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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL370143
CHEMBL370143
Compound Name PAROMOMYCIN
ChEMBL Synonyms HUMATIN | PAROMOMYCIN SULFATE | Aminosidine | CRESTOMYCIN SULFATE | Monomycin | AMINOSIDINE SULFATE | ESTOMYCIN SULFATE | GABBRORAL | PAROMOMYCIN
Max Phase 4 (Approved)
Trade Names HUMATIN | PAROMOMYCIN SULFATE | GABBRORAL
Molecular Formula C23H45N5O14

Additional synonyms for CHEMBL370143 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES NC[C@@H]1O[C@H](O[C@H]2[C@@H](O)[C@H](O[C@@H]3[C@@H](O)[C@H] ...
Download SMILES
Standard InChI InChI=1S/C23H45N5O14/c24-2-7-13(32)15(34)10(27)21(37-7)41-19 ...
Download InChI
Standard InChI Key UOZODPSAJZTQNH-LSWIJEOBSA-N

Sources

  • British National Formulary
  • Gene Expression Atlas Compounds
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL370143

Molecule Features

CHEMBL370143 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Bacterial 70S ribosome inhibitor Bacterial 70S ribosome DailyMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
LeishmaniasisD007896EFO:0005044Leishmaniasis3ClinicalTrials
ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection2ClinicalTrials
Leishmaniasis, CutaneousD016773EFO:0005046cutaneous Leishmaniasis3ClinicalTrials
OsteomyelitisD010019EFO:0003102osteomyelitis0ClinicalTrials
ClinicalTrials
Leishmaniasis, VisceralD007898EFO:0005045visceral Leishmaniasis3ClinicalTrials
ClinicalTrials

Clinical Data

ClinicalTrials.gov PAROMOMYCIN
The Cochrane Collaboration PAROMOMYCIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
615.6 615.2963 -8.86 9 347.32 BASE


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
19 13 3 19 18 3


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
12.93 9.52 -5.8 -11.02 0 42 0.11

Structural Alerts

There are 3 structural alerts for CHEMBL370143. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A07 - ANTIDIARRHEALS, INTESTINAL ANTIINFLAMMATORY/ANTIINFECTIVE AGENTS
A07A - INTESTINAL ANTIINFECTIVES
A07AA - Antibiotics
A07AA06 - paromomycin

ChemSpider ChemSpider:UOZODPSAJZTQNH-LSWIJEOBSA-N
DailyMed paromomycin sulfate
Wikipedia Paromomycin

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL370143



ACToR 7542-37-2 84420-34-8
Brenda 210630 2215
ChEBI 7934
DrugBank DB01421
DrugCentral 2067
eMolecules 4786830
EPA CompTox Dashboard DTXSID8023424
FDA SRS 61JJC8N5ZK
Human Metabolome Database HMDB0015490
IBM Patent System 400C369A825FD6D1E7CB2FEEC35FE54C
KEGG Ligand C00832
Mcule MCULE-1528618434
MolPort MolPort-002-510-747
Nikkaji J8.952D
PDBe PAR
PharmGKB PA164784023
PubChem 165580
PubChem: Thomson Pharma 24380735
SureChEMBL SCHEMBL4072
ZINC ZINC000060183170

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/UOZODPSAJZTQNH-LSWIJEOBSA-N spacer
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