20/chembl/api/data/target?limit=20&offset=20&pref_name__istartswith=serotonin23Sus scrofaSerotonin 4 (5-HT4) receptorCHEMBL2696Q6Q2535-hydroxytryptamine receptor 41032PROTEINSINGLE PROTEIN5-HT4RGENE_SYMBOL5-hydroxytryptamine receptor 4UNIPROTSerotonin receptor 4UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0032098regulation of appetiteGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005768endosomeGoComponentGO:0005886plasma membraneGoComponentGO:0010008endosome membraneGoComponentGO:0045202synapseGoComponentQ6Q2535-hydroxytryptamine receptor 4UniProtQ6Q253AlphaFoldDBIPR0015205HT4_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF66OCTOPAMINE RECEPTOR BETA-3RPANTHERPF000017tm_1PfamSINGLE PROTEIN9823Ovis ariesSerotonin N-acetyltransferaseCHEMBL5452Q29495Serotonin N-acetyltransferase3745PROTEINSINGLE PROTEINSNATGENE_SYMBOL_OTHERAANATGENE_SYMBOLSerotonin N-acetyltransferaseUNIPROTAralkylamine N-acetyltransferaseUNIPROTSerotonin acetylaseUNIPROTAA-NATUNIPROT2.3.1.87EC_NUMBER1IB1APDBe1CJWAPDBe1KUYAPDBe1L0CAPDBe1B6BAPDBe1KUXAPDBe1KUVAPDBeGO:0004059aralkylamine N-acetyltransferase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008080N-acetyltransferase activityGoFunctionGO:0016746acyltransferase activityGoFunctionGO:0016747acyltransferase activity, transferring groups other than amino-acyl groupsGoFunctionGO:0006474N-terminal protein amino acid acetylationGoProcessGO:0007623circadian rhythmGoProcessGO:0030187melatonin biosynthetic processGoProcessGO:0048511rhythmic processGoProcessGO:0071320cellular response to cAMPGoProcessGO:0005737cytoplasmGoComponentGO:0048471perinuclear region of cytoplasmGoComponentPA24366aralkylamine N-acetyltransferasePharmGKBQ29495Serotonin N-acetyltransferaseUniProt1B6BPDB1CJWPDB1IB1PDB1KUVPDB1KUXPDB1KUYPDB1L0CPDBQ29495AlphaFoldDBQ29495IntActIPR016181Acyl_CoA_acyltransferaseInterProIPR000182GNAT_domInterProIPR051635SNAT-likeInterProPTHR10908SEROTONIN N-ACETYLTRANSFERASEPANTHERPTHR10908:SF0SEROTONIN N-ACETYLTRANSFERASEPANTHERPF00583Acetyltransf_1PfamSINGLE PROTEIN9940Rattus norvegicusSerotonin N-acetyltransferaseCHEMBL1075242Q64666Serotonin N-acetyltransferase4517PROTEINSINGLE PROTEINSnatGENE_SYMBOL_OTHERAanatGENE_SYMBOLSerotonin N-acetyltransferaseUNIPROTAralkylamine N-acetyltransferaseUNIPROTSerotonin acetylaseUNIPROTAA-NATUNIPROT2.3.1.87EC_NUMBERGO:0004059aralkylamine N-acetyltransferase activityGoFunctionGO:0004060arylamine N-acetyltransferase activityGoFunctionGO:0008080N-acetyltransferase activityGoFunctionGO:0016746acyltransferase activityGoFunctionGO:0016747acyltransferase activity, transferring groups other than amino-acyl groupsGoFunctionGO:007188914-3-3 protein bindingGoFunctionGO:0006474N-terminal protein amino acid acetylationGoProcessGO:0007623circadian rhythmGoProcessGO:0030187melatonin biosynthetic processGoProcessGO:0043153entrainment of circadian clock by photoperiodGoProcessGO:0048511rhythmic processGoProcessGO:0071320cellular response to cAMPGoProcessGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0048471perinuclear region of cytoplasmGoComponentQ4JL74Serotonin N-acetyltransferaseUniProtQ64553Serotonin N-acetyltransferaseUniProtQ64666Serotonin N-acetyltransferaseUniProtQ64666AlphaFoldDBR-RNO-209931Serotonin and melatonin biosynthesisReactomeIPR016181Acyl_CoA_acyltransferaseInterProIPR000182GNAT_domInterProIPR051635SNAT-likeInterProPTHR10908SEROTONIN N-ACETYLTRANSFERASEPANTHERPTHR10908:SF0SEROTONIN N-ACETYLTRANSFERASEPANTHERPF00583Acetyltransf_1PfamSINGLE PROTEIN10116Rattus norvegicusSerotonin 2 (5-HT2) receptorCHEMBL2093870P309945-hydroxytryptamine receptor 2B2194PROTEINGROUP MEMBERSrlGENE_SYMBOL_OTHERHtr2bGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROT5-HT-2FUNIPROTSerotonin receptor 2BUNIPROTStomach fundus serotonin receptorUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROTGO:0007507heart developmentGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0002031G protein-coupled receptor internalizationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035733hepatic stellate cell activationGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0043647inositol phosphate metabolic processGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071418cellular response to amine stimulusGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:1904015cellular response to serotoninGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentQ9QW445-hydroxytryptamine receptor 2BUniProtP309945-hydroxytryptamine receptor 2BUniProtP30994AlphaFoldDBP30994IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamP089095-hydroxytryptamine receptor 2C2748PROTEINGROUP MEMBER5ht1cGENE_SYMBOL_OTHERHtr1cGENE_SYMBOL_OTHERHtr2cGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROTGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionGoProcessGO:0014057positive regulation of acetylcholine secretion, neurotransmissionGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031100animal organ regenerationGoProcessGO:0031583phospholipase D-activating G protein-coupled receptor signaling pathwayGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045963negative regulation of dopamine metabolic processGoProcessGO:0046960sensitizationGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP089095-hydroxytryptamine