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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1747
CHEMBL1747
Compound Name TOBRAMYCIN
ChEMBL Synonyms TYMBRINEB | VANTOBRA | BRAMITOB | AKTOB | TOBREX | Obramycin | Nebicin | Nebramycin | TOBRAVISC | TOBRALEX | NEBRIS | Tobradex ST | Tobradex | TOBRAMYCIN | NEBRAMYCIN FACTOR 6 | BETHKIS | TOBRAMYCIN SULFATE (PHARMACY BULK) | TOBI | NEBCIN | KITABIS PAK | 47663 | TOBRAMYCIN SULFATE | TOBI PODHALER
Max Phase 4 (Approved)
Trade Names AKTOB | BRAMITOB | TOBI PODHALER | TYMBRINEB | Nebramycin | Nebicin | Obramycin | TOBREX | NEBRIS | TOBRALEX | TOBRAVISC | TOBRAMYCIN SULFATE (PHARMACY BULK) | BETHKIS | TOBRAMYCIN | Tobradex | Tobradex ST | KITABIS PAK | NEBCIN | TOBI | VANTOBRA | TOBRAMYCIN SULFATE
Molecular Formula C18H37N5O9

Additional synonyms for CHEMBL1747 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O[C@H]3O[C@H ...
Download SMILES
Standard InChI InChI=1S/C18H37N5O9/c19-3-9-8(25)2-7(22)17(29-9)31-15-5(20)1 ...
Download InChI
Standard InChI Key NLVFBUXFDBBNBW-PBSUHMDJSA-N

Sources

  • British National Formulary
  • Curated Drug Pharmacokinetic Data
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1747

Molecule Features

CHEMBL1747 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:Y Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
70S ribosome inhibitor 70S ribosome FDA PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
BlepharitisD0017623ClinicalTrials
BronchiectasisD001987HP:0002110Bronchiectasis2ClinicalTrials
InflammationD007249MP:0001845inflammation3ClinicalTrials
Pneumonia, BacterialD018410EFO:1001272bacterial pneumonia2ClinicalTrials
Communicable DiseasesD003141EFO:0005741infectious disease3ClinicalTrials
Dry Eye SyndromesD015352EFO:1000906dry eye syndrome1ClinicalTrials
Cystic FibrosisD003550Orphanet:586Cystic fibrosis3ClinicalTrials
PneumoniaD011014EFO:0003106pneumonia3ClinicalTrials
Conjunctivitis, BacterialD003234EFO:1000829bacterial conjunctivitis3ClinicalTrials
InfectionD007239EFO:0000544infection3ClinicalTrials
CataractD002386EFO:0001059cataract3ClinicalTrials
OsteomyelitisD010019EFO:0003102osteomyelitis0ClinicalTrials
Pseudomonas InfectionsD011552EFO:0001076Pseudomonas infection3ClinicalTrials

Clinical Data

ClinicalTrials.gov TOBRAMYCIN
The Cochrane Collaboration TOBRAMYCIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
467.5 467.2591 -6.3 6 268.17 BASE


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
14 10 2 14 15 2


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
13.07 9.52 -4.22 -9.54 0 32 0.17

Structural Alerts

There are 2 structural alerts for CHEMBL1747. To view alerts please click here.

Compound Cross References

ATC J - ANTIINFECTIVES FOR SYSTEMIC USE
J01 - ANTIBACTERIALS FOR SYSTEMIC USE
J01G - AMINOGLYCOSIDE ANTIBACTERIALS
J01GB - Other aminoglycosides
J01GB01 - tobramycin

S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01A - ANTIINFECTIVES
S01AA - Antibiotics
S01AA12 - tobramycin

ChemSpider ChemSpider:NLVFBUXFDBBNBW-PBSUHMDJSA-N
DailyMed tobramycin tobramycin sulfate
PubChem SID: 144204177
Wikipedia Tobramycin Tobramycin/dexamethasone

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1747



ACToR 11098-01-4 32986-56-4
BindingDB 50366778
Brenda 51945 94477 939 107368 107369
ChEBI 28864
ChemicalBook CB7154445
DrugBank DB00684
DrugCentral 2684
eMolecules 36516853 3716283
EPA CompTox Dashboard DTXSID8023680
FDA SRS VZ8RRZ51VK
Human Metabolome Database HMDB0014822
IBM Patent System CF24A9D2F36255F68A42E080B6E58F8A
KEGG Ligand C00397
LINCS LSM-6534
Metabolights MTBLC28864
MolPort MolPort-003-665-548
Nikkaji J4.533K
PDBe TOY
PharmGKB PA451704
PubChem 36294
PubChem: Thomson Pharma 14931869 14760717
Selleck Tobramycin(free-base)
SureChEMBL SCHEMBL2838
ZINC ZINC000008214692

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/NLVFBUXFDBBNBW-PBSUHMDJSA-N spacer
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