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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1287628
Target Type SINGLE PROTEIN
Preferred Name NADPH oxidase 1
Synonyms MOX-1 | MOX1 | Mitogenic oxidase 1 | NADH/NADPH mitogenic oxidase subunit P65-MOX | NADPH oxidase 1 | NOH-1 | NOH1 | NOX-1 | NOX1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > transmembrane 1-electron transfer carriers

Target Components

Component Description Relationship Accession
NADPH oxidase 1 SINGLE PROTEIN Q9Y5S8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000007952
Ensembl ENSG00000007952
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005769 (early endosome)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0042995 (cell projection)
GO:0043020 (NADPH oxidase complex)
GO:0071438 (invadopodium membrane)
GO Molecular Function GO:0005244 (voltage-gated ion channel activity)
GO:0005515 (protein binding)
GO:0016175 (superoxide-generating NADPH oxidase activity)
GO:0016491 (oxidoreductase activity)
GO:0046872 (metal ion binding)
GO:0048365 (Rac GTPase binding)
GO:0050661 (NADP binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0003081 (regulation of systemic arterial blood pressure by renin-angiotensin)
GO:0006739 (NADP metabolic process)
GO:0006811 (ion transport)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0008217 (regulation of blood pressure)
GO:0008284 (positive regulation of cell proliferation)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0016477 (cell migration)
GO:0030198 (extracellular matrix organization)
GO:0034220 (ion transmembrane transport)
GO:0034765 (regulation of ion transmembrane transport)
GO:0042554 (superoxide anion generation)
GO:0042743 (hydrogen peroxide metabolic process)
GO:0043410 (positive regulation of MAPK cascade)
GO:0045726 (positive regulation of integrin biosynthetic process)
GO:0045730 (respiratory burst)
GO:0046330 (positive regulation of JNK cascade)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0051454 (intracellular pH elevation)
GO:0055114 (oxidation-reduction process)
GO:0071455 (cellular response to hyperoxia)
GO:0072592 (oxygen metabolic process)
GO:1902177 (positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway)
GO:1990451 (cellular stress response to acidic pH)
Wikipedia NOX1

Target Cross References - Protein

Human Protein Atlas ENSG00000007952
IntAct Q9Y5S8
Open Targets ENSG00000007952
PharmGKB PA31690
Pharos Q9Y5S8 (Tchem)
Reactome R-HSA-5668599 (RHO GTPases Activate NADPH Oxidases.)
UniProt A8K836 O95691 Q2PP02 Q9Y5S8

Target Cross References - Domain

InterPro IPR000778 (Cyt_b245_heavy_chain.)
IPR013112 (FAD-bd_8.)
IPR013121 (Fe_red_NAD-bd_6.)
IPR013130 (Fe3_Rdtase_TM_dom.)
IPR017927 (Fd_Rdtase_FAD-bd.)
IPR017938 (Riboflavin_synthase-like_b-brl.)
IPR029650 (NOX1.)
Pfam PF01794 (Ferric_reduct)
PF08022 (FAD_binding_8)
PF08030 (NAD_binding_6)
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