206Homo sapiensVoltage-dependent L-type calcium channel subunit alpha-1CCHEMBL1940Q13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINSINGLE PROTEINCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamSINGLE PROTEIN9606Homo sapiensVoltage-gated L-type calcium channelCHEMBL2095229Q13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINGROUP MEMBERCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamQ13698Voltage-dependent L-type calcium channel subunit alpha-1S2123PROTEINGROUP MEMBERCACN1GENE_SYMBOL_OTHERCACNL1A3GENE_SYMBOL_OTHERSynonyms=CACH1GENE_SYMBOL_OTHERCACNL1A3 {ECO:0000303|PubMed:7713519GENE_SYMBOL_OTHERCACNA1SGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1SUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.1UNIPROT2VAYAPDBe6B27APDBeGO:0005516calmodulin bindingGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0001501skeletal system developmentGoProcessGO:0002074extraocular skeletal muscle developmentGoProcessGO:0006816calcium ion transportGoProcessGO:0007519skeletal muscle tissue developmentGoProcessGO:0007520myoblast fusionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0048741skeletal muscle fiber developmentGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0055001muscle cell developmentGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0071313cellular response to caffeineGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0031674I bandGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA85calcium voltage-gated channel subunit alpha1 SPharmGKBA4IF51Voltage-dependent L-type calcium channel subunit alpha-1SUniProtB1ALM2Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ12896Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ13934Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ13698Voltage-dependent L-type calcium channel subunit alpha-1SUniProt2VAYPDB6B27PDBQ13698AlphaFoldDBQ13698IntActHGNC:1397CACNA1SHGNCR-HSA-419037NCAM1 interactionsReactomeQ13698PharosQ13698ExpressionAtlasIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005450VDCC_L_a1ssuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF9VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1SPANTHERPF08763Ca_chan_IQPfamPF16905GPHHPfamPF00520Ion_transPfamQ01668Voltage-dependent L-type calcium channel subunit alpha-1D2457PROTEINGROUP MEMBERCACH3GENE_SYMBOL_OTHERCACN4GENE_SYMBOL_OTHERCACNL1A2GENE_SYMBOL_OTHERCCHL1A2GENE_SYMBOL_OTHERCACNA1DGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1DUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 2UNIPROTVoltage-gated calcium channel subunit alpha Cav1.3UNIPROT3LV3APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030506ankyrin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086059voltage-gated calcium channel activity involved SA node cell action potentialGoFunctionGO:0006816calcium ion transportGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007605sensory perception of soundGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0051928positive regulation of calcium ion transportGoProcessGO:0060372regulation of atrial cardiac muscle cell membrane repolarizationGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086046membrane depolarization during SA node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:1901016regulation of potassium ion transmembrane transporter activityGoProcessGO:1901379regulation of potassium ion transmembrane transportGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA84calcium voltage-gated channel subunit alpha1 DPharmGKBB0FYA3Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ13916Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ13931Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ71UT1Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ9UDC3Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ01668Voltage-dependent L-type calcium channel subunit alpha-1DUniProt3LV3PDB7UHFPDB7UHGPDB8E59PDB8E5APDB8E5BPDBQ01668AlphaFoldDBQ01668IntActHGNC:1391CACNA1DHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-9662360Sensory processing of sound by inner hair cells of the cochleaReactomeQ01668PharosQ01668ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR005452LVDCC_a1dsuInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF11VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1DPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamO60840Voltage-dependent L-type calcium channel subunit alpha-1F3882PROTEINGROUP MEMBERCACNAF1GENE_SYMBOL_OTHERCACNA1FGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1FUNIPROTVoltage-gated calcium channel subunit alpha Cav1.4UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0007601visual perceptionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0001750photoreceptor outer segmentGoComponentGO:0016020membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043204perikaryonGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26010calcium voltage-gated channel subunit alpha1 FPharmGKBA6NI29Voltage-dependent L-type calcium channel subunit alpha-1FUniProtF5CIQ9Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO43901Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO95226Voltage-dependent L-type calcium channel subunit alpha-1FUniProtQ9UHB1Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO60840Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO60840AlphaFoldDBO60840IntActHGNC:1393CACNA1FHGNCO60840PharosO60840ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF2VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1FPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamPROTEIN FAMILY9606Homo sapiensVoltage-gated calcium channelCHEMBL2363032O95180Voltage-dependent T-type calcium channel subunit alpha-1H167PROTEINGROUP MEMBERCACNA1HGENE_SYMBOLVoltage-dependent T-type calcium channel subunit alpha-1HUNIPROTLow-voltage-activated calcium channel alpha1 3.2 subunitUNIPROTVoltage-gated calcium channel subunit alpha Cav3.2UNIPROTGO:0005244voltage-gated monoatomic ion channel activityGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005261monoatomic cation channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0008332low voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046873metal ion transmembrane transporter activityGoFunctionGO:0097110scaffold protein bindingGoFunctionGO:0007517muscle organ developmentGoProcessGO:0007520myoblast fusionGoProcessGO:0008016regulation of heart contractionGoProcessGO:0032342aldosterone biosynthetic processGoProcessGO:0032870cellular response to hormone stimulusGoProcessGO:0034651cortisol biosynthetic processGoProcessGO:0035865cellular response to potassium ionGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:2000344positive regulation of acrosome reactionGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA380calcium voltage-gated channel subunit alpha1 HPharmGKBB5ME00Voltage-dependent T-type calcium channel subunit alpha-1HUniProtF8WFD1Voltage-dependent T-type calcium channel subunit alpha-1HUniProtO95802Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ8WWI6Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ96QI6Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ96RZ9Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ9NYY4Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ9NYY5Voltage-dependent T-type calcium channel subunit alpha-1HUniProtO95180Voltage-dependent T-type calcium channel subunit alpha-1HUniProt9AYGPDB9AYHPDB9AYJPDB9AYKPDB9AYLPDBO95180AlphaFoldDBO95180IntActHGNC:1395CACNA1HHGNCR-HSA-419037NCAM1 interactionsReactomeR-HSA-445355Smooth Muscle ContractionReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeO95180PharosO95180ExpressionAtlasIPR005821Ion_trans_domInterProIPR050599VDCC_alpha-1_subunitInterProIPR005445VDCC_T_a1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF37VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1HPANTHERPF00520Ion_transPfamP54289Voltage-dependent calcium channel subunit alpha-2/delta-1236PROTEINGROUP MEMBERCACNL2AGENE_SYMBOL_OTHERCCHL2AGENE_SYMBOL_OTHERMHS3GENE_SYMBOL_OTHERCACNA2D1GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-1UNIPROTVoltage-dependent calcium channel subunit alpha-2-1UNIPROTVoltage-dependent calcium channel subunit delta-1UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086057voltage-gated calcium channel activity involved in bundle of His cell action potentialGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0051924regulation of calcium ion transportGoProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086048membrane