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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1454
CHEMBL1454
Compound Name LEVAMISOLE
ChEMBL Synonyms R-12564 | Totalon | Levasole | Ripercol | Levamisole HCl | Tramisol | Verban-H | Ergamisol | Spartakon | Ergamisole | Levamisole | Rid O Worm | Nilverm | Levicon | Telskoot
Max Phase 4 (Approved)
Trade Names Levicon | Nilverm | Totalon | Levasole | Ripercol | Telskoot | Tramisol | Verban-H | Ergamisol | Spartakon | Ergamisole | Rid O Worm
Molecular Formula C11H12N2S

Additional synonyms for CHEMBL1454 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES C1CN2C[C@@H](N=C2S1)c3ccccc3
Standard InChI InChI=1S/C11H12N2S/c1-2-4-9(5-3-1)10-8-13-6-7-14-11(13)12-10 ...
Download InChI
Standard InChI Key HLFSDGLLUJUHTE-SNVBAGLBSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Nicotinic acetylcholine receptor alpha subunit agonist Nicotinic acetylcholine receptor alpha subunit PubMed PubMed

Molecule Features

CHEMBL1454 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Discontinued

Clinical Data

Number of clinical trials registered at clinicaltrials.gov
Number of reviews at The Cochrane Collaboration
Number of entries at British National Formulary

Structural Alerts

There are no structural alerts for CHEMBL1454

Alternate Forms of Compound in ChEMBL


CHEMBL1454

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1454. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL1293237 Bloom syndrome protein Homo sapiens 0.614

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
204.3 204.0721 2.29 1 40.9 BASE


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
3 0 0 2 0 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 10 1.84 -.06 1 14 0.7

Compound Cross References

ATC P - ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P02 - ANTHELMINTICS
P02C - ANTINEMATODAL AGENTS
P02CE - Imidazothiazole derivatives
P02CE01 - levamisole

ChemSpider ChemSpider:HLFSDGLLUJUHTE-SNVBAGLBSA-N
PubChem SID: 90341409
Wikipedia Levamisole

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1454



ACToR 14769-73-4
BindinDB 50241179
ChEBI 6432
DrugBank DB00848
eMolecules 29542986
FDA SRS 2880D3468G
Guide to Pharmacology 7210
Human Metabolome Database HMDB14986
IBM Patent System E211EF47690EB3CA115194A4D17BE049
IBM Patents US20040101927 EP1587816B1 EP1978930A2 EP1915151A2 EP1902732A1 EP1389127A1 WO2007041637A2 US4005218 US6153430 US4473551 WO2006055742A1 WO2003089422A1 US5641773 EP1940841A2 EP1668129B1 EP1451308A2 US6075010 EP1684779A1 WO1999029714A2 US20040025199 US20090169478 WO1992021980A1 EP1592794A2 US20100303736 US4255537 US6596746 US20050187140 US20040053972 US20090105167 US6458799 US20080242648 EP1296678A2 EP1966182A1 EP2101805A2 US20060173017 US20080279851 US20080188570 WO2007005955A2 EP1931760A2 WO2010106097A1 US20040005680 EP1578362A2 WO2005016231A2 EP0010851A2 US20100172903 EP1653942A1 EP1656140A1 US5051408 WO2009075582A2 US20050208602 EP1598338A1 US4593024 EP2079486A2 US5074857 US20060069101 US20050214208 WO2007084498A1 EP1597238A1 US20070274951 US20100069442 EP1751118A1 US20090098124 US7655463 EP2259844A1 US20100209355 WO2008144767A1 WO2008027445A2 EP1888072A1 US20070122350 WO2006113909A2 WO1994017177A1 EP2260869A2 EP0904112B1 EP1569919A2 US20040045045 US20090264415 US6024976 EP1816996A1 EP1460067A1 EP1264595A1 WO2007073737A1 US5919454 US6762025 EP1958616A1 US20060142219 US6037467 US20080187515 US6911464 US20060194940 EP2247185A2 US20080220049 US20100093645 WO2009029716A1 EP2225235A2 US20060018900 WO2005069894A2 US6160018 WO1992008448A1 EP1268473A1 EP1608628A2
KEGG Ligand C07070
LINCS LSM-6655
Mcule MCULE-4392506462
Nikkaji J8.518I
PharmGKB PA450205
PubChem 26879
PubChem: Thomson Pharma 14748767 15171780
SureChEMBL SCHEMBL19227

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/HLFSDGLLUJUHTE-SNVBAGLBSA-N spacer
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