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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1200412
CHEMBL1200412
Compound Name NANDROLONE PHENPROPIONATE
ChEMBL Synonyms NORTESTOSTERONE PHENYLPROPIONATE | NORANDROSTENOLONE PHENYLPROPIONATE | NORTESTOSTERONE FURANPROPIONATE | NANDROLONE PHENYLPROPIONATE | NANDROLONE PHENPROPIONATE | DURABOLIN
Max Phase 4 (Approved)
Trade Names NANDROLONE PHENPROPIONATE | DURABOLIN
Molecular Formula C27H34O3

Additional synonyms for CHEMBL1200412 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES C[C@]12CC[C@H]3[C@@H](CCC4=CC(=O)CC[C@H]34)[C@@H]1CC[C@@H]2O ...
Download SMILES
Standard InChI InChI=1S/C27H34O3/c1-27-16-15-22-21-11-9-20(28)17-19(21)8-10 ...
Download InChI
Standard InChI Key UBWXUGDQUBIEIZ-QNTYDACNSA-N

Sources

  • British National Formulary
  • Orange Book
  • PubChem BioAssays
  • USP Dictionary of USAN and International Drug Names

Alternate Forms of Compound in ChEMBL


CHEMBL1200412

Molecule Features

CHEMBL1200412 compound icon
Drug Type:Natural Product-derived Rule of Five:N First In Class:N Chirality:Single Stereoisomer Prodrug:Y Oral:N Parenteral:Y Topical:N Black Box:N Availability Type:Discontinued

Mechanism of Action

Mechanism of Action ChEMBL Target References
Androgen Receptor agonist Androgen Receptor PubMed PubMed PubMed

Clinical Data

ClinicalTrials.gov NANDROLONE PHENPROPIONATE
The Cochrane Collaboration NANDROLONE PHENPROPIONATE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1200412. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL1856 Steroid 5-alpha-reductase 2 Homo sapiens 1.000
CHEMBL1787 Steroid 5-alpha-reductase 1 Homo sapiens 1.000
CHEMBL1871 Androgen Receptor Homo sapiens 1.000
CHEMBL3072 Androgen Receptor Rattus norvegicus 1.000
CHEMBL1978 Cytochrome P450 19A1 Homo sapiens 0.999
CHEMBL3559 Steryl-sulfatase Homo sapiens 0.998
CHEMBL3456 Progesterone receptor Oryctolagus cuniculus 0.996
CHEMBL233 Mu opioid receptor Homo sapiens 0.991
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 0.971
CHEMBL4261 Hypoxia-inducible factor 1 alpha Homo sapiens 0.948
CHEMBL3056 Androgen Receptor Mus musculus 0.935
CHEMBL237 Kappa opioid receptor Homo sapiens 0.818
CHEMBL4681 Aldo-keto-reductase family 1 member C3 Homo sapiens 0.654
CHEMBL208 Progesterone receptor Homo sapiens 0.402
CHEMBL2034 Glucocorticoid receptor Homo sapiens 0.313



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL1856 Steroid 5-alpha-reductase 2 Homo sapiens 1.000
CHEMBL1787 Steroid 5-alpha-reductase 1 Homo sapiens 1.000
CHEMBL1871 Androgen Receptor Homo sapiens 1.000
CHEMBL3072 Androgen Receptor Rattus norvegicus 1.000
CHEMBL4430 Cytochrome P450 17A1 Rattus norvegicus 0.998
CHEMBL3394 Tubulin beta chain Bos taurus 0.998
CHEMBL1978 Cytochrome P450 19A1 Homo sapiens 0.998
CHEMBL3456 Progesterone receptor Oryctolagus cuniculus 0.996
CHEMBL233 Mu opioid receptor Homo sapiens 0.994
CHEMBL3559 Steryl-sulfatase Homo sapiens 0.986
CHEMBL3056 Androgen Receptor Mus musculus 0.979
CHEMBL237 Kappa opioid receptor Homo sapiens 0.971
CHEMBL3746 11-beta-hydroxysteroid dehydrogenase 2 Homo sapiens 0.954
CHEMBL1697668 Solute carrier organic anion transporter family member 1B1 Homo sapiens 0.934
CHEMBL236 Delta opioid receptor Homo sapiens 0.481
CHEMBL340 Cytochrome P450 3A4 Homo sapiens 0.481
CHEMBL2034 Glucocorticoid receptor Homo sapiens 0.474
CHEMBL3251 Nuclear factor NF-kappa-B p105 subunit Homo sapiens 0.411
CHEMBL3522 Cytochrome P450 17A1 Homo sapiens 0.321
CHEMBL3368 Glucocorticoid receptor Rattus norvegicus 0.301

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
406.6 406.2508 5.67 4 43.37 -


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
3 0 1 3 0 1


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
- - 6 6 1 30 0.6

Structural Alerts

There are 3 structural alerts for CHEMBL1200412. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A14 - ANABOLIC AGENTS FOR SYSTEMIC USE
A14A - ANABOLIC STEROIDS
A14AB - Estren derivatives
A14AB01 - nandrolone

S - SENSORY ORGANS
S01 - OPHTHALMOLOGICALS
S01X - OTHER OPHTHALMOLOGICALS
S01XA - Other ophthalmologicals
S01XA11 - nandrolone

ChemSpider ChemSpider:UBWXUGDQUBIEIZ-QNTYDACNSA-N
PubChem SID: 144206893 SID: 170465193

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1200412



ACToR 62-90-8
ChEBI 7468
ChemicalBook CB3680120
DrugBank DB00984
DrugCentral 1882
eMolecules 3716108
EPA CompTox Dashboard DTXSID2023353
FDA SRS KF7Z9K2T3W
Human Metabolome Database HMDB0015119
IBM Patent System 7B712E042FE12FB900DE5E549B3DF793
KEGG Ligand C08155
Nikkaji J8.621E
PubChem 229455
PubChem: Thomson Pharma 14830847
SureChEMBL SCHEMBL8443
ZINC ZINC000003881613

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/UBWXUGDQUBIEIZ-QNTYDACNSA-N spacer
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