depolarization during bundle of His cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA86calcium voltage-gated channel auxiliary subunit alpha2delta 1PharmGKBQ17R45Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD80Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD81Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD82Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtP54289Voltage-dependent calcium channel subunit alpha-2/delta-1UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDB8E59PDB8E5APDB8E5BPDB8EPLPDB8EPMPDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8IF3PDB8IF4PDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDB8X90PDB8X91PDB8X93PDBP54289AlphaFoldDBP54289IntActHGNC:1399CACNA2D1HGNCR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54289PharosP54289ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1PANTHERPF08473VGCC_alpha2PfamPF00092VWAPfamPF08399VWA_NPfamQ13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINGROUP MEMBERCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamQ8IZS8Voltage-dependent calcium channel subunit alpha-2/delta-32080PROTEINGROUP MEMBERCACNA2D3GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-3UNIPROTVoltage-dependent calcium channel subunit alpha-2-3UNIPROTVoltage-dependent calcium channel subunit delta-3UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-3UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0070588calcium ion transmembrane transportGoProcessGO:0099174regulation of presynapse organizationGoProcessGO:0016020membraneGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26013calcium voltage-gated channel auxiliary subunit alpha2delta 3PharmGKBB2RPL6Voltage-dependent calcium channel subunit alpha-2/delta-3UniProtQ9NY16Voltage-dependent calcium channel subunit alpha-2/delta-3UniProtQ9NY18Voltage-dependent calcium channel subunit alpha-2/delta-3UniProtQ8IZS8Voltage-dependent calcium channel subunit alpha-2/delta-3UniProtQ8IZS8AlphaFoldDBQ8IZS8IntActHGNC:15460CACNA2D3HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeQ8IZS8PharosQ8IZS8ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF25VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-3PANTHERPF08473VGCC_alpha2PfamPF13768VWA_3PfamPF08399VWA_NPfamQ13698Voltage-dependent L-type calcium channel subunit alpha-1S2123PROTEINGROUP MEMBERCACN1GENE_SYMBOL_OTHERCACNL1A3GENE_SYMBOL_OTHERSynonyms=CACH1GENE_SYMBOL_OTHERCACNL1A3 {ECO:0000303|PubMed:7713519GENE_SYMBOL_OTHERCACNA1SGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1SUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 3, skeletal muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.1UNIPROT2VAYAPDBe6B27APDBeGO:0005516calmodulin bindingGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0001501skeletal system developmentGoProcessGO:0002074extraocular skeletal muscle developmentGoProcessGO:0006816calcium ion transportGoProcessGO:0007519skeletal muscle tissue developmentGoProcessGO:0007520myoblast fusionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0048741skeletal muscle fiber developmentGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0055001muscle cell developmentGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0071313cellular response to caffeineGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0031674I bandGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA85calcium voltage-gated channel subunit alpha1 SPharmGKBA4IF51Voltage-dependent L-type calcium channel subunit alpha-1SUniProtB1ALM2Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ12896Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ13934Voltage-dependent L-type calcium channel subunit alpha-1SUniProtQ13698Voltage-dependent L-type calcium channel subunit alpha-1SUniProt2VAYPDB6B27PDBQ13698AlphaFoldDBQ13698IntActHGNC:1397CACNA1SHGNCR-HSA-419037NCAM1 interactionsReactomeQ13698PharosQ13698ExpressionAtlasIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005450VDCC_L_a1ssuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF9VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1SPANTHERPF08763Ca_chan_IQPfamPF16905GPHHPfamPF00520Ion_transPfamQ9NY47Voltage-dependent calcium channel subunit alpha-2/delta-22216PROTEINGROUP MEMBERKIAA0558GENE_SYMBOL_OTHERCACNA2D2GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-2UNIPROTVoltage-dependent calcium channel subunit alpha-2-2UNIPROTVoltage-dependent calcium channel subunit delta-2UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-2UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0007528neuromuscular junction developmentGoProcessGO:0035265organ growthGoProcessGO:0040014regulation of multicellular organism growthGoProcessGO:0046622positive regulation of organ growthGoProcessGO:0055001muscle cell developmentGoProcessGO:0060024rhythmic synaptic transmissionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098696regulation of neurotransmitter receptor localization to postsynaptic specialization membraneGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26012calcium voltage-gated channel auxiliary subunit alpha2delta 2PharmGKBA7MD15Voltage-dependent calcium channel subunit alpha-2/delta-2UniProtQ9NY48Voltage-dependent calcium channel subunit alpha-2/delta-2UniProtQ9UEW0Voltage-dependent calcium channel subunit alpha-2/delta-2UniProtQ9Y268Voltage-dependent calcium channel subunit alpha-2/delta-2UniProtQ9NY47Voltage-dependent calcium channel subunit alpha-2/delta-2UniProtQ9NY47AlphaFoldDBQ9NY47IntActHGNC:1400CACNA2D2HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9662360Sensory processing of sound by inner hair cells of the cochleaReactomeQ9NY47PharosQ9NY47ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF7VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-2PANTHERPF08473VGCC_alpha2PfamPF00092VWAPfamPF08399VWA_NPfamQ01668Voltage-dependent L-type calcium channel subunit alpha-1D2457PROTEINGROUP MEMBERCACH3GENE_SYMBOL_OTHERCACN4GENE_SYMBOL_OTHERCACNL1A2GENE_SYMBOL_OTHERCCHL1A2GENE_SYMBOL_OTHERCACNA1DGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1DUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 2UNIPROTVoltage-gated calcium channel subunit alpha Cav1.3UNIPROT3LV3APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030506ankyrin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086059voltage-gated calcium channel activity involved SA node cell action potentialGoFunctionGO:0006816calcium ion transportGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007605sensory perception of soundGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0051928positive regulation of calcium ion transportGoProcessGO:0060372regulation of atrial cardiac muscle cell membrane repolarizationGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086046membrane depolarization during SA node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:1901016regulation of potassium ion transmembrane transporter activityGoProcessGO:1901379regulation of potassium ion transmembrane transportGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA84calcium voltage-gated channel subunit alpha1 DPharmGKBB0FYA3Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ13916Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ13931Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ71UT1Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ9UDC3Voltage-dependent L-type calcium channel subunit alpha-1DUniProtQ01668Voltage-dependent L-type calcium channel subunit alpha-1DUniProt3LV3PDB7UHFPDB7UHGPDB8E59PDB8E5APDB8E5BPDBQ01668AlphaFoldDBQ01668IntActHGNC:1391CACNA1DHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-9662360Sensory processing of sound by inner hair cells of the cochleaReactomeQ01668PharosQ01668ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR005452LVDCC_a1dsuInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF11VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1DPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamO00555Voltage-dependent P/Q-type calcium channel subunit alpha-1A2585PROTEINGROUP MEMBERCACH4GENE_SYMBOL_OTHERCACN3GENE_SYMBOL_OTHERCACNL1A4GENE_SYMBOL_OTHERSynonyms=CACH4GENE_SYMBOL_OTHERCACNA1AGENE_SYMBOLVoltage-dependent P/Q-type calcium channel subunit alpha-1AUNIPROTBrain calcium channel IUNIPROTCalcium channel, L type, alpha-1 polypeptide isoform 4UNIPROTVoltage-gated calcium channel subunit alpha Cav2.1UNIPROT3BXKAPDBeGO:0001540amyloid-beta bindingGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0019905syntaxin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0050804modulation