20/chembl/api/data/target_component?limit=20&offset=2012856O090281PROTEINGamma-aminobutyric acid receptor subunit piGO:0003674GO:0005575GO:0005886GO:0006810GO:0016020GO:0022857GO:0055085Rattus norvegicus1173MSYSLYLAFVCLNLLAQRMCIQGNQFNVEVSRSDKLSLPGFENLTAGYNKFLRPNFGGDPVRIALTLDIASISSISESNMDYTATIYLRQRWTDPRLVFEGNKSFTLDARLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVTCNMDLSKYPMDTQTCKLQLESWGYDGNDVEFSWLRGNDSVRGLENLRLAQYTIQQYFTLVTVSQQETGNYTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLESVPARTCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAVKDRGPAKDSEEVNITNIINSSISSFKRKISFASIEISGDNVNYSDLTMKASDKFKFVFREKIGRIIDYFTIQNPSNVDRYSKLLFPLIFMLANVFYWAYYMYFGABA(A) receptor subunit piUNIPROTGABAAR subunit piUNIPROTGabrpGENE_SYMBOLGamma-aminobutyric acid receptor subunit piUNIPROTO09028AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0016324apical plasma membraneGoComponentGO:0034707chloride channel complexGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1902711GABA-A receptor complexGoComponentGO:0004890GABA-A receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005254chloride channel activityGoFunctionGO:0022851GABA-gated chloride ion channel activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0006821chloride transportGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:1902476chloride transmembrane transportGoProcessIPR006028GABAA/Glycine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR008100GABAAp_rcptInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProIPR047032GABAAR_pi_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamO09028Gamma-aminobutyric acid receptor subunit piUniProtCHEMBL1907607CHEMBL209668310116P027082PROTEINAcetylcholine receptor subunit alphaGO:0003674GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0034330GO:0040007GO:0043167GO:0050877GO:0055085Homo sapiens422MEPWPLLLLFSLCSAGLVLGSEHETRLVAKLFKDYSSVVRPVEDHRQVVEVTVGLQLIQLINVDEVNQIVTTNVRLKQQWVDYNLKWNPDDYGGVKKIHIPSEKIWRPDLVLYNNADGDFAIVKFTKVLLQYTGHITWTPPAIFKSYCEIIVTHFPFDEQNCSMKLGTWTYDGSVVAINPESDQPDLSNFMESGEWVIKESRGWKHSVTYSCCPDTPYLDITYHFVMQRLPLYFIVNVIIPCLLFSFLTGLVFYLPTDSGEKMTLSISVLLSLTVFLLVIVELIPSTSSAVPLIGKYMLFTMVFVIASIIITVIVINTHHRSPSTHVMPNWVRKVFIDTIPNIMFFSTMKRPSREKQDKKIFTEDIDISDISGKPGPPPMGFHSPLIKHPEVKSAIEGIKYIAETMKSDQESNNAAAEWKYVAMVMDHILLGVFMLVCIIGTLAVFAGRLIELNQQGAcetylcholine receptor subunit alphaUNIPROTACHRAGENE_SYMBOL_OTHERCHNRAGENE_SYMBOL_OTHERCHRNA1GENE_SYMBOLP02708AlphaFoldDBP02708ExpressionAtlasGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0031594neuromuscular junctionGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006812monoatomic cation transportGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007274neuromuscular synaptic transmissionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0019228neuronal action potentialGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0048630skeletal muscle tissue growthGoProcessGO:0050881musculoskeletal movementGoProcessGO:0050905neuromuscular processGoProcessGO:0051899membrane depolarizationGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessHGNC:1955CHRNA1HGNCP02708IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHER4ZJSPDB5HBTPDB4ZJSAPDBe5HBTAPDBePF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPA26487cholinergic receptor nicotinic alpha 1 subunitPharmGKBP02708PharosR-HSA-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-HSA-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeB4DRV6Acetylcholine receptor subunit alphaUniProtD3DPE8Acetylcholine receptor subunit alphaUniProtP02708Acetylcholine receptor subunit alphaUniProtCHEMBL4808CHEMBL1907588CHEMBL2362997CHEMBL3038458CHEMBL3038459CHEMBL3885508CHEMBL4106145CHEMBL45241339606P046373PROTEINCellular tumor antigen p53GO:0002376GO:0003677GO:0003682GO:0003729GO:0005102GO:0005515GO:0005575GO:0005634GO:0005654GO:0005730GO:0005737GO:0005739GO:0005783GO:0005815GO:0005829GO:0005856GO:0005975GO:0006091GO:0006259GO:0006914GO:0006950GO:0007005GO:0007165GO:0008134GO:0008150GO:0008152GO:0008219GO:0008283GO:0009056GO:0009790GO:0019899GO:0019904GO:0030154GO:0030234GO:0030674GO:0040007GO:0042802GO:0043065GO:0043167GO:0044281GO:0046677GO:0046982GO:0048646GO:0048856GO:0050790GO:0050821GO:0051276GO:0061024GO:0065003Homo sapiens12MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSDAntigen NY-CO-13UNIPROTCellular tumor antigen p53UNIPROTP53GENE_SYMBOL_OTHERPhosphoprotein p53UNIPROTTP53GENE_SYMBOLTumor suppressor p53UNIPROTP04637AlphaFoldDBP04637ExpressionAtlasGO:0000785chromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005657replication forkGoComponentGO:0005667transcription regulator complexGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0016363nuclear matrixGoComponentGO:0016604nuclear bodyGoComponentGO:0016605PML bodyGoComponentGO:0017053transcription repressor complexGoComponentGO:0032991protein-containing complexGoComponentGO:0035861site of double-strand breakGoComponentGO:0043073germ cell nucleusGoComponentGO:0000976transcription cis-regulatory region bindingGoFunctionGO:0000977RNA polymerase II transcription regulatory region sequence-specific DNA bindingGoFunctionGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingGoFunctionGO:0000987cis-regulatory region sequence-specific DNA bindingGoFunctionGO:0001046core promoter sequence-specific DNA bindingGoFunctionGO:0001094TFIID-class transcription factor complex bindingGoFunctionGO:0002020protease bindingGoFunctionGO:0002039p53 bindingGoFunctionGO:0003677DNA bindingGoFunctionGO:0003682chromatin bindingGoFunctionGO:0003730mRNA 3'-UTR bindingGoFunctionGO:0005507copper ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0008270zinc ion bindingGoFunctionGO:0019899enzyme bindingGoFunctionGO:0030971receptor tyrosine kinase bindingGoFunctionGO:0031625ubiquitin protein ligase bindingGoFunctionGO:0035033histone deacetylase regulator activityGoFunctionGO:0036310ATP-dependent DNA/DNA annealing activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0042826histone deacetylase bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046982protein heterodimerization activityGoFunctionGO:0051087protein-folding chaperone bindingGoFunctionGO:0051721protein phosphatase 2A bindingGoFunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingGoFunctionGO:007188914-3-3 protein bindingGoFunctionGO:0097371MDM2/MDM4 family protein bindingGoFunctionGO:0097718disordered domain specific bindingGoFunctionGO:0140296general transcription initiation factor bindingGoFunctionGO:0140693molecular condensate scaffold activityGoFunctionGO:1990841promoter-specific chromatin bindingGoFunctionGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000423mitophagyGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0001756somitogenesisGoProcessGO:0001836release of cytochrome c from mitochondriaGoProcessGO:0002244hematopoietic progenitor cell differentiationGoProcessGO:0002309T cell proliferation involved in immune responseGoProcessGO:0002326B cell lineage commitmentGoProcessGO:0002360T cell lineage commitmentGoProcessGO:0002931response to ischemiaGoProcessGO:0006289nucleotide-excision repairGoProcessGO:0006302double-strand break repairGoProcessGO:0006914autophagyGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0006977DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestGoProcessGO:0006978DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorGoProcessGO:0006979response to oxidative stressGoProcessGO:0006983ER overload responseGoProcessGO:0007179transforming growth factor beta receptor signaling pathwayGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0007369gastrulationGoProcessGO:0007405neuroblast proliferationGoProcessGO:0007406negative regulation of neuroblast proliferationGoProcessGO:0007417central nervous system developmentGoProcessGO:0007507heart developmentGoProcessGO:0007623circadian rhythmGoProcessGO:0008104protein localizationGoProcessGO:0008156negative regulation of DNA replicationGoProcessGO:0008283cell population proliferationGoProcessGO:0008285negative regulation of cell population proliferationGoProcessGO:0008340determination of adult lifespanGoProcessGO:0009651response to salt stressGoProcessGO:0009792embryo development ending in birth or egg hatchingGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010659cardiac muscle cell apoptotic processGoProcessGO:0010666positive regulation of cardiac muscle cell apoptotic processGoProcessGO:0014009glial cell proliferationGoProcessGO:0016032viral processGoProcessGO:0019661glucose catabolic process to lactate via pyruvateGoProcessGO:0021549cerebellum developmentGoProcessGO:0030308negative regulation of cell growthGoProcessGO:0030330DNA damage response, signal transduction by p53 class mediatorGoProcessGO:0030512negative regulation of transforming growth factor beta receptor signaling pathwayGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032211negative regulation of telomere maintenance via telomeraseGoProcessGO:0033077T cell differentiation in thymusGoProcessGO:0033209tumor necrosis factor-mediated signaling pathwayGoProcessGO:0033554cellular response to stressGoProcessGO:0034103regulation of tissue remodelingGoProcessGO:0034644cellular response to UVGoProcessGO:0035264multicellular organism growthGoProcessGO:0035794positive regulation of mitochondrial membrane permeabilityGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0042149cellular