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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201798
CHEMBL1201798
Compound Name SEVELAMER
ChEMBL Synonyms SEVELAMER | GT335-012 | RENVELA | RENAGEL | Sevelamer carbonate
Max Phase 4 (Approved)
Trade Names RENVELA | RENAGEL
Molecular Formula C6H12ClNO

Additional synonyms for CHEMBL1201798 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES NCC=C.ClCC1CO1
Standard InChI InChI=1S/C3H5ClO.C3H7N/c4-1-3-2-5-3;1-2-3-4/h3H,1-2H2;2H,1,3 ...
Download InChI
Standard InChI Key ZNSIZMQNQCNRBW-UHFFFAOYSA-N

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1201798

Molecule Features

CHEMBL1201798 compound icon
Drug Type:Polymer Rule of Five:N First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Unknown Not Available FDA

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
HIV InfectionsD015658EFO:0000180HIV-1 infection2ClinicalTrials
Renal Insufficiency, ChronicD051436EFO:0003884chronic kidney disease4ClinicalTrials
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
Diabetic NephropathiesD003928EFO:0000401diabetic nephropathy2ClinicalTrials

Clinical Data

ClinicalTrials.gov SEVELAMER
The Cochrane Collaboration SEVELAMER

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
149.6 149.0607 - - - -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
- - - - - -


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - - - - - -0

Structural Alerts

There are no structural alerts for CHEMBL1201798

Compound Cross References

ATC V - VARIOUS
V03 - ALL OTHER THERAPEUTIC PRODUCTS
V03A - ALL OTHER THERAPEUTIC PRODUCTS
V03AE - Drugs for treatment of hyperkalemia and hyperphosphatemia
V03AE02 - sevelamer

ChemSpider ChemSpider:ZNSIZMQNQCNRBW-UHFFFAOYSA-N
DailyMed sevelamer carbonate

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1201798



ACToR 52757-95-6 198342-66-4
DrugBank DB00658
PharmGKB PA164781197
PubChem 3085017
PubChem: Thomson Pharma 15194705
SureChEMBL SCHEMBL726092

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/ZNSIZMQNQCNRBW-UHFFFAOYSA-N spacer
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