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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL525610
CHEMBL525610
Compound Name TERIPARATIDE
ChEMBL Synonyms FORSTEO | FORTEO | TERIPARATIDE | TERIPARATIDE RECOMBINANT HUMAN
Max Phase 4 (Approved)
Trade Names FORSTEO | FORTEO
Molecular Formula C181H291N55O51S2

Additional synonyms for CHEMBL525610 found using NCI Chemical Identifier Resolver

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL525610 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Parathyroid hormone receptor agonist Parathyroid hormone receptor DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
HypoparathyroidismD0070112ClinicalTrials
Hip FracturesD006620EFO:0003964hip fracture3ClinicalTrials
OsteoporosisD010024EFO:0003882osteoporosis3ClinicalTrials
Osteogenesis ImperfectaD010013Orphanet:666Osteogenesis imperfecta2ClinicalTrials
Osteoporosis, PostmenopausalD015663EFO:0003854postmenopausal osteoporosis3ClinicalTrials
Radius FracturesD011885EFO:0003957radius fracture2ClinicalTrials
OsteoarthritisD010003EFO:0002506osteoarthritis2ClinicalTrials
Osteoarthritis, KneeD020370EFO:0004616osteoarthritis, knee2ClinicalTrials
Arthropathy, NeurogenicD001177EFO:1001378neurogenic arthropathy2ClinicalTrials
Fractures, BoneD050723EFO:0003931bone fracture3ClinicalTrials
HypocalcemiaD006996HP:0002901Hypocalcemia2ClinicalTrials

Clinical Data

ClinicalTrials.gov TERIPARATIDE
The Cochrane Collaboration TERIPARATIDE

HELM Notation

CHEMBL525610 HELM Notation
PEPTIDE1{S.V.S.E.I.Q.L.M.H.N.L.G.K.H.L.N.S.M.E.R.V.E.W.L.R.K.K.L.Q.D.V.H.N.F}$$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC H - SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H05 - CALCIUM HOMEOSTASIS
H05A - PARATHYROID HORMONES AND ANALOGUES
H05AA - Parathyroid hormones and analogues
H05AA02 - teriparatide

ChemSpider ChemSpider:OGBMKVWORPGQRR-UMXFMPSGSA-N
DailyMed teriparatide recombinant human

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL525610



BindingDB 50318885
ChEBI 135983
DrugCentral 4514
IBM Patent System 560F38A8FEB981412CB05038C0A253B2
MolPort MolPort-006-167-842
PharmGKB PA451620
PubChem 16132393 132274287 91933454 129631922 16133850
PubChem: Thomson Pharma 14891346

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/OGBMKVWORPGQRR-UMXFMPSGSA-N spacer
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