receptor 2CUniProt2MHOPDBP08909AlphaFoldDBP08909IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamP148425-hydroxytryptamine receptor 2A2961PROTEINGROUP MEMBERHtr2GENE_SYMBOL_OTHERHtr2aGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT4OAJAPDBeGO:0006096glycolytic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP148425-hydroxytryptamine receptor 2AUniProt4OAJPDBP14842AlphaFoldDBP14842IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamPROTEIN FAMILY10116CPX-2775-hydroxytryptamine-3A/B receptor complexComplexPortalRattus norvegicusSerotonin 3 (5-HT3) receptorCHEMBL2094116P355635-hydroxytryptamine receptor 3A752PROTEINPROTEIN SUBUNIT5ht3GENE_SYMBOL_OTHERHtr3GENE_SYMBOL_OTHERHtr3aGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROTGO:0034220monoatomic ion transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0048149behavioral response to ethanolGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0042734presynaptic membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0016020membraneGoComponentGO:0030424axonGoComponentGO:0032154cleavage furrowGoComponentGO:0043025neuronal cell bodyGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentP355635-hydroxytryptamine receptor 3AUniProtP35563AlphaFoldDBR-RNO-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamQ9JJ165-hydroxytryptamine receptor 3B1779PROTEINPROTEIN SUBUNITHtr3bGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0007210serotonin receptor signaling pathwayGoProcessGO:0098655monoatomic cation transmembrane transportGoProcessGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0009986cell surfaceGoComponentGO:0030424axonGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentQ9ERJ55-hydroxytryptamine receptor 3BUniProtQ9JJ165-hydroxytryptamine receptor 3BUniProtQ9JJ16AlphaFoldDBR-RNO-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPROTEIN COMPLEX10116Rattus norvegicusSerotonin (5-HT) receptorCHEMBL2094123P355635-hydroxytryptamine receptor 3A752PROTEINGROUP MEMBER5ht3GENE_SYMBOL_OTHERHtr3GENE_SYMBOL_OTHERHtr3aGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROTGO:0034220monoatomic ion transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0048149behavioral response to ethanolGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0042734presynaptic membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0016020membraneGoComponentGO:0030424axonGoComponentGO:0032154cleavage furrowGoComponentGO:0043025neuronal cell bodyGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentP355635-hydroxytryptamine receptor 3AUniProtP35563AlphaFoldDBR-RNO-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamP353655-hydroxytryptamine receptor 5B953PROTEINGROUP MEMBER5ht5bGENE_SYMBOL_OTHERSynonyms=5ht5bGENE_SYMBOL_OTHERHtr5bGENE_SYMBOL5-hydroxytryptamine receptor 5BUNIPROTMR22UNIPROTSerotonin receptor 5BUNIPROT5-HT-5BUNIPROT5-HT5BUNIPROTGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0001664G protein-coupled receptor bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentP353655-hydroxytryptamine receptor 5BUniProtP35365AlphaFoldDBIPR0004315HT5B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2025-HYDROXYTRYPTAMINE RECEPTOR 5APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP323055-hydroxytryptamine receptor 71545PROTEINGROUP MEMBERHtr7GENE_SYMBOL5-hydroxytryptamine receptor 7UNIPROT5-HT-XUNIPROTGPRFOUNIPROTSerotonin receptor 7UNIPROT5-HT-7UNIPROT5-HT7UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0007623circadian rhythmGoProcessGO:0010976positive regulation of neuron projection developmentGoProcessGO:0014063negative regulation of serotonin secretionGoProcessGO:0042310vasoconstrictionGoProcessGO:0048266behavioral response to painGoProcessGO:0060291long-term synaptic potentiationGoProcessGO:0062086regulation of vein smooth muscle contractionGoProcessGO:0071542dopaminergic neuron differentiationGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0016020membraneGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043679axon terminusGoComponentP979365-hydroxytryptamine receptor 7UniProtP323055-hydroxytryptamine receptor 7UniProtP32305AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-9706019RHOBTB3 ATPase cycleReactomeP32305ExpressionAtlasIPR0010695HT_7_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF199IP13425P-RELATEDPANTHERPF000017tm_1PfamP313885-hydroxytryptamine receptor 61694PROTEINGROUP MEMBERHtr6GENE_SYMBOL5-hydroxytryptamine receptor 6UNIPROTST-B17UNIPROTSerotonin receptor 6UNIPROT5-HT-6UNIPROT5-HT6UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007612learningGoProcessGO:0014050negative regulation of glutamate secretionGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionGoProcessGO:0014058negative regulation of acetylcholine secretion, neurotransmissionGoProcessGO:0021795cerebral cortex cell migrationGoProcessGO:0032008positive regulation of TOR signalingGoProcessGO:0033603positive regulation of dopamine secretionGoProcessGO:0060291long-term synaptic potentiationGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005929ciliumGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentP313885-hydroxytryptamine receptor 6UniProtP31388AlphaFoldDBP31388IntActR-RNO-390666Serotonin