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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL930
CHEMBL930
Compound Name GLUTAMINE
ChEMBL Synonyms ENDARI | L-GLUTAMINE | GLUTAMINE | NUTRESTORE | LEVOGLUTAMIDE
Max Phase 4 (Approved)
Trade Names ENDARI | NUTRESTORE
Molecular Formula C5H10N2O3

Additional synonyms for CHEMBL930 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES N[C@@H](CCC(=O)N)C(=O)O
Standard InChI InChI=1S/C5H10N2O3/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H2,7,8 ...
Download InChI
Standard InChI Key ZDXPYRJPNDTMRX-VKHMYHEASA-N

Sources

  • BindingDB Database
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL930

Molecule Features

CHEMBL930 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Unknown Not Available FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
NeoplasmsD009369EFO:0000311cancer3ClinicalTrials
Short Bowel SyndromeD012778Orphanet:365563Primary short bowel syndrome4DailyMed
Clostridium InfectionsD003015EFO:1000874commensal Clostridium infectious disease2ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection1ClinicalTrials
Peripheral Nervous System DiseasesD010523EFO:0003100peripheral neuropathy3ClinicalTrials
Propionic AcidemiaD056693Orphanet:35Propionic acidemia1ClinicalTrials
Anemia, Sickle CellD000755Orphanet:232Sickle cell anemia3ClinicalTrials
ThalassemiaD013789EFO:1001996Thalassemia2ClinicalTrials
Fetal Growth RetardationD005317EFO:0000495fetal growth restriction3ClinicalTrials
Herpes LabialisD006560EFO:1001347Herpes Labialis2ClinicalTrials
LymphomaD008223EFO:0000574lymphoma2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma2ClinicalTrials
Muscular Dystrophy, DuchenneD020388Orphanet:98896Duchenne muscular dystrophy3ClinicalTrials
Nutrition DisordersD009748EFO:0001069nutritional disorder3ClinicalTrials
Premature BirthD047928EFO:0003917premature birth3ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma2ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma2ClinicalTrials
Diabetes MellitusD003920EFO:0000400diabetes mellitus1ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm3ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease1ClinicalTrials
Wounds and InjuriesD014947EFO:0000546injury2ClinicalTrials
Crohn DiseaseD003424EFO:0000384Crohn's disease1ClinicalTrials
DiarrheaD003967HP:0002014diarrhea3ClinicalTrials
InfectionD007239EFO:0000544infection2ClinicalTrials
Irritable Bowel SyndromeD043183EFO:0000555irritable bowel syndrome2ClinicalTrials
PeriodontitisD010518EFO:0000649periodontitis2ClinicalTrials
Diabetes Mellitus, Type 2D003924EFO:0001360type II diabetes mellitus1ClinicalTrials
SepsisD018805HP:0100806sepsis3ClinicalTrials
Colorectal NeoplasmsD015179EFO:0004142colorectal neoplasm3ClinicalTrials
Coronary Artery DiseaseD003324EFO:0000378coronary artery disease3ClinicalTrials
Cystic FibrosisD003550Orphanet:586Cystic fibrosis2ClinicalTrials
Heart FailureD006333EFO:0003144heart failure2ClinicalTrials
StomatitisD013280EFO:1001904oral mucositis3ClinicalTrials

Clinical Data

ClinicalTrials.gov GLUTAMINE
The Cochrane Collaboration GLUTAMINE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
146.2 146.0691 -1.34 4 106.41 ZWITTERION


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
3 3 0 5 5 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
2.27 9.36 -1.58 -4.08 0 10 0.46

Structural Alerts

There are 2 structural alerts for CHEMBL930. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A16 - OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16A - OTHER ALIMENTARY TRACT AND METABOLISM PRODUCTS
A16AA - Amino acids and derivatives
A16AA03 - glutamine

ChemSpider ChemSpider:ZDXPYRJPNDTMRX-VKHMYHEASA-N
DailyMed glutamine l-glutamine
PubChem SID: 26747519 SID: 50106343 SID: 90341595
Wikipedia Glutamine

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL930



ACToR 585-21-7 32640-56-5 26700-71-0
Atlas glutamine
BindingDB 18121
Brenda 145028 138052 755 102 145026 337 36640 145942 378 69708
ChEBI 58359 18050
ChemicalBook CB6280105
DrugBank DB00130
DrugCentral 1311
eMolecules 514487
EPA CompTox Dashboard DTXSID1023100
FDA SRS 0RH81L854J
Guide to Pharmacology 723 4633 4634
Human Metabolome Database HMDB0000641
IBM Patent System B4DC536DD1D18AD1BD2B1C118BC863D5
KEGG Ligand C00064
LINCS LSM-4741
Mcule MCULE-8718820108
Metabolights MTBLC18050 MTBLC58359
MolPort MolPort-001-794-053
Nikkaji J9.170G
PDBe GLN
PharmGKB PA10090
PubChem 6992086 5961
PubChem: Thomson Pharma 15297396
Recon gln_L
Rhea 58359
Selleck Glutamine
SureChEMBL SCHEMBL7453
ZINC ZINC000001532526

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/ZDXPYRJPNDTMRX-VKHMYHEASA-N spacer
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