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ChEMBL Statistics
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Compound Report Card

Compound Name and Classification

Compound ID CHEMBL1073
CHEMBL1073
Compound Name GLIPIZIDE
ChEMBL Synonyms GLIPIZIDE | MINODIAB 2.5 | K 4024 | GLUCOTROL XL | GLIBENESE | GLUCOTROL | MINODIAB 5 | CP-28,720
Max Phase 4 (Approved)
Trade Names GLUCOTROL XL | MINODIAB 5 | GLIBENESE | GLIPIZIDE | MINODIAB 2.5 | GLUCOTROL
Molecular Formula C21H27N5O4S

Additional synonyms for CHEMBL1073 found using NCI Chemical Identifier Resolver

Compound Representations

Molfile Download MolFile
Canonical SMILES Cc1cnc(cn1)C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
Standard InChI InChI=1S/C21H27N5O4S/c1-15-13-24-19(14-23-15)20(27)22-12-11- ...
Download InChI
Standard InChI Key ZJJXGWJIGJFDTL-UHFFFAOYSA-N

Sources

  • AstraZeneca Deposited Data
  • British National Formulary
  • DrugMatrix
  • Gene Expression Atlas Compounds
  • Orange Book
  • PubChem BioAssays
  • Scientific Literature
  • USP Dictionary of USAN and International Drug Names
  • WHO Anatomical Therapeutic Chemical Classification

Alternate Forms of Compound in ChEMBL


CHEMBL1073

Molecule Features

CHEMBL1073 compound icon
Drug Type:Synthetic Small Molecule Rule of Five:Y First In Class:N Chirality:Achiral Molecule Prodrug:N Oral:Y Parenteral:N Topical:N Black Box:N Availability Type:Prescription-only

Mechanism of Action

Mechanism of Action ChEMBL Target References
Sulfonylurea receptor 1, Kir6.2 blocker Sulfonylurea receptor 1, Kir6.2 DailyMed PubMed

Indications

MESH Heading MESH ID EFO ID EFO Term Max phase for indication References
Diabetes Mellitus, Type 2D003924EFO:0001360type II diabetes mellitus4ClinicalTrials
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
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DailyMed
DailyMed
DailyMed
DailyMed
DailyMed
AtherosclerosisD050197EFO:0003914atherosclerosis3ClinicalTrials
Diabetes MellitusD003920EFO:0000400diabetes mellitus4ATC
ClinicalTrials

Clinical Data

ClinicalTrials.gov GLIPIZIDE
The Cochrane Collaboration GLIPIZIDE

Compound Bioactivity Summary

Compound Assay Summary

Compound Target Summary

Target Predictions

The two tables below display ChEMBL single-protein targets which are predicted to interact with CHEMBL1073. A 1uM and 10 uM cut-off have been applied to ChEMBL bioactivity data used to generate the respective models and the yellow coloured rows correspond to genuine predictions, i.e. targets not included in the original training set for this compound.


1uM


ChEMBL_ID Target Name Organism Score
CHEMBL2069 Thromboxane A2 receptor Homo sapiens 1.000
CHEMBL2409 Epoxide hydratase Homo sapiens 0.997
CHEMBL218 Cannabinoid CB1 receptor Homo sapiens 0.964
CHEMBL2026 Beta-lactamase AmpC Escherichia coli K-12 0.507
CHEMBL3510 Carbonic anhydrase XIV Homo sapiens 0.454
CHEMBL261 Carbonic anhydrase I Homo sapiens 0.289
CHEMBL333 Matrix metalloproteinase-2 Homo sapiens 0.247



10uM


ChEMBL_ID Target Name Organism Score
CHEMBL2069 Thromboxane A2 receptor Homo sapiens 0.998
CHEMBL2409 Epoxide hydratase Homo sapiens 0.996
CHEMBL218 Cannabinoid CB1 receptor Homo sapiens 0.962
CHEMBL2026 Beta-lactamase AmpC Escherichia coli K-12 0.772
CHEMBL333 Matrix metalloproteinase-2 Homo sapiens 0.616
CHEMBL261 Carbonic anhydrase I Homo sapiens 0.328
CHEMBL5857 Trace amine-associated receptor 1 Homo sapiens 0.234

Calculated Compound Parent Properties

Mol. Weight Mol. Weight Monoisotopic ALogP #Rotatable Bonds Polar Surface Area Molecular Species
445.6 445.1784 2.08 7 130.15 ACID


HBA HBD #Ro5 Violations HBA (Lipinski) HBD (Lipinski) #Ro5 Violations (Lipinski)
6 3 0 9 3 0


ACD Acidic pKa ACD Basic pKa ACD LogP ACD LogD pH7.4 Aromatic Rings Heavy Atoms QED Weighted
5.08 1.33 1.88 .05 2 31 0.6

Structural Alerts

There are 1 structural alerts for CHEMBL1073. To view alerts please click here.

Compound Cross References

ATC A - ALIMENTARY TRACT AND METABOLISM
A10 - DRUGS USED IN DIABETES
A10B - BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
A10BB - Sulfonylureas
A10BB07 - glipizide

ChemSpider ChemSpider:ZJJXGWJIGJFDTL-UHFFFAOYSA-N
DailyMed glipizide
PubChem SID: 11111214 SID: 11112714 SID: 144203707 SID: 144212151 SID: 170465089 SID: 50104189 SID: 56422485 SID: 855947
Wikipedia Glipizide

UniChem Cross References

View the UniChem Connectivity matches for CHEMBL1073



ACToR 172964-66-8 29094-61-9
Atlas glipizide
BindingDB 50012956
Brenda 88880
ChEBI 5384
ChemicalBook CB9185001
DrugBank DB01067
DrugCentral 1301
eMolecules 496510 27520373
EPA CompTox Dashboard DTXSID0040676
FDA SRS X7WDT95N5C
Guide to Pharmacology 6821
Human Metabolome Database HMDB0015200
IBM Patent System CE1B63EBB2A2B28BC7704184EF08D24F
LINCS LSM-2251
Mcule MCULE-5142805548
MolPort MolPort-002-885-830
NIH Clinical Collection SAM002564210
Nikkaji J20.336J
PharmGKB PA449762
PubChem 3478
PubChem: Thomson Pharma 14906210
Selleck Glipizide(Glucotrol)
SureChEMBL SCHEMBL17094
ZINC ZINC000000537795

UniChem REST Service Call:
https://www.ebi.ac.uk/unichem/rest/verbose_inchikey/ZJJXGWJIGJFDTL-UHFFFAOYSA-N spacer
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