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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075138
Target Type SINGLE PROTEIN
Preferred Name Tyrosyl-DNA phosphodiesterase 1
Synonyms TDP1 | Tyr-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tyrosyl-DNA phosphodiesterase 1 SINGLE PROTEIN Q9NUW8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000042088
Ensembl ENSG00000042088
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0004518 (nuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0017005 (3'-tyrosyl-DNA phosphodiesterase activity)
GO Biological Process GO:0000012 (single strand break repair)
GO:0006281 (DNA repair)
GO:0006302 (double-strand break repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia TDP1

Target Cross References - Protein

canSAR Q9NUW8
CGD Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy
Human Protein Atlas ENSG00000042088
IntAct Q9NUW8
Open Targets ENSG00000042088
PharmGKB PA421
Reactome R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
UniProt Q2HXX4 Q86TV8 Q96BK7 Q9NUW8 Q9NZM7 Q9NZM8

Target Cross References - Domain

InterPro IPR010347 (Tdp1.)
IPR027415 (TDP_C.)
Pfam PF06087 (Tyr-DNA_phospho)

Target Cross References - Structure

PDBe 1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0
CREDO 1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0
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