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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL395429
CHEMBL395429
Compound Name OXYTOCIN
ChEMBL Synonyms SYNTOMETRINE | SYNTOCINON | OXYTOCIN | PITOCIN | Orasthin
Max Phase 4 (Approved)
Trade Names PITOCIN | SYNTOMETRINE | Orasthin | OXYTOCIN | SYNTOCINON
Molecular Formula C43H66N12O12S2

Additional synonyms for CHEMBL395429 found using NCI Chemical Identifier Resolver

Sources

  • British National Formulary
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL395429 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:Y Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Oxytocin receptor agonist Oxytocin receptor FDA ISBN

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Attention Deficit Disorder with HyperactivityD001289EFO:0003888attention deficit hyperactivity disorder0ClinicalTrials
Fragile X SyndromeD005600Orphanet:908Fragile X syndrome2ClinicalTrials
Weight GainD015430EFO:0004566body weight gain2ClinicalTrials
DystociaD004420EFO:1000911dystocia3ClinicalTrials
HemorrhageD006470MP:0001914hemorrhage3ClinicalTrials
ObesityD009765EFO:0001073obesity2ClinicalTrials
Obsessive-Compulsive DisorderD009771EFO:0004242obsessive-compulsive disorder2ClinicalTrials
Autistic DisorderD001321EFO:0003758autism2ClinicalTrials
Carcinoma, Intraductal, NoninfiltratingD002285EFO:0000432ductal carcinoma in situ0ClinicalTrials
Pre-EclampsiaD011225EFO:0000668preeclampsia0ClinicalTrials
Stress Disorders, Post-TraumaticD013313EFO:0001358post-traumatic stress disorder2ClinicalTrials
Arrhythmias, CardiacD001145EFO:0004269cardiac arrhythmia0ClinicalTrials
InflammationD007249MP:0001845inflammation1ClinicalTrials
Substance Withdrawal SyndromeD013375EFO:0004777alcohol withdrawal2ClinicalTrials
AgingD000375GO:0007568aging2ClinicalTrials
Anorexia NervosaD000856EFO:0004215anorexia nervosa0ClinicalTrials
Cocaine-Related DisordersD019970EFO:0002610cocaine dependence2ClinicalTrials
Mood DisordersD019964EFO:0004247mood disorder2ClinicalTrials
Opioid-Related DisordersD009293EFO:0005611opioid dependence1ClinicalTrials
Prader-Willi SyndromeD011218Orphanet:739Prader-Willi syndrome2ClinicalTrials
Sexual Dysfunction, PhysiologicalD012735EFO:0004714sexual dysfunction2ClinicalTrials
Atrophic VaginitisD059268EFO:1001271Atrophic Vaginitis2ClinicalTrials
Depressive DisorderD003866EFO:0003761unipolar depression2ClinicalTrials
NeuralgiaD009437EFO:0005762neuropathic pain2ClinicalTrials
AlcoholismD000437EFO:0003829alcohol dependence3ClinicalTrials
Child Development Disorders, PervasiveD002659EFO:0003756autism spectrum disorder2ClinicalTrials
Frontotemporal DementiaD057180Orphanet:282Frontotemporal dementia2ClinicalTrials
GastroparesisD018589EFO:1000948gastroparesis0ClinicalTrials
Myocardial InfarctionD009203EFO:0000612myocardial infarction2ClinicalTrials
Phobia, SocialD000072861EFO:1001917social anxiety disorder2ClinicalTrials
Sleep Apnea, ObstructiveD020181EFO:0003918obstructive sleep apnea2ClinicalTrials
AtrophyD001284EFO:1000096Atrophy2ClinicalTrials
PainD010146EFO:0003843pain2ClinicalTrials
SchizophreniaD012559EFO:0000692schizophrenia3ClinicalTrials

Clinical Data

ClinicalTrials.gov OXYTOCIN
The Cochrane Collaboration OXYTOCIN

HELM Notation

CHEMBL395429 HELM Notation
PEPTIDE1{C.Y.I.Q.N.C.P.L.G.[am]}$PEPTIDE1,PEPTIDE1,6:R3-1:R3$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC H - SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01 - PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H01B - POSTERIOR PITUITARY LOBE HORMONES
H01BB - Oxytocin and analogues
H01BB02 - oxytocin

ChemSpider ChemSpider:XNOPRXBHLZRZKH-DSZYJQQASA-N
DailyMed oxytocin
PubChem SID: 50112429

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL395429



ACToR 50-56-6
BindingDB 50205990
Brenda 3838
ChEBI 7872
DrugCentral 2042
eMolecules 29548283
EPA CompTox Dashboard DTXSID8048361
Guide to Pharmacology 2176 2174
IBM Patent System 9F81BB8FE4DC7E7CAA2CEFA29A0FB582
KEGG Ligand C00746
MolPort MolPort-003-938-941
Nikkaji J1.360I
PharmGKB PA450760
PubChem 439302
PubChem: Drugs of the Future 12014072
PubChem: Thomson Pharma 14816702 14865724
SureChEMBL SCHEMBL29048

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/XNOPRXBHLZRZKH-DSZYJQQASA-N spacer
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