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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200633
CHEMBL1200633
Compound Name IVERMECTIN
ChEMBL Synonyms IVERMECTIN | SKLICE | Ivomec | Cardomec | Heartguard | Eqvalan | IVERMECTIN COMPONENT B1A | Mectizan | SOOLANTRA | STROMECTOL
Max Phase 4 (Approved)
Trade Names SOOLANTRA | STROMECTOL | Eqvalan | Mectizan | Ivomec | SKLICE | IVERMECTIN | Cardomec | Heartguard
Molecular Formula C95H146O28

Additional synonyms for CHEMBL1200633 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES CC[C@H](C)[C@H]1O[C@]2(CC[C@@H]1C)C[C@@H]3C[C@@H](C\C=C(/C)\ ...
Download SMILES
Standard InChI InChI=1S/C48H74O14.C47H72O14/c1-11-25(2)43-28(5)17-18-47(62- ...
Download InChI
Standard InChI Key SPBDXSGPUHCETR-JFUDTMANSA-N

Sources

  • British National Formulary
  • DrugMatrix
  • Orange Book
  • Scientific Literature
  • TP-search Transporter Database
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1200633

Molecule Features

CHEMBL1200633 compound icon
Drug Type:Unknown Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:N Oral:Y Parenteral:N Topical:Y Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Glutamate-gated chloride channel modulator Glutamate-gated chloride channel FDA ISBN PubMed
Glutamate-gated chloride channel modulator Glutamate-gated chloride channel FDA ISBN PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
MalariaD008288EFO:0001068malaria3ClinicalTrials
RosaceaD012393EFO:1000760rosacea3ClinicalTrials
AlcoholismD000437EFO:0003829alcohol dependence1ClinicalTrials
OnchocerciasisD009855EFO:0007402onchocerciasis3ClinicalTrials
Severe DengueD019595EFO:0004227Dengue Hemorrhagic Fever2ClinicalTrials
StrongyloidiasisD013322EFO:0007501strongyloidiasis3ClinicalTrials
Elephantiasis, FilarialD004605EFO:0007272filarial elephantiasis2ClinicalTrials
InfectionD007239EFO:0000544infection1ClinicalTrials
BlepharitisD0017623ClinicalTrials
DengueD003715EFO:0005547dengue disease2ClinicalTrials

Clinical Data

ClinicalTrials.gov IVERMECTIN
The Cochrane Collaboration IVERMECTIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
1736.2 1735.0001 - - - -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
- - - - - -


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - - - - - -0

Structural Alerts

There are no structural alerts for CHEMBL1200633

Compound Cross References

ATC P - ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS
P02 - ANTHELMINTICS
P02C - ANTINEMATODAL AGENTS
P02CF - Avermectines
P02CF01 - ivermectin

D - DERMATOLOGICALS
D11 - OTHER DERMATOLOGICAL PREPARATIONS
D11A - OTHER DERMATOLOGICAL PREPARATIONS
D11AX - Other dermatologicals
D11AX22 - ivermectin

ChemSpider ChemSpider:SPBDXSGPUHCETR-JFUDTMANSA-N
DailyMed ivermectin

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200633



PubChem 9812710
PubChem: Thomson Pharma 16898720 14768765
SureChEMBL SCHEMBL44294

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/SPBDXSGPUHCETR-JFUDTMANSA-N spacer
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