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Target Report Card

Target Name and Classification

Target ID CHEMBL1293224
Preferred Name Microtubule-associated protein tau
Synonyms MAPT | MAPTL | MTBT1 | Microtubule-associated protein tau | Neurofibrillary tangle protein | PHF-tau | Paired helical filament-tau | TAU
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Microtubule-associated protein tau SINGLE PROTEIN P10636

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000186868 ENSG00000276155 ENSG00000277956
Ensembl ENSG00000186868 ENSG00000276155 ENSG00000277956
GO Cellular Component GO:0005576 (extracellular region)
GO:0005622 (intracellular)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005874 (microtubule)
GO:0005875 (microtubule associated complex)
GO:0005886 (plasma membrane)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0016607 (nuclear speck)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030426 (growth cone)
GO:0030673 (axolemma)
GO:0034399 (nuclear periphery)
GO:0036464 (cytoplasmic ribonucleoprotein granule)
GO:0036477 (somatodendritic compartment)
GO:0042995 (cell projection)
GO:0043025 (neuronal cell body)
GO:0043197 (dendritic spine)
GO:0044297 (cell body)
GO:0044304 (main axon)
GO:0045298 (tubulin complex)
GO:0097418 (neurofibrillary tangle)
GO:1904115 (axon cytoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003680 (AT DNA binding)
GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0003723 (RNA binding)
GO:0003779 (actin binding)
GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0015631 (tubulin binding)
GO:0017124 (SH3 domain binding)
GO:0019899 (enzyme binding)
GO:0019901 (protein kinase binding)
GO:0030674 (protein binding, bridging)
GO:0034185 (apolipoprotein binding)
GO:0034452 (dynactin binding)
GO:0035091 (phosphatidylinositol binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0043565 (sequence-specific DNA binding)
GO:0048018 (receptor agonist activity)
GO:0051087 (chaperone binding)
GO:0051721 (protein phosphatase 2A binding)
GO:0051879 (Hsp90 protein binding)
GO:0071813 (lipoprotein particle binding)
GO:0099077 (histone-dependent DNA binding)
GO:0099609 (microtubule lateral binding)
GO:1902936 (phosphatidylinositol bisphosphate binding)
GO Biological Process GO:0000226 (microtubule cytoskeleton organization)
GO:0001774 (microglial cell activation)
GO:0006475 (internal protein amino acid acetylation)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007267 (cell-cell signaling)
GO:0007416 (synapse assembly)
GO:0007611 (learning or memory)
GO:0007613 (memory)
GO:0010288 (response to lead ion)
GO:0010469 (regulation of receptor activity)
GO:0010506 (regulation of autophagy)
GO:0010629 (negative regulation of gene expression)
GO:0010917 (negative regulation of mitochondrial membrane potential)
GO:0016072 (rRNA metabolic process)
GO:0019896 (axonal transport of mitochondrion)
GO:0021954 (central nervous system neuron development)
GO:0031110 (regulation of microtubule polymerization or depolymerization)
GO:0031113 (regulation of microtubule polymerization)
GO:0031116 (positive regulation of microtubule polymerization)
GO:0031122 (cytoplasmic microtubule organization)
GO:0031175 (neuron projection development)
GO:0032930 (positive regulation of superoxide anion generation)
GO:0033044 (regulation of chromosome organization)
GO:0033673 (negative regulation of kinase activity)
GO:0034063 (stress granule assembly)
GO:0034605 (cellular response to heat)
GO:0034614 (cellular response to reactive oxygen species)
GO:0045773 (positive regulation of axon extension)
GO:0046785 (microtubule polymerization)
GO:0048143 (astrocyte activation)
GO:0048167 (regulation of synaptic plasticity)
GO:0048312 (intracellular distribution of mitochondria)
GO:0048699 (generation of neurons)
GO:0050808 (synapse organization)
GO:0050848 (regulation of calcium-mediated signaling)
GO:0051259 (protein oligomerization)
GO:0051260 (protein homooligomerization)
GO:0061564 (axon development)
GO:0070507 (regulation of microtubule cytoskeleton organization)
GO:0072386 (plus-end-directed organelle transport along microtubule)
GO:0090140 (regulation of mitochondrial fission)
GO:0090258 (negative regulation of mitochondrial fission)
GO:0097435 (fibril organization)
GO:0098930 (axonal transport)
GO:1900034 (regulation of cellular response to heat)
GO:1900452 (regulation of long term synaptic depression)
GO:1901216 (positive regulation of neuron death)
GO:1902474 (positive regulation of protein localization to synapse)
GO:1902988 (neurofibrillary tangle assembly)
GO:1903748 (negative regulation of establishment of protein localization to mitochondrion)
GO:1903829 (positive regulation of cellular protein localization)
GO:1904428 (negative regulation of tubulin deacetylation)
GO:1905689 (positive regulation of diacylglycerol kinase activity)
GO:1990000 (amyloid fibril formation)
GO:1990090 (cellular response to nerve growth factor stimulus)
GO:1990416 (cellular response to brain-derived neurotrophic factor stimulus)
GO:2001020 (regulation of response to DNA damage stimulus)
Wikipedia Tau_protein

Target Cross References - Protein

canSAR P10636
CGD Supranuclear palsy, progressive; Frontotemporal dementia; Parkinson-dementia sydnrome; Pick disease
Human Protein Atlas ENSG00000186868 ENSG00000276155 ENSG00000277956
IntAct P10636
Open Targets ENSG00000186868 ENSG00000276155 ENSG00000277956
PharmGKB PA238
Reactome R-HSA-264870 (Caspase-mediated cleavage of cytoskeletal proteins.)
UniProt P10636 P18518 Q14799 Q15549 Q15550 Q15551 Q1RMF6 Q53YB1 Q5CZI7 Q5XWF0 Q6QT54 Q9UDJ3 Q9UMH0 Q9UQ96

Target Cross References - Domain

InterPro IPR001084 (MAP_tubulin-bd_rpt.)
IPR002955 (Tau.)
Pfam PF00418 (Tubulin-binding)

Target Cross References - Structure

PDBe 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3
CREDO 2ON9 3OVL 4E0M 4E0N 4E0O 4FL5 4GLR 4NP8 4TQE 4Y32 4Y3B 4Y5I 5DMG 5E2V 5E2W 5HF3