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ChEMBL

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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL11359
CHEMBL11359
Compound Name CISPLATIN
ChEMBL Synonyms CISPLATIN | PLATINOL | CIS-DDP | PLATINOL-AQ | CIS-PLATINUM II
Max Phase 4 (Approved)
Trade Names PLATINOL-AQ | PLATINOL | CISPLATIN
Molecular Formula H6Cl2N2Pt+2

Sources

  • British National Formulary
  • Orange Book
  • PubChem BioAssays
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Molecule Features

CHEMBL11359 compound icon
Drug Type:Inorganic Rule of Five:N First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:N Parenteral:Y Topical:N Black Box:Y Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
DNA inhibitor DNA FDA ISBN

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
AdenocarcinomaD000230EFO:0000228adenocarcinoma3ClinicalTrials
Carcinoma, Non-Small-Cell LungD002289EFO:0003060non-small cell lung carcinoma3ClinicalTrials
CholangiocarcinomaD018281EFO:1001961intrahepatic cholangiocarcinoma3ClinicalTrials
Colorectal NeoplasmsD015179EFO:0005842colorectal cancer3ClinicalTrials
Lymphoma, T-Cell, PeripheralD016411EFO:0000211unspecified peripheral T-cell lymphoma2ClinicalTrials
NauseaD009325EFO:0006911Chemotherapy-induced nausea and vomiting2ClinicalTrials
Ureteral NeoplasmsD014516EFO:0003844ureteral neoplasm2ClinicalTrials
Urinary Bladder NeoplasmsD001749EFO:0000294bladder tumor3ClinicalTrials
EpendymomaD004806EFO:1000028ependymoma3ClinicalTrials
GliomaD005910EFO:0000326central nervous system cancer3ClinicalTrials
MalariaD008288EFO:0001068malaria3ClinicalTrials
MelanomaD008545EFO:0000389cutaneous melanoma3ClinicalTrials
MelanomaD008545EFO:0000756melanoma3ClinicalTrials
NeoplasmsD009369EFO:0000311cancer3ClinicalTrials
NeoplasmsD009369EFO:0000616neoplasm3ClinicalTrials
Testicular NeoplasmsD013736EFO:0004281testicular neoplasm3ClinicalTrials
Urinary Bladder NeoplasmsD001749EFO:0000292bladder carcinoma3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000708squamous cell lung carcinoma3ClinicalTrials
Gallbladder NeoplasmsD005706EFO:0004606gallbladder neoplasm3ClinicalTrials
Mouth NeoplasmsD009062EFO:0003868mouth neoplasm2ClinicalTrials
Ovarian NeoplasmsD010051EFO:0001075ovarian carcinoma3ClinicalTrials
Penile NeoplasmsD010412EFO:1001094penile neoplasm2ClinicalTrials
RetinoblastomaD012175Orphanet:790Retinoblastoma3ClinicalTrials
SarcomaD012509EFO:1001968soft tissue sarcoma3ClinicalTrials
Testicular NeoplasmsD013736EFO:0005088testicular carcinoma3ClinicalTrials
Urethral NeoplasmsD014523EFO:0003846urethral neoplasm3ClinicalTrials
Urogenital NeoplasmsD014565EFO:0003863urogenital neoplasm3ClinicalTrials
Anus NeoplasmsD001005EFO:0003835anal neoplasm3ClinicalTrials
Breast NeoplasmsD001943EFO:0000305breast carcinoma3ClinicalTrials
Carcinoma, HepatocellularD006528EFO:0000182hepatocellular carcinoma3ClinicalTrials
Carcinoma, Renal CellD002292EFO:0000681renal cell carcinoma2ClinicalTrials
Colorectal NeoplasmsD015179EFO:0004142colorectal neoplasm3ClinicalTrials
Digestive System DiseasesD004066EFO:0000405digestive system disease2ClinicalTrials
Endometrial NeoplasmsD016889EFO:0004230endometrial neoplasm3ClinicalTrials
Inflammatory Breast NeoplasmsD058922EFO:1000984inflammatory breast carcinoma3ClinicalTrials
LeukemiaD007938EFO:0000565leukemia2ClinicalTrials
Liver DiseasesD008107EFO:0001421liver disease1ClinicalTrials
Lymphoma, Non-HodgkinD008228EFO:0005952non-Hodgkins lymphoma2ClinicalTrials
MelanomaD008545EFO:0002617metastatic melanoma3ClinicalTrials
Neoplasms, Germ Cell and EmbryonalD009373EFO:0000514germ cell tumor3ClinicalTrials
NeuroblastomaD009447EFO:0000621neuroblastoma3ClinicalTrials
OsteosarcomaD012516EFO:0000637osteosarcoma3ClinicalTrials
Prostatic NeoplasmsD011471EFO:0001663prostate carcinoma2ClinicalTrials
Salivary Gland NeoplasmsD012468EFO:0003826salivary gland neoplasm2ClinicalTrials
SarcomaD012509EFO:0000691sarcoma3ClinicalTrials
Stomach NeoplasmsD013274EFO:0000503gastric adenocarcinoma3ClinicalTrials
Triple Negative Breast NeoplasmsD064726EFO:0005537triple-negative breast cancer2ClinicalTrials
Uterine Cervical NeoplasmsD002583EFO:0001061cervical carcinoma3ClinicalTrials