of chemical synaptic transmissionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0043025neuronal cell bodyGoComponentGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0042995cell projectionGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26007calcium voltage-gated channel subunit alpha1 APharmGKBJ3KP41Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtP78510Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtP78511Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ16290Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ92690Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ99790Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ99791Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ99792Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ99793Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ9NS88Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtQ9UDC4Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProtO00555Voltage-dependent P/Q-type calcium channel subunit alpha-1AUniProt3BXKPDB8X90PDB8X91PDB8X93PDBO00555AlphaFoldDBO00555IntActHGNC:1388CACNA1AHGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-422356Regulation of insulin secretionReactomeO00555PharosO00555ExpressionAtlasIPR005448CACNA1AInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF3VOLTAGE-DEPENDENT P_Q-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1APANTHERPF08763Ca_chan_IQPfamPF16905GPHHPfamPF00520Ion_transPfamQ00975Voltage-dependent N-type calcium channel subunit alpha-1B2795PROTEINGROUP MEMBERCACH5GENE_SYMBOL_OTHERCACNL1A5GENE_SYMBOL_OTHERCACNA1BGENE_SYMBOLVoltage-dependent N-type calcium channel subunit alpha-1BUNIPROTBrain calcium channel IIIUNIPROTCalcium channel, L type, alpha-1 polypeptide isoform 5UNIPROTVoltage-gated calcium channel subunit alpha Cav2.2UNIPROTBIIIUNIPROTGO:0001540amyloid-beta bindingGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005509calcium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0050804modulation of chemical synaptic transmissionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0043025neuronal cell bodyGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26008calcium voltage-gated channel subunit alpha1 BPharmGKBB1AQK5Voltage-dependent N-type calcium channel subunit alpha-1BUniProtQ00975Voltage-dependent N-type calcium channel subunit alpha-1BUniProt2LCMPDB7MIXPDB7MIYPDB7VFSPDB7VFUPDB7VFVPDB7VFWPDBQ00975AlphaFoldDBQ00975IntActHGNC:1389CACNA1BHGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeQ00975PharosQ00975ExpressionAtlasIPR002048EF_hand_domInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005447VDCC_N_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF6VOLTAGE-DEPENDENT N-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1BPANTHERPF08763Ca_chan_IQPfamPF16905GPHHPfamPF00520Ion_transPfamO43497Voltage-dependent T-type calcium channel subunit alpha-1G2958PROTEINGROUP MEMBERKIAA1123GENE_SYMBOL_OTHERCACNA1GGENE_SYMBOLVoltage-dependent T-type calcium channel subunit alpha-1GUNIPROTCav3.1cUNIPROTNBR13UNIPROTVoltage-gated calcium channel subunit alpha Cav3.1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005261monoatomic cation channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0008332low voltage-gated calcium channel activityGoFunctionGO:0046873metal ion transmembrane transporter activityGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0086059voltage-gated calcium channel activity involved SA node cell action potentialGoFunctionGO:0097110scaffold protein bindingGoFunctionGO:0001508action potentialGoProcessGO:0002027regulation of heart rateGoProcessGO:0003163sinoatrial node developmentGoProcessGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0060371regulation of atrial cardiac muscle cell membrane depolarizationGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086015SA node cell action potentialGoProcessGO:0086016AV node cell action potentialGoProcessGO:0086018SA node cell to atrial cardiac muscle cell signalingGoProcessGO:0086027AV node cell to bundle of His cell signalingGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086046membrane depolarization during SA node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA381calcium voltage-gated channel subunit alpha1 GPharmGKBD6RA64Voltage-dependent T-type calcium channel subunit alpha-1GUniProtE7EPR0Voltage-dependent T-type calcium channel subunit alpha-1GUniProtO43498Voltage-dependent T-type calcium channel subunit alpha-1GUniProtO94770Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QY8Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QY9Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ0Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ1Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ2Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ3Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ4Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ5Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ6Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ7Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ8Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19QZ9Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R00Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R01Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R02Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R03Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R04Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R05Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R06Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R07Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R08Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R09Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R10Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R11Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R12Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R13Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R15Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R16Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R17Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ19R18Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ2TAC4Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU4Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU5Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU6Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU7Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU8Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYU9Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYV0Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9NYV1Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9UHN9Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9UHP0Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9ULU6Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9UNG7Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9Y5T2Voltage-dependent T-type calcium channel subunit alpha-1GUniProtQ9Y5T3Voltage-dependent T-type calcium channel subunit alpha-1GUniProtO43497Voltage-dependent T-type calcium channel subunit alpha-1GUniProt6KZOPDB6KZPPDBO43497AlphaFoldDBO43497IntActHGNC:1394CACNA1GHGNCR-HSA-419037NCAM1 interactionsReactomeR-HSA-445355Smooth Muscle ContractionReactomeO43497PharosO43497ExpressionAtlasIPR005821Ion_trans_domInterProIPR050599VDCC_alpha-1_subunitInterProIPR005445VDCC_T_a1InterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF33VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1GPANTHERPF00520Ion_transPfamQ7Z3S7Voltage-dependent calcium channel subunit alpha-2/delta-43672PROTEINGROUP MEMBERCACNA2D4GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-4UNIPROTVoltage-dependent calcium channel subunit alpha-2-4UNIPROTVoltage-dependent calcium channel subunit delta-4UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-4UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0070588calcium ion transmembrane transportGoProcessGO:0016020membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA130546913calcium voltage-gated channel auxiliary subunit alpha2delta 4PharmGKBQ7Z3S8Voltage-dependent calcium channel subunit alpha-2/delta-4UniProtQ86XZ5Voltage-dependent calcium channel subunit alpha-2/delta-4UniProtQ8IZS9Voltage-dependent calcium channel subunit alpha-2/delta-4UniProtQ7Z3S7Voltage-dependent calcium channel subunit