receptorsReactomeP31388ExpressionAtlasIPR0022325HT6_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF2365-HYDROXYTRYPTAMINE RECEPTOR 6PANTHERPF000017tm_1PfamQ9JJ165-hydroxytryptamine receptor 3B1779PROTEINGROUP MEMBERHtr3bGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0007210serotonin receptor signaling pathwayGoProcessGO:0098655monoatomic cation transmembrane transportGoProcessGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0009986cell surfaceGoComponentGO:0030424axonGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentQ9ERJ55-hydroxytryptamine receptor 3BUniProtQ9JJ165-hydroxytryptamine receptor 3BUniProtQ9JJ16AlphaFoldDBR-RNO-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamP285645-hydroxytryptamine receptor 1B1780PROTEINGROUP MEMBER5ht1bGENE_SYMBOL_OTHERHtr1bGENE_SYMBOL5-hydroxytryptamine receptor 1BUNIPROTSerotonin receptor 1BUNIPROT5-HT-1BUNIPROT5-HT1BUNIPROTGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0009636response to toxic substanceGoProcessGO:0046849bone remodelingGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0002031G protein-coupled receptor internalizationGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007631feeding behaviorGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014063negative regulation of serotonin secretionGoProcessGO:0032229negative regulation of synaptic transmission, GABAergicGoProcessGO:0042310vasoconstrictionGoProcessGO:0042756drinking behaviorGoProcessGO:0050795regulation of behaviorGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0071312cellular response to alkaloidGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0044305calyx of HeldGoComponentGO:0099154serotonergic synapseGoComponentGO:0005737cytoplasmGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP285645-hydroxytryptamine receptor 1BUniProtP28564AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0021475HT1B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2015-HYDROXYTRYPTAMINE RECEPTOR 1BPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP309945-hydroxytryptamine receptor 2B2194PROTEINGROUP MEMBERSrlGENE_SYMBOL_OTHERHtr2bGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROT5-HT-2FUNIPROTSerotonin receptor 2BUNIPROTStomach fundus serotonin receptorUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROTGO:0007507heart developmentGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0002031G protein-coupled receptor internalizationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035733hepatic stellate cell activationGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0043647inositol phosphate metabolic processGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071418cellular response to amine stimulusGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:1904015cellular response to serotoninGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentQ9QW445-hydroxytryptamine receptor 2BUniProtP309945-hydroxytryptamine receptor 2BUniProtP30994AlphaFoldDBP30994IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamQ627585-hydroxytryptamine receptor 42634PROTEINGROUP MEMBERHtr4GENE_SYMBOL5-hydroxytryptamine receptor 4UNIPROTSerotonin receptor 4UNIPROT5-HT-4UNIPROT5-HT4UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0030277maintenance of gastrointestinal epitheliumGoProcessGO:0032098regulation of appetiteGoProcessGO:0050890cognitionGoProcessGO:0070254mucus secretionGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0150052regulation of postsynapse assemblyGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0098794postsynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0010008endosome membraneGoComponentGO:0016020membraneGoComponentO890345-hydroxytryptamine receptor 4UniProtQ627575-hydroxytryptamine receptor 4UniProtQ630065-hydroxytryptamine receptor 4UniProtQ627585-hydroxytryptamine receptor 4UniProtQ62758AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeIPR0015205HT4_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF66OCTOPAMINE RECEPTOR BETA-3RPANTHERPF000017tm_1PfamP089095-hydroxytryptamine receptor 2C2748PROTEINGROUP MEMBER5ht1cGENE_SYMBOL_OTHERHtr1cGENE_SYMBOL_OTHERHtr2cGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROTGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionGoProcessGO:0014057positive regulation of acetylcholine secretion, neurotransmissionGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031100animal organ regenerationGoProcessGO:0031583phospholipase D-activating G protein-coupled receptor signaling pathwayGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045963negative regulation of dopamine metabolic processGoProcessGO:0046960sensitizationGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP089095-hydroxytryptamine receptor 2CUniProt2MHOPDBP08909AlphaFoldDBP08909IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamP148425-hydroxytryptamine receptor 2A2961PROTEINGROUP MEMBERHtr2GENE_SYMBOL_OTHERHtr2aGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT4OAJAPDBeGO:0006096glycolytic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP148425-hydroxytryptamine receptor 2AUniProt4OAJPDBP14842AlphaFoldDBP14842IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamP309405-hydroxytryptamine receptor 1F2964PROTEINGROUP MEMBER5ht1fGENE_SYMBOL_OTHERHtr1fGENE_SYMBOL5-hydroxytryptamine