Uterine NeoplasmsD014594EFO:0003859uterine neoplasm3ClinicalTrials
CarcinomaD002277EFO:0000313carcinoma3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000707squamous cell carcinoma3ClinicalTrials
Gestational Trophoblastic DiseaseD031901Orphanet:59305Gestational trophoblastic neoplasm3ClinicalTrials
Head and Neck NeoplasmsD006258EFO:0006859head and neck malignant neoplasia3ClinicalTrials
Hodgkin DiseaseD006689EFO:0000183Hodgkins lymphoma3ClinicalTrials
Leukemia, Biphenotypic, AcuteD015456EFO:0000209T-cell acute lymphoblastic leukemia2ClinicalTrials
LymphomaD008223EFO:0000574lymphoma3ClinicalTrials
Lymphoma, Large-Cell, AnaplasticD017728EFO:0003032anaplastic large cell lymphoma2ClinicalTrials
MesotheliomaD008654EFO:0000588mesothelioma3ClinicalTrials
Multiple MyelomaD009101EFO:0001378multiple myeloma3ClinicalTrials
Pleural EffusionD0109963ClinicalTrials
Stomach NeoplasmsD013274EFO:0000178gastric carcinoma3ClinicalTrials
Stomach NeoplasmsD013274EFO:0003897stomach neoplasm3ClinicalTrials
Adrenocortical CarcinomaD018268EFO:0003093adrenocortical carcinoma3ClinicalTrials
Biliary Tract NeoplasmsD001661EFO:0003891biliary tract neoplasm3ClinicalTrials
Carcinoma, Squamous CellD002294EFO:0000181head and neck squamous cell carcinoma3ClinicalTrials
Immunoblastic LymphadenopathyD007119EFO:0000255angioimmunoblastic T-cell lymphoma2ClinicalTrials
Laryngeal NeoplasmsD007822EFO:0003817laryngeal neoplasm2ClinicalTrials
Lung NeoplasmsD008175EFO:0001071lung carcinoma3ClinicalTrials
Lymphoma, AIDS-RelatedD016483EFO:1001365Lymphoma, AIDS-Related2ClinicalTrials
Lymphoma, Mantle-CellD020522EFO:1001469Mantle cell lymphoma3ClinicalTrials
Nasopharyngeal NeoplasmsD009303EFO:0004252nasopharyngeal neoplasm3ClinicalTrials
Ovarian NeoplasmsD010051EFO:0003893ovarian neoplasm3ClinicalTrials
ThymomaD013945EFO:1000581Thymoma2ClinicalTrials
Uterine Cervical NeoplasmsD002583EFO:0001416cervical adenocarcinoma3ClinicalTrials
Breast NeoplasmsD001943EFO:0003869breast neoplasm3ClinicalTrials
Carcinoma, Merkel CellD015266EFO:1001471Merkel cell skin cancer1ClinicalTrials
Carcinoma, Renal CellD002292EFO:0002890renal carcinoma2ClinicalTrials
CholangiocarcinomaD018281EFO:0005221cholangiocarcinoma3ClinicalTrials
Choroid Plexus NeoplasmsD016545EFO:0007206choroid plexus cancer3ClinicalTrials
Esophageal NeoplasmsD004938EFO:0005922esophageal squamous cell carcinoma3ClinicalTrials
HepatoblastomaD018197EFO:1000292Hepatoblastoma3ClinicalTrials
Lymphoma, FollicularD008224EFO:0000096neoplasm of mature B-cells1ClinicalTrials
Lymphoma, Large B-Cell, DiffuseD016403EFO:0000403diffuse large B-cell lymphoma3ClinicalTrials
Neuroectodermal Tumors, PrimitiveD018242EFO:0005235primitive neuroectodermal tumor3ClinicalTrials
Oropharyngeal NeoplasmsD009959EFO:1001931oropharynx cancer3ClinicalTrials
Thyroid NeoplasmsD013964EFO:0002892thyroid carcinoma1ClinicalTrials
Vulvar NeoplasmsD014846EFO:0002921vulvar carcinoma3ClinicalTrials
Carcinoma, Pancreatic DuctalD021441EFO:0002517pancreatic ductal adenocarcinoma2ClinicalTrials
Esophageal NeoplasmsD004938EFO:0002916esophageal carcinoma3ClinicalTrials
Gallbladder NeoplasmsD005706EFO:1001956gallbladder carcinoma3ClinicalTrials
Head and Neck NeoplasmsD006258EFO:0004284upper aerodigestive tract neoplasm3ClinicalTrials
MedulloblastomaD008527EFO:0002939medulloblastoma3ClinicalTrials
MesotheliomaD008654EFO:0000770malignant pleural mesothelioma3ClinicalTrials
Pancreatic NeoplasmsD010190EFO:0002618pancreatic carcinoma3ClinicalTrials
Small Cell Lung CarcinomaD055752EFO:0000702small cell lung carcinoma3ClinicalTrials
StomatitisD0132803ClinicalTrials
Thymus NeoplasmsD013953EFO:0002626thymus neoplasm3ClinicalTrials
Tongue NeoplasmsD014062EFO:0003871tongue neoplasm2ClinicalTrials

Clinical Data

ClinicalTrials.gov CISPLATIN
The Cochrane Collaboration CISPLATIN

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Compound Cross References

ATC L - ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
L01 - ANTINEOPLASTIC AGENTS
L01X - OTHER ANTINEOPLASTIC AGENTS
L01XA - Platinum compounds
L01XA01 - cisplatin

ChemSpider ChemSpider Identifier not yet assigned
DailyMed cisplatin
PubChem SID: 17389100 SID: 301178 SID: 50105439 SID: 557830 SID: 90340859
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