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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201581
CHEMBL1201581
Compound Name INFLIXIMAB
ChEMBL Synonyms REMSIMA | INFLECTRA | INFLIXIMAB | cA2 | REMICADE
Max Phase 4 (Approved)
Trade Names REMICADE | REMSIMA | INFLECTRA

Sources

  • British National Formulary
  • Clinical Candidates
  • Manually Added Drugs
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201581 compound icon
Drug Type:Antibody Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
TNF-alpha inhibitor TNF-alpha DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
BerylliosisD001607EFO:0007168berylliosis1ClinicalTrials
ColitisD003092EFO:0003872colitis2ClinicalTrials
Giant Cell ArteritisD013700EFO:1001209temporal arteritis2ClinicalTrials
Immune System DiseasesD007154EFO:0000540immune system disease4ATC
Inflammatory Bowel DiseasesD015212EFO:0003767inflammatory bowel disease3ClinicalTrials
Pulmonary Disease, Chronic ObstructiveD029424EFO:0000341chronic obstructive pulmonary disease3ClinicalTrials
Reperfusion InjuryD015427EFO:0002687ischemia reperfusion injury2ClinicalTrials
Diabetes Mellitus, Type 1D003922EFO:0001359type I diabetes mellitus2ClinicalTrials
Graft vs Host DiseaseD006086EFO:0004599acute graft vs. host disease3ClinicalTrials
MelanomaD008545EFO:0000756melanoma1ClinicalTrials
MyositisD009220EFO:0000783myositis2ClinicalTrials
Paraparesis, Tropical SpasticD015493EFO:0007527tropical spastic paraparesis2ClinicalTrials
Stevens-Johnson SyndromeD013262EFO:0004775toxic epidermal necrolysis2ClinicalTrials
Arthritis, ReactiveD016918EFO:0007460reactive arthritis2ClinicalTrials
Arthritis, RheumatoidD001172EFO:0000685rheumatoid arthritis4ClinicalTrials
DailyMed
EndometriosisD004715EFO:0001065endometriosis2ClinicalTrials
Granulomatosis with PolyangiitisD014890EFO:0005297Wegener's granulomatosis2ClinicalTrials
OsteoarthritisD010003EFO:0002506osteoarthritis2ClinicalTrials
SarcoidosisD012507Orphanet:797Sarcoidosis3ClinicalTrials
Spondylitis, AnkylosingD013167EFO:0003898ankylosing spondylitis4ClinicalTrials
DailyMed
Arthritis, PsoriaticD015535EFO:0003778psoriatic arthritis4ClinicalTrials
DailyMed
Behcet SyndromeD001528EFO:0003780Behcet's syndrome3ClinicalTrials
Hepatitis CD006526EFO:0003047hepatitis C infection2ClinicalTrials
Microscopic PolyangiitisD055953EFO:1000784microscopic polyangiitis2ClinicalTrials
PolymyositisD017285EFO:0003063polymyositis2ClinicalTrials
ScleritisD0154232ClinicalTrials
Bipolar DisorderD001714EFO:0000289bipolar disorder2ClinicalTrials
Colitis, UlcerativeD003093EFO:0000729ulcerative colitis4ClinicalTrials
DailyMed
Hepatitis C, ChronicD019698EFO:0004220Chronic Hepatitis C infection3ClinicalTrials
DermatomyositisD003882EFO:0000398dermatomyositis2ClinicalTrials
Diabetic RetinopathyD003930EFO:0003770diabetic retinopathy3ClinicalTrials
Hidradenitis SuppurativaD017497EFO:1000710hidradenitis suppurativa2ClinicalTrials
Mucocutaneous Lymph Node SyndromeD009080EFO:0004246mucocutaneous lymph node syndrome3ClinicalTrials
PemphigusD010392EFO:0004719pemphigus vulgaris2ClinicalTrials
Arthritis, JuvenileD001171EFO:0002609chronic childhood arthritis3ClinicalTrials
Crohn DiseaseD003424EFO:0000384Crohn's disease4ClinicalTrials
DailyMed
Eosinophilic EsophagitisD057765EFO:0004232eosinophilic esophagitis2ClinicalTrials
Myelodysplastic SyndromesD009190EFO:0000198myelodysplastic syndrome2ClinicalTrials
SpondylarthropathiesD025242EFO:0000706spondyloarthropathy2ClinicalTrials
Depressive DisorderD003866EFO:0003761unipolar depression1ClinicalTrials
ParapsoriasisD010267EFO:1000747parapsoriasis3ClinicalTrials
PsoriasisD011565EFO:0000676psoriasis4ClinicalTrials
DailyMed

Clinical Data

ClinicalTrials.gov INFLIXIMAB
The Cochrane Collaboration INFLIXIMAB

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L04 - IMMUNOSUPPRESSANTS
L04A - IMMUNOSUPPRESSANTS
L04AB - Tumor necrosis factor alpha (TNF-α) inhibitors
L04AB02 - infliximab

ChemSpider ChemSpider Identifier not yet assigned
DailyMed infliximab
Wikipedia Infliximab
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