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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1293226
Target Type SINGLE PROTEIN
Preferred Name Lysine-specific demethylase 4D-like
Synonyms KDM4D-like protein | KDM4DL | KDM4E | Lysine-specific demethylase 4D-like | Lysine-specific demethylase 4E
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > lysine demethylase > jumonji domain-containing

Target Components

Component Description Relationship Accession
Lysine-specific demethylase 4E SINGLE PROTEIN B2RXH2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000235268
Ensembl ENSG00000235268
GO Cellular Component GO:0005634 (nucleus)
GO Molecular Function GO:0016491 (oxidoreductase activity)
GO:0032454 (histone demethylase activity (H3-K9 specific))
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0033169 (histone H3-K9 demethylation)
GO:0055114 (oxidation-reduction process)

Target Cross References - Protein

Human Protein Atlas ENSG00000235268
Guide to Pharmacology 2679
Open Targets ENSG00000235268
PharmGKB PA165543440
UniProt B2RXH2

Target Cross References - Domain

InterPro IPR003347 (JmjC_dom.)
IPR003349 (JmjN.)
Pfam PF02373 (JmjC)
PF02375 (JmjN)

Target Cross References - Structure

PDBe 2W2I
CREDO 2W2I
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