response to glucose starvationGoProcessGO:0042771intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorGoProcessGO:0042981regulation of apoptotic processGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043153entrainment of circadian clock by photoperiodGoProcessGO:0043504mitochondrial DNA repairGoProcessGO:0043516regulation of DNA damage response, signal transduction by p53 class mediatorGoProcessGO:0043523regulation of neuron apoptotic processGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045815transcription initiation-coupled chromatin remodelingGoProcessGO:0045861negative regulation of proteolysisGoProcessGO:0045892negative regulation of DNA-templated transcriptionGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0045899positive regulation of RNA polymerase II transcription preinitiation complex assemblyGoProcessGO:0045930negative regulation of mitotic cell cycleGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046677response to antibioticGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048147negative regulation of fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048512circadian behaviorGoProcessGO:0048539bone marrow developmentGoProcessGO:0048568embryonic organ developmentGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050821protein stabilizationGoProcessGO:0051097negative regulation of helicase activityGoProcessGO:0051262protein tetramerizationGoProcessGO:0051276chromosome organizationGoProcessGO:0051402neuron apoptotic processGoProcessGO:0051726regulation of cell cycleGoProcessGO:0060218hematopoietic stem cell differentiationGoProcessGO:0060253negative regulation of glial cell proliferationGoProcessGO:0060333type II interferon-mediated signaling pathwayGoProcessGO:0060411cardiac septum morphogenesisGoProcessGO:0062100positive regulation of programmed necrotic cell deathGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070059intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressGoProcessGO:0070242thymocyte apoptotic processGoProcessGO:0070243regulation of thymocyte apoptotic processGoProcessGO:0070245positive regulation of thymocyte apoptotic processGoProcessGO:0070266necroptotic processGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0071479cellular response to ionizing radiationGoProcessGO:0071480cellular response to gamma radiationGoProcessGO:0071494cellular response to UV-CGoProcessGO:0072089stem cell proliferationGoProcessGO:0072331signal transduction by p53 class mediatorGoProcessGO:0072332intrinsic apoptotic signaling pathway by p53 class mediatorGoProcessGO:0072593reactive oxygen species metabolic processGoProcessGO:0072717cellular response to actinomycin DGoProcessGO:0090200positive regulation of release of cytochrome c from mitochondriaGoProcessGO:0090398cellular senescenceGoProcessGO:0090399replicative senescenceGoProcessGO:0090403oxidative stress-induced premature senescenceGoProcessGO:0097193intrinsic apoptotic signaling pathwayGoProcessGO:0097252oligodendrocyte apoptotic processGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901525negative regulation of mitophagyGoProcessGO:1902108regulation of mitochondrial membrane permeability involved in apoptotic processGoProcessGO:1902253regulation of intrinsic apoptotic signaling pathway by p53 class mediatorGoProcessGO:1902749regulation of cell cycle G2/M phase transitionGoProcessGO:1902895positive regulation of miRNA transcriptionGoProcessGO:1903451negative regulation of G1 to G0 transitionGoProcessGO:1903799negative regulation of miRNA processingGoProcessGO:1904024negative regulation of glucose catabolic process to lactate via pyruvateGoProcessGO:1905856negative regulation of pentose-phosphate shuntGoProcessGO:1990144intrinsic apoptotic signaling pathway in response to hypoxiaGoProcessGO:2000269regulation of fibroblast apoptotic processGoProcessGO:2000378negative regulation of reactive oxygen species metabolic processGoProcessGO:2000379positive regulation of reactive oxygen species metabolic processGoProcessGO:2000647negative regulation of stem cell proliferationGoProcessGO:2000774positive regulation of cellular senescenceGoProcessGO:2001244positive regulation of intrinsic apoptotic signaling pathwayGoProcessHGNC:11998TP53HGNCP04637IntActIPR002117p53_tumour_suppressorInterProIPR008967p53-like_TF_DNA-bd_sfInterProIPR010991p53_tetrameristnInterProIPR011615p53_DNA-bdInterProIPR012346p53/RUNT-type_TF_DNA-bd_sfInterProIPR013872p53_transactivation_domainInterProIPR036674p53_tetramer_sfInterProIPR040926p53_TAD2InterProPTHR11447CELLULAR TUMOR ANTIGEN P53PANTHERPTHR11447:SF6CELLULAR TUMOR ANTIGEN 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_tetramerPfamPF08563P53_TADPfamPF18521TAD2PfamPA36679tumor protein p53PharmGKBP04637PharosR-HSA-111448Activation of NOXA and translocation to mitochondriaReactomeR-HSA-139915Activation of PUMA and translocation to mitochondriaReactomeR-HSA-1912408Pre-NOTCH Transcription and TranslationReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559584Formation of Senescence-Associated Heterochromatin Foci (SAHF)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-3232118SUMOylation of transcription factorsReactomeR-HSA-349425Autodegradation of the E3 ubiquitin ligase COP1ReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-5620971PyroptosisReactomeR-HSA-5628897TP53 Regulates Metabolic GenesReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksReactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signalingReactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-HSA-6803204TP53 Regulates Transcription of Genes Involved in Cytochrome C ReleaseReactomeR-HSA-6803205TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertainReactomeR-HSA-6803207TP53 Regulates Transcription of Caspase Activators and CaspasesReactomeR-HSA-6803211TP53 Regulates Transcription of Death Receptors and LigandsReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804115TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertainReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804754Regulation of TP53 ExpressionReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-6804758Regulation of TP53 Activity through AcetylationReactomeR-HSA-6804759Regulation of TP53 Activity through Association with Co-factorsReactomeR-HSA-6804760Regulation of TP53 Activity through MethylationReactomeR-HSA-6811555PI5P Regulates TP53 AcetylationReactomeR-HSA-69473G2/M DNA damage checkpointReactomeR-HSA-69481G2/M CheckpointsReactomeR-HSA-69541Stabilization of p53ReactomeR-HSA-69895Transcriptional activation of cell cycle inhibitor p21ReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8853884Transcriptional Regulation by VENTXReactomeR-HSA-8941855RUNX3 regulates CDKN1A transcriptionReactomeR-HSA-8943724Regulation of PTEN gene transcriptionReactomeR-HSA-9723905Loss of function of TP53 in cancer due to loss of tetramerization abilityReactomeR-HSA-9725370Signaling by ALK fusions and activated point mutantsReactomeR-HSA-9758274Regulation of NF-kappa B signalingReactomeR-HSA-9819196Zygotic genome activation (ZGA)ReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeR-HSA-9833482PKR-mediated signalingReactomeP04637Cellular tumor antigen p53UniProtQ15086Cellular tumor antigen p53UniProtQ15087Cellular tumor antigen p53UniProtQ15088Cellular tumor antigen p53UniProtQ16535Cellular tumor antigen p53UniProtQ16807Cellular tumor antigen p53UniProtQ16808Cellular tumor antigen p53UniProtQ16809Cellular tumor antigen p53UniProtQ16810Cellular tumor antigen p53UniProtQ16811Cellular tumor antigen p53UniProtQ16848Cellular tumor antigen p53UniProtQ2XN98Cellular tumor antigen p53UniProtQ3LRW1Cellular tumor antigen p53UniProtQ3LRW2Cellular tumor antigen p53UniProtQ3LRW3Cellular tumor antigen p53UniProtQ3LRW4Cellular tumor antigen p53UniProtQ3LRW5Cellular tumor antigen p53UniProtQ86UG1Cellular tumor antigen p53UniProtQ8J016Cellular tumor antigen p53UniProtQ99659Cellular tumor antigen p53UniProtQ9BTM4Cellular tumor antigen p53UniProtQ9HAQ8Cellular tumor antigen p53UniProtQ9NP68Cellular tumor antigen p53UniProtQ9NPJ2Cellular tumor antigen p53UniProtQ9NZD0Cellular tumor antigen p53UniProtQ9UBI2Cellular tumor antigen p53UniProtQ9UQ61Cellular tumor antigen p53UniProtCHEMBL4096CHEMBL1907611CHEMBL2221344CHEMBL3301383CHEMBL3885543CHEMBL3885544CHEMBL3885545CHEMBL3883306CHEMBL4879538CHEMBL6066147CHEMBL60668349606P047574PROTEINNeuronal acetylcholine receptor subunit alpha-3GO:0003674GO:0005575GO:0005783GO:0005794GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0043167GO:0048856GO:0055085Rattus norvegicus422MGVVLLPPPLSMLMLVLMLLPAASASEAEHRLFQYLFEDYNEIIRPVANVSHPVIIQFEVSMSQLVKVDEVNQIMETNLWLKQIWNDYKLKWKPSDYQGVEFMRVPAEKIWKPDIVLYNNADGDFQVDDKTKALLKYTGEVTWIPPAIFKSSCKIDVTYFPFDYQNCTMKFGSWSYDKAKIDLVLIGSSMNLKDYWESGEWAIIKAPGYKHEIKYNCCEEIYQDITYSLYIRRLPLFYTINLIIPCLLISFLTVLVFYLPSDCGEKVTLCISVLLSLTVFLLVITETIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHYRTPTTHTMPTWVKAVFLNLLPRVMFMTRPTSGEGDTPKTRTFYGAELSNLNCFSRADSKSCKEGYPCQDGTCGYCHHRRVKISNFSANLTRSSSSESVNAVLSLSALSPEIKEAIQSVKYIAENMKAQNVAKEIQDDWKYVAMVIDRIFLWVFILVCILGTAGLFLQPLMARDDTAcra3GENE_SYMBOL_OTHERChrna3GENE_SYMBOLNeuronal acetylcholine receptor subunit alpha-3UNIPROTP04757AlphaFoldDBGO:0005783endoplasmic reticulumGoComponentGO:0005794Golgi apparatusGoComponentGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0030425dendriteGoComponentGO:0032991protein-containing