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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200951
CHEMBL1200951
Compound Name FLUPHENAZINE ENANTHATE
ChEMBL Synonyms PROLIXIN | FLUPHENAZINE | FLUPHENAZINE ENANTATE | FLUPHENAZINE MALEATE | PROLIXIN ENANTHATE | MODITEN ENANT | FLUPHENAZINE ENANTHATE
Max Phase 4 (Approved)
Trade Names PROLIXIN ENANTHATE | MODITEN ENANT | PROLIXIN
Molecular Formula C29H38F3N3O2S

Additional synonyms for CHEMBL1200951 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CCCCCCC(=O)OCCN1CCN(CCCN2c3ccccc3Sc4ccc(cc24)C(F)(F)F)CC1
Standard InChI InChI=1S/C29H38F3N3O2S/c1-2-3-4-5-11-28(36)37-21-20-34-18-16 ...
Download InChI
Standard InChI Key LRWSFOSWNAQHHW-UHFFFAOYSA-N

Sources

  • British National Formulary
  • Orange Book
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names

Alternate Forms of Compound in ChEMBL


CHEMBL1200951

Molecule Features

CHEMBL1200951 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:N First In Class:N Chirality:Achiral Molecule Prodrug:Y Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Discontinued

Mechanism of Action

Mechanism of Action ChEMBL Target References
Dopamine D2 receptor antagonist Dopamine D2 receptor PubMed PubMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Psychotic DisordersD011618EFO:0005407psychosis4ATC
SchizophreniaD012559EFO:0000692schizophrenia3ClinicalTrials
DementiaD003704HP:0000726dementia3ClinicalTrials
AnxietyD001007EFO:0005230anxiety3ClinicalTrials
Depressive DisorderD003866EFO:0003761unipolar depression3ClinicalTrials
PsoriasisD011565EFO:0000676psoriasis2ClinicalTrials

Clinical Data

ClinicalTrials.gov FLUPHENAZINE ENANTHATE
The Cochrane Collaboration FLUPHENAZINE ENANTHATE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1200951. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL231 Histamine H1 receptor Homo sapiens 1.000
CHEMBL2035 Muscarinic acetylcholine receptor M5 Homo sapiens 1.000
CHEMBL217 Dopamine D2 receptor Homo sapiens 1.000
CHEMBL273 Serotonin 1a (5-HT1a) receptor Rattus norvegicus 1.000
CHEMBL315 Alpha-1b adrenergic receptor Rattus norvegicus 1.000
CHEMBL322 Serotonin 2a (5-HT2a) receptor Rattus norvegicus 1.000
CHEMBL216 Muscarinic acetylcholine receptor M1 Homo sapiens 1.000
CHEMBL276 Muscarinic acetylcholine receptor M1 Rattus norvegicus 0.999
CHEMBL287 Sigma opioid receptor Homo sapiens 0.994
CHEMBL339 Dopamine D2 receptor Rattus norvegicus 0.993
CHEMBL1821 Muscarinic acetylcholine receptor M4 Homo sapiens 0.990
CHEMBL3762 Voltage-gated L-type calcium channel alpha-1C subunit Rattus norvegicus 0.990
CHEMBL1942 Alpha-2b adrenergic receptor Homo sapiens 0.984
CHEMBL3155 Serotonin 7 (5-HT7) receptor Homo sapiens 0.929
CHEMBL1867 Alpha-2a adrenergic receptor Homo sapiens 0.914
CHEMBL289 Cytochrome P450 2D6 Homo sapiens 0.839
CHEMBL4931 3-beta-hydroxysteroid-delta(8),delta(7)-isomerase Homo sapiens 0.751
CHEMBL1850 Dopamine D5 receptor Homo sapiens 0.738
CHEMBL3223 Serotonin 7 (5-HT7) receptor Rattus norvegicus 0.628
CHEMBL225 Serotonin 2c (5-HT2c) receptor Homo sapiens 0.560



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL231 Histamine H1 receptor Homo sapiens 1.000
CHEMBL276 Muscarinic acetylcholine receptor M1 Rattus norvegicus 1.000
CHEMBL217 Dopamine D2 receptor Homo sapiens 1.000
CHEMBL273 Serotonin 1a (5-HT1a) receptor Rattus norvegicus 1.000
CHEMBL315 Alpha-1b adrenergic receptor Rattus norvegicus 1.000
CHEMBL322 Serotonin 2a (5-HT2a) receptor Rattus norvegicus 1.000
CHEMBL3459 Serotonin 1b (5-HT1b) receptor Rattus norvegicus 0.999
CHEMBL2035 Muscarinic acetylcholine receptor M5 Homo sapiens 0.999
CHEMBL3762 Voltage-gated L-type calcium channel alpha-1C subunit Rattus norvegicus 0.999
CHEMBL339 Dopamine D2 receptor Rattus norvegicus 0.996
CHEMBL1941 Histamine H2 receptor Homo sapiens 0.992
CHEMBL216 Muscarinic acetylcholine receptor M1 Homo sapiens 0.983
CHEMBL5131 Trypanothione reductase Trypanosoma cruzi 0.968
CHEMBL287 Sigma opioid receptor Homo sapiens 0.953
CHEMBL3155 Serotonin 7 (5-HT7) receptor Homo sapiens 0.922
CHEMBL1942 Alpha-2b adrenergic receptor Homo sapiens 0.891
CHEMBL1867 Alpha-2a adrenergic receptor Homo sapiens 0.773
CHEMBL1821 Muscarinic acetylcholine receptor M4 Homo sapiens 0.769
CHEMBL1850 Dopamine D5 receptor Homo sapiens 0.713
CHEMBL224 Serotonin 2a (5-HT2a) receptor Homo sapiens 0.627

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
549.7 549.2637 6.83 12 36.02 NEUTRAL


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
6 0 2 5 0 2


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- 7.32 7.29 7.01 2 38 0.21

Structural Alerts

There are 5 structural alerts for CHEMBL1200951. To view alerts please click here.

Compound Cross References

ATC N - NERVOUS SYSTEM
N05 - PSYCHOLEPTICS
N05A - ANTIPSYCHOTICS
N05AB - Phenothiazines with piperazine structure
N05AB02 - fluphenazine

ChemSpider ChemSpider:LRWSFOSWNAQHHW-UHFFFAOYSA-N

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200951



ACToR 2746-81-8
ChEBI 5125
DrugCentral 1214
EPA CompTox Dashboard DTXSID6023070
FDA SRS QSB34YF0W9
IBM Patent System DAFE0AE0CC7958DBFF05828EE5A7F901
KEGG Ligand C07955
Nikkaji J7.903K
PubChem 3389
PubChem: Thomson Pharma 15359019
SureChEMBL SCHEMBL120793
ZINC ZINC000022446649

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/LRWSFOSWNAQHHW-UHFFFAOYSA-N spacer
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