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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1308
CHEMBL1308
Compound Name FOMEPIZOLE
ChEMBL Synonyms ANTIZOL | 4-METHYLPYRAZOLE | FOMEPIZOLE | 4-MP | 4-Methylpyrazole Hydrochloride
Max Phase 4 (Approved)
Trade Names ANTIZOL | FOMEPIZOLE
Molecular Formula C4H6N2

Additional synonyms for CHEMBL1308 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cc1cn[nH]c1
Standard InChI InChI=1S/C4H6N2/c1-4-2-5-6-3-4/h2-3H,1H3,(H,5,6)
Standard InChI Key RIKMMFOAQPJVMX-UHFFFAOYSA-N

Sources

  • Curated Drug Metabolism Pathways
  • DrugMatrix
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1308

Molecule Features

CHEMBL1308 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Alcohol dehydrogenase class I inhibitor Alcohol dehydrogenase class I DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Macular DegenerationD008268EFO:0001365age-related macular degeneration1ClinicalTrials

Clinical Data

ClinicalTrials.gov FOMEPIZOLE
The Cochrane Collaboration FOMEPIZOLE

Metabolites for CHEMBL1308

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Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
82.1 82.0531 0.72 0 28.68 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
1 1 0 2 1 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 3.35 1.1 1.1 1 6 0.49

Structural Alerts

There are no structural alerts for CHEMBL1308

Compound Cross References

ATC V - VARIOUS
V03 - ALL OTHER THERAPEUTIC PRODUCTS
V03A - ALL OTHER THERAPEUTIC PRODUCTS
V03AB - Antidotes
V03AB34 - fomepizole

ChemSpider ChemSpider:RIKMMFOAQPJVMX-UHFFFAOYSA-N
DailyMed fomepizole
PubChem SID: 11111426 SID: 50111124 SID: 90341211
Wikipedia Fomepizole

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1308



ACToR 7554-65-6
Brenda 2464 174510
ChEBI 5141
ChemicalBook CB8233079
DrugBank DB01213
DrugCentral 1233
eMolecules 489528
EPA CompTox Dashboard DTXSID3040649
FDA SRS 83LCM6L2BY
Human Metabolome Database HMDB0015344
IBM Patent System BED73606773F7448D8403509C1FDB838 6FCED09F5A5C0C1447291222543EF978 B0C9E8B0B69901487F4980D4158B49D1
KEGG Ligand C07837
LINCS LSM-5671
Mcule MCULE-2732751720
MolPort MolPort-016-633-159
Nikkaji J35.396E
PDBe 4PZ
PharmGKB PA449697
PubChem 3406
PubChem: Thomson Pharma 15170375
SureChEMBL SCHEMBL10591
ZINC ZINC000000897288

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/RIKMMFOAQPJVMX-UHFFFAOYSA-N spacer
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