alpha-2/delta-4UniProtQ7Z3S7AlphaFoldDBQ7Z3S7IntActHGNC:20202CACNA2D4HGNCQ7Z3S7PharosQ7Z3S7ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF59VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-4PANTHERPF08473VGCC_alpha2PfamPF13768VWA_3PfamPF08399VWA_NPfamQ9P0X4Voltage-dependent T-type calcium channel subunit alpha-1I3849PROTEINGROUP MEMBERKIAA1120GENE_SYMBOL_OTHERCACNA1IGENE_SYMBOLVoltage-dependent T-type calcium channel subunit alpha-1IUNIPROTVoltage-gated calcium channel subunit alpha Cav3.3UNIPROTCa(v)3.3UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005261monoatomic cation channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046873metal ion transmembrane transporter activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0007165signal transductionGoProcessGO:0019228neuronal action potentialGoProcessGO:0030431sleepGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26011calcium voltage-gated channel subunit alpha1 IPharmGKBB0QY12Voltage-dependent T-type calcium channel subunit alpha-1IUniProtB0QY13Voltage-dependent T-type calcium channel subunit alpha-1IUniProtB0QY14Voltage-dependent T-type calcium channel subunit alpha-1IUniProtO95504Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ5JZ88Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ7Z6S9Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ8NFX6Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9NZC8Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9UH15Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9UH30Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9ULU9Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9UNE6Voltage-dependent T-type calcium channel subunit alpha-1IUniProtQ9P0X4Voltage-dependent T-type calcium channel subunit alpha-1IUniProt7WLIPDB7WLJPDB7WLKPDB7WLLPDBQ9P0X4AlphaFoldDBQ9P0X4IntActHGNC:1396CACNA1IHGNCR-HSA-419037NCAM1 interactionsReactomeR-HSA-445355Smooth Muscle ContractionReactomeQ9P0X4PharosIPR005821Ion_trans_domInterProIPR050599VDCC_alpha-1_subunitInterProIPR005445VDCC_T_a1InterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF39VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1IPANTHERPF00520Ion_transPfamO60840Voltage-dependent L-type calcium channel subunit alpha-1F3882PROTEINGROUP MEMBERCACNAF1GENE_SYMBOL_OTHERCACNA1FGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1FUNIPROTVoltage-gated calcium channel subunit alpha Cav1.4UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0007601visual perceptionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0001750photoreceptor outer segmentGoComponentGO:0016020membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043204perikaryonGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26010calcium voltage-gated channel subunit alpha1 FPharmGKBA6NI29Voltage-dependent L-type calcium channel subunit alpha-1FUniProtF5CIQ9Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO43901Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO95226Voltage-dependent L-type calcium channel subunit alpha-1FUniProtQ9UHB1Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO60840Voltage-dependent L-type calcium channel subunit alpha-1FUniProtO60840AlphaFoldDBO60840IntActHGNC:1393CACNA1FHGNCO60840PharosO60840ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF2VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1FPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamQ15878Voltage-dependent R-type calcium channel subunit alpha-1E5205PROTEINGROUP MEMBERCACH6GENE_SYMBOL_OTHERCACNL1A6GENE_SYMBOL_OTHERCACNA1EGENE_SYMBOLVoltage-dependent R-type calcium channel subunit alpha-1EUNIPROTBrain calcium channel IIUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 6UNIPROTVoltage-gated calcium channel subunit alpha Cav2.3UNIPROTBIIUNIPROT3BXLAPDBeGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005509calcium ion bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0022843voltage-gated monoatomic cation channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0043025neuronal cell bodyGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26009calcium voltage-gated channel subunit alpha1 EPharmGKBB1AM12Voltage-dependent R-type calcium channel subunit alpha-1EUniProtB1AM13Voltage-dependent R-type calcium channel subunit alpha-1EUniProtB1AM14Voltage-dependent R-type calcium channel subunit alpha-1EUniProtQ14580Voltage-dependent R-type calcium channel subunit alpha-1EUniProtQ14581Voltage-dependent R-type calcium channel subunit alpha-1EUniProtQ15878Voltage-dependent R-type calcium channel subunit alpha-1EUniProt3BXLPDB7XLQPDB7YG5PDB8EPLPDB8EPMPDBQ15878AlphaFoldDBQ15878IntActHGNC:1392CACNA1EHGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-422356Regulation of insulin secretionReactomeQ15878PharosQ15878ExpressionAtlasIPR002048EF_hand_domInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005449VDCC_R_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF5VOLTAGE-DEPENDENT R-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1EPANTHERPF08763Ca_chan_IQPfamPF16905GPHHPfamPF00520Ion_transPfamO00305Voltage-dependent L-type calcium channel subunit beta-47366PROTEINGROUP MEMBERCACNLB4GENE_SYMBOL_OTHERCACNB4GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-4UNIPROTCalcium channel voltage-dependent subunit beta 4UNIPROTCAB4UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0006816calcium ion transportGoProcessGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0007628adult walking behaviorGoProcessGO:0008285negative regulation of cell population proliferationGoProcessGO:0014051gamma-aminobutyric acid secretionGoProcessGO:0019227neuronal action potential propagationGoProcessGO:0035249synaptic transmission, glutamatergicGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0046058cAMP metabolic processGoProcessGO:0048536spleen developmentGoProcessGO:0048538thymus developmentGoProcessGO:0048541Peyer's patch developmentGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0050877nervous system processGoProcessGO:0055001muscle cell developmentGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1901385regulation of voltage-gated calcium channel activityGoProcessGO:1904751positive regulation of protein localization to nucleolusGoProcessGO:2000134negative regulation of G1/S transition of mitotic cell cycleGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005829cytosolGoComponentGO:0009898cytoplasmic side of plasma membraneGoComponentGO:0016607nuclear speckGoComponentGO:0098793presynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26014calcium voltage-gated channel auxiliary subunit beta 4PharmGKBA7BJ74Voltage-dependent L-type calcium channel subunit beta-4UniProtA8K1Y4Voltage-dependent L-type calcium channel subunit beta-4UniProtB4DG40Voltage-dependent L-type calcium channel subunit beta-4UniProtO60515Voltage-dependent L-type calcium channel subunit beta-4UniProtQ6B000Voltage-dependent L-type calcium channel subunit beta-4UniProtQ96L40Voltage-dependent L-type calcium channel subunit beta-4UniProtO00305Voltage-dependent L-type calcium channel subunit beta-4UniProt2D46PDBO00305AlphaFoldDBO00305IntActHGNC:1404CACNB4HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-419037NCAM1 interactionsReactomeO00305PharosO00305ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamQ08289Voltage-dependent L-type calcium channel subunit beta-27367PROTEINGROUP MEMBERCACNLB2GENE_SYMBOL_OTHERMYSBGENE_SYMBOL_OTHERCACNB2GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-2UNIPROTCalcium channel voltage-dependent subunit beta 2UNIPROTLambert-Eaton myasthenic syndrome antigen BUNIPROTCAB2UNIPROTMYSBUNIPROTGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0007601visual perceptionGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0051928positive regulation of calcium ion transportGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1901843positive regulation of high voltage-gated calcium channel activityGoProcessGO:1904879positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0005886plasma membraneGoComponentGO:0042383sarcolemmaGoComponentGO:0098684photoreceptor ribbon synapseGoComponentGO:0098793presynapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA88calcium voltage-gated channel auxiliary subunit beta 2PharmGKBA6PVM5Voltage-dependent L-type calcium channel subunit beta-2UniProtA6PVM7Voltage-dependent L-type calcium channel subunit beta-2UniProtA6PVM8Voltage-dependent L-type calcium channel subunit