complexGoComponentGO:0043005neuron projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0044853plasma membrane raftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098691dopaminergic synapseGoComponentGO:0098793presynapseGoComponentGO:0098981cholinergic synapseGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006937regulation of muscle contractionGoProcessGO:0006940regulation of smooth muscle contractionGoProcessGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007399nervous system developmentGoProcessGO:0007507heart developmentGoProcessGO:0007626locomotory behaviorGoProcessGO:0014056regulation of acetylcholine secretion, neurotransmissionGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0048814regulation of dendrite morphogenesisGoProcessGO:0051899membrane depolarizationGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0060084synaptic transmission involved in micturitionGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessP04757IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamR-RNO-629587Highly sodium permeable postsynaptic acetylcholine nicotinic receptorsReactomeR-RNO-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-RNO-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeP04757Neuronal acetylcholine receptor subunit alpha-3UniProtCHEMBL1907587CHEMBL1907593CHEMBL2094110CHEMBL3137275CHEMBL3137276CHEMBL410614610116P051065PROTEINIntegrin beta-3GO:0001618GO:0001968GO:0003674GO:0005102GO:0005178GO:0005515GO:0005575GO:0005634GO:0005654GO:0005886GO:0006810GO:0007155GO:0007165GO:0008150GO:0016020GO:0016192GO:0016853GO:0019838GO:0019899GO:0022607GO:0030154GO:0031994GO:0032880GO:0034330GO:0040011GO:0042802GO:0043085GO:0043167GO:0043226GO:0044403GO:0048646GO:0048856GO:0048870GO:0050840GO:0051604Homo sapiens11MRARPRPRPLWATVLALGALAGVGVGGPNICTTRGVSSCQQCLAVSPMCAWCSDEALPLGSPRCDLKENLLKDNCAPESIEFPVSEARVLEDRPLSDKGSGDSSQVTQVSPQRIALRLRPDDSKNFSIQVRQVEDYPVDIYYLMDLSYSMKDDLWSIQNLGTKLATQMRKLTSNLRIGFGAFVDKPVSPYMYISPPEALENPCYDMKTTCLPMFGYKHVLTLTDQVTRFNEEVKKQSVSRNRDAPEGGFDAIMQATVCDEKIGWRNDASHLLVFTTDAKTHIALDGRLAGIVQPNDGQCHVGSDNHYSASTTMDYPSLGLMTEKLSQKNINLIFAVTENVVNLYQNYSELIPGTTVGVLSMDSSNVLQLIVDAYGKIRSKVELEVRDLPEELSLSFNATCLNNEVIPGLKSCMGLKIGDTVSFSIEAKVRGCPQEKEKSFTIKPVGFKDSLIVQVTFDCDCACQAQAEPNSHRCNNGNGTFECGVCRCGPGWLGSQCECSEEDYRPSQQDECSPREGQPVCSQRGECLCGQCVCHSSDFGKITGKYCECDDFSCVRYKGEMCSGHGQCSCGDCLCDSDWTGYYCNCTTRTDTCMSSNGLLCSGRGKCECGSCVCIQPGSYGDTCEKCPTCPDACTFKKECVECKKFDRGALHDENTCNRYCRDEIESVKELKDTGKDAVNCTYKNEDDCVVRFQYYEDSSGKSILYVVEEPECPKGPDILVVLLSVMGAILLIGLAALLIWKLLITIHDRKEFAKFEEERARAKWDTANNPLYKEATSTFTNITYRGTCD_antigen=CD61UNIPROTGP3AGENE_SYMBOL_OTHERGPIIIaUNIPROTIntegrin beta-3UNIPROTITGB3GENE_SYMBOLPlatelet membrane glycoprotein IIIaUNIPROTP05106AlphaFoldDBP05106ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0005911cell-cell junctionGoComponentGO:0005925focal adhesionGoComponentGO:0008305integrin complexGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016324apical plasma membraneGoComponentGO:0031092platelet alpha granule membraneGoComponentGO:0031258lamellipodium membraneGoComponentGO:0031527filopodium membraneGoComponentGO:0031528microvillus membraneGoComponentGO:0032587ruffle membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0034683integrin alphav-beta3 complexGoComponentGO:0035866alphav-beta3 integrin-PKCalpha complexGoComponentGO:0035867alphav-beta3 integrin-IGF-1-IGF1R complexGoComponentGO:0035868alphav-beta3 integrin-HMGB1 complexGoComponentGO:0042995cell projectionGoComponentGO:0043235receptor complexGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0070161anchoring junctionGoComponentGO:0070442integrin alphaIIb-beta3 complexGoComponentGO:0071062alphav-beta3 integrin-vitronectin complexGoComponentGO:0071133alpha9-beta1 integrin-ADAM8 complexGoComponentGO:0097060synaptic membraneGoComponentGO:0098690glycinergic synapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0001618virus receptor activityGoFunctionGO:0001968fibronectin bindingGoFunctionGO:0002020protease bindingGoFunctionGO:0003756protein disulfide isomerase activityGoFunctionGO:0005080protein kinase C bindingGoFunctionGO:0005161platelet-derived growth factor receptor bindingGoFunctionGO:0005178integrin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0015026coreceptor activityGoFunctionGO:0017134fibroblast growth factor bindingGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019960C-X3-C chemokine bindingGoFunctionGO:0031994insulin-like growth factor I bindingGoFunctionGO:0038132neuregulin bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0043184vascular endothelial growth factor receptor 2 bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0050839cell adhesion molecule bindingGoFunctionGO:0050840extracellular matrix bindingGoFunctionGO:0001934positive regulation of protein phosphorylationGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0001954positive regulation of cell-matrix adhesionGoProcessGO:0002687positive regulation of leukocyte migrationGoProcessGO:0007044cell-substrate junction assemblyGoProcessGO:0007155cell adhesionGoProcessGO:0007160cell-matrix adhesionGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0007566embryo implantationGoProcessGO:0007596blood coagulationGoProcessGO:0008277regulation of G protein-coupled receptor signaling pathwayGoProcessGO:0010595positive regulation of endothelial cell migrationGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010745negative regulation of macrophage derived foam cell differentiationGoProcessGO:0010763positive regulation of fibroblast migrationGoProcessGO:0010888negative regulation of lipid storageGoProcessGO:0014909smooth muscle cell migrationGoProcessGO:0014911positive regulation of smooth muscle cell migrationGoProcessGO:0030168platelet activationGoProcessGO:0030335positive regulation of cell migrationGoProcessGO:0030949positive regulation of vascular endothelial growth factor receptor signaling pathwayGoProcessGO:0031589cell-substrate adhesionGoProcessGO:0032147activation of protein kinase activityGoProcessGO:0032369negative regulation of lipid transportGoProcessGO:0032880regulation of protein localizationGoProcessGO:0032956regulation of actin cytoskeleton organizationGoProcessGO:0033627cell adhesion mediated by integrinGoProcessGO:0033630positive regulation of cell adhesion mediated by integrinGoProcessGO:0033690positive regulation of osteoblast proliferationGoProcessGO:0034113heterotypic cell-cell adhesionGoProcessGO:0034446substrate adhesion-dependent cell spreadingGoProcessGO:0035295tube developmentGoProcessGO:0035313wound healing, spreading of epidermal cellsGoProcessGO:0038027apolipoprotein A-I-mediated signaling pathwayGoProcessGO:0043277apoptotic cell clearanceGoProcessGO:0045124regulation of bone resorptionGoProcessGO:0045766positive regulation of angiogenesisGoProcessGO:0045780positive regulation of bone resorptionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048008platelet-derived growth factor receptor signaling pathwayGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0048333mesodermal cell differentiationGoProcessGO:0048661positive regulation of smooth muscle cell proliferationGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050748negative regulation of lipoprotein metabolic processGoProcessGO:0050919negative chemotaxisGoProcessGO:0051279regulation of release of sequestered calcium ion into cytosolGoProcessGO:0051611regulation of serotonin uptakeGoProcessGO:0060055angiogenesis involved in wound healingGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0070527platelet aggregationGoProcessGO:0071260cellular response to mechanical stimulusGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0072126positive regulation of glomerular mesangial cell proliferationGoProcessGO:0072378blood coagulation, fibrin clot formationGoProcessGO:0098880maintenance of postsynaptic specialization structureGoProcessGO:0099149regulation of postsynaptic neurotransmitter receptor internalizationGoProcessGO:0150054regulation of postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:1900026positive regulation of substrate adhesion-dependent cell spreadingGoProcessGO:1900731positive regulation of adenylate cyclase-inhibiting opioid receptor signaling pathwayGoProcessGO:1901163regulation of trophoblast cell migrationGoProcessGO:1903053regulation of extracellular matrix organizationGoProcessGO:1905598negative regulation of low-density lipoprotein receptor activityGoProcessGO:1990314cellular response to insulin-like growth factor stimulusGoProcessGO:2000352negative regulation of endothelial cell apoptotic processGoProcessGO:2000406positive regulation of T cell migrationGoProcessHGNC:6156ITGB3HGNCP05106IntActIPR002369Integrin_bsu_VWAInterProIPR012896Integrin_bsu_tailInterProIPR013111EGF_extracellInterProIPR014836Integrin_bsu_cyt_domInterProIPR015812Integrin_bsuInterProIPR016201PSIInterProIPR032695Integrin_dom_sfInterProIPR033760Integrin_beta_NInterProIPR036349Integrin_bsu_tail_dom_sfInterProIPR036465vWFA_dom_sfInterProIPR040622I-EGF_1InterProPTHR10082INTEGRIN BETA SUBUNITPANTHERPTHR10082:SF25INTEGRIN BETA-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_betaPfamPF07965Integrin_B_tailPfamPF07974EGF_2PfamPF08725Integrin_b_cytPfamPF17205PSI_integrinPfamPF18372I-EGF_1PfamPF23105EGF_integrinPfamPA205integrin subunit beta 