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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1201420
CHEMBL1201420
Compound Name UROKINASE
ChEMBL Synonyms ABBOKINASE | UKIDAN | KINLYTIC | UROKINASE
Max Phase 4 (Approved)
Trade Names UKIDAN | KINLYTIC | ABBOKINASE

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL1201420 compound icon
Drug Type:Enzyme Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Discontinued

Mechanism of Action

Mechanism of Action ChEMBL Target References
Plasminogen activator Plasminogen DailyMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Myocardial InfarctionD009203EFO:0000612myocardial infarction2ClinicalTrials
ThrombosisD013927HP:0004419Recurrent thrombophlebitis4ATC
InfectionD007239EFO:0000544infection3ClinicalTrials
EmpyemaD004653EFO:0003097empyema3ClinicalTrials
Pulmonary EmbolismD011655EFO:0003827pulmonary embolism2ClinicalTrials

Clinical Data

ClinicalTrials.gov UROKINASE
The Cochrane Collaboration UROKINASE

Biological Sequence

Description Sequence
Urokinase-type plasminogen activator precursor MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLMSPCWVISATHCFIDYPKKEDYIVYLG RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR SHTKEENGLAL

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC B - BLOOD AND BLOOD FORMING ORGANS
B01 - ANTITHROMBOTIC AGENTS
B01A - ANTITHROMBOTIC AGENTS
B01AD - Enzymes
B01AD04 - urokinase

ChemSpider ChemSpider Identifier not yet assigned
Wikipedia Urokinase
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