beta-2UniProtO00304Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5QJ99Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5QJA0Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VVG9Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VVH0Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VWV6Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME1Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME2Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME3Voltage-dependent L-type calcium channel subunit beta-2UniProtQ8WX81Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ3Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ4Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ5Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9BWU2Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9HD32Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9Y340Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9Y341Voltage-dependent L-type calcium channel subunit beta-2UniProtQ08289Voltage-dependent L-type calcium channel subunit beta-2UniProt8HLPPDB8HMAPDB8HMBPDBQ08289AlphaFoldDBQ08289IntActHGNC:1402CACNB2HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9662360Sensory processing of sound by inner hair cells of the cochleaReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeQ08289PharosQ08289ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR035605CACNB2_SH3InterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR005444VDCC_L_b2suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamQ02641Voltage-dependent L-type calcium channel subunit beta-17368PROTEINGROUP MEMBERCACNLB1GENE_SYMBOL_OTHERCACNB1GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-1UNIPROTCalcium channel voltage-dependent subunit beta 1UNIPROTCAB1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0042383sarcolemmaGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0030315T-tubuleGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA87calcium voltage-gated channel auxiliary subunit beta 1PharmGKBA8K114Voltage-dependent L-type calcium channel subunit beta-1UniProtO15331Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02639Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02640Voltage-dependent L-type calcium channel subunit beta-1UniProtQ8N3X9Voltage-dependent L-type calcium channel subunit beta-1UniProtQ9C085Voltage-dependent L-type calcium channel subunit beta-1UniProtQ9UD79Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02641Voltage-dependent L-type calcium channel subunit beta-1UniProt7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDBQ02641AlphaFoldDBQ02641IntActHGNC:1401CACNB1HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeQ02641PharosQ02641ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR005443VDCC_L_b1suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamP54284Voltage-dependent L-type calcium channel subunit beta-37369PROTEINGROUP MEMBERCACNLB3GENE_SYMBOL_OTHERCACNB3GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-3UNIPROTCalcium channel voltage-dependent subunit beta 3UNIPROTCAB3UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1901843positive regulation of high voltage-gated calcium channel activityGoProcessGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA89calcium voltage-gated channel auxiliary subunit beta 3PharmGKBA8K0Z4Voltage-dependent L-type calcium channel subunit beta-3UniProtB7Z4Q1Voltage-dependent L-type calcium channel subunit beta-3UniProtB7Z973Voltage-dependent L-type calcium channel subunit beta-3UniProtB7ZAK8Voltage-dependent L-type calcium channel subunit beta-3UniProtF5GZW7Voltage-dependent L-type calcium channel subunit beta-3UniProtF5H2P6Voltage-dependent L-type calcium channel subunit beta-3UniProtF8VSG3Voltage-dependent L-type calcium channel subunit beta-3UniProtQ13913Voltage-dependent L-type calcium channel subunit beta-3UniProtP54284Voltage-dependent L-type calcium channel subunit beta-3UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB8E59PDB8E5APDB8E5BPDB8EPLPDB8FHSPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8X90PDB8X91PDB8X93PDBP54284AlphaFoldDBP54284IntActHGNC:1403CACNB3HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54284PharosP54284ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR035760CACNB3_SH3InterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR008079VDCC_L_b3suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamP62955Voltage-dependent calcium channel gamma-7 subunit7370PROTEINGROUP MEMBERCACNG7GENE_SYMBOLVoltage-dependent calcium channel gamma-7 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-7 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-7UNIPROTTARP gamma-7UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0019226transmission of nerve impulseGoProcessGO:0043488regulation of mRNA stabilityGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:0099645neurotransmitter receptor localization to postsynaptic specialization membraneGoProcessGO:1903861positive regulation of dendrite extensionGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0005769early endosomeGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0044300cerebellar mossy fiberGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0032281AMPA glutamate receptor complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA26021calcium voltage-gated channel auxiliary subunit gamma 7PharmGKBQ52LL8Voltage-dependent calcium channel gamma-7 subunitUniProtQ8VBX3Voltage-dependent calcium channel gamma-7 subunitUniProtQ8WXS6Voltage-dependent calcium channel gamma-7 subunitUniProtQ9BXT1Voltage-dependent calcium channel gamma-7 subunitUniProtP62955Voltage-dependent calcium channel gamma-7 subunitUniProtP62955AlphaFoldDBP62955IntActHGNC:13626CACNG7HGNCR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP62955PharosP62955ExpressionAtlasIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR008371VDCC_g7suInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF12VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-7 SUBUNITPANTHERPF13903Claudin_2PfamQ9UF02Voltage-dependent calcium channel gamma-5 subunit7371PROTEINGROUP MEMBERCACNG5GENE_SYMBOLVoltage-dependent calcium channel gamma-5 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-5 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-5UNIPROTTARP gamma-5UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0015075monoatomic ion transmembrane transporter activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0019226transmission of nerve impulseGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0032281AMPA glutamate receptor complexGoComponentPA26019calcium voltage-gated channel auxiliary subunit gamma 5PharmGKBA8K2A6Voltage-dependent calcium channel gamma-5 subunitUniProtQ547R3Voltage-dependent calcium channel gamma-5 subunitUniProtQ8WXS7Voltage-dependent calcium channel gamma-5 subunitUniProtQ9UHM3Voltage-dependent calcium channel gamma-5 subunitUniProtQ9UF02Voltage-dependent calcium channel gamma-5 subunitUniProtQ9UF02AlphaFoldDBQ9UF02IntActHGNC:1409CACNG5HGNCQ9UF02PharosQ9UF02ExpressionAtlasIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR008369VDCC_g5suInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF4VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-5 SUBUNITPANTHERPF13903Claudin_2PfamQ9Y698Voltage-dependent calcium channel gamma-2 subunit7372PROTEINGROUP MEMBERCACNG2GENE_SYMBOLVoltage-dependent calcium channel gamma-2 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-2 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-2UNIPROTTARP gamma-2UNIPROT6TNOAPDBeGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0035255ionotropic glutamate receptor bindingGoFunctionGO:0006612protein targeting to membraneGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0019226transmission of nerve impulseGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0050877nervous system processGoProcessGO:0051899membrane depolarizationGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0060081membrane hyperpolarizationGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099072regulation of postsynaptic membrane neurotransmitter receptor levelsGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:0099645neurotransmitter receptor localization to postsynaptic specialization membraneGoProcessGO:1904510positive regulation of protein localization to basolateral plasma membraneGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0005886plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0030666endocytic vesicle membraneGoComponentGO:0036477somatodendritic