3PharmGKBP05106PharosR-HSA-114608Platelet degranulationReactomeR-HSA-1566948Elastic fibre formationReactomeR-HSA-210990PECAM1 interactionsReactomeR-HSA-2129379Molecules associated with elastic fibresReactomeR-HSA-216083Integrin cell surface interactionsReactomeR-HSA-2173789TGF-beta receptor signaling activates SMADsReactomeR-HSA-3000170Syndecan interactionsReactomeR-HSA-3000178ECM proteoglycansReactomeR-HSA-354192Integrin signalingReactomeR-HSA-354194GRB2:SOS provides linkage to MAPK signaling for IntegrinsReactomeR-HSA-372708p130Cas linkage to MAPK signaling for integrinsReactomeR-HSA-4420097VEGFA-VEGFR2 PathwayReactomeR-HSA-445144Signal transduction by L1ReactomeR-HSA-5674135MAP2K and MAPK activationReactomeR-HSA-6802946Signaling by moderate kinase activity BRAF mutantsReactomeR-HSA-6802948Signaling by high-kinase activity BRAF mutantsReactomeR-HSA-6802952Signaling by BRAF and RAF1 fusionsReactomeR-HSA-6802955Paradoxical activation of RAF signaling by kinase inactive BRAFReactomeR-HSA-9649948Signaling downstream of RAS mutantsReactomeR-HSA-9656223Signaling by RAF1 mutantsReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeR-HSA-9860927Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cellsReactomeA0PJW2Integrin beta-3UniProtD3DXJ8Integrin beta-3UniProtO15495Integrin beta-3UniProtP05106Integrin beta-3UniProtQ12806Integrin beta-3UniProtQ13413Integrin beta-3UniProtQ14648Integrin beta-3UniProtQ16499Integrin beta-3UniProtCHEMBL207CHEMBL2093869CHEMBL1907598CHEMBL2111443CHEMBL2111425CHEMBL2111461CHEMBL41061509606P055566PROTEINIntegrin beta-1GO:0000902GO:0001618GO:0001968GO:0002376GO:0003013GO:0003674GO:0005178GO:0005515GO:0005575GO:0005737GO:0005768GO:0005886GO:0006810GO:0007010GO:0007017GO:0007155GO:0007165GO:0008092GO:0008150GO:0008283GO:0009790GO:0016020GO:0016192GO:0019899GO:0022607GO:0030154GO:0030198GO:0032880GO:0040007GO:0042592GO:0043065GO:0043085GO:0043167GO:0043226GO:0044403GO:0046982GO:0048646GO:0048856GO:0048870GO:0050840GO:0050877Homo sapiens11MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGKCD_antigen=CD29UNIPROTFibronectin receptor subunit betaUNIPROTFNRBGENE_SYMBOL_OTHERGlycoprotein IIaUNIPROTGPIIAUNIPROTIntegrin beta-1UNIPROTITGB1GENE_SYMBOLMDF2GENE_SYMBOL_OTHERMSK12GENE_SYMBOL_OTHERVLA-4 subunit betaUNIPROTP05556AlphaFoldDBP05556ExpressionAtlasGO:0001726ruffleGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0005886plasma membraneGoComponentGO:0005925focal adhesionGoComponentGO:0008305integrin complexGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0010008endosome membraneGoComponentGO:0014704intercalated discGoComponentGO:0016020membraneGoComponentGO:0030027lamellipodiumGoComponentGO:0030175filopodiumGoComponentGO:0031594neuromuscular junctionGoComponentGO:0032154cleavage furrowGoComponentGO:0032587ruffle membraneGoComponentGO:0034665integrin alpha1-beta1 complexGoComponentGO:0034666integrin alpha2-beta1 complexGoComponentGO:0034667integrin alpha3-beta1 complexGoComponentGO:0034668integrin alpha4-beta1 complexGoComponentGO:0034674integrin alpha5-beta1 complexGoComponentGO:0034675integrin alpha6-beta1 complexGoComponentGO:0034677integrin alpha7-beta1 complexGoComponentGO:0034678integrin alpha8-beta1 complexGoComponentGO:0034679integrin alpha9-beta1 complexGoComponentGO:0034680integrin alpha10-beta1 complexGoComponentGO:0034681integrin alpha11-beta1 complexGoComponentGO:0034682integrin alphav-beta1 complexGoComponentGO:0035748myelin sheath abaxonal regionGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043197dendritic spineGoComponentGO:0043235receptor complexGoComponentGO:0045121membrane raftGoComponentGO:0045202synapseGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0055037recycling endosomeGoComponentGO:0070062extracellular exosomeGoComponentGO:0070161anchoring junctionGoComponentGO:0097060synaptic membraneGoComponentGO:0097386glial cell projectionGoComponentGO:0098685Schaffer collateral - CA1 synapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0150053cerebellar climbing fiber to Purkinje cell synapseGoComponentGO:0000287magnesium ion bindingGoFunctionGO:0001618virus receptor activityGoFunctionGO:0001968fibronectin bindingGoFunctionGO:0002020protease bindingGoFunctionGO:0003779actin bindingGoFunctionGO:0005178integrin bindingGoFunctionGO:0005509calcium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0015026coreceptor activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019960C-X3-C chemokine bindingGoFunctionGO:0038023signaling receptor activityGoFunctionGO:0043236laminin bindingGoFunctionGO:0045296cadherin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046982protein heterodimerization activityGoFunctionGO:0050839cell adhesion molecule bindingGoFunctionGO:0098639collagen binding involved in cell-matrix adhesionGoFunctionGO:0098640integrin binding involved in cell-matrix adhesionGoFunctionGO:1990782protein tyrosine kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000132establishment of mitotic spindle orientationGoProcessGO:0001525angiogenesisGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0002042cell migration involved in sprouting angiogenesisGoProcessGO:0002052positive regulation of neuroblast proliferationGoProcessGO:0006909phagocytosisGoProcessGO:0007155cell adhesionGoProcessGO:0007156homophilic cell adhesion via plasma membrane adhesion moleculesGoProcessGO:0007159leukocyte cell-cell adhesionGoProcessGO:0007160cell-matrix adhesionGoProcessGO:0007161calcium-independent cell-matrix adhesionGoProcessGO:0007179transforming growth factor beta receptor signaling pathwayGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0007405neuroblast proliferationGoProcessGO:0007517muscle organ developmentGoProcessGO:0007520myoblast fusionGoProcessGO:0008283cell population proliferationGoProcessGO:0008354germ cell migrationGoProcessGO:0008542visual learningGoProcessGO:0010763positive regulation of fibroblast migrationGoProcessGO:0016477cell migrationGoProcessGO:0021943formation of radial glial scaffoldsGoProcessGO:0023035CD40 signaling pathwayGoProcessGO:0030032lamellipodium assemblyGoProcessGO:0030182neuron differentiationGoProcessGO:0030183B cell differentiationGoProcessGO:0030198extracellular matrix organizationGoProcessGO:0030335positive regulation of cell migrationGoProcessGO:0031589cell-substrate adhesionGoProcessGO:0031623receptor internalizationGoProcessGO:0033627cell adhesion mediated by integrinGoProcessGO:0033631cell-cell adhesion mediated by integrinGoProcessGO:0034113heterotypic cell-cell adhesionGoProcessGO:0035024negative regulation of Rho protein signal transductionGoProcessGO:0035313wound healing, spreading of epidermal cellsGoProcessGO:0035633maintenance of blood-brain barrierGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043149stress fiber assemblyGoProcessGO:0043547positive regulation of GTPase activityGoProcessGO:0045214sarcomere organizationGoProcessGO:0045445myoblast differentiationGoProcessGO:0045665negative regulation of neuron differentiationGoProcessGO:0045743positive regulation of fibroblast growth factor receptor signaling pathwayGoProcessGO:0045766positive regulation of angiogenesisGoProcessGO:0045906negative regulation of vasoconstrictionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048333mesodermal cell differentiationGoProcessGO:0048626myoblast fate specificationGoProcessGO:0048675axon extensionGoProcessGO:0048813dendrite morphogenesisGoProcessGO:0050804modulation of chemical synaptic transmissionGoProcessGO:0050901leukocyte tethering or rollingGoProcessGO:0051726regulation of cell cycleGoProcessGO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionGoProcessGO:0051951positive regulation of glutamate uptake involved in transmission of nerve impulseGoProcessGO:0055007cardiac muscle cell differentiationGoProcessGO:0060379cardiac muscle cell myoblast differentiationGoProcessGO:0060912cardiac cell fate specificationGoProcessGO:0071404cellular response to low-density lipoprotein particle stimulusGoProcessGO:0071711basement membrane organizationGoProcessGO:0090303positive regulation of wound healingGoProcessGO:0098609cell-cell adhesionGoProcessGO:0150003regulation of spontaneous synaptic transmissionGoProcessGO:1900748positive regulation of vascular endothelial growth factor signaling pathwayGoProcessGO:1901979regulation of inward rectifier potassium channel activityGoProcessGO:1903078positive regulation of protein localization to plasma membraneGoProcessGO:1905806regulation of synapse pruningGoProcessGO:2000811negative regulation of anoikisGoProcessHGNC:6153ITGB1HGNCP05556IntActIPR002369Integrin_bsu_VWAInterProIPR012896Integrin_bsu_tailInterProIPR013111EGF_extracellInterProIPR014836Integrin_bsu_cyt_domInterProIPR015812Integrin_bsuInterProIPR016201PSIInterProIPR032695Integrin_dom_sfInterProIPR033760Integrin_beta_NInterProIPR036349Integrin_bsu_tail_dom_sfInterProIPR036465vWFA_dom_sfInterProIPR040622I-EGF_1InterProPTHR10082INTEGRIN BETA SUBUNITPANTHERPTHR10082:SF28INTEGRIN BETA-1PANTHER3G9WPDB3T9KPDB3VI3PDB3VI4PDB4DX9PDB4WJKPDB4WK0PDB4WK2PDB4WK4PDB7CEBPDB7CECPDB7NWLPDB7NXDPDB8RPQPDB8W30PDB9B9JPDB9B9KPDB9CKVPDB3G9WAPDBe3T9KAPDBe3VI3APDBe3VI4APDBe4DX9APDBe4WJKAPDBe4WK0APDBe4WK2APDBe4WK4APDBe7CEBAPDBe8W30APDBePF00362Integrin_betaPfamPF07965Integrin_B_tailPfamPF07974EGF_2PfamPF08725Integrin_b_cytPfamPF17205PSI_integrinPfamPF18372I-EGF_1PfamPF23105EGF_integrinPfamPA29953integrin