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Target Report Card

Target Name and Classification

Target ID CHEMBL1075189
Preferred Name Pyruvate kinase isozymes M1/M2
Synonyms CTHBP | Cytosolic thyroid hormone-binding protein | OIP-3 | OIP3 | Opa-interacting protein 3 | PK2 | PK3 | PKM | PKM2 | Pyruvate kinase 2/3 | Pyruvate kinase PKM | Pyruvate kinase muscle isozyme | THBP1 | Thyroid hormone-binding protein 1 | Tumor M2-PK | p58
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Pyruvate kinase PKM SINGLE PROTEIN P14618

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000067225
Ensembl ENSG00000067225
GO Cellular Component GO:0005576 (extracellular region)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005829 (cytosol)
GO:0005929 (cilium)
GO:0031012 (extracellular matrix)
GO:0031982 (vesicle)
GO:0034774 (secretory granule lumen)
GO:0043209 (myelin sheath)
GO:0070062 (extracellular exosome)
GO:1902912 (pyruvate kinase complex)
GO:1903561 (extracellular vesicle)
GO:1904813 (ficolin-1-rich granule lumen)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0003723 (RNA binding)
GO:0003824 (catalytic activity)
GO:0004743 (pyruvate kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0023026 (MHC class II protein complex binding)
GO:0030955 (potassium ion binding)
GO:0042802 (identical protein binding)
GO:0043531 (ADP binding)
GO:0045296 (cadherin binding)
GO:0046872 (metal ion binding)
GO:0070324 (thyroid hormone binding)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001889 (liver development)
GO:0006006 (glucose metabolic process)
GO:0006096 (glycolytic process)
GO:0006754 (ATP biosynthetic process)
GO:0007584 (response to nutrient)
GO:0008152 (metabolic process)
GO:0009629 (response to gravity)
GO:0010033 (response to organic substance)
GO:0012501 (programmed cell death)
GO:0014870 (response to muscle inactivity)
GO:0016310 (phosphorylation)
GO:0031100 (organ regeneration)
GO:0032868 (response to insulin)
GO:0032869 (cellular response to insulin stimulus)
GO:0042866 (pyruvate biosynthetic process)
GO:0043312 (neutrophil degranulation)
GO:0043403 (skeletal muscle tissue regeneration)
GO:0051289 (protein homotetramerization)
GO:0061621 (canonical glycolysis)
Wikipedia PKM2

Target Cross References - Protein

canSAR P14618
Human Protein Atlas ENSG00000067225
IntAct P14618
Open Targets ENSG00000067225
PharmGKB PA33353
Pharos P14618 (Tchem)
Reactome R-HSA-6798695 (Neutrophil degranulation.)
R-HSA-70171 (Glycolysis.)
UniProt A6NFK3 B2R5N8 B3KRY0 B4DFX8 B4DUU6 P14618 P14786 Q53GK4 Q96E76 Q9BWB5 Q9UCV6 Q9UPF2

Target Cross References - Domain

InterPro IPR001697 (Pyr_Knase.)
IPR011037 (Pyrv_Knase-like_insert_dom_sf.)
IPR015793 (Pyrv_Knase_brl.)
IPR015795 (Pyrv_Knase_C.)
IPR015806 (Pyrv_Knase_insert_dom_sf.)
IPR015813 (Pyrv/PenolPyrv_Kinase-like_dom.)
IPR018209 (Pyrv_Knase_AS.)
IPR036918 (Pyrv_Knase_C_sf.)
Pfam PF00224 (PK)
PF02887 (PK_C)

Target Cross References - Structure

PDBe 1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 More...
CREDO 1T5A 1ZJH 3BJF 3BJT 3G2G 3GQY 3GR4 3H6O 3ME3 3SRD 3SRF 3SRH 3U2Z 4B2D 4FXF 4FXJ 4G1N 4JPG 4QG6 4QG8 4QG9 4QGC 4RPP 4WJ8 More...