compartmentGoComponentGO:0043005neuron projectionGoComponentGO:0044300cerebellar mossy fiberGoComponentGO:0045202synapseGoComponentGO:0098685Schaffer collateral - CA1 synapseGoComponentGO:0098686hippocampal mossy fiber to CA3 synapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0032281AMPA glutamate receptor complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26016calcium voltage-gated channel auxiliary subunit gamma 2PharmGKBQ2M1M1Voltage-dependent calcium channel gamma-2 subunitUniProtQ5TGT3Voltage-dependent calcium channel gamma-2 subunitUniProtQ9UGZ7Voltage-dependent calcium channel gamma-2 subunitUniProtQ9Y698Voltage-dependent calcium channel gamma-2 subunitUniProt6DLZPDB6DM0PDB6DM1PDB6O9GPDB6TNOPDBQ9Y698AlphaFoldDBHGNC:1406CACNG2HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-399719Trafficking of AMPA receptorsReactomeR-HSA-5682910LGI-ADAM interactionsReactomeQ9Y698PharosIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR005422VDCC_g2suInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF1VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-2 SUBUNITPANTHERPF00822PMP22_ClaudinPfamQ9UBN1Voltage-dependent calcium channel gamma-4 subunit7373PROTEINGROUP MEMBERCACNG4GENE_SYMBOLVoltage-dependent calcium channel gamma-4 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-4 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-4UNIPROTTARP gamma-4UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0035255ionotropic glutamate receptor bindingGoFunctionGO:0019226transmission of nerve impulseGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0005886plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0030666endocytic vesicle membraneGoComponentGO:0036477somatodendritic compartmentGoComponentGO:0044297cell bodyGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0032281AMPA glutamate receptor complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA26018calcium voltage-gated channel auxiliary subunit gamma 4PharmGKBB2RCK0Voltage-dependent calcium channel gamma-4 subunitUniProtQ9UBN1Voltage-dependent calcium channel gamma-4 subunitUniProtQ9UBN1AlphaFoldDBQ9UBN1IntActHGNC:1408CACNG4HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-399719Trafficking of AMPA receptorsReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-5682910LGI-ADAM interactionsReactomeQ9UBN1PharosQ9UBN1ExpressionAtlasIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR005423VDCC_g4suInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF7VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-4 SUBUNITPANTHERPF00822PMP22_ClaudinPfamQ8WXS5Voltage-dependent calcium channel gamma-8 subunit7374PROTEINGROUP MEMBERCACNG6GENE_SYMBOL_OTHERCACNG8GENE_SYMBOLVoltage-dependent calcium channel gamma-8 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-8 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-8UNIPROTTARP gamma-8UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0019226transmission of nerve impulseGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030666endocytic vesicle membraneGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0032281AMPA glutamate receptor complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA26022calcium voltage-gated channel auxiliary subunit gamma 8PharmGKBQ9BXT0Voltage-dependent calcium channel gamma-8 subunitUniProtQ9BY23Voltage-dependent calcium channel gamma-8 subunitUniProtQ8WXS5Voltage-dependent calcium channel gamma-8 subunitUniProtQ8WXS5AlphaFoldDBQ8WXS5IntActHGNC:13628CACNG8HGNCR-HSA-399719Trafficking of AMPA receptorsReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-5682910LGI-ADAM interactionsReactomeQ8WXS5PharosQ8WXS5ExpressionAtlasIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR008372VDCC_g8suInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF2VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-8 SUBUNITPANTHERPF00822PMP22_ClaudinPfamO60359Voltage-dependent calcium channel gamma-3 subunit7375PROTEINGROUP MEMBERCACNG3GENE_SYMBOLVoltage-dependent calcium channel gamma-3 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-3 subunitUNIPROTTransmembrane AMPAR regulatory protein gamma-3UNIPROTTARP gamma-3UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0030165PDZ domain bindingGoFunctionGO:0035255ionotropic glutamate receptor bindingGoFunctionGO:0006605protein targetingGoProcessGO:0006816calcium ion transportGoProcessGO:0008104protein localizationGoProcessGO:0019226transmission of nerve impulseGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098943neurotransmitter receptor transport, postsynaptic endosome to lysosomeGoProcessGO:0098970postsynaptic neurotransmitter receptor diffusion trappingGoProcessGO:0099590neurotransmitter receptor internalizationGoProcessGO:0099645neurotransmitter receptor localization to postsynaptic specialization membraneGoProcessGO:2000311regulation of AMPA receptor activityGoProcessGO:0098839postsynaptic density membraneGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030425dendriteGoComponentGO:0030666endocytic vesicle membraneGoComponentGO:0036477somatodendritic compartmentGoComponentGO:0060076excitatory synapseGoComponentGO:0098685Schaffer collateral - CA1 synapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0032281AMPA glutamate receptor complexGoComponentGO:0034702monoatomic ion channel complexGoComponentPA26017calcium voltage-gated channel auxiliary subunit gamma 3PharmGKBO60359Voltage-dependent calcium channel gamma-3 subunitUniProtO60359AlphaFoldDBO60359IntActHGNC:1407CACNG3HGNCR-HSA-399719Trafficking of AMPA receptorsReactomeR-HSA-5682910LGI-ADAM interactionsReactomeO60359PharosIPR051072CACNG_subunitInterProIPR004031PMP22/EMP/MP20/ClaudinInterProIPR008368VDCC_gsuInterProPTHR12107VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA SUBUNITPANTHERPTHR12107:SF5VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-3 SUBUNITPANTHERPF00822PMP22_ClaudinPfamQ9BXT2Voltage-dependent calcium channel gamma-6 subunit7376PROTEINGROUP MEMBERCACNG6GENE_SYMBOLVoltage-dependent calcium channel gamma-6 subunitUNIPROTNeuronal voltage-gated calcium channel gamma-6 subunitUNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA26020calcium voltage-gated channel auxiliary subunit gamma 6PharmGKBHGNC:13625CACNG6HGNCQ9BXT2Voltage-dependent calcium channel gamma-6 subunitUniProtQ9BXT2AlphaFoldDBQ9BXT2IntActR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ9BXT2PharosQ9BXT2ExpressionAtlasIPR004031PMP22/EMP/MP20/ClaudinInterProIPR008370VDCC_g6suInterProIPR008368VDCC_gsuInterProPTHR15025VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATEDPANTHERPTHR15025:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-6 SUBUNITPANTHERPF13903Claudin_2PfamQ06432Voltage-dependent calcium channel gamma-1 subunit7377PROTEINGROUP MEMBERCACNLGGENE_SYMBOL_OTHERSynonyms=CACNLGGENE_SYMBOL_OTHERSynonyms=CACNLG {ECO:0000303|PubMed:8387489GENE_SYMBOL_OTHERCACNG1GENE_SYMBOLVoltage-dependent calcium channel gamma-1 subunitUNIPROTDihydropyridine-sensitive L-type, skeletal muscle calcium channel subunit gammaUNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0045933positive regulation of muscle contractionGoProcessGO:0070296sarcoplasmic reticulum calcium ion transportGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0030315T-tubuleGoComponentGO:0042383sarcolemmaGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA26015calcium voltage-gated channel auxiliary subunit gamma 1PharmGKBB2R9N3Voltage-dependent calcium channel gamma-1 subunitUniProtQ14D59Voltage-dependent calcium channel gamma-1 subunitUniProtQ06432Voltage-dependent calcium channel gamma-1 subunitUniProtQ06432AlphaFoldDBQ06432IntActHGNC:1405CACNG1HGNCQ06432PharosIPR004031PMP22/EMP/MP20/ClaudinInterProIPR005421VDCC_g1suInterProIPR008368VDCC_gsuInterProPTHR15025:SF1VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNITPANTHERPTHR15025VOLTAGE-DEPENDENT CALCIUM CHANNEL GAMMA-1 SUBUNIT-RELATEDPANTHERPF13903Claudin_2PfamPROTEIN COMPLEX GROUP9606Homo sapiensVoltage-dependent L-type calcium channel alpha1C/alpha2delta/beta1bCHEMBL3988638P54289Voltage-dependent calcium channel subunit alpha-2/delta-1236PROTEINPROTEIN SUBUNITCACNL2AGENE_SYMBOL_OTHERCCHL2AGENE_SYMBOL_OTHERMHS3GENE_SYMBOL_OTHERCACNA2D1GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-1UNIPROTVoltage-dependent calcium channel subunit alpha-2-1UNIPROTVoltage-dependent calcium channel subunit delta-1UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086057voltage-gated calcium channel activity