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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1723
CHEMBL1723
Compound Name ALFUZOSIN HYDROCHLORIDE
ChEMBL Synonyms BENESTAN | ZUFAL XL | SL-77499-10 | URION S | XATRAL SR | KELANU XL | SL 77 499-10 | VASRAN XL | FUZATAL XL | ALFUTRAL SR | BENESTAN RET | XATRAL | ALFUZOSIN HYDROCHLORIDE | BESAVAR XL | UROXATRAL
Max Phase 4 (Approved)
Trade Names ALFUTRAL SR | ALFUZOSIN HYDROCHLORIDE | BENESTAN | BENESTAN RET | BESAVAR XL | FUZATAL XL | KELANU XL | URION S | UROXATRAL | VASRAN XL | XATRAL | XATRAL SR | ZUFAL XL
Molecular Formula C19H28ClN5O4

Additional synonyms for CHEMBL1723 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cl.COc1cc2nc(nc(N)c2cc1OC)N(C)CCCNC(=O)C3CCCO3
Standard InChI InChI=1S/C19H27N5O4.ClH/c1-24(8-5-7-21-18(25)14-6-4-9-28-14) ...
Download InChI
Standard InChI Key YTNKWDJILNVLGX-UHFFFAOYSA-N

Sources

  • British National Formulary
  • Curated Drug Pharmacokinetic Data
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names

Alternate Forms of Compound in ChEMBL


CHEMBL1723

Molecule Features

CHEMBL1723 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Adrenergic receptor alpha-1 agonist Adrenergic receptor alpha-1 DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Prostatic HyperplasiaD011470EFO:0000284benign prostatic hyperplasia4ATC
ClinicalTrials
ClinicalTrials
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
Kidney CalculiD007669EFO:0003845kidney stone3ClinicalTrials
ClinicalTrials

Clinical Data

ClinicalTrials.gov ALFUZOSIN HYDROCHLORIDE
The Cochrane Collaboration ALFUZOSIN HYDROCHLORIDE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
389.5 389.2063 1.35 8 111.83 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
8 2 0 9 3 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 8.06 1.26 .35 2 28 0.65

Structural Alerts

There are 3 structural alerts for CHEMBL1723. To view alerts please click here.

Compound Cross References

ChemSpider ChemSpider:YTNKWDJILNVLGX-UHFFFAOYSA-N
DailyMed alfuzosin hydrochloride
PubChem SID: 144204252 SID: 170465022

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1723



ACToR 81403-68-1 133880-44-1
ChEBI 32286
ChemicalBook CB8703590
eMolecules 6719554
EPA CompTox Dashboard DTXSID3045514
MolPort MolPort-006-391-851
PubChem 71764 25137863
PubChem: Drugs of the Future 12012888
PubChem: Thomson Pharma 14758527
Selleck Alfuzosin-hydrochloride
SureChEMBL SCHEMBL179910

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/YTNKWDJILNVLGX-UHFFFAOYSA-N spacer
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