receptor 1FUNIPROTSerotonin receptor 1FUNIPROT5-HT-1FUNIPROT5-HT1FUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentP309405-hydroxytryptamine receptor 1FUniProtP30940AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0004505HT1F_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP353645-hydroxytryptamine receptor 5A2973PROTEINGROUP MEMBER5ht5aGENE_SYMBOL_OTHERSynonyms=5ht5aGENE_SYMBOL_OTHERHtr5aGENE_SYMBOL5-hydroxytryptamine receptor 5AUNIPROTREC17UNIPROTSerotonin receptor 5AUNIPROT5-HT-5AUNIPROT5-HT5AUNIPROTGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0021766hippocampus developmentGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0099634postsynaptic specialization membraneGoComponentGO:0043204perikaryonGoComponentP353645-hydroxytryptamine receptor 5AUniProtP35364AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0013975HT5A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2025-HYDROXYTRYPTAMINE RECEPTOR 5APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP193275-hydroxytryptamine receptor 1A3093PROTEINGROUP MEMBER5ht1aGENE_SYMBOL_OTHERHtr1aGENE_SYMBOL5-hydroxytryptamine receptor 1AUNIPROTSerotonin receptor 1AUNIPROT5-HT-1AUNIPROT5-HT1AUNIPROTGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0090722receptor-receptor interactionGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014062regulation of serotonin secretionGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0031117positive regulation of microtubule depolymerizationGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0035640exploration behaviorGoProcessGO:0042428serotonin metabolic processGoProcessGO:0046883regulation of hormone secretionGoProcessGO:0050795regulation of behaviorGoProcessGO:0060259regulation of feeding behaviorGoProcessGO:0097114NMDA glutamate receptor clusteringGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043203axon hillockGoComponentP193275-hydroxytryptamine receptor 1AUniProtP19327AlphaFoldDBP19327IntActR-RNO-390666Serotonin receptorsReactomeIPR0006105HT1A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1915-HYDROXYTRYPTAMINE RECEPTOR 1APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP285655-hydroxytryptamine receptor 1D3743PROTEINGROUP MEMBERHtr1dGENE_SYMBOL5-hydroxytryptamine receptor 1DUNIPROTSerotonin receptor 1DUNIPROT5-HT-1DUNIPROT5-HT1DUNIPROTGO:0009636response to toxic substanceGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessGO:0042310vasoconstrictionGoProcessGO:0050795regulation of behaviorGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0098978glutamatergic synapseGoComponentP285655-hydroxytryptamine receptor 1DUniProtP28565AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0005055HT1D_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamPROTEIN FAMILY10116Homo sapiensSerotonin 3 (5-HT3) receptorCHEMBL2094132P460985-hydroxytryptamine receptor 3A214PROTEINGROUP MEMBER5HT3RGENE_SYMBOL_OTHERHTR3GENE_SYMBOL_OTHERHTR3AGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0032154cleavage furrowGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295555-hydroxytryptamine receptor 3APharmGKBB4DSY65-hydroxytryptamine receptor 3AUniProtG5E9865-hydroxytryptamine receptor 3AUniProtO608545-hydroxytryptamine receptor 3AUniProtQ7KZM75-hydroxytryptamine receptor 3AUniProtQ999185-hydroxytryptamine receptor 3AUniProtQ9BSZ95-hydroxytryptamine receptor 3AUniProtP460985-hydroxytryptamine receptor 3AUniProt8AXDPDB8BL8PDB8BLAPDB8BLBPDBP46098AlphaFoldDBP46098IntActHGNC:5297HTR3AHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeP46098PharosP46098ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamA5X5Y05-hydroxytryptamine receptor 3E2130PROTEINGROUP MEMBERHTR3EGENE_SYMBOL5-hydroxytryptamine receptor 3EUNIPROTSerotonin receptor 3EUNIPROT5-HT3-EUNIPROT5-HT3EUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1349002265-hydroxytryptamine receptor 3EPharmGKBA8IKD75-hydroxytryptamine receptor 3EUniProtE9PGF15-hydroxytryptamine receptor 3EUniProtQ495G15-hydroxytryptamine receptor 3EUniProtQ495G35-hydroxytryptamine receptor 3EUniProtQ6V7065-hydroxytryptamine receptor 3EUniProtQ6V7075-hydroxytryptamine receptor 3EUniProtQ7Z6B25-hydroxytryptamine receptor 3EUniProtA5X5Y05-hydroxytryptamine receptor 3EUniProtA5X5Y0AlphaFoldDBA5X5Y0IntActHGNC:24005HTR3EHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeA5X5Y0PharosA5X5Y0ExpressionAtlasIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamO952645-hydroxytryptamine receptor 3B2215PROTEINGROUP MEMBERHTR3BGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0009986cell surfaceGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295565-hydroxytryptamine receptor 3BPharmGKBB0YJ235-hydroxytryptamine receptor 3BUniProtQ0VJC35-hydroxytryptamine receptor 3BUniProtO952645-hydroxytryptamine receptor 3BUniProtO95264AlphaFoldDBO95264IntActHGNC:5298HTR3BHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeO95264PharosO95264ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamQ70Z445-hydroxytryptamine receptor 3D2991PROTEINGROUP MEMBERHTR3DGENE_SYMBOL5-hydroxytryptamine receptor 3DUNIPROTSerotonin receptor 3DUNIPROT5-HT3-DUNIPROT5-HT3DUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1348667555-hydroxytryptamine receptor 3DPharmGKBC9J2I65-hydroxytryptamine