subunit beta 1PharmGKBP05556PharosR-HSA-1566948Elastic fibre formationReactomeR-HSA-1566977Fibronectin matrix formationReactomeR-HSA-198933Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cellReactomeR-HSA-202733Cell surface interactions at the vascular wallReactomeR-HSA-210991Basigin interactionsReactomeR-HSA-2129379Molecules associated with elastic fibresReactomeR-HSA-216083Integrin cell surface interactionsReactomeR-HSA-2173789TGF-beta receptor signaling activates SMADsReactomeR-HSA-3000157Laminin interactionsReactomeR-HSA-3000170Syndecan interactionsReactomeR-HSA-3000178ECM proteoglycansReactomeR-HSA-416700Other semaphorin interactionsReactomeR-HSA-445144Signal transduction by L1ReactomeR-HSA-446343Localization of the PINCH-ILK-PARVIN complex to focal adhesionsReactomeR-HSA-447041CHL1 interactionsReactomeR-HSA-5663220RHO GTPases Activate ForminsReactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signalingReactomeR-HSA-75892Platelet Adhesion to exposed collagenReactomeR-HSA-8874081MET activates PTK2 signalingReactomeR-HSA-8875513MET interacts with TNS proteinsReactomeR-HSA-9013149RAC1 GTPase cycleReactomeR-HSA-9013404RAC2 GTPase cycleReactomeR-HSA-9013408RHOG GTPase cycleReactomeR-HSA-9013423RAC3 GTPase cycleReactomeR-HSA-9609690HCMV Early EventsReactomeR-HSA-9634597GPER1 signalingReactomeR-HSA-9679191Potential therapeutics for SARSReactomeR-HSA-9725554Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian SkinReactomeR-HSA-9830674Formation of the ureteric budReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeR-HSA-9860927Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cellsReactomeA8K6N2Integrin beta-1UniProtD3DRX9Integrin beta-1UniProtD3DRY3Integrin beta-1UniProtD3DRY4Integrin beta-1UniProtD3DRY5Integrin beta-1UniProtP05556Integrin beta-1UniProtP78466Integrin beta-1UniProtP78467Integrin beta-1UniProtQ13089Integrin beta-1UniProtQ13090Integrin beta-1UniProtQ13091Integrin beta-1UniProtQ13212Integrin beta-1UniProtQ14622Integrin beta-1UniProtQ14647Integrin beta-1UniProtQ29RW2Integrin beta-1UniProtQ7Z3V1Integrin beta-1UniProtQ8WUM6Integrin beta-1UniProtCHEMBL1905CHEMBL1907599CHEMBL2095226CHEMBL2111425CHEMBL2111407CHEMBL3137268CHEMBL3137278CHEMBL3430895CHEMBL3885596CHEMBL3885597CHEMBL60665869606P064937PROTEINCyclin-dependent kinase 1GO:0001618GO:0003682GO:0005515GO:0005575GO:0005634GO:0005654GO:0005737GO:0005739GO:0005815GO:0005829GO:0005856GO:0006259GO:0006950GO:0007010GO:0007017GO:0007165GO:0008150GO:0008219GO:0008283GO:0009636GO:0016020GO:0016301GO:0016310GO:0030154GO:0030554GO:0032880GO:0043167GO:0043226GO:0044403GO:0048856GO:0048870GO:0051276GO:0051301GO:0061024GO:0065003Homo sapiens323MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRHPNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCHSRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSARYSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNTFPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM2.7.11.22EC_NUMBER2.7.11.23EC_NUMBERCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDK1GENE_SYMBOLCDK1UNIPROTCDKN1GENE_SYMBOL_OTHERCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTCyclin-dependent kinase 1UNIPROTP34CDC2GENE_SYMBOL_OTHERp34 protein kinaseUNIPROTP06493AlphaFoldDBP06493ExpressionAtlasGO:0000781chromosome, telomeric regionGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessHGNC:1722CDK1HGNCP06493IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR050108CDKInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHER4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDB4Y72APDBe4YC3APDBe4YC6APDBe5HQ0APDBe5LQFAPDBe6GU2APDBe6GU3APDBe6GU4APDBe6GU6APDBe6GU7APDBe6TWNAPDBePF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP06493PharosR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProtCHEMBL308CHEMBL1907602CHEMBL2094127CHEMBL3038467CHEMBL3038468CHEMBL3559691CHEMBL3885551CHEMBL4296065CHEMBL4296066CHEMBL4523683CHEMBL4523963CHEMBL5483182CHEMBL5483189CHEMBL60661219606P067568PROTEINIntegrin alpha-VGO:0001618GO:0001968GO:0003674GO:0005102GO:0005178GO:0005515GO:0005575GO:0005829GO:0005886GO:0006810GO:0007155GO:0007165GO:0008150GO:0016020GO:0016192GO:0019838GO:0019899GO:0022857GO:0030154GO:0031994GO:0040011GO:0043167GO:0043226GO:0044403GO:0048646GO:0048856GO:0048870GO:0050840GO:0055085Homo sapiens11MAFPPRRRLRLGPRGLPLLLSGLLLPLCRAFNLDVDSPAEYSGPEGSYFGFAVDFFVPSASSRMFLLVGAPKANTTQPGIVEGGQVLKCDWSSTRRCQPIEFDATGNRDYAKDDPLEFKSHQWFGASVRSKQDKILACAPLYHWRTEMKQEREPVGTCFLQDGTKTVEYAPCRSQDIDADGQGFCQGGFSIDFTKADRVLLGGPGSFYWQGQLISDQVAEIVSKYDPNVYSIKYNNQLATRTAQAIFDDSYLGYSVAVGDFNGDGIDDFVSGVPRAARTLGMVYIYDGKNMSSLYNFTGEQMAAYFGFSVAATDINGDDYADVFIGAPLFMDRGSDGKLQEVGQVSVSLQRASGDFQTTKLNGFEVFARFGSAIAPLGDLDQDGFNDIAIAAPYGGEDKKGIVYIFNGRSTGLNAVPSQILEGQWAARSMPPSFGYSMKGATDIDKNGYPDLIVGAFGVDRAILYRARPVITVNAGLEVYPSILNQDNKTCSLPGTALKVSCFNVRFCLKADGKGVLPRKLNFQVELLLDKLKQKGAIRRALFLYSRSPSHSKNMTISRGGLMQCEELIAYLRDESEFRDKLTPITIFMEYRLDYRTAADTTGLQPILNQFTPANISRQAHILLDCGEDNVCKPKLEVSVDSDQKKIYIGDDNPLTLIVKAQNQGEGAYEAELIVSIPLQADFIGVVRNNEALARLSCAFKTENQTRQVVCDLGNPMKAGTQLLAGLRFSVHQQSEMDTSVKFDLQIQSSNLFDKVSPVVSHKVDLAVLAAVEIRGVSSPDHVFLPIPNWEHKENPETEEDVGPVVQHIYELRNNGPSSFSKAMLHLQWPYKYNNNTLLYILHYDIDGPMNCTSDMEINPLRIKISSLQTTEKNDTVAGQGERDHLITKRDLALSEGDIHTLGCGVAQCLKIVCQVGRLDRGKSAILYVKSLLWTETFMNKENQNHSYSLKSSASFNVIEFPYKNLPIEDITNSTLVTTNVTWGIQPAPMPVPVWVIILAVLAGLLLLAVLVFVMYRMGFFKRVRPPQEEQEREQLQPHENGEGNSETCD_antigen=CD51UNIPROTIntegrin alpha-VUNIPROTIntegrin alpha-V heavy chainUNIPROTIntegrin alpha-V light chainUNIPROTITGAVGENE_SYMBOLSynonyms=MSK8GENE_SYMBOL_OTHERVitronectin receptorUNIPROTVitronectin receptor subunit alphaUNIPROTVNRAGENE_SYMBOL_OTHERVNRA GN GENE_SYMBOL_OTHERP06756AlphaFoldDBP06756ExpressionAtlasGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0005925focal adhesionGoComponentGO:0008305integrin complexGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0031258lamellipodium membraneGoComponentGO:0031527filopodium membraneGoComponentGO:0031528microvillus membraneGoComponentGO:0032587ruffle membraneGoComponentGO:0034682integrin alphav-beta1 complexGoComponentGO:0034683integrin alphav-beta3 complexGoComponentGO:0034684integrin alphav-beta5 complexGoComponentGO:0034685integrin alphav-beta6 complexGoComponentGO:0034686integrin alphav-beta8 complexGoComponentGO:0035579specific granule membraneGoComponentGO:0035866alphav-beta3 integrin-PKCalpha complexGoComponentGO:0035867alphav-beta3 integrin-IGF-1-IGF1R complexGoComponentGO:0035868alphav-beta3 integrin-HMGB1 complexGoComponentGO:0070062extracellular exosomeGoComponentGO:0070161anchoring junctionGoComponentGO:0001618virus receptor activityGoFunctionGO:0001846opsonin bindingGoFunctionGO:0001968fibronectin bindingGoFunctionGO:0002020protease bindingGoFunctionGO:0005080protein kinase C bindingGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005178integrin bindingGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015026coreceptor activityGoFunctionGO:0017134fibroblast growth factor bindingGoFunctionGO:0019960C-X3-C chemokine bindingGoFunctionGO:0031994insulin-like growth factor I bindingGoFunctionGO:0038132neuregulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0050431transforming growth factor beta bindingGoFunctionGO:0050840extracellular matrix bindingGoFunctionGO:1990430extracellular matrix protein bindingGoFunctionGO:0001525angiogenesisGoProcessGO:0001568blood vessel developmentGoProcessGO:0001570vasculogenesisGoProcessGO:0007155cell adhesionGoProcessGO:0007160cell-matrix adhesionGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010745negative regulation of macrophage derived foam cell differentiationGoProcessGO:0010888negative regulation of lipid storageGoProcessGO:0016477cell migrationGoProcessGO:0030335positive regulation of cell migrationGoProcessGO:0031589cell-substrate adhesionGoProcessGO:0032369negative regulation of lipid transportGoProcessGO:0033627cell adhesion mediated by integrinGoProcessGO:0033690positive regulation of osteoblast proliferationGoProcessGO:0034113heterotypic cell-cell adhesionGoProcessGO:0034446substrate adhesion-dependent cell spreadingGoProcessGO:0035313wound healing, spreading of epidermal cellsGoProcessGO:0035987endodermal cell differentiationGoProcessGO:0038027apolipoprotein A-I-mediated signaling pathwayGoProcessGO:0043277apoptotic cell clearanceGoProcessGO:0045785positive regulation of cell adhesionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0050748negative regulation of lipoprotein metabolic processGoProcessGO:0050764regulation of phagocytosisGoProcessGO:0050919negative chemotaxisGoProcessGO:0051057positive regulation of small GTPase mediated signal transductionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0071604transforming growth factor beta productionGoProcessGO:0085017entry into host cell by a symbiont-containing vacuoleGoProcessGO:0097192extrinsic apoptotic signaling pathway in absence of ligandGoProcessGO:0098609cell-cell adhesionGoProcessGO:1902533positive regulation of intracellular signal transductionGoProcessGO:1905598negative regulation of low-density lipoprotein receptor activityGoProcessGO:2000536negative regulation of entry of bacterium into host cellGoProcessGO:2001237negative regulation of extrinsic apoptotic signaling