ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL1075322
Preferred Name G-protein coupled receptor 55
Synonyms G-protein coupled receptor 55 | GPR55
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > small molecule receptor (family a gpcr) > lipid-like ligand receptor (family a gpcr) > lysophosphatidylinositol receptor

Target Components

Component Description Relationship Accession
G-protein coupled receptor 55 SINGLE PROTEIN Q9Y2T6

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135898
Ensembl ENSG00000135898
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004949 (cannabinoid receptor activity)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007202 (activation of phospholipase C activity)
GO:0035025 (positive regulation of Rho protein signal transduction)
GO:0038171 (cannabinoid signaling pathway)
GO:0045453 (bone resorption)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0051482 (positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
Wikipedia GPR55

Target Cross References - Protein

canSAR Q9Y2T6
Human Protein Atlas ENSG00000135898
Guide to Pharmacology 109
Open Targets ENSG00000135898
PharmGKB PA28900
Pharos Q9Y2T6 (Tchem)
Reactome R-HSA-373076 (Class A/1 (Rhodopsin-like receptors).)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt Q8N580 Q9Y2T6

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR017452 (GPCR_Rhodpsn_7TM.)
IPR028334 (GPR55.)
Pfam PF00001 (7tm_1)