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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5103
Target Type SINGLE PROTEIN
Preferred Name Histone deacetylase 10
Synonyms HD10 | HDAC10 | Histone deacetylase 10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > eraser > histone deacetylase > hdac class iib

Target Components

Component Description Relationship Accession
Histone deacetylase 10 SINGLE PROTEIN Q969S8

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2093865 Histone deacetylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100429
Ensembl ENSG00000100429
GO Cellular Component GO:0000118 (histone deacetylase complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004407 (histone deacetylase activity)
GO:0005515 (protein binding)
GO:0016787 (hydrolase activity)
GO:0019899 (enzyme binding)
GO:0032041 (NAD-dependent histone deacetylase activity (H3-K14 specific))
GO:0033558 (protein deacetylase activity)
GO:0042826 (histone deacetylase binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006325 (chromatin organization)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006476 (protein deacetylation)
GO:0014003 (oligodendrocyte development)
GO:0016575 (histone deacetylation)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0070932 (histone H3 deacetylation)
Wikipedia HDAC10

Target Cross References - Protein

canSAR Q969S8
Human Protein Atlas ENSG00000100429
IntAct Q969S8
Guide to Pharmacology 2614
Open Targets ENSG00000100429
PharmGKB PA38297
Reactome R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3214815 (HDACs deacetylate histones.)
UniProt Q08AP4 Q6STF9 Q969S8 Q96P77 Q96P78 Q9H028 Q9UGX1 Q9UGX2

Target Cross References - Domain

InterPro IPR000286 (His_deacetylse.)
IPR023696 (Ureohydrolase_dom_sf.)
IPR023801 (His_deacetylse_dom.)
IPR037138 (His_deacetylse_dom_sf.)
Pfam PF00850 (Hist_deacetyl)
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