pathwayGoProcessHGNC:6150ITGAVHGNCP06756IntActIPR000413Integrin_alphaInterProIPR013517FG-GAPInterProIPR013519Int_alpha_beta-pInterProIPR013649Integrin_alpha_Ig-like_1InterProIPR018184Integrin_alpha_C_CSInterProIPR028994Integrin_alpha_NInterProIPR032695Integrin_dom_sfInterProIPR048285Integrin_alpha_Ig-like_2InterProIPR048286Integrin_alpha_Ig-like_3InterProPTHR23220INTEGRIN ALPHAPANTHERPTHR23220:SF4INTEGRIN ALPHA-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_alphaPfamPF01839FG-GAPPfamPF08441Integrin_A_Ig_1PfamPF20805Integrin_A_Ig_2PfamPF20806Integrin_A_Ig_3PfamPA37336integrin subunit alpha VPharmGKBP06756PharosR-HSA-1236973Cross-presentation of particulate exogenous antigens (phagosomes)ReactomeR-HSA-1566948Elastic fibre formationReactomeR-HSA-210990PECAM1 interactionsReactomeR-HSA-2129379Molecules associated with elastic fibresReactomeR-HSA-216083Integrin cell surface interactionsReactomeR-HSA-2173789TGF-beta receptor signaling activates SMADsReactomeR-HSA-3000157Laminin interactionsReactomeR-HSA-3000170Syndecan interactionsReactomeR-HSA-3000178ECM proteoglycansReactomeR-HSA-4420097VEGFA-VEGFR2 PathwayReactomeR-HSA-445144Signal transduction by L1ReactomeR-HSA-6798695Neutrophil degranulationReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeR-HSA-9860927Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cellsReactomeA0AV67Integrin alpha-VUniProtB0LPF4Integrin alpha-VUniProtB7Z883Integrin alpha-VUniProtB7ZLX0Integrin alpha-VUniProtD3DPG8Integrin alpha-VUniProtE7EWZ6Integrin alpha-VUniProtP06756Integrin alpha-VUniProtQ53SK4Integrin alpha-VUniProtQ59EB7Integrin alpha-VUniProtQ6LD15Integrin alpha-VUniProtCHEMBL3660CHEMBL1907598CHEMBL2096675CHEMBL2111416CHEMBL2111443CHEMBL2111425CHEMBL2111407CHEMBL3430892CHEMBL3430893CHEMBL41061509606P075109PROTEINAcetylcholine receptor subunit gammaGO:0003674GO:0005515GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0055085Homo sapiens424MHGGQGPLLLLLLLAVCLGAQGRNQEERLLADLMQNYDPNLRPAERDSDVVNVSLKLTLTNLISLNEREEALTTNVWIEMQWCDYRLRWDPRDYEGLWVLRVPSTMVWRPDIVLENNVDGVFEVALYCNVLVSPDGCIYWLPPAIFRSACSISVTYFPFDWQNCSLIFQSQTYSTNEIDLQLSQEDGQTIEWIFIDPEAFTENGEWAIQHRPAKMLLDPAAPAQEAGHQKVVFYLLIQRKPLFYVINIIAPCVLISSVAILIHFLPAKAGGQKCTVAINVLLAQTVFLFLVAKKVPETSQAVPLISKYLTFLLVVTILIVVNAVVVLNVSLRSPHTHSMARGVRKVFLRLLPQLLRMHVRPLAPAAVQDTQSRLQNGSSGWSITTGEEVALCLPRSELLFQQWQRQGLVAAALEKLEKGPELGLSQFCGSLKQAAPAIQACVEACNLIACARHQQSHFDNGNEEWFLVGRVLDRVCFLAMLSLFICGTAGIFLMAHYNRVPALPFPGDPRPYLPSPDAcetylcholine receptor subunit gammaUNIPROTACHRGGENE_SYMBOL_OTHERCHRNGGENE_SYMBOLP07510AlphaFoldDBP07510ExpressionAtlasGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015267channel activityGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0051899membrane depolarizationGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessHGNC:1967CHRNGHGNCP07510IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPA26499cholinergic receptor nicotinic gamma subunitPharmGKBP07510PharosR-HSA-629587Highly sodium permeable postsynaptic acetylcholine nicotinic receptorsReactomeB3KWM8Acetylcholine receptor subunit gammaUniProtP07510Acetylcholine receptor subunit gammaUniProtQ14DU4Acetylcholine receptor subunit gammaUniProtQ53RG2Acetylcholine receptor subunit gammaUniProtCHEMBL1907588CHEMBL2362997CHEMBL45241339606P0848210PROTEINMuscarinic acetylcholine receptor M1GO:0004930GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0032880GO:0050877Rattus norvegicus559MNTSVPPAVSPNITVLAPGKGPWQVAFIGITTGLLSLATVTGNLLVLISFKVNTELKTVNNYFLLSLACADLIIGTFSMNLYTTYLLMGHWALGTLACDLWLALDYVASNASVMNLLLISFDRYFSVTRPLSYRAKRTPRRAALMIGLAWLVSFVLWAPAILFWQYLVGERTVLAGQCYIQFLSQPIITFGTAMAAFYLPVTVMCTLYWRIYRETENRARELAALQGSETPGKGGGSSSSSERSQPGAEGSPESPPGRCCRCCRAPRLLQAYSWKEEEEEDEGSMESLTSSEGEEPGSEVVIKMPMVDSEAQAPTKQPPKSSPNTVKRPTKKGRDRGGKGQKPRGKEQLAKRKTFSLVKEKKAARTLSAILLAFILTWTPYNIMVLVSTFCKDCVPETLWELGYWLCYVNSTVNPMCYALCNKAFRDTFRLLLLCRWDKRRWRKIPKRPGSVHRTPSRQCChrm-1GENE_SYMBOL_OTHERChrm1GENE_SYMBOLMuscarinic acetylcholine receptor M1UNIPROTP08482AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0032279asymmetric synapseGoComponentGO:0042734presynaptic membraneGoComponentGO:0043679axon terminusGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098685Schaffer collateral - CA1 synapseGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098981cholinergic synapseGoComponentGO:0004930G protein-coupled receptor activityGoFunctionGO:0016907G protein-coupled acetylcholine receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007197adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007213G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007274neuromuscular synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessGO:0043270positive regulation of monoatomic ion transportGoProcessGO:0046541saliva secretionGoProcessGO:0050890cognitionGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0090316positive regulation of intracellular protein transportGoProcessGO:0099170postsynaptic modulation of chemical synaptic transmissionGoProcessIPR000276GPCR_RhodpsnInterProIPR000995Musac_Ach_rcptInterProIPR002228Musac_Ach_M1_rcptInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF182MUSCARINIC ACETYLCHOLINE RECEPTOR M1PANTHERPF000017tm_1PfamR-RNO-390648Muscarinic acetylcholine receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeP08482Muscarinic acetylcholine receptor M1UniProtCHEMBL276CHEMBL1907609CHEMBL211143310116P0848311PROTEINMuscarinic acetylcholine receptor M3GO:0003013GO:0004930GO:0005102GO:0005515GO:0005575GO:0005783GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0032880GO:0043167Rattus norvegicus559MTLHSNSTTSPLFPNISSSWVHSPSEAGLPLGTVTQLGSYNISQETGNFSSNDTSSDPLGGHTIWQVVFIAFLTGFLALVTIIGNILVIVAFKVNKQLKTVNNYFLLSLACADLIIGVISMNLFTTYIIMNRWALGNLACDLWLSIDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTTKRAGVMIGLAWVISFVLWAPAILFWQYFVGKRTVPPGECFIQFLSEPTITFGTAIAAFYMPVTIMTILYWRIYKETEKRTKELAGLQASGTEAEAENFVHPTGSSRSCSSYELQQQGVKRSSRRKYGRCHFWFTTKSWKPSAEQMDQDHSSSDSWNNNDAAASLENSASSDEEDIGSETRAIYSIVLKLPGHSSILNSTKLPSSDNLQVSNEDLGTVDVERNAHKLQAQKSMGDGDNCQKDFTKLPIQLESAVDTGKTSDTNSSADKTTATLPLSFKEATLAKRFALKTRSQITKRKRMSLIKEKKAAQTLSAILLAFIITWTPYNIMVLVNTFCDSCIPKTYWNLGYWLCYINSTVNPVCYALCNKTFRTTFKTLLLCQCDKRKRRKQQYQQRQSVIFHKRVPEQALChrm-3GENE_SYMBOL_OTHERChrm3GENE_SYMBOLMuscarinic acetylcholine receptor M3UNIPROTP08483AlphaFoldDBGO:0005783endoplasmic reticulumGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005886plasma membraneGoComponentGO:0009925basal plasma membraneGoComponentGO:0016323basolateral plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0032279asymmetric synapseGoComponentGO:0042734presynaptic membraneGoComponentGO:0043679axon terminusGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0004930G protein-coupled receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016907G protein-coupled acetylcholine receptor activityGoFunctionGO:0031789G protein-coupled acetylcholine receptor bindingGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:0003063negative regulation of heart rate by acetylcholineGoProcessGO:0006940regulation of smooth muscle contractionGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007197adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007207phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007213G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0032024positive regulation of insulin secretionGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045987positive regulation of smooth muscle contractionGoProcessGO:0046541saliva secretionGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessGO:0099105ion channel modulating, G protein-coupled receptor signaling pathwayGoProcessGO:1904695positive regulation of vascular associated smooth muscle contractionGoProcessGO:1990806ligand-gated ion channel signaling pathwayGoProcessP08483IntActIPR000276GPCR_RhodpsnInterProIPR000995Musac_Ach_rcptInterProIPR001183Musac_Ach_M3_rcptInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF183MUSCARINIC ACETYLCHOLINE RECEPTOR M3PANTHER4DAJPDB4U14PDB4U15PDB4U16PDB5ZHPPDB4DAJAPDBe4U14APDBe4U15APDBe4U16APDBe5ZHPAPDBePF000017tm_1PfamR-RNO-390648Muscarinic acetylcholine receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeP08483Muscarinic acetylcholine receptor M3UniProtQ9QWK9Muscarinic acetylcholine receptor M3UniProtCHEMBL320CHEMBL1907609CHEMBL211134710116P0848512PROTEINMuscarinic acetylcholine receptor M4GO:0004930GO:0005085GO:0005515GO:0005575GO:0005886GO:0007165GO:0007267GO:0008150GO:0016020Rattus norvegicus559MXNFTPVNGSSANQSVRLVTAAHNHLETVEMVFIATVTGSLSLVTVVGNILVMLSIKVNRQLQTVNNYFLFSLGCADLIIGAFSMNLYTLYIIKGYWPLGAVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPARRTTKMAGLMIAAAWVLSFVLWAPAILFWQFVVGKRTVPDNQCFIQFLSNPAVTFGTAIAAFYLPVVIMTVLYIHISLASRSRVHKHRPEGPKEKKAKTLAFLKSPLMKPSIKKPPPGGASREELRNGKLEEAPPPALPPPPRPVPDKDTSNESSSGSATQNTKERPPTELSTAEATTPALPAPTLQPRTLNPASKWSKIQIVTKQTGNECVTAIEIVPATPAGMRPAANVARKFASIARNQVRKKRQMAARERKVTRTIFAILLAFILTWTPYNVMVLVNTFCQSCIPERVWSIGYWLCYVNSTINPACYALCNATFKKTFRHLLLCQYRNIGTARChrm-4GENE_SYMBOL_OTHERChrm4GENE_SYMBOLMuscarinic acetylcholine receptor M4UNIPROTGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030425dendriteGoComponentGO:0032279asymmetric synapseGoComponentGO:0042383sarcolemmaGoComponentGO:0042734presynaptic membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043679axon terminusGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0004930G protein-coupled receptor activityGoFunctionGO:0005085guanyl-nucleotide exchange factor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016907G protein-coupled acetylcholine receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007197adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessP08485IntActIPR000276GPCR_RhodpsnInterProIPR000995Musac_Ach_rcptInterProIPR001432Musac_Ach_M4_rcptInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF180MUSCARINIC ACETYLCHOLINE RECEPTOR M4PANTHERPF000017tm_1PfamR-RNO-390648Muscarinic acetylcholine receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeP08485Muscarinic acetylcholine receptor M4UniProtCHEMBL317CHEMBL190760910116P0891113PROTEINMuscarinic acetylcholine receptor M5GO:0004930GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0016020GO:0050877Rattus norvegicus559MEGESYNESTVNGTPVNHQALERHGLWEVITIAVVTAVVSLMTIVGNVLVMISFKVNSQLKTVNNYYLLSLACADLIIGIFSMNLYTTYILMGRWVLGSLACDLWLALDYVASNASVMNLLVISFDRYFSITRPLTYRAKRTPKRAGIMIGLAWLVSFILWAPAILCWQYLVGKRTVPPDECQIQFLSEPTITFGTAIAAFYIPVSVMTILYCRIYRETEKRTKDLADLQGSDSVAEAKKREPAQRTLLRSFFSCPRPSLAQRERNQASWSSSRRSTSTTGKTTQATDLSADWEKAEQVTTCSSYPSSEDEAKPTTDPVFQMVYKSEAKESPGKESNTQETKETVVNTRTENSDYDTPKYFLSPAAAHRLKSQKCVAYKFRLVVKADGTQETNNGCRKVKIMPCSFPVSKDPSTKGPDPNLSHQMTKRKRMVLVKERKAAQTLSAILLAFIITWTPYNIMVLVSTFCDKCVPVTLWHLGYWLCYVNSTINPICYALCNRTFRKTFKLLLLCRWKKKKVEEKLYWQGNSKLPChrm-5GENE_SYMBOL_OTHERChrm5GENE_SYMBOLMuscarinic acetylcholine receptor M5UNIPROTP08911AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0004930G protein-coupled receptor activityGoFunctionGO:0016907G protein-coupled acetylcholine receptor activityGoFunctionGO:0001696gastric acid secretionGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007197adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0015872dopamine transportGoProcessGO:0019226transmission of nerve impulseGoProcessP08911IntActIPR000276GPCR_RhodpsnInterProIPR000502Musac_Ach_M5_rcptInterProIPR000995Musac_Ach_rcptInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF209MUSCARINIC ACETYLCHOLINE RECEPTOR M5PANTHERPF000017tm_1PfamR-RNO-390648Muscarinic acetylcholine receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeP08911Muscarinic acetylcholine receptor M5UniProtCHEMBL277CHEMBL190760910116P0948314PROTEINNeuronal acetylcholine receptor subunit alpha-4GO:0002376GO:0003674GO:0005515GO:0005575GO:0005886GO:0006259GO:0006810GO:0006950GO:0007165GO:0007267GO:0007585GO:0008150GO:0016020GO:0022857GO:0043167GO:0050877GO:0055085Rattus norvegicus422MANSGTGAPPPLLLLPLLLLLGTGLLPASSHIETRAHAEERLLKRLFSGYNKWSRPVANISDVVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPGDYENVTSIRIPSELIWRPDIVLYNNADGDFAVTHLTKAHLFYDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFGSWTYDKAKIDLVSMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFIIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKVTLCISVLLSLTVFLLLITEIIPSPTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPAWVRRVFLDIVPRLLFMKRPSVVKDNCRRLIESMHKMANAPRFWPEPVGEPGILSDICNQGLSPAPTFCNPTDTAVETQPTCRSPPLEVPDLKTSEVEKASPCPSPGSCPPPKSSSGAPMLIKARSLSVQHVPSSQEAAEDGIRCRSRSIQYCVSQDGAASLADSKPTSSPTSLKARPSQLPVSDQASPCKCTCKEPSPVSPVTVLKAGGTKAPPQHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDRIFLWMFIIVCLLGTVGLFLPPWLAACAcra4GENE_SYMBOL_OTHERChrna4GENE_SYMBOLNeuronal acetylcholine receptor subunit alpha-4UNIPROTP09483AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0009897external side of plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030425dendriteGoComponentGO:0032991protein-containing complexGoComponentGO:0042734presynaptic membraneGoComponentGO:0043005neuron projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098691dopaminergic synapseGoComponentGO:0098793presynapseGoComponentGO:0098981cholinergic synapseGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005216monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0001666response to hypoxiaGoProcessGO:0006281DNA repairGoProcessGO:0006816calcium ion transportGoProcessGO:0006979response to oxidative stressGoProcessGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007585respiratory gaseous exchange by respiratory systemGoProcessGO:0007626locomotory behaviorGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0019228neuronal action potentialGoProcessGO:0019233sensory perception of painGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0035640exploration behaviorGoProcessGO:0042113B cell activationGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0050877nervous system processGoProcessGO:0050890cognitionGoProcessGO:0051899membrane depolarizationGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0060080inhibitory postsynaptic potentialGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessP09483IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamR-RNO-629587Highly sodium permeable postsynaptic acetylcholine nicotinic receptorsReactomeR-RNO-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-RNO-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeO35769Neuronal acetylcholine receptor subunit alpha-4UniProtP09483Neuronal acetylcholine receptor subunit alpha-4UniProtCHEMBL307CHEMBL1907595CHEMBL1907596CHEMBL209411010116P1098015PROTEINMuscarinic acetylcholine receptor M2GO:0004930GO:0005515GO:0005575GO:0005886GO:0007165GO:0007267GO:0008150GO:0016020Rattus norvegicus559MNNSTNSSNNGLAITSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNYFLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFDRYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQFFSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKEKKEPVANQDPVSPSLVQGRIVKPNNNNMPGGDGGLEHNKIQNGKAPRDGVTENCVQGEEKESSNDSTSVSAVASNMRDDEITQDENTVSTSLGHSRDDNSKQTCIKIVTKAQKGDVCTPTSTTVELVGSSGQNGDEKQNIVARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNTVWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATRChrm-2GENE_SYMBOL_OTHERChrm2GENE_SYMBOLMuscarinic acetylcholine receptor M2UNIPROTP10980AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030425dendriteGoComponentGO:0032279asymmetric synapseGoComponentGO:0032280symmetric synapseGoComponentGO:0042734presynaptic membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043679axon terminusGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098981cholinergic synapseGoComponentGO:0004930G protein-coupled receptor activityGoFunctionGO:0016907G protein-coupled acetylcholine receptor activityGoFunctionGO:1990763arrestin family protein bindingGoFunctionGO:0006940regulation of smooth muscle contractionGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007197adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007213G protein-coupled acetylcholine receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0008016regulation of heart contractionGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessIPR000276GPCR_RhodpsnInterProIPR000995Musac_Ach_rcptInterProIPR001065Musac_Ach_M2_rcptInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF207MUSCARINIC ACETYLCHOLINE RECEPTOR M2PANTHERPF000017tm_1PfamR-RNO-390648Muscarinic acetylcholine receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeR-RNO-8856825Cargo recognition for clathrin-mediated endocytosisReactomeR-RNO-8856828Clathrin-mediated endocytosisReactomeP10980Muscarinic acetylcholine receptor M2UniProtQ9Z2Z1Muscarinic acetylcholine receptor M2UniProtCHEMBL309CHEMBL1907609CHEMBL2111433CHEMBL211134710116P1123016PROTEINAcetylcholine receptor subunit betaGO:0003674GO:0005515GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0043167GO:0048856GO:0050877GO:0055085GO:0061024Homo sapiens406MTPGALLMLLGALGAPLAPGVRGSEAEGRLREKLFSGYDSSVRPAREVGDRVRVSVGLILAQLISLNEKDEEMSTKVYLDLEWTDYRLSWDPAEHDGIDSLRITAESVWLPDVVLLNNNDGNFDVALDISVVVSSDGSVRWQPPGIYRSSCSIQVTYFPFDWQNCTMVFSSYSYDSSEVSLQTGLGPDGQGHQEIHIHEGTFIENGQWEIIHKPSRLIQPPGDPRGGREGQRQEVIFYLIIRRKPLFYLVNVIAPCILITLLAIFVFYLPPDAGEKMGLSIFALLTLTVFLLLLADKVPETSLSVPIIIKYLMFTMVLVTFSVILSVVVLNLHHRSPHTHQMPLWVRQIFIHKLPLYLRLKRPKPERDLMPEPPHCSSPGSGWGRGTDEYFIRKPPSDFLFPKPNRFQPELSAPDLRRFIDGPNRAVALLPELREVVSSISYIARQLQEQEDHDALKEDWQFVAMVVDRLFLWTFIIFTSVGTLVIFLDATYHLPPPDPFPAcetylcholine receptor subunit betaUNIPROTACHRBGENE_SYMBOL_OTHERCHRNBGENE_SYMBOL_OTHERCHRNB1GENE_SYMBOLP11230AlphaFoldDBP11230ExpressionAtlasGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0031594neuromuscular junctionGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015267channel activityGoFunctionGO:0015276ligand-gated monoatomic ion channel activityGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0001941postsynaptic membrane organizationGoProcessGO:0006812monoatomic cation transportGoProcessGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007274neuromuscular synaptic transmissionGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0050877nervous system processGoProcessGO:0051899membrane depolarizationGoProcessGO:0055001muscle cell developmentGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessHGNC:1961CHRNB1HGNCP11230IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPA26494cholinergic receptor nicotinic beta 1 subunitPharmGKBP11230PharosB7Z5H1Acetylcholine receptor subunit betaUniProtP11230Acetylcholine receptor subunit betaUniProtQ8IZ46Acetylcholine receptor subunit betaUniProtQ96FB8Acetylcholine receptor subunit betaUniProtCHEMBL1907588CHEMBL2111384CHEMBL2362997CHEMBL3885508CHEMBL4106145CHEMBL45241339606P1180217PROTEINCyclin-dependent kinase 4GO:0005515GO:0005575GO:0005634GO:0005654GO:0005730GO:0005737GO:0005829GO:0007165GO:0008150GO:0016020GO:0016301GO:0016310GO:0030554GO:0043167GO:0051301Homo