receptor 3DUniProtJ3QT785-hydroxytryptamine receptor 3DUniProtQ495N55-hydroxytryptamine receptor 3DUniProtQ495N65-hydroxytryptamine receptor 3DUniProtQ7Z6B35-hydroxytryptamine receptor 3DUniProtQ70Z445-hydroxytryptamine receptor 3DUniProtQ70Z44AlphaFoldDBQ70Z44IntActHGNC:24004HTR3DHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeQ70Z44PharosQ70Z44ExpressionAtlasIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamQ8WXA85-hydroxytryptamine receptor 3C3112PROTEINGROUP MEMBERHTR3CGENE_SYMBOL5-hydroxytryptamine receptor 3CUNIPROTSerotonin receptor 3CUNIPROT5-HT3-CUNIPROT5-HT3CUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1349257415-hydroxytryptamine receptor 3CPharmGKBA2RRR55-hydroxytryptamine receptor 3CUniProtQ8WXA85-hydroxytryptamine receptor 3CUniProtQ8WXA8AlphaFoldDBQ8WXA8IntActHGNC:24003HTR3CHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeQ8WXA8PharosIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPROTEIN COMPLEX GROUP9606Rattus norvegicusSerotonin 1 (5-HT1) receptorCHEMBL2095159P285645-hydroxytryptamine receptor 1B1780PROTEINGROUP MEMBER5ht1bGENE_SYMBOL_OTHERHtr1bGENE_SYMBOL5-hydroxytryptamine receptor 1BUNIPROTSerotonin receptor 1BUNIPROT5-HT-1BUNIPROT5-HT1BUNIPROTGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0009636response to toxic substanceGoProcessGO:0046849bone remodelingGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0002031G protein-coupled receptor internalizationGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007631feeding behaviorGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014063negative regulation of serotonin secretionGoProcessGO:0032229negative regulation of synaptic transmission, GABAergicGoProcessGO:0042310vasoconstrictionGoProcessGO:0042756drinking behaviorGoProcessGO:0050795regulation of behaviorGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0071312cellular response to alkaloidGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0044305calyx of HeldGoComponentGO:0099154serotonergic synapseGoComponentGO:0005737cytoplasmGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP285645-hydroxytryptamine receptor 1BUniProtP28564AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0021475HT1B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2015-HYDROXYTRYPTAMINE RECEPTOR 1BPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP309405-hydroxytryptamine receptor 1F2964PROTEINGROUP MEMBER5ht1fGENE_SYMBOL_OTHERHtr1fGENE_SYMBOL5-hydroxytryptamine receptor 1FUNIPROTSerotonin receptor 1FUNIPROT5-HT-1FUNIPROT5-HT1FUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentP309405-hydroxytryptamine receptor 1FUniProtP30940AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0004505HT1F_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP193275-hydroxytryptamine receptor 1A3093PROTEINGROUP MEMBER5ht1aGENE_SYMBOL_OTHERHtr1aGENE_SYMBOL5-hydroxytryptamine receptor 1AUNIPROTSerotonin receptor 1AUNIPROT5-HT-1AUNIPROT5-HT1AUNIPROTGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0090722receptor-receptor interactionGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014062regulation of serotonin secretionGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0031117positive regulation of microtubule depolymerizationGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0035640exploration behaviorGoProcessGO:0042428serotonin metabolic processGoProcessGO:0046883regulation of hormone secretionGoProcessGO:0050795regulation of behaviorGoProcessGO:0060259regulation of feeding behaviorGoProcessGO:0097114NMDA glutamate receptor clusteringGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043203axon hillockGoComponentP193275-hydroxytryptamine receptor 1AUniProtP19327AlphaFoldDBP19327IntActR-RNO-390666Serotonin receptorsReactomeIPR0006105HT1A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1915-HYDROXYTRYPTAMINE RECEPTOR 1APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP285655-hydroxytryptamine receptor 1D3743PROTEINGROUP MEMBERHtr1dGENE_SYMBOL5-hydroxytryptamine receptor 1DUNIPROTSerotonin receptor 1DUNIPROT5-HT-1DUNIPROT5-HT1DUNIPROTGO:0009636response to toxic substanceGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessGO:0042310vasoconstrictionGoProcessGO:0050795regulation of behaviorGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0098978glutamatergic synapseGoComponentP285655-hydroxytryptamine receptor 1DUniProtP28565AlphaFoldDBR-RNO-390666Serotonin receptorsReactomeR-RNO-418594G alpha (i) signalling eventsReactomeIPR0005055HT1D_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamPROTEIN FAMILY10116Homo sapiensSerotonin 2 (5-HT2) receptorCHEMBL2095200P415955-hydroxytryptamine receptor 2B133PROTEINGROUP MEMBERHTR2BGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROTSerotonin receptor 2BUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROT4NC3APDBe6DS0APDBe5TUDAPDBe6DRYAPDBe6DRXAPDBe5TVNAPDBe4IB4APDBe6DRZAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007507heart developmentGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA295545-hydroxytryptamine receptor 2BPharmGKBB2R9D55-hydroxytryptamine receptor 2BUniProtQ53TI15-hydroxytryptamine receptor 2BUniProtQ622215-hydroxytryptamine receptor 2BUniProtQ6P5235-hydroxytryptamine receptor 2BUniProtP415955-hydroxytryptamine