ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1690
ChEMBL Synonyms Quensyl | Ercoquin | Plaquenil | Oxichlorochine | Oxichlorochine Sulfate | Hydroxychloroquine Sulfate
Max Phase 4 (Approved)
Trade Names Ercoquin | Hydroxychloroquine Sulfate | Oxichlorochine | Plaquenil | Quensyl
Molecular Formula C18H28ClN3O5S

Additional synonyms for CHEMBL1690 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12.OS(=O)(=O)O
Standard InChI InChI=1S/C18H26ClN3O.H2O4S/c1-3-22(11-12-23)10-4-5-14(2)21-1 ...
Download InChI

Mechanism of Action

Mechanism of Action ChEMBL Target References
Ferriprotoporphyrin IX inhibitor Ferriprotoporphyrin IX PubMed
Toll-like receptor 7 antagonist Toll-like receptor 7 DailyMed PubMed PubMed
Toll-like receptor 9 antagonist Toll-like receptor 9 DailyMed PubMed PubMed

Molecule Features

CHEMBL1690 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:Y Availability Type:Prescription-only

Clinical Data

Number of clinical trials registered at
Number of reviews at The Cochrane Collaboration
Number of entries at British National Formulary

Structural Alerts

There are 1 structural alerts for CHEMBL1690. To view alerts please click here.

Alternate Forms of Compound in ChEMBL


Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1690. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


ChEMBL_ID Target Name Organism Score
CHEMBL5903 Activin receptor type-1 Homo sapiens 0.682
CHEMBL2041 Tyrosine-protein kinase receptor RET Homo sapiens 0.368


ChEMBL_ID Target Name Organism Score
CHEMBL2414 C-C chemokine receptor type 4 Homo sapiens 0.995
CHEMBL5903 Activin receptor type-1 Homo sapiens 0.947
CHEMBL3241 Histamine N-methyltransferase Rattus norvegicus 0.838
CHEMBL3721 Cytochrome P450 2C8 Homo sapiens 0.703
CHEMBL2689 Macrophage-stimulating protein receptor Homo sapiens 0.330
CHEMBL1957 Insulin-like growth factor I receptor Homo sapiens 0.257
CHEMBL2041 Tyrosine-protein kinase receptor RET Homo sapiens 0.222
CHEMBL289 Cytochrome P450 2D6 Homo sapiens 0.207

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
335.9 335.1764 3.46 9 48.39 BASE

HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
4 2 0 4 2 0

ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 8.87 3.53 2 2 23 0.74

Compound Cross References

DailyMed hydroxychloroquine sulfate
PubChem SID: 144205260 SID: 26748879

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1690

ACToR 747-36-4
eMolecules 713810
Mcule MCULE-4122662001
MolPort MolPort-003-666-519
PubChem 12947
PubChem: Thomson Pharma 14881072

UniChem REST Service Call: spacer