sapiens148MATSRYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRVPNGGGGGGGLPISTVREVALLRRLEAFEHPNVVRLMDVCATSRTDREIKVTLVFEHVDQDLRTYLDKAPPPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGTVKLADFGLARIYSYQMALTPVVVTLWYRAPEVLLQSTYATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDVSLPRGAFPPRGPRPVQSVVPEMEESGAQLLLEMLTFNPHKRISAFRALQHSYLHKDEGNPE2.7.11.22EC_NUMBERCDK4GENE_SYMBOLCell division protein kinase 4UNIPROTCyclin-dependent kinase 4UNIPROTPSK-J3UNIPROTP11802AlphaFoldDBP11802ExpressionAtlasGO:0000785chromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005667transcription regulator complexGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessHGNC:1773CDK4HGNCP11802IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR050108CDKInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHER2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDB2W96APDBe2W99APDBe2W9FAPDBe2W9ZAPDBe3G33APDBe6P8EAPDBe6P8FAPDBe6P8GAPDBe6P8HAPDBe7SJ3APDBePF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBP11802PharosR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtCHEMBL331CHEMBL1907601CHEMBL2095942CHEMBL2111326CHEMBL3038472CHEMBL3038517CHEMBL3301385CHEMBL3559691CHEMBL3885548CHEMBL3885553CHEMBL3885554CHEMBL4106184CHEMBL4523686CHEMBL4523715CHEMBL4523732CHEMBL4523963CHEMBL4630748CHEMBL48884449606P1238918PROTEINNeuronal acetylcholine receptor subunit alpha-2GO:0003674GO:0005575GO:0005654GO:0005737GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0055085Rattus norvegicus422MTLSHSALQFWTHLYLWCLLLVPAVLTQQGSHTHAEDRLFKHLFGGYNRWARPVPNTSDVVIVRFGLSIAQLIDVDEKNQMMTTNVWLKQEWNDYKLRWDPAEFGNVTSLRVPSEMIWIPDIVLYNNADGEFAVTHMTKAHLFFTGTVHWVPPAIYKSSCSIDVTFFPFDQQNCKMKFGSWTYDKAKIDLEQMERTVDLKDYWESGEWAIINATGTYNSKKYDCCAEIYPDVTYYFVIRRLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTSLVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPSTHNMPNWVRVALLGRVPRWLMMNRPLPPMELHGSPDLKLSPSYHWLETNMDAGEREETEEEEEEEDENICVCAGLPDSSMGVLYGHGGLHLRAMEPETKTPSQASEILLSPQIQKALEGVHYIADRLRSEDADSSVKEDWKYVAMVVDRIFLWLFIIVCFLGTIGLFLPPFLAGMIAcra2GENE_SYMBOL_OTHERChrna2GENE_SYMBOLNeuronal acetylcholine receptor subunit alpha-2UNIPROTP12389AlphaFoldDBGO:0005654nucleoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0032991protein-containing complexGoComponentGO:0043005neuron projectionGoComponentGO:0045171intercellular bridgeGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0071944cell peripheryGoComponentGO:0120111neuron projection cytoplasmGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0051899membrane depolarizationGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0071316cellular response to nicotineGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessGO:0098828modulation of inhibitory postsynaptic potentialGoProcessIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamR-RNO-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-RNO-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeO08952Neuronal acetylcholine receptor subunit alpha-2UniProtP12389Neuronal acetylcholine receptor subunit alpha-2UniProtQ53YK3Neuronal acetylcholine receptor subunit alpha-2UniProtCHEMBL2584CHEMBL1907590CHEMBL1907592CHEMBL209411010116P1239019PROTEINNeuronal acetylcholine receptor subunit beta-2GO:0002376GO:0003674GO:0005515GO:0005575GO:0005886GO:0006810GO:0006950GO:0007165GO:0007267GO:0008150GO:0008283GO:0016020GO:0022857GO:0043167GO:0048856GO:0050877GO:0055085Rattus norvegicus406MAGHSNSMALFSFSLLWLCSGVLGTDTEERLVEHLLDPSRYNKLIRPATNGSELVTVQLMVSLAQLISVHEREQIMTTNVWLTQEWEDYRLTWKPEDFDNMKKVRLPSKHIWLPDVVLYNNADGMYEVSFYSNAVVSYDGSIFWLPPAIYKSACKIEVKHFPFDQQNCTMKFRSWTYDRTEIDLVLKSDVASLDDFTPSGEWDIIALPGRRNENPDDSTYVDITYDFIIRRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTVFLLLISKIVPPTSLDVPLVGKYLMFTMVLVTFSIVTSVCVLNVHHRSPTTHTMAPWVKVVFLEKLPTLLFLQQPRHRCARQRLRLRRRQREREGAGALFFREGPAADPCTCFVNPASVQGLAGAFRAEPTAAGPGRSVGPCSCGLREAVDGVRFIADHMRSEDDDQSVREDWKYVAMVIDRLFLWIFVFVCVFGTVGMFLQPLFQNYTATTFLHPDHSAPSSKAcrb2GENE_SYMBOL_OTHERChrnb2GENE_SYMBOLN-alpha 1UNIPROTNeuronal acetylcholine receptor non-alpha-1 chainUNIPROTNeuronal acetylcholine receptor subunit beta-2UNIPROTP12390AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0009897external side of plasma membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0042734presynaptic membraneGoComponentGO:0043005neuron projectionGoComponentGO:0044853plasma membrane raftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098691dopaminergic synapseGoComponentGO:0098793presynapseGoComponentGO:0098981cholinergic synapseGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0001508action potentialGoProcessGO:0001661conditioned taste aversionGoProcessGO:0001666response to hypoxiaGoProcessGO:0006816calcium ion transportGoProcessGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007601visual perceptionGoProcessGO:0007605sensory perception of soundGoProcessGO:0007612learningGoProcessGO:0007613memoryGoProcessGO:0007626locomotory behaviorGoProcessGO:0008306associative learningGoProcessGO:0008542visual learningGoProcessGO:0014046dopamine secretionGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0019228neuronal action potentialGoProcessGO:0019233sensory perception of painGoProcessGO:0021562vestibulocochlear nerve developmentGoProcessGO:0021631optic nerve morphogenesisGoProcessGO:0021771lateral geniculate nucleus developmentGoProcessGO:0021952central nervous system projection neuron axonogenesisGoProcessGO:0021955central nervous system neuron axonogenesisGoProcessGO:0030890positive regulation of B cell proliferationGoProcessGO:0032225regulation of synaptic transmission, dopaminergicGoProcessGO:0032226positive regulation of synaptic transmission, dopaminergicGoProcessGO:0033603positive regulation of dopamine secretionGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0035176social behaviorGoProcessGO:0042100B cell proliferationGoProcessGO:0042113B cell activationGoProcessGO:0042320regulation of circadian sleep/wake cycle, REM sleepGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0045188regulation of circadian sleep/wake cycle, non-REM sleepGoProcessGO:0048814regulation of dendrite morphogenesisGoProcessGO:0050877nervous system processGoProcessGO:0050890cognitionGoProcessGO:0051899membrane depolarizationGoProcessGO:0051963regulation of synapse assemblyGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0060084synaptic transmission involved in micturitionGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1904456negative regulation of neuronal action potentialGoProcessP12390IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamR-RNO-629587Highly sodium permeable postsynaptic acetylcholine nicotinic receptorsReactomeR-RNO-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-RNO-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeP12390Neuronal acetylcholine receptor subunit beta-2UniProtQ53YK1Neuronal acetylcholine receptor subunit beta-2UniProtCHEMBL3001CHEMBL1907587CHEMBL1907592CHEMBL1907596CHEMBL2094110CHEMBL313727510116P1239220PROTEINNeuronal acetylcholine receptor subunit beta-4GO:0003674GO:0005515GO:0005575GO:0005886GO:0006810GO:0007165GO:0007267GO:0008150GO:0016020GO:0022857GO:0043167GO:0055085Rattus norvegicus406MRGTPLLLVSLFSLLQDGDCRLANAEEKLMDDLLNKTRYNNLIRPATSSSQLISIRLELSLSQLISVNEREQIMTTSIWLKQEWTDYRLAWNSSCYEGVNILRIPAKRVWLPDIVLYNNADGTYEVSVYTNVIVRSNGSIQWLPPAIYKSACKIEVKHFPFDQQNCTLKFRSWTYDHTEIDMVLKSPTAIMDDFTPSGEWDIVALPGRRTVNPQDPSYVDVTYDFIIKRKPLFYTINLIIPCVLITSLAILVFYLPSDCGEKMTLCISVLLALTFFLLLISKIVPPTSLDIPLIGKYLLFTMVLVTFSIVTTVCVLNVHHRSPSTHTMASWVKECFLHKLPTFLFMKRPGLEVSLVRVPHPSQLHLATADTAATSALGPTSPSNLYGSSMYFVNPVPAAPKSAVSSHTAGLPRDARLRSSGRFREDLQEALEGVSFIAQHLESDDRDQSVIEDWKFVAMVVDRLFLWVFVFVCILGTMGLFLPPLFQIHAPSKDSAcrb4GENE_SYMBOL_OTHERChrnb4GENE_SYMBOLN-alpha 2UNIPROTNeuronal acetylcholine receptor non-alpha-2 chainUNIPROTNeuronal acetylcholine receptor subunit beta-4UNIPROTP12392AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0005892acetylcholine-gated channel complexGoComponentGO:0032991protein-containing complexGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098981cholinergic synapseGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0015464acetylcholine receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0042166acetylcholine bindingGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006940regulation of smooth muscle contractionGoProcessGO:0007165signal transductionGoProcessGO:0007271synaptic transmission, cholinergicGoProcessGO:0007626locomotory behaviorGoProcessGO:0019228neuronal action potentialGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0051899membrane depolarizationGoProcessGO:0051971positive regulation of transmission of nerve impulseGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0060084synaptic transmission involved in micturitionGoProcessGO:0095500acetylcholine receptor signaling pathwayGoProcessP12392IntActIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamR-RNO-629587Highly sodium permeable postsynaptic acetylcholine nicotinic receptorsReactomeR-RNO-629594Highly calcium permeable postsynaptic nicotinic acetylcholine receptorsReactomeR-RNO-629597Highly calcium permeable nicotinic acetylcholine receptorsReactomeR-RNO-6798695Neutrophil degranulationReactomeP12392Neuronal acetylcholine receptor subunit beta-4UniProtQ63361Neuronal acetylcholine receptor subunit beta-4UniProtCHEMBL2658CHEMBL1907590CHEMBL1907593CHEMBL1907595CHEMBL2094110CHEMBL3137276CHEMBL4106146CHEMBL452360710116