receptor 2BUniProt4IB4PDB4NC3PDB5TUDPDB5TVNPDB6DRXPDB6DRYPDB6DRZPDB6DS0PDB7SRQPDB7SRRPDB7SRSPDB9JGKPDBP41595AlphaFoldDBP41595IntActHGNC:5294HTR2BHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP41595PharosIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamP282235-hydroxytryptamine receptor 2A308PROTEINGROUP MEMBERHTR2GENE_SYMBOL_OTHERHTR2AGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT8ZMGAPDBe7WC5APDBe7WC6APDBe7WC4APDBe7WC9APDBe8JT8APDBe7VODAPDBe7WC7APDBe7VOEAPDBe7WC8APDBe6WH4APDBe6WGTAPDBe6A93APDBe6A94APDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001618virus receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006096glycolytic processGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1935-hydroxytryptamine receptor 2APharmGKBB2RAC55-hydroxytryptamine receptor 2AUniProtB4DZ795-hydroxytryptamine receptor 2AUniProtF5GWE85-hydroxytryptamine receptor 2AUniProtQ5T8C05-hydroxytryptamine receptor 2AUniProtP282235-hydroxytryptamine receptor 2AUniProt6A93PDB6A94PDB6WGTPDB6WH4PDB6WHAPDB7RANPDB7VODPDB7VOEPDB7WC4PDB7WC5PDB7WC6PDB7WC7PDB7WC8PDB7WC9PDB8JT8PDB8UWLPDB8V6UPDB8ZMGPDB9ARXPDB9ARYPDB9ARZPDB9AS0PDB9AS1PDB9AS2PDB9AS3PDB9AS4PDB9AS5PDB9AS6PDB9AS7PDB9AS8PDB9AS9PDB9ASAPDBP28223AlphaFoldDBP28223IntActHGNC:5293HTR2AHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28223PharosP28223ExpressionAtlasIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamP283355-hydroxytryptamine receptor 2C309PROTEINGROUP MEMBERHTR1CGENE_SYMBOL_OTHERHTR2CGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROT8ZMFAPDBe6BQHAPDBe6BQGAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1945-hydroxytryptamine receptor 2CPharmGKBB1AMW45-hydroxytryptamine receptor 2CUniProtQ5VUF85-hydroxytryptamine receptor 2CUniProtQ9NP285-hydroxytryptamine receptor 2CUniProtP283355-hydroxytryptamine receptor 2CUniProt6BQGPDB6BQHPDB8DPFPDB8DPGPDB8DPHPDB8DPIPDB8ZMFPDBP28335AlphaFoldDBP28335IntActHGNC:5295HTR2CHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28335PharosIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamPROTEIN FAMILY9606Homo sapiensSerotonin 1 receptors; 5-HT1B & 5-HT1DCHEMBL2095230P282225-hydroxytryptamine receptor 1B212PROTEINCOMPARATIVE PROTEINHTR1DBGENE_SYMBOL_OTHERHTR1BGENE_SYMBOL5-hydroxytryptamine receptor 1BUNIPROTS12UNIPROTSerotonin 1D beta receptorUNIPROTSerotonin receptor 1BUNIPROT5-HT-1BUNIPROT5-HT1BUNIPROT5-HT-1D-betaUNIPROT5V54APDBe4IAQAPDBe7C61APDBe4IARAPDBeGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007631feeding behaviorGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014063negative regulation of serotonin secretionGoProcessGO:0032229negative regulation of synaptic transmission, GABAergicGoProcessGO:0042310vasoconstrictionGoProcessGO:0042756drinking behaviorGoProcessGO:0046849bone remodelingGoProcessGO:0050795regulation of behaviorGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0071312cellular response to alkaloidGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0042734presynaptic membraneGoComponentGO:0044305calyx of HeldGoComponentGO:0099154serotonergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA295495-hydroxytryptamine receptor 1BPharmGKBQ4VAY75-hydroxytryptamine receptor 1BUniProtP282225-hydroxytryptamine receptor 1BUniProt4IAQPDB4IARPDB5V54PDB6G79PDB7C61PDBP28222AlphaFoldDBP28222IntActHGNC:5287HTR1BHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP28222PharosP28222ExpressionAtlasIPR0021475HT1B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2015-HYDROXYTRYPTAMINE RECEPTOR 1BPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP282215-hydroxytryptamine receptor 1D307PROTEINCOMPARATIVE PROTEINHTR1DAGENE_SYMBOL_OTHERHTRLGENE_SYMBOL_OTHERHTR1DGENE_SYMBOL5-hydroxytryptamine receptor 1DUNIPROTSerotonin 1D alpha receptorUNIPROTSerotonin receptor 1DUNIPROT5-HT-1DUNIPROT5-HT1DUNIPROT5-HT-1D-alphaUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessGO:0042310vasoconstrictionGoProcessGO:0050795regulation of behaviorGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentPA295505-hydroxytryptamine receptor 1DPharmGKBP282215-hydroxytryptamine receptor 1DUniProt7E32PDBP28221AlphaFoldDBHGNC:5289HTR1DHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP28221PharosIPR0005055HT1D_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamSELECTIVITY GROUP9606Homo sapiensSerotonin 2 receptors; 5-HT2a & 5-HT2cCHEMBL2096662P282235-hydroxytryptamine receptor 2A308PROTEINCOMPARATIVE PROTEINHTR2GENE_SYMBOL_OTHERHTR2AGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT8ZMGAPDBe7WC5APDBe7WC6APDBe7WC4APDBe7WC9APDBe8JT8APDBe7VODAPDBe7WC7APDBe7VOEAPDBe7WC8APDBe6WH4APDBe6WGTAPDBe6A93APDBe6A94APDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001618virus receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006096glycolytic processGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1935-hydroxytryptamine receptor 2APharmGKBB2RAC55-hydroxytryptamine receptor 2AUniProtB4DZ795-hydroxytryptamine receptor 2AUniProtF5GWE85-hydroxytryptamine receptor 2AUniProtQ5T8C05-hydroxytryptamine receptor 2AUniProtP282235-hydroxytryptamine receptor 