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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201607
CHEMBL1201607
Compound Name NATALIZUMAB
ChEMBL Synonyms ANTEGRAN | NATALIZUMAB | AN100226M | TYSABRI
Max Phase 4 (Approved)
Trade Names TYSABRI

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201607 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Integrin alpha-4/beta-1 inhibitor Integrin alpha-4/beta-1 DailyMed
Integrin alpha-4/beta-7 inhibitor Integrin alpha-4/beta-7 DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Multiple MyelomaD009101EFO:0001378multiple myeloma1ClinicalTrials
SchizophreniaD012559EFO:0000692schizophrenia1ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis2ClinicalTrials
Multiple SclerosisD009103EFO:0003885multiple sclerosis4ClinicalTrials
DailyMed
FDA
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease2ClinicalTrials
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
Crohn DiseaseD003424EFO:0000384Crohn's disease4ClinicalTrials
DailyMed
FDA
Multiple Sclerosis, Chronic ProgressiveD020528EFO:0003840chronic progressive multiple sclerosis3ClinicalTrials
Multiple Sclerosis, Relapsing-RemittingD020529EFO:0003929relapsing-remitting multiple sclerosis3ClinicalTrials
Myositis, Inclusion BodyD018979EFO:0007323inclusion body myositis1ClinicalTrials

Clinical Data

ClinicalTrials.gov NATALIZUMAB
The Cochrane Collaboration NATALIZUMAB

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AA - Selective immunosuppressants
L04AA23 - natalizumab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed natalizumab
Wikipedia Natalizumab
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