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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201828
CHEMBL1201828
Compound Name ECULIZUMAB
ChEMBL Synonyms SOLIRIS | 5G1.1 | H5G1.1VHC+H5G1.1VLC | H5G1.1 | ECULIZUMAB
Max Phase 4 (Approved)
Trade Names SOLIRIS

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201828 compound icon
Drug Type:Antibody Rule of Five:N First In Class:Y Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Complement C5 inhibitor Complement C5 DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
ThrombocytopeniaD013921HP:0001873thrombocytopenia2ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease2ClinicalTrials
Anti-Neutrophil Cytoplasmic Antibody-Associated VasculitisD056648EFO:0004826anti-neutrophil antibody associated vasculitis2ClinicalTrials
Atypical Hemolytic Uremic SyndromeD065766Orphanet:2134Atypical hemolytic-uremic syndrome4ClinicalTrials
DailyMed
Diabetes MellitusD003920EFO:0000400diabetes mellitus2ClinicalTrials
Neuromyelitis OpticaD009471EFO:0004256neuromyelitis optica3ClinicalTrials
AsthmaD001249EFO:0000270asthma2ClinicalTrials
Hemoglobinuria, ParoxysmalD006457Orphanet:447Paroxysmal nocturnal hemoglobinuria4ClinicalTrials
DailyMed
DermatomyositisD003882EFO:0000398dermatomyositis2ClinicalTrials
Glomerulonephritis, MembranoproliferativeD015432Orphanet:93571Dense deposit disease1ClinicalTrials
Guillain-Barre SyndromeD020275EFO:0007292Guillain-Barre syndrome2ClinicalTrials
Macular DegenerationD008268EFO:0001365age-related macular degeneration2ClinicalTrials
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease1ClinicalTrials
LeukemiaD007938EFO:0000565leukemia3ClinicalTrials
Myasthenia GravisD009157EFO:0004991Myasthenia gravis3ClinicalTrials

Clinical Data

ClinicalTrials.gov ECULIZUMAB
The Cochrane Collaboration ECULIZUMAB

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AA - Selective immunosuppressants
L04AA25 - eculizumab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed eculizumab
Wikipedia Eculizumab
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