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Doc ID CHEMBL1131655
Journal Bioorg. Med. Chem. Lett. (1998) 8:691-694
Title Diimidazo[1,2-c:4',5'-e]pyrimidines: adenosine agonist activity demonstrated by microphysiometry.
Authors Camp D, Green JM, Kaiser SM, Moni RW, Townsend-Nicholson A, Schofield PR, Quinn RJ.
Abstract Silicon-based microphysiometry, measuring extracellular acidification rate of cells in culture, demonstrated that a series of diimidazo[1,2-c:4',5'-e]pyrimidines were agonists at the human adenosine A1 receptor. 5-amino-7,8-dihydro-3-ribofuranose-8-(R)-(phenyl)-3H-diimidazo [1,2-c:4',5'-e]pyrimidine (2a) had an EC50 of 100 microM and reached 90% of the Emax produced by R-PIA.
CiteXplore 9871584
DOI 10.1016/s0960-894x(98)00102-4

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