO:0010906 (regulation of glucose metabolic process)
GO:0019218 (regulation of steroid metabolic process)
GO:0030154 (cell differentiation)
GO:0030522 (intracellular receptor signaling pathway)
GO:0032620 (interleukin-17 production)
GO:0032922 (circadian regulation of gene expression)
GO:0033077 (T cell differentiation in thymus)
GO:0036315 (cellular response to sterol)
GO:0042093 (T-helper cell differentiation)
GO:0042753 (positive regulation of circadian rhythm)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045586 (regulation of gamma-delta T cell differentiation)
GO:0045598 (regulation of fat cell differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046632 (alpha-beta T cell differentiation)
GO:0048511 (rhythmic process)
GO:0048535 (lymph node development)
GO:0048537 (mucosal-associated lymphoid tissue development)
GO:0048541 (Peyer's patch development)
GO:0060612 (adipose tissue development)
GO:0060850 (regulation of transcription involved in cell fate commitment)
GO:0070244 (negative regulation of thymocyte apoptotic process)
GO:0072539 (T-helper 17 cell differentiation)
GO:0072615 (interleukin-17 secretion)

Target Cross References - Protein

IntAct P51450
Reactome R-MMU-383280 (Nuclear Receptor transcription pathway.)
UniProt E9Q8I1 P51450 Q3U513 Q61027 Q91YT5 Q9QXD9 Q9R177

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR003079 (ROR_rcpt.)
IPR013088 (Znf_NHR/GATA.)
IPR035500 (NHR_like_dom_sf.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)