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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL457547
CHEMBL457547
Compound Name MICAFUNGIN
ChEMBL Synonyms FK463 | MICAFUNGIN SODIUM | Fungard | MYCAMINE | MICAFUNGIN
Max Phase 4 (Approved)
Trade Names Fungard | MYCAMINE
Molecular Formula C56H71N9O23S

Additional synonyms for CHEMBL457547 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCCCCOc1ccc(cc1)c2onc(c2)c3ccc(cc3)C(=O)N[C@H]4C[C@@H](O)[C@ ...
Download SMILES
Standard InChI InChI=1S/C56H71N9O23S/c1-4-5-6-17-86-32-14-11-28(12-15-32)39 ...
Download InChI
Standard InChI Key PIEUQSKUWLMALL-YABMTYFHSA-N

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL457547

Molecule Features

CHEMBL457547 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
1,3-beta-glucan synthase inhibitor 1,3-beta-glucan synthase FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
InfectionD007239EFO:0000544infection3ClinicalTrials
ClinicalTrials
Hematologic DiseasesD006402HP:0001871abnormality of blood and blood-forming tissues2ClinicalTrials
CandidemiaD058387EFO:1001282Candidemia3ClinicalTrials
Candidiasis, InvasiveD058365EFO:1001283Candidiasis, Invasive3ClinicalTrials
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
Candidiasis, OralD002180EFO:0007406oral candidiasis3ClinicalTrials
NeoplasmsD009369EFO:0000311cancer1ClinicalTrials
AspergillosisD001228EFO:0007157aspergillosis3ClinicalTrials
ClinicalTrials

Clinical Data

ClinicalTrials.gov MICAFUNGIN
The Cochrane Collaboration MICAFUNGIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
1270.3 1269.4384 - - - -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
- - - - - -


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - - - - - -0

Structural Alerts

There are no structural alerts for CHEMBL457547

Compound Cross References

ATC J - ANTIINFECTIVES FOR SYSTEMIC USE
J02 - ANTIMYCOTICS FOR SYSTEMIC USE
J02A - ANTIMYCOTICS FOR SYSTEMIC USE
J02AX - Other antimycotics for systemic use
J02AX05 - micafungin

ChemSpider ChemSpider:PIEUQSKUWLMALL-YABMTYFHSA-N
DailyMed micafungin sodium

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL457547



Brenda 155389
ChEBI 600520
ChemicalBook CB71471028
DrugBank DB01141
FDA SRS R10H71BSWG
Human Metabolome Database HMDB0015272
IBM Patent System 0894FC7312973D54CA382D5204EB3EC5
Nikkaji J1.154.979I
PharmGKB PA164781026
PubChem 477468
PubChem: Thomson Pharma 16262692 14915042
SureChEMBL SCHEMBL11893279

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/PIEUQSKUWLMALL-YABMTYFHSA-N spacer
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