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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1252
CHEMBL1252
Compound Name ABARELIX
ChEMBL Synonyms ABARELIX | R3827 | R-3827 | PPI-149 | Plenaxis
Max Phase 4 (Approved)
Trade Names PLENAXIS
Molecular Formula C72H95ClN14O14

Additional synonyms for CHEMBL1252 found using NCI Chemical Identifier Resolver

Sources

  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1252 compound icon
Drug Type:Oligopeptide Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Discontinued

Mechanism of Action

Mechanism of Action ChEMBL Target References
Gonadotropin-releasing hormone receptor antagonist Gonadotropin-releasing hormone receptor FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
NEOPLASMSD009369EFO:0000616NEOPLASM4ATC
PROSTATIC NEOPLASMSD011471EFO:0001663PROSTATE CARCINOMA3ClinicalTrials

Clinical Data

ClinicalTrials.gov ABARELIX
The Cochrane Collaboration ABARELIX

HELM Notation

CHEMBL1252 HELM Notation
PEPTIDE1{[ac].[dNal].[dPhe(4-Cl)].[d3-Pal].S.[meY].[dN].L.[X4].P.[dA].[am]}$$$$

The ChEMBL HELM monomer library is available to download here.

For more details about HELM Notation, please visit the HELM Homepage.

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L02 - ENDOCRINE THERAPY
L02B - HORMONE ANTAGONISTS AND RELATED AGENTS
L02BX - Other hormone antagonists and related agents
L02BX01 - abarelix

ChemSpider ChemSpider:AIWRTTMUVOZGPW-HSPKUQOVSA-N
Wikipedia Abarelix

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1252



ACToR 183552-38-7
BindingDB 50102442
ChEBI 337298
DrugCentral 35
EPA CompTox Dashboard DTXSID20171443
FDA SRS W486SJ5824
Guide to Pharmacology 1188
IBM Patent System 984BF04A754C502C3543FEEFA0786877
Nikkaji J1.401.931F
PharmGKB PA164754915
PubChem 16131215
PubChem: Drugs of the Future 12015126
PubChem: Thomson Pharma 14768525 14915219
SureChEMBL SCHEMBL9533

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/AIWRTTMUVOZGPW-HSPKUQOVSA-N spacer
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