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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL372795
CHEMBL372795
Compound Name STREPTOMYCIN
ChEMBL Synonyms STREPTOMYCIN | NSC-14083 | STREPTOMYCIN SULFATE | Chemform | Streptorex | Agri-Strep | Vetstrep | Gerox | Strepcen
Max Phase 4 (Approved)
Trade Names Streptorex | STREPTOMYCIN SULFATE | Vetstrep | Agri-Strep
Molecular Formula C21H39N7O12

Additional synonyms for CHEMBL372795 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@H] ...
Download SMILES
Standard InChI InChI=1S/C21H39N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)1 ...
Download InChI
Standard InChI Key UCSJYZPVAKXKNQ-HZYVHMACSA-N

Sources

  • British National Formulary
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL372795

Molecule Features

CHEMBL372795 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Bacterial 70S ribosome inhibitor Bacterial 70S ribosome FDA PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
TuberculosisD014376Orphanet:3389Tuberculosis4DailyMed
TularemiaD014406EFO:1001444Tularemia4DailyMed
ChancroidD0026024DailyMed
Granuloma InguinaleD006100EFO:0007291granuloma inguinale4DailyMed
Buruli UlcerD054312EFO:1001281Buruli Ulcer2ClinicalTrials
Urinary Tract InfectionsD014552EFO:0003103urinary tract infection4DailyMed
OsteomyelitisD010019EFO:0003102osteomyelitis0ClinicalTrials
PlagueD010930EFO:0007481septicemic plague4DailyMed
ClinicalTrials
PneumoniaD011014EFO:0003106pneumonia4DailyMed
Mycobacterium avium-intracellulare InfectionD015270EFO:0007386Mycobacterium avium complex disease2ClinicalTrials

Clinical Data

ClinicalTrials.gov STREPTOMYCIN
The Cochrane Collaboration STREPTOMYCIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
581.6 581.2657 -8.16 9 336.43 BASE


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
15 12 3 19 16 3


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
11.51 10.95 -1.75 -5.65 0 40 0.07

Structural Alerts

There are 10 structural alerts for CHEMBL372795. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A07 - ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A - INTESTINAL ANTIINFECTIVES
A07AA - Antibiotics
A07AA54 - streptomycin, combinations

A - ALIMENTARY TRACT AND METABOLISM
A07 - ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A - INTESTINAL ANTIINFECTIVES
A07AA - Antibiotics
A07AA04 - streptomycin

J - ANTIINFECTIVES FOR SYSTEMIC USE
J01 - ANTIBACTERIALS FOR SYSTEMIC USE
J01G - AMINOGLYCOSIDE ANTIBACTERIALS
J01GA - Streptomycins
J01GA01 - streptomycin

ChemSpider ChemSpider:UCSJYZPVAKXKNQ-HZYVHMACSA-N
DailyMed streptomycin sulfate

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL372795



ACToR 57-92-1
BindingDB 50103513
Brenda 2358
ChEBI 17076
DrugBank DB01082
DrugCentral 2481
EPA CompTox Dashboard DTXSID4023597
FDA SRS Y45QSO73OB
Human Metabolome Database HMDB0015214
IBM Patent System 14ED5CDE2564368D7C76F637AD217D15
KEGG Ligand C00413
Metabolights MTBLC17076
Nikkaji J4.500D
PDBe SRY
PharmGKB PA451512
PubChem 19649
PubChem: Thomson Pharma 14911392 14911393
SureChEMBL SCHEMBL3276
ZINC ZINC000008214681

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/UCSJYZPVAKXKNQ-HZYVHMACSA-N spacer
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