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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1287622
Target Type SINGLE PROTEIN
Preferred Name Lethal(3)malignant brain tumor-like protein 1
Synonyms H-l(3)mbt protein | H-l(3)mbt | KIAA0681 | L(3)mbt protein homolog | L(3)mbt-like | L3MBT | L3MBTL | L3MBTL1 | L3MBTL1 | Lethal(3)malignant brain tumor-like protein 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > mbt domain

Target Components

Component Description Relationship Accession
Lethal(3)malignant brain tumor-like protein 1 SINGLE PROTEIN Q9Y468

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000185513
Ensembl ENSG00000185513
GO Cellular Component GO:0000785 (chromatin)
GO:0000793 (condensed chromosome)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0003682 (chromatin binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0031491 (nucleosome binding)
GO:0031493 (nucleosomal histone binding)
GO:0032093 (SAM domain binding)
GO:0035064 (methylated histone binding)
GO:0042393 (histone binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0007088 (regulation of mitotic nuclear division)
GO:0030097 (hemopoiesis)
GO:0045652 (regulation of megakaryocyte differentiation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0051726 (regulation of cell cycle)
GO:1901796 (regulation of signal transduction by p53 class mediator)
Wikipedia L3MBTL

Target Cross References - Protein

Human Protein Atlas ENSG00000185513
IntAct Q9Y468
Open Targets ENSG00000185513
PharmGKB PA30260
Reactome R-HSA-6804760 (Regulation of TP53 Activity through Methylation.)
UniProt B4DRC9 E1P5W7 Q5H8Y8 Q5H8Y9 Q8IUV7 Q9H1E6 Q9H1G5 Q9UG06 Q9UJB9 Q9Y468 Q9Y4C9

Target Cross References - Domain

InterPro IPR001660 (SAM.)
IPR002515 (Znf_C2HC.)
IPR004092 (Mbt.)
IPR013761 (SAM/pointed_sf.)
IPR036060 (Znf_C2HC_sf.)
Pfam PF00536 (SAM_1)
PF01530 (zf-C2HC)
PF02820 (MBT)

Target Cross References - Structure

PDBe 1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN
CREDO 1OYX 1OZ2 1OZ3 2PQW 2RHI 2RHU 2RHX 2RHY 2RHZ 2RI2 2RI3 2RI5 2RJC 2RJD 2RJE 2RJF 3OQ5 3P8H 3UWN
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