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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075138
Target Type SINGLE PROTEIN
Preferred Name Tyrosyl-DNA phosphodiesterase 1
Synonyms TDP1 | Tyr-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Tyrosyl-DNA phosphodiesterase 1 SINGLE PROTEIN Q9NUW8

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000042088
Ensembl ENSG00000042088
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003690 (double-stranded DNA binding)
GO:0003697 (single-stranded DNA binding)
GO:0004518 (nuclease activity)
GO:0004527 (exonuclease activity)
GO:0005515 (protein binding)
GO:0008081 (phosphoric diester hydrolase activity)
GO:0016787 (hydrolase activity)
GO:0017005 (3'-tyrosyl-DNA phosphodiesterase activity)
GO Biological Process GO:0000012 (single strand break repair)
GO:0006281 (DNA repair)
GO:0006302 (double-strand break repair)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0090305 (nucleic acid phosphodiester bond hydrolysis)
Wikipedia TDP1

Target Cross References - Protein

canSAR Q9NUW8
CGD Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy
Human Protein Atlas ENSG00000042088
IntAct Q9NUW8
Open Targets ENSG00000042088
PharmGKB PA421
Reactome R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
UniProt Q2HXX4 Q86TV8 Q96BK7 Q9NUW8 Q9NZM7 Q9NZM8

Target Cross References - Domain

InterPro IPR010347 (Tdp1.)
IPR027415 (TDP_C.)
Pfam PF06087 (Tyr-DNA_phospho)

Target Cross References - Structure

PDBe 1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0 5NW9 5NWA
CREDO 1JY1 1MU7 1MU9 1NOP 1QZQ 1RFF 1RFI 1RG1 1RG2 1RGT 1RGU 1RH0 5NW9 5NWA
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