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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL535650
CHEMBL535650
Compound Name MEFLOQUINE HYDROCHLORIDE
ChEMBL Synonyms Ro-215998001 | Lariam | SID56463353 | Mefloquine HCl
Max Phase 4 (Approved)
Trade Names Lariam | Mefloquine HCl
Molecular Formula C17H17ClF6N2O

Additional synonyms for CHEMBL535650 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cl.OC(C1CCCCN1)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
Standard InChI InChI=1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12 ...
Download InChI
Standard InChI Key WESWYMRNZNDGBX-UHFFFAOYSA-N

Mechanism of Action

Mechanism of Action ChEMBL Target References
Ferriprotoporphyrin IX inhibitor Ferriprotoporphyrin IX PubMed

Molecule Features

CHEMBL535650 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:Y Availability Type:Prescription-only

Clinical Trials for Compound

Number of clinical trials registered at clinicaltrials.gov

Alternate Forms of Compound in ChEMBL


CHEMBL535650

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Ro5 Violations #Rotatable Bonds Ro3 Med Chem Friendly Molecular Species
378.3 378.1167 4.3 0 4 No Yes BASE


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms Num Alerts QED Weighted
12.81 9.24 2.2 .5 2 26 1 0.78

Compound Cross References

ChemSpider ChemSpider:WESWYMRNZNDGBX-UHFFFAOYSA-N
DailyMed mefloquine hydrochloride
PubChem SID: 56463353

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL535650



eMolecules 33507316
SureChem SureCN41095
PubChem: Thomson Pharma 14806643
PubChem 44326656 441362 57516060

UniChem REST Service Call: https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/WESWYMRNZNDGBX-UHFFFAOYSA-N spacer
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