involved in bundle of His cell action potentialGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0051924regulation of calcium ion transportGoProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086048membrane depolarization during bundle of His cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA86calcium voltage-gated channel auxiliary subunit alpha2delta 1PharmGKBQ17R45Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD80Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD81Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD82Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtP54289Voltage-dependent calcium channel subunit alpha-2/delta-1UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDB8E59PDB8E5APDB8E5BPDB8EPLPDB8EPMPDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8IF3PDB8IF4PDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDB8X90PDB8X91PDB8X93PDBP54289AlphaFoldDBP54289IntActHGNC:1399CACNA2D1HGNCR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54289PharosP54289ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1PANTHERPF08473VGCC_alpha2PfamPF00092VWAPfamPF08399VWA_NPfamQ13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINPROTEIN SUBUNITCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamQ02641Voltage-dependent L-type calcium channel subunit beta-17368PROTEINPROTEIN SUBUNITCACNLB1GENE_SYMBOL_OTHERCACNB1GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-1UNIPROTCalcium channel voltage-dependent subunit beta 1UNIPROTCAB1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0042383sarcolemmaGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0030315T-tubuleGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA87calcium voltage-gated channel auxiliary subunit beta 1PharmGKBA8K114Voltage-dependent L-type calcium channel subunit beta-1UniProtO15331Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02639Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02640Voltage-dependent L-type calcium channel subunit beta-1UniProtQ8N3X9Voltage-dependent L-type calcium channel subunit beta-1UniProtQ9C085Voltage-dependent L-type calcium channel subunit beta-1UniProtQ9UD79Voltage-dependent L-type calcium channel subunit beta-1UniProtQ02641Voltage-dependent L-type calcium channel subunit beta-1UniProt7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDBQ02641AlphaFoldDBQ02641IntActHGNC:1401CACNB1HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeQ02641PharosQ02641ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR005443VDCC_L_b1suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamPROTEIN COMPLEX9606Homo sapiensL-type calcium channel alpha-1c/beta-2/alpha2delta-1CHEMBL4106164P54289Voltage-dependent calcium channel subunit alpha-2/delta-1236PROTEINPROTEIN SUBUNITCACNL2AGENE_SYMBOL_OTHERCCHL2AGENE_SYMBOL_OTHERMHS3GENE_SYMBOL_OTHERCACNA2D1GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-1UNIPROTVoltage-dependent calcium channel subunit alpha-2-1UNIPROTVoltage-dependent calcium channel subunit delta-1UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086057voltage-gated calcium channel activity involved in bundle of His cell action potentialGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0051924regulation of calcium ion transportGoProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086048membrane depolarization during bundle of His cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA86calcium voltage-gated channel auxiliary subunit alpha2delta 1PharmGKBQ17R45Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD80Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD81Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD82Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtP54289Voltage-dependent calcium channel subunit alpha-2/delta-1UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDB8E59PDB8E5APDB8E5BPDB8EPLPDB8EPMPDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8IF3PDB8IF4PDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDB8X90PDB8X91PDB8X93PDBP54289AlphaFoldDBP54289IntActHGNC:1399CACNA2D1HGNCR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54289PharosP54289ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1PANTHERPF08473VGCC_alpha2PfamPF00092VWAPfamPF08399VWA_NPfamQ13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINPROTEIN SUBUNITCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamQ08289Voltage-dependent L-type calcium channel subunit beta-27367PROTEINPROTEIN SUBUNITCACNLB2GENE_SYMBOL_OTHERMYSBGENE_SYMBOL_OTHERCACNB2GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-2UNIPROTCalcium channel voltage-dependent subunit beta 2UNIPROTLambert-Eaton myasthenic syndrome antigen BUNIPROTCAB2UNIPROTMYSBUNIPROTGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0007601visual perceptionGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0051928positive regulation of calcium ion transportGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1901843positive regulation of high voltage-gated calcium channel activityGoProcessGO:1904879positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0005886plasma membraneGoComponentGO:0042383sarcolemmaGoComponentGO:0098684photoreceptor ribbon synapseGoComponentGO:0098793presynapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA88calcium voltage-gated channel auxiliary subunit beta 2PharmGKBA6PVM5Voltage-dependent L-type calcium channel subunit beta-2UniProtA6PVM7Voltage-dependent L-type calcium channel subunit beta-2UniProtA6PVM8Voltage-dependent L-type calcium channel subunit beta-2UniProtO00304Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5QJ99Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5QJA0Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VVG9Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VVH0Voltage-dependent L-type calcium channel subunit beta-2UniProtQ5VWV6Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME1Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME2Voltage-dependent L-type calcium channel subunit beta-2UniProtQ6TME3Voltage-dependent L-type calcium channel subunit beta-2UniProtQ8WX81Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ3Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ4Voltage-dependent L-type calcium channel subunit beta-2UniProtQ96NZ5Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9BWU2Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9HD32Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9Y340Voltage-dependent L-type calcium channel subunit beta-2UniProtQ9Y341Voltage-dependent L-type calcium channel subunit beta-2UniProtQ08289Voltage-dependent L-type calcium channel subunit beta-2UniProt8HLPPDB8HMAPDB8HMBPDBQ08289AlphaFoldDBQ08289IntActHGNC:1402CACNB2HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeR-HSA-9662360Sensory processing of sound by inner hair cells of the cochleaReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeQ08289PharosQ08289ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR035605CACNB2_SH3InterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR005444VDCC_L_b2suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamPROTEIN COMPLEX9606Homo sapiensVoltage-dependent L-type calcium channel subunit alpha-1C/L-type calcium channel subunit beta-3/calcium channel subunit alpha-2/delta-1CHEMBL6066567P54289Voltage-dependent calcium channel subunit alpha-2/delta-1236PROTEINPROTEIN SUBUNITCACNL2AGENE_SYMBOL_OTHERCCHL2AGENE_SYMBOL_OTHERMHS3GENE_SYMBOL_OTHERCACNA2D1GENE_SYMBOLVoltage-dependent calcium channel subunit alpha-2/delta-1UNIPROTVoltage-dependent calcium channel subunit alpha-2-1UNIPROTVoltage-dependent calcium channel subunit delta-1UNIPROTVoltage-gated calcium channel subunit alpha-2/delta-1UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0086057voltage-gated calcium channel activity involved in bundle of His cell action potentialGoFunctionGO:0005262calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006816calcium ion transportGoProcessGO:0051924regulation of calcium ion transportGoProcessGO:0060307regulation of ventricular cardiac muscle cell membrane repolarizationGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086048membrane depolarization during bundle of His cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1902514regulation of calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:0005886plasma membraneGoComponentGO:0016529sarcoplasmic reticulumGoComponentGO:0030315T-tubuleGoComponentGO:0048787presynaptic active zone membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA86calcium voltage-gated channel auxiliary subunit alpha2delta 1PharmGKBQ17R45Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD80Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD81Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtQ9UD82Voltage-dependent calcium channel subunit alpha-2/delta-1UniProtP54289Voltage-dependent calcium channel subunit alpha-2/delta-1UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB7VFSPDB7VFUPDB7VFVPDB7VFWPDB7XLQPDB7YG5PDB8E59PDB8E5APDB8E5BPDB8EPLPDB8EPMPDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8IF3PDB8IF4PDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDB8X90PDB8X91PDB8X93PDBP54289AlphaFoldDBP54289IntActHGNC:1399CACNA2D1HGNCR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54289PharosP54289ExpressionAtlasIPR051173Ca_channel_alpha-2/deltaInterProIPR013680VDCC_a2/dsuInterProIPR013608VWA_NInterProIPR002035VWF_AInterProIPR036465vWFA_dom_sfInterProPTHR10166VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2/DELTA-RELATEDPANTHERPTHR10166:SF6VOLTAGE-DEPENDENT CALCIUM CHANNEL SUBUNIT ALPHA-2_DELTA-1PANTHERPF08473VGCC_alpha2PfamPF00092VWAPfamPF08399VWA_NPfamQ13936Voltage-dependent L-type calcium channel subunit alpha-1C261PROTEINPROTEIN SUBUNITCACH2GENE_SYMBOL_OTHERCACN2GENE_SYMBOL_OTHERCACNL1A1GENE_SYMBOL_OTHERCCHL1A1GENE_SYMBOL_OTHERCACNA1CGENE_SYMBOLVoltage-dependent L-type calcium channel subunit alpha-1CUNIPROTCalcium channel, L type, alpha-1 polypeptide, isoform 1, cardiac muscleUNIPROTVoltage-gated calcium channel subunit alpha Cav1.2UNIPROT5V2PAPDBe6DADAPDBe6U3DAPDBe1T0JAPDBe6DAFAPDBe3G43APDBe6DAEAPDBe2F3ZAPDBe2F3YAPDBe3OXQAPDBe6U3AAPDBe2BE6APDBe6U3BAPDBe8UKPAPDBe5V2QAPDBe8UKOAPDBe6U39APDBeGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potentialGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051393alpha-actinin bindingGoFunctionGO:0086056voltage-gated calcium channel activity involved in AV node cell action potentialGoFunctionGO:0002520immune system developmentGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007507heart developmentGoProcessGO:0010881regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ionGoProcessGO:0035115embryonic forelimb morphogenesisGoProcessGO:0043010camera-type eye developmentGoProcessGO:0045762positive regulation of adenylate cyclase activityGoProcessGO:0045933positive regulation of muscle contractionGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061337cardiac conductionGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0086002cardiac muscle cell action potential involved in contractionGoProcessGO:0086012membrane depolarization during cardiac muscle cell action potentialGoProcessGO:0086045membrane depolarization during AV node cell action potentialGoProcessGO:0086091regulation of heart rate by cardiac conductionGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:0098911regulation of ventricular cardiac muscle cell action potentialGoProcessGO:0098912membrane depolarization during atrial cardiac muscle cell action potentialGoProcessGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0030425dendriteGoComponentGO:0042383sarcolemmaGoComponentGO:0042995cell projectionGoComponentGO:0043204perikaryonGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098839postsynaptic density membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA83calcium voltage-gated channel subunit alpha1 CPharmGKBR-HSA-419037NCAM1 interactionsReactomeB2RUT3Voltage-dependent L-type calcium channel subunit alpha-1CUniProtE9PDJ0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13917Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13918Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13919Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13920Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13921Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13922Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13923Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13924Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13925Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13926Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13927Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13928Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13929Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13930Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13932Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13933Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14743Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ14744Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ15877Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI8Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ4VMI9Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ6PKM7Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ8N6C0Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99025Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99241Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ99875Voltage-dependent L-type calcium channel subunit alpha-1CUniProtQ13936Voltage-dependent L-type calcium channel subunit alpha-1CUniProt1T0JPDB2BE6PDB2F3YPDB2F3ZPDB2LQCPDB3G43PDB3OXQPDB5V2PPDB5V2QPDB6C0APDB6DADPDB6DAEPDB6DAFPDB6U39PDB6U3APDB6U3BPDB6U3DPDB7L8VPDB8EOGPDB8EOIPDB8FD7PDB8FHSPDB8HLPPDB8HMAPDB8HMBPDB8UKOPDB8UKPPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8WEAPDBQ13936AlphaFoldDBQ13936IntActHGNC:1390CACNA1CHGNCR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-5576892Phase 0 - rapid depolarisationReactomeR-HSA-5576893Phase 2 - plateau phaseReactomeQ13936PharosQ13936ExpressionAtlasIPR031688CAC1F_CInterProIPR031649GPHH_domInterProIPR005821Ion_trans_domInterProIPR014873VDCC_a1su_IQInterProIPR050599VDCC_alpha-1_subunitInterProIPR005451VDCC_L_a1csuInterProIPR005446VDCC_L_a1suInterProIPR002077VDCCAlpha1InterProIPR027359Volt_channel_dom_sfInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF10VOLTAGE-DEPENDENT L-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1CPANTHERPF08763Ca_chan_IQPfamPF16885CAC1F_CPfamPF16905GPHHPfamPF00520Ion_transPfamP54284Voltage-dependent L-type calcium channel subunit beta-37369PROTEINPROTEIN SUBUNITCACNLB3GENE_SYMBOL_OTHERCACNB3GENE_SYMBOLVoltage-dependent L-type calcium channel subunit beta-3UNIPROTCalcium channel voltage-dependent subunit beta 3UNIPROTCAB3UNIPROTGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0006816calcium ion transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0060402calcium ion transport into cytosolGoProcessGO:0061577calcium ion transmembrane transport via high voltage-gated calcium channelGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098903regulation of membrane repolarization during action potentialGoProcessGO:1901843positive regulation of high voltage-gated calcium channel activityGoProcessGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:1990454L-type voltage-gated calcium channel complexGoComponentPA89calcium voltage-gated channel auxiliary subunit beta 3PharmGKBA8K0Z4Voltage-dependent L-type calcium channel subunit beta-3UniProtB7Z4Q1Voltage-dependent L-type calcium channel subunit beta-3UniProtB7Z973Voltage-dependent L-type calcium channel subunit beta-3UniProtB7ZAK8Voltage-dependent L-type calcium channel subunit beta-3UniProtF5GZW7Voltage-dependent L-type calcium channel subunit beta-3UniProtF5H2P6Voltage-dependent L-type calcium channel subunit beta-3UniProtF8VSG3Voltage-dependent L-type calcium channel subunit beta-3UniProtQ13913Voltage-dependent L-type calcium channel subunit beta-3UniProtP54284Voltage-dependent L-type calcium channel subunit beta-3UniProt7MIXPDB7MIYPDB7UHFPDB7UHGPDB8E59PDB8E5APDB8E5BPDB8EPLPDB8FHSPDB8WE6PDB8WE7PDB8WE8PDB8WE9PDB8X90PDB8X91PDB8X93PDBP54284AlphaFoldDBP54284IntActHGNC:1403CACNB3HGNCR-HSA-112308Presynaptic depolarization and calcium channel openingReactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretionReactomeR-HSA-419037NCAM1 interactionsReactomeR-HSA-422356Regulation of insulin secretionReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeP54284PharosP54284ExpressionAtlasIPR046937CAB1-4_N_A-domInterProIPR035760CACNB3_SH3InterProIPR008145GK/Ca_channel_bsuInterProIPR027417P-loop_NTPaseInterProIPR036028SH3-like_dom_sfInterProIPR001452SH3_domainInterProIPR008079VDCC_L_b3suInterProIPR000584VDCC_L_bsuInterProPTHR11824VOLTAGE-DEPENDENT CALCIUM CHANNEL BETA SUBUNITPANTHERPF00625Guanylate_kinPfamPF12052VGCC_beta4Aa_NPfamPROTEIN COMPLEX9606