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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL1075108
Preferred Name Solute carrier family 12 member 5
Synonyms Electroneutral potassium-chloride cotransporter 2 | Furosemide-sensitive K-Cl cotransporter | K-Cl cotransporter 2 | Kcc2 | Neuronal K-Cl cotransporter | Slc12a5 | Solute carrier family 12 member 5 | rKCC2
Organism Rattus norvegicus
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc12 family of cation-coupled chloride transporters

Target Components

Component Description Relationship Accession
Solute carrier family 12 member 5 SINGLE PROTEIN Q63633

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0032590 (dendrite membrane)
GO:0043204 (perikaryon)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005515 (protein binding)
GO:0008519 (ammonium transmembrane transporter activity)
GO:0015293 (symporter activity)
GO:0015377 (cation:chloride symporter activity)
GO:0015379 (potassium:chloride symporter activity)
GO Biological Process GO:0006811 (ion transport)
GO:0006813 (potassium ion transport)
GO:0006821 (chloride transport)
GO:0007268 (chemical synaptic transmission)
GO:0015696 (ammonium transport)
GO:0051452 (intracellular pH reduction)
GO:0055085 (transmembrane transport)
GO:0060996 (dendritic spine development)
GO:0071805 (potassium ion transmembrane transport)
GO:0072488 (ammonium transmembrane transport)
GO:1902476 (chloride transmembrane transport)

Target Cross References - Protein

canSAR Q63633
IntAct Q63633
UniProt A7Y821 Q63633

Target Cross References - Domain

InterPro IPR000076 (KCL_cotranspt.)
IPR004841 (AA-permease/SLC12A_dom.)
IPR004842 (SLC12A_fam.)
IPR018491 (SLC12_C.)
IPR030358 (KCC2.)
Pfam PF00324 (AA_permease)
PF03522 (SLC12)