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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL703
CHEMBL703
Compound Name SUXAMETHONIUM
ChEMBL Synonyms QUELICIN PRESERVATIVE FREE | Suxamethonium Chloride | SUXAMETHONIUM BROMIDE | Succinylcholine | SUXAMETHONE | Anectine | Quelicin | SUCCINYLCHOLINE CHLORIDE | Sucostrin | SUXAMETHONIUM | QUELICIN | ANECTINE | SCOLINE | SUCOSTRIN
Max Phase 4 (Approved)
Trade Names ANECTINE | QUELICIN | SUCCINYLCHOLINE CHLORIDE | SCOLINE | QUELICIN PRESERVATIVE FREE | Suxamethonium Chloride | SUCOSTRIN
Molecular Formula C14H30N2O4+2

Additional synonyms for CHEMBL703 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
Standard InChI InChI=1S/C14H30N2O4/c1-15(2,3)9-11-19-13(17)7-8-14(18)20-12- ...
Download InChI
Standard InChI Key AXOIZCJOOAYSMI-UHFFFAOYSA-N

Sources

  • British National Formulary
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL703

Molecule Features

CHEMBL703 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Muscle-type nicotinic acetylcholine receptor agonist Muscle-type nicotinic acetylcholine receptor ISBN

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
StrokeD020521EFO:0000712stroke3ClinicalTrials

Clinical Data

ClinicalTrials.gov SUXAMETHONIUM
The Cochrane Collaboration SUXAMETHONIUM

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL703. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL3762 Voltage-gated L-type calcium channel alpha-1C subunit Rattus norvegicus 0.990
CHEMBL4140 Epoxide hydratase Mus musculus 0.852
CHEMBL2026 Beta-lactamase AmpC Escherichia coli K-12 0.418
CHEMBL3510 Carbonic anhydrase XIV Homo sapiens 0.373
CHEMBL2001 Purinergic receptor P2Y12 Homo sapiens 0.373
CHEMBL1835 Thromboxane-A synthase Homo sapiens 0.336
CHEMBL276 Muscarinic acetylcholine receptor M1 Rattus norvegicus 0.307
CHEMBL2409 Epoxide hydratase Homo sapiens 0.258
CHEMBL3250 Lysophosphatidic acid receptor Edg-7 Homo sapiens 0.203



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL3762 Voltage-gated L-type calcium channel alpha-1C subunit Rattus norvegicus 0.995
CHEMBL4140 Epoxide hydratase Mus musculus 0.877
CHEMBL1741179 Probable DNA dC->dU-editing enzyme APOBEC-3A Homo sapiens 0.564
CHEMBL2001 Purinergic receptor P2Y12 Homo sapiens 0.488
CHEMBL1835 Thromboxane-A synthase Homo sapiens 0.395
CHEMBL2026 Beta-lactamase AmpC Escherichia coli K-12 0.307
CHEMBL2409 Epoxide hydratase Homo sapiens 0.217

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
290.4 290.2195 0.27 9 52.6 -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
4 0 0 6 0 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - -5 -5 0 20 0.45

Structural Alerts

There are 5 structural alerts for CHEMBL703. To view alerts please click here.

Compound Cross References

ATC M - MUSCULO-SKELETAL SYSTEM
M03 - MUSCLE RELAXANTS
M03A - MUSCLE RELAXANTS, PERIPHERALLY ACTING AGENTS
M03AB - Choline derivatives
M03AB01 - suxamethonium

ChemSpider ChemSpider:AXOIZCJOOAYSMI-UHFFFAOYSA-N
DailyMed succinylcholine chloride
PubChem SID: 11111825 SID: 90341285

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL703



ACToR 306-40-1
BindingDB 50061568
Brenda 36929
ChEBI 45652
DrugBank DB00202
DrugCentral 2489
EPA CompTox Dashboard DTXSID7048455
FDA SRS J2R869A8YF
Guide to Pharmacology 4004
Human Metabolome Database HMDB0014347
IBM Patent System 502DF2631FF83AABC0A26D273CF40745
KEGG Ligand C07546
Mcule MCULE-7641058357
MolPort MolPort-002-964-486
Nikkaji J11.690D
NMRShiftDB 20209097
PDBe SCK
PharmGKB PA451522
PubChem 5314
PubChem: Thomson Pharma 14873361
SureChEMBL SCHEMBL41537
ZINC ZINC000001530820

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/AXOIZCJOOAYSMI-UHFFFAOYSA-N spacer
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