2AUniProt6A93PDB6A94PDB6WGTPDB6WH4PDB6WHAPDB7RANPDB7VODPDB7VOEPDB7WC4PDB7WC5PDB7WC6PDB7WC7PDB7WC8PDB7WC9PDB8JT8PDB8UWLPDB8V6UPDB8ZMGPDB9ARXPDB9ARYPDB9ARZPDB9AS0PDB9AS1PDB9AS2PDB9AS3PDB9AS4PDB9AS5PDB9AS6PDB9AS7PDB9AS8PDB9AS9PDB9ASAPDBP28223AlphaFoldDBP28223IntActHGNC:5293HTR2AHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28223PharosP28223ExpressionAtlasIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamP283355-hydroxytryptamine receptor 2C309PROTEINCOMPARATIVE PROTEINHTR1CGENE_SYMBOL_OTHERHTR2CGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROT8ZMFAPDBe6BQHAPDBe6BQGAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1945-hydroxytryptamine receptor 2CPharmGKBB1AMW45-hydroxytryptamine receptor 2CUniProtQ5VUF85-hydroxytryptamine receptor 2CUniProtQ9NP285-hydroxytryptamine receptor 2CUniProtP283355-hydroxytryptamine receptor 2CUniProt6BQGPDB6BQHPDB8DPFPDB8DPGPDB8DPHPDB8DPIPDB8ZMFPDBP28335AlphaFoldDBP28335IntActHGNC:5295HTR2CHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28335PharosIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamSELECTIVITY GROUP9606Mus musculusSerotonin 2 (5-HT2) receptorCHEMBL2096671Q021525-hydroxytryptamine receptor 2B919PROTEINGROUP MEMBERHtr2bGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROT5-HT-2FUNIPROTNP75 proteinUNIPROTSerotonin receptor 2BUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROTGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007507heart developmentGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentQ8JZK55-hydroxytryptamine receptor 2BUniProtQ9QWS25-hydroxytryptamine receptor 2BUniProtQ021525-hydroxytryptamine receptor 2BUniProtQ02152AlphaFoldDBR-MMU-390666Serotonin receptorsReactomeR-MMU-416476G alpha (q) signalling eventsReactomeQ02152ExpressionAtlasIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamP349685-hydroxytryptamine receptor 2C1335PROTEINGROUP MEMBER5ht1cGENE_SYMBOL_OTHERHtr1cGENE_SYMBOL_OTHERHtr2cGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROTGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0009897external side of plasma membraneGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentB1ATN55-hydroxytryptamine receptor 2CUniProtQ5WRU65-hydroxytryptamine receptor 2CUniProtP349685-hydroxytryptamine receptor 2CUniProtP34968AlphaFoldDBR-MMU-390666Serotonin receptorsReactomeR-MMU-416476G alpha (q) signalling eventsReactomeP34968ExpressionAtlasIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamP353635-hydroxytryptamine receptor 2A3673PROTEINGROUP MEMBERHtr2GENE_SYMBOL_OTHERHtr2aGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROTGO:0006096glycolytic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005883neurofilamentGoComponentGO:0005886plasma membraneGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP353635-hydroxytryptamine receptor 2AUniProtP35363AlphaFoldDBP35363IntActR-MMU-390666Serotonin receptorsReactomeR-MMU-416476G alpha (q) signalling eventsReactomeP35363ExpressionAtlasIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamPROTEIN FAMILY10090Homo sapiensSerotonin (5-HT) receptorCHEMBL2096904P309395-hydroxytryptamine receptor 1F99PROTEINGROUP MEMBERHTR1ELGENE_SYMBOL_OTHERSynonyms=HTR1ELGENE_SYMBOL_OTHERHTR1FGENE_SYMBOL5-hydroxytryptamine receptor 1FUNIPROTSerotonin receptor 1FUNIPROT5-HT-1FUNIPROT5-HT1FUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentPA295535-hydroxytryptamine receptor 1FPharmGKBP309395-hydroxytryptamine receptor 1FUniProt7EXDPDBP30939AlphaFoldDBHGNC:5292HTR1FHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP30939PharosIPR0004505HT1F_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP415955-hydroxytryptamine receptor 2B133PROTEINGROUP MEMBERHTR2BGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROTSerotonin receptor 2BUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROT4NC3APDBe6DS0APDBe5TUDAPDBe6DRYAPDBe6DRXAPDBe5TVNAPDBe4IB4APDBe6DRZAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007507heart developmentGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA295545-hydroxytryptamine receptor 2BPharmGKBB2R9D55-hydroxytryptamine receptor 2BUniProtQ53TI15-hydroxytryptamine receptor 2BUniProtQ622215-hydroxytryptamine receptor 2BUniProtQ6P5235-hydroxytryptamine receptor 2BUniProtP415955-hydroxytryptamine receptor 2BUniProt4IB4PDB4NC3PDB5TUDPDB5TVNPDB6DRXPDB6DRYPDB6DRZPDB6DS0PDB7SRQPDB7SRRPDB7SRSPDB9JGKPDBP41595AlphaFoldDBP41595IntActHGNC:5294HTR2BHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP41595PharosIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamQ136395-hydroxytryptamine receptor 4191PROTEINGROUP MEMBERHTR4GENE_SYMBOL5-hydroxytryptamine receptor 4UNIPROTSerotonin receptor 4UNIPROT5-HT-4UNIPROT5-HT4UNIPROT5EM9APDBeGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0030277maintenance of gastrointestinal epitheliumGoProcessGO:0032098regulation of appetiteGoProcessGO:0070254mucus secretionGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0150052regulation of postsynapse assemblyGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0010008endosome membraneGoComponentGO:0016020membraneGoComponentGO:0098794postsynapseGoComponentGO:0098978glutamatergic synapseGoComponentPA295575-hydroxytryptamine receptor 4PharmGKBC4WYH45-hydroxytryptamine receptor 4UniProtQ546Q15-hydroxytryptamine receptor 4UniProtQ684M05-hydroxytryptamine receptor 4UniProtQ712M95-hydroxytryptamine receptor 4UniProtQ96KH95-hydroxytryptamine receptor 4UniProtQ96KI05-hydroxytryptamine receptor 4UniProtQ9H1995-hydroxytryptamine receptor 4UniProtQ9NY735-hydroxytryptamine receptor 4UniProtQ9UBM65-hydroxytryptamine receptor 4UniProtQ9UBT45-hydroxytryptamine receptor 4UniProtQ9UE225-hydroxytryptamine receptor 4UniProtQ9UE235-hydroxytryptamine receptor 4UniProtQ9UQR65-hydroxytryptamine receptor 4UniProtQ136395-hydroxytryptamine receptor 4UniProt5EM9PDB7XT8PDB7XT9PDB7XTAPDBQ13639AlphaFoldDBQ13639IntActHGNC:5299HTR4HGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418555G alpha (s) signalling eventsReactomeQ13639PharosQ13639ExpressionAtlasIPR0015205HT4_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF66OCTOPAMINE RECEPTOR BETA-3RPANTHERPF000017tm_1PfamP282225-hydroxytryptamine receptor 1B212PROTEINGROUP MEMBERHTR1DBGENE_SYMBOL_OTHERHTR1BGENE_SYMBOL5-hydroxytryptamine receptor 1BUNIPROTS12UNIPROTSerotonin 1D beta receptorUNIPROTSerotonin receptor 1BUNIPROT5-HT-1BUNIPROT5-HT1BUNIPROT5-HT-1D-betaUNIPROT5V54APDBe4IAQAPDBe7C61APDBe4IARAPDBeGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0099626voltage-gated calcium channel activity involved in regulation of presynaptic cytosolic calcium levelsGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007631feeding behaviorGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014063negative regulation of serotonin secretionGoProcessGO:0032229negative regulation of synaptic transmission, GABAergicGoProcessGO:0042310vasoconstrictionGoProcessGO:0042756drinking behaviorGoProcessGO:0046849bone remodelingGoProcessGO:0050795regulation of behaviorGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0071312cellular response to alkaloidGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0099509regulation of presynaptic cytosolic calcium ion concentrationGoProcessGO:1904707positive regulation of vascular associated smooth muscle cell proliferationGoProcessGO:2000300regulation of synaptic vesicle exocytosisGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0042734presynaptic membraneGoComponentGO:0044305calyx of HeldGoComponentGO:0099154serotonergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA295495-hydroxytryptamine receptor 1BPharmGKBQ4VAY75-hydroxytryptamine receptor 1BUniProtP282225-hydroxytryptamine receptor 1BUniProt4IAQPDB4IARPDB5V54PDB6G79PDB7C61PDBP28222AlphaFoldDBP28222IntActHGNC:5287HTR1BHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP28222PharosP28222ExpressionAtlasIPR0021475HT1B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2015-HYDROXYTRYPTAMINE RECEPTOR 1BPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP460985-hydroxytryptamine receptor 3A214PROTEINGROUP MEMBER5HT3RGENE_SYMBOL_OTHERHTR3GENE_SYMBOL_OTHERHTR3AGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0032154cleavage furrowGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295555-hydroxytryptamine receptor 3APharmGKBB4DSY65-hydroxytryptamine receptor 3AUniProtG5E9865-hydroxytryptamine receptor 3AUniProtO608545-hydroxytryptamine receptor 3AUniProtQ7KZM75-hydroxytryptamine receptor 3AUniProtQ999185-hydroxytryptamine receptor 3AUniProtQ9BSZ95-hydroxytryptamine receptor 3AUniProtP460985-hydroxytryptamine receptor 3AUniProt8AXDPDB8BL8PDB8BLAPDB8BLBPDBP46098AlphaFoldDBP46098IntActHGNC:5297HTR3AHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeP46098PharosP46098ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamP089085-hydroxytryptamine receptor 1A266PROTEINGROUP MEMBERADRB2RL1GENE_SYMBOL_OTHERADRBRL1GENE_SYMBOL_OTHERHTR1AGENE_SYMBOL5-hydroxytryptamine receptor 1AUNIPROTG-21UNIPROTSerotonin receptor 1AUNIPROT5-HT-1AUNIPROT5-HT1AUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0090722receptor-receptor interactionGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0014062regulation of serotonin secretionGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0035640exploration behaviorGoProcessGO:0042428serotonin metabolic processGoProcessGO:0046883regulation of hormone secretionGoProcessGO:0050795regulation of behaviorGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042995cell projectionGoComponentGO:0045202synapseGoComponentPA1925-hydroxytryptamine receptor 1APharmGKBQ6LAE75-hydroxytryptamine receptor 1AUniProtP089085-hydroxytryptamine receptor 1AUniProt7E2XPDB7E2YPDB7E2ZPDB8FY8PDB8FYEPDB8FYLPDB8FYTPDB8FYXPDB8JSPPDB8JT6PDB8PJKPDB8PKMPDB8W8BPDB9DYDPDB9DYEPDB9DYFPDB9GL2PDB9MD1PDBP08908AlphaFoldDBP08908IntActHGNC:5286HTR1AHGNCR-HSA-390666Serotonin receptorsReactomeP08908PharosP08908ExpressionAtlasIPR0006105HT1A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1915-HYDROXYTRYPTAMINE RECEPTOR 1APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP282215-hydroxytryptamine receptor 1D307PROTEINGROUP MEMBERHTR1DAGENE_SYMBOL_OTHERHTRLGENE_SYMBOL_OTHERHTR1DGENE_SYMBOL5-hydroxytryptamine receptor 1DUNIPROTSerotonin 1D alpha receptorUNIPROTSerotonin receptor 1DUNIPROT5-HT-1DUNIPROT5-HT1DUNIPROT5-HT-1D-alphaUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0040012regulation of locomotionGoProcessGO:0042310vasoconstrictionGoProcessGO:0050795regulation of behaviorGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentPA295505-hydroxytryptamine receptor 1DPharmGKBP282215-hydroxytryptamine receptor 1DUniProt7E32PDBP28221AlphaFoldDBHGNC:5289HTR1