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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL3039583
CHEMBL3039583
Compound Name PASIREOTIDE
ChEMBL Synonyms SIGNIFOR | PASIREOTIDE PAMOATE | PASIREOTIDE DIASPARTATE | PASIREOTIDE | SOM230 | SIGNIFOR LAR
Max Phase 4 (Approved)
Trade Names SIGNIFOR LAR | SIGNIFOR
Molecular Formula C58H66N10O9

Additional synonyms for CHEMBL3039583 found using NCI Chemical Identifier Resolver

Sources

  • British National Formulary
  • Orange Book
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL3039583 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Somatostatin receptor 1 agonist Somatostatin receptor 1 DailyMed DailyMed PubMed PubMed
Somatostatin receptor 2 agonist Somatostatin receptor 2 DailyMed DailyMed PubMed PubMed
Somatostatin receptor 3 agonist Somatostatin receptor 3 DailyMed DailyMed PubMed PubMed
Somatostatin receptor 5 agonist Somatostatin receptor 5 DailyMed DailyMed PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma2ClinicalTrials
Carcinoma, Intraductal, NoninfiltratingD002285EFO:0000432ductal carcinoma in situ1ClinicalTrials
NeoplasmsD009369EFO:0000311cancer2ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm2ClinicalTrials
Pituitary NeoplasmsD010911EFO:1000478Pituitary Gland Adenoma2ClinicalTrials
Postoperative ComplicationsD011183EFO:0005323post-operative sign or symptom2ClinicalTrials
Adenoma, Islet CellD007516EFO:0007331islet cell tumor2ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma2ClinicalTrials
Cushing SyndromeD003480EFO:0003099Cushing syndrome2ClinicalTrials
MeningiomaD008579Orphanet:2495Meningioma2ClinicalTrials
AdenomaD000236EFO:0000232adenoma2ClinicalTrials
Carcinoid TumorD002276EFO:0004243carcinoid tumor3ClinicalTrials
PainD010146EFO:0003843pain2ClinicalTrials
Prostatic NeoplasmsD011471EFO:0000673prostate adenocarcinoma2ClinicalTrials
Thyroid NeoplasmsD013964EFO:0002892thyroid carcinoma2ClinicalTrials
ACTH Syndrome, EctopicD000182EFO:1001256ACTH Syndrome, Ectopic2ClinicalTrials
AcromegalyD000172EFO:1001485acromegaly4ClinicalTrials
DailyMed
Carcinoma, Merkel CellD015266EFO:1001471Merkel cell skin cancer1ClinicalTrials
Hematologic NeoplasmsD019337EFO:0001642lymphoid neoplasm2ClinicalTrials
HyperglycemiaD006943HP:0003074Hyperglycemia2ClinicalTrials
Lung NeoplasmsD008175EFO:0001071lung carcinoma2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma2ClinicalTrials
Pancreatic NeoplasmsD010190EFO:0002618pancreatic carcinoma3ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma2ClinicalTrials
Small Cell Lung CarcinomaD055752EFO:0000702small cell lung carcinoma2ClinicalTrials
ThymomaD013945EFO:1000581Thymoma2ClinicalTrials
Dumping SyndromeD004377EFO:1001307dumping syndrome2ClinicalTrials
Pituitary ACTH HypersecretionD047748EFO:1001110pituitary-dependent Cushing's disease3ClinicalTrials

Clinical Data

ClinicalTrials.gov PASIREOTIDE
The Cochrane Collaboration PASIREOTIDE

HELM Notation

CHEMBL3039583 HELM Notation
PEPTIDE1{[Phg].[dW].K.[Tyr(Bzl)].F.[X1765]}$PEPTIDE1,PEPTIDE1,6:R2-1:R1$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Cross References

ATC H - SYSTEMIC HORMONAL PREPARATIONS, EXCL. SEX HORMONES AND INSULINS
H01 - PITUITARY AND HYPOTHALAMIC HORMONES AND ANALOGUES
H01C - HYPOTHALAMIC HORMONES
H01CB - Somatostatin and analogues
H01CB05 - pasireotide

ChemSpider ChemSpider:VMZMNAABQBOLAK-IXZCVAHUSA-N
DailyMed pasireotide diaspartate pasireotide pamoate

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL3039583



PubChem 73348210

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/VMZMNAABQBOLAK-IXZCVAHUSA-N spacer
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