ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Compound Report Card

Compound Name and Classification

Compound ID CHEMBL160
CHEMBL160
Compound Name CYCLOSPORINE
ChEMBL Synonyms RESTASIS | 27-400 | CAPSORIN | OPTIMMUNE | GENGRAF | DEXIMUNE | CYCLOSPORINE | CICLOSPORIN | SANDIMMUNE | NEORAL | IKERVIS | VANQUORAL | CAPIMUNE | CYCLOSPORIN A | SANGCYA | SANDIMMUN | RESTASIS MULTIDOSE
Max Phase 4 (Approved)
Trade Names CAPSORIN | DEXIMUNE | RESTASIS | OPTIMMUNE | GENGRAF | CYCLOSPORINE | NEORAL | SANDIMMUNE | IKERVIS | CAPIMUNE | VANQUORAL | RESTASIS MULTIDOSE | SANDIMMUN | SANGCYA
Molecular Formula C62H111N11O12

Additional synonyms for CHEMBL160 found using NCI Chemical Identifier Resolver

Sources

  • BindingDB Database
  • British National Formulary
  • Curated Drug Metabolism Pathways
  • Curated Drug Pharmacokinetic Data
  • DrugMatrix
  • Gene Expression Atlas Compounds
  • Harvard Malaria Screening
  • HeCaToS Compounds
  • Open TG-GATEs
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL160 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:Y Topical:Y Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Cyclophilin A modulator Cyclophilin A FDA PubMed PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Acute Kidney InjuryD058186HP:0001919Acute kidney injury2ClinicalTrials
Colorectal NeoplasmsD015179EFO:1001951colorectal carcinoma3ClinicalTrials
EczemaD004485HP:0000964Eczema3ClinicalTrials
Glomerulosclerosis, Focal SegmentalD005923EFO:0004236focal segmental glomerulosclerosis3ClinicalTrials
Leukemia, Prolymphocytic, T-CellD015461EFO:1000560T-Cell Prolymphocytic Leukemia2ClinicalTrials
NeuroblastomaD009447EFO:0000621neuroblastoma2ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma2ClinicalTrials
PterygiumD011625EFO:0000678pterygium2ClinicalTrials
Venous ThromboembolismD054556EFO:0004286venous thromboembolism1ClinicalTrials
Anemia, AplasticD000741EFO:0006927severe aplastic anemia3ClinicalTrials
Angioedemas, HereditaryD054179Orphanet:91378Hereditary angioedema1ClinicalTrials
Aortic Aneurysm, AbdominalD017544EFO:0004214Abdominal Aortic Aneurysm2ClinicalTrials
AspergillosisD001228EFO:0007157aspergillosis1ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma3ClinicalTrials
Bronchiolitis ObliteransD001989EFO:0007183bronchiolitis obliterans3ClinicalTrials
GlaucomaD005901EFO:0000516glaucoma2ClinicalTrials
Glomerulonephritis, MembranousD015433EFO:0004254membranous glomerulonephritis3ClinicalTrials
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
Leukemia, LymphoidD007945EFO:0004289lymphoid leukemia2ClinicalTrials
Leukemia, Mast-CellD007946EFO:0007359mast-cell leukemia2ClinicalTrials
Liver DiseasesD008107EFO:0001421liver disease2ClinicalTrials
Lymphohistiocytosis, HemophagocyticD051359Orphanet:158038Primary hemophagocytic lymphohistiocytosis3ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm2ClinicalTrials
PeriodontitisD010518EFO:0000649periodontitis2ClinicalTrials
AnemiaD000740EFO:0004272anemia2ClinicalTrials
DiGeorge SyndromeD004062Orphanet:56722q11.2 deletion syndrome1ClinicalTrials
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease3ClinicalTrials
Hematologic NeoplasmsD019337EFO:0001642lymphoid neoplasm2ClinicalTrials
Hepatitis, AutoimmuneD019693EFO:0005676Autoimmune Hepatitis3ClinicalTrials
Keratoconjunctivitis SiccaD007638EFO:1001001keratoconjunctivitis sicca3ClinicalTrials
Leukemia, Myelogenous, Chronic, BCR-ABL PositiveD015464EFO:0000339chronic myelogenous leukemia2ClinicalTrials
Myelodysplastic SyndromesD009190EFO:0000198myelodysplastic syndrome3ClinicalTrials
NeoplasmsD009369EFO:0000311cancer2ClinicalTrials
Skin NeoplasmsD012878EFO:0004198skin neoplasm3ClinicalTrials
Carcinoma, Renal CellD002292EFO:0002890renal carcinoma2ClinicalTrials
Death, Sudden, CardiacD016757EFO:0004278sudden cardiac arrest3ClinicalTrials
LeukemiaD007938EFO:0000565leukemia3ClinicalTrials
Leukemia, Prolymphocytic, B-CellD054403EFO:1000102B-Cell Prolymphocytic Leukemia2ClinicalTrials
Pulmonary Disease, Chronic ObstructiveD029424EFO:0000341chronic obstructive pulmonary disease1ClinicalTrials
RetinoblastomaD012175Orphanet:790Retinoblastoma2ClinicalTrials
beta-ThalassemiaD017086Orphanet:848Beta-thalassemia1ClinicalTrials
Dry Eye SyndromesD015352EFO:1000906dry eye syndrome3ClinicalTrials
Fanconi AnemiaD005199Orphanet:84Fanconi anemia1ClinicalTrials
Hepatitis C, ChronicD019698EFO:0004220Chronic Hepatitis C infection3ClinicalTrials
Hyperlipoproteinemia Type ID008072Orphanet:309015Familial lipoprotein lipase deficiency2ClinicalTrials
InfectionD007239EFO:0000544infection3ClinicalTrials
Leukemia, Lymphocytic, Chronic, B-CellD015451EFO:0000095chronic lymphocytic leukemia2ClinicalTrials
Leukemia, Myeloid, AcuteD015470EFO:0000222acute myeloid leukemia3ClinicalTrials
Lung DiseasesD008171EFO:0003818lung disease2ClinicalTrials
Lymphoma, Non-HodgkinD008228EFO:0005952non-Hodgkins lymphoma3ClinicalTrials
MelanomaD008545EFO:0000389cutaneous melanoma2ClinicalTrials
MucopolysaccharidosesD009083Orphanet:79213Mucopolysaccharidosis1ClinicalTrials
UrticariaD014581EFO:0005531urticaria1ClinicalTrials
Wounds and InjuriesD014947EFO:0000546injury1ClinicalTrials
Anemia, AplasticD000741HP:0001915aplastic anemia3ClinicalTrials
Anemia, Sickle CellD000755Orphanet:232Sickle cell anemia1ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma3ClinicalTrials
DermatomyositisD003882EFO:0000557juvenile dermatomyositis3ClinicalTrials
Granulomatous Disease, ChronicD006105Orphanet:379Chronic granulomatous disease2ClinicalTrials
Heart DiseasesD006331EFO:0003777heart disease3ClinicalTrials
Hodgkin DiseaseD006689EFO:0000183Hodgkins lymphoma3ClinicalTrials
Lymphoma, AIDS-RelatedD016483EFO:1001365Lymphoma, AIDS-Related2ClinicalTrials
Osteogenesis ImperfectaD010013Orphanet:666Osteogenesis imperfecta1ClinicalTrials
Precursor Cell Lymphoblastic Leukemia-LymphomaD054198EFO:0000220acute lymphoblastic leukemia3ClinicalTrials
PsoriasisD011565EFO:0000676psoriasis3ClinicalTrials
SarcomaD012509EFO:0000691sarcoma2ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis3ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma2ClinicalTrials
Conjunctivitis, AllergicD003233EFO:0007141allergic conjunctivitis3ClinicalTrials
Cystitis, InterstitialD018856EFO:1000869chronic interstitial cystitis2ClinicalTrials
Diabetes Mellitus, Type 1D003922EFO:0001359type I diabetes mellitus3ClinicalTrials
Epidermolysis BullosaD004820EFO:1000690epidermolysis bullosa2ClinicalTrials
Hepatitis CD006526EFO:0003047hepatitis C infection2ClinicalTrials
LeprosyD007918EFO:0001054leprosy2ClinicalTrials
Optic Atrophy, Hereditary, LeberD029242Orphanet:104Leber hereditary optic neuropathy2ClinicalTrials
Purpura, Thrombocytopenic, IdiopathicD016553EFO:0007160autoimmune thrombocytopenic purpura3ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease3ClinicalTrials
Dermatitis, AtopicD003876EFO:0000274atopic eczema3ClinicalTrials
Diabetes MellitusD003920EFO:0000400diabetes mellitus2ClinicalTrials
HIV InfectionsD015658EFO:0000764HIV infection2ClinicalTrials
Lupus NephritisD008181EFO:0005761lupus nephritis3ClinicalTrials
LymphomaD008223EFO:0000574lymphoma2ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma2ClinicalTrials
Myocardial InfarctionD009203EFO:0000612myocardial infarction3ClinicalTrials
Paraparesis, Tropical SpasticD015493EFO:0007527tropical spastic paraparesis2ClinicalTrials
Stevens-Johnson SyndromeD013262EFO:0004276Stevens-Johnson syndrome3ClinicalTrials

Clinical Data

ClinicalTrials.gov CYCLOSPORINE
The Cochrane Collaboration CYCLOSPORINE

Metabolites for CHEMBL160

Open in full screen

HELM Notation

CHEMBL160 HELM Notation
PEPTIDE1{[meL].[meV].[X1670].[Abu].[Sar].[meL].V.[meL].A.[dA].[meL]}$PEPTIDE1,PEPTIDE1,11:R2-1:R1$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01X - OTHER OPHTHALMOLOGICALS
S01XA - Other ophthalmologicals
S01XA18 - ciclosporin

L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AD - Calcineurin inhibitors
L04AD01 - ciclosporin

ChemSpider ChemSpider:PMATZTZNYRCHOR-CGLBZJNRSA-N
DailyMed cyclosporine
PubChem SID: 11532934 SID: 144204218 SID: 144212166 SID: 170466812 SID: 26757675 SID: 56422786
Wikipedia Ciclosporin

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL160



ACToR 59865-13-3 55126-45-9
Atlas cyclosporine A ciclosporin
BindingDB 50022815
Brenda 88208 170708
ChEBI 4031
ChemicalBook CB5163816
DrugBank DB00091
DrugCentral 760
eMolecules 496010
EPA CompTox Dashboard DTXSID0020365
FDA SRS 83HN0GTJ6D
Guide to Pharmacology 1024
LINCS LSM-42883
Metabolights MTBLC4031
MolPort MolPort-006-705-994
Nikkaji J34.321H
PubChem 5284373
PubChem: Drugs of the Future 12013381
PubChem: Thomson Pharma 14817127 14817125
SureChEMBL SCHEMBL4442

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/PMATZTZNYRCHOR-CGLBZJNRSA-N spacer
spacer