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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201535
CHEMBL1201535
Compound Name PHENYLPROPANOLAMINE POLISTIREX
ChEMBL Synonyms PHENYLPROPANOLAMINE POLISTIREX
Max Phase 4 (Approved)
Withdrawn Yes
Trade Names

Sources

  • Orange Book
  • USP Dictionary of USAN and International Drug Names
  • Withdrawn Drugs

Molecule Features

CHEMBL1201535 compound icon
Drug Type:Polymer Rule of Five:N First In Class:N Chirality:Racemic Mixture Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Withdrawn

Withdrawal Information

Year 2002
Country United States
Reason Increased risk of hemorrhagic stroke
Class Neurotoxicity

Mechanism of Action

Mechanism of Action ChEMBL Target References
Alpha-1a adrenergic receptor agonist Alpha-1a adrenergic receptor PubMed
Norepinephrine transporter releasing agent Norepinephrine transporter PubMed

Clinical Data

ClinicalTrials.gov PHENYLPROPANOLAMINE POLISTIREX
The Cochrane Collaboration PHENYLPROPANOLAMINE POLISTIREX

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1201535. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL286 Renin Homo sapiens 0.972
CHEMBL238 Dopamine transporter Homo sapiens 0.889
CHEMBL222 Norepinephrine transporter Homo sapiens 0.883
CHEMBL2590 Aminopeptidase N Sus scrofa 0.813
CHEMBL3399910 Probable G-protein coupled receptor 88 Homo sapiens 0.656
CHEMBL246 Beta-3 adrenergic receptor Homo sapiens 0.537
CHEMBL1907 Aminopeptidase N Homo sapiens 0.448
CHEMBL4027 Neurokinin 1 receptor Rattus norvegicus 0.237
CHEMBL289 Cytochrome P450 2D6 Homo sapiens 0.212



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL2590 Aminopeptidase N Sus scrofa 0.995
CHEMBL286 Renin Homo sapiens 0.964
CHEMBL238 Dopamine transporter Homo sapiens 0.900
CHEMBL222 Norepinephrine transporter Homo sapiens 0.868
CHEMBL246 Beta-3 adrenergic receptor Homo sapiens 0.501
CHEMBL3399910 Probable G-protein coupled receptor 88 Homo sapiens 0.500
CHEMBL1907 Aminopeptidase N Homo sapiens 0.493
CHEMBL228 Serotonin transporter Homo sapiens 0.362
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 0.236
CHEMBL243 Human immunodeficiency virus type 1 protease Human immunodeficiency virus 1 0.215

Compound Cross References

ChemSpider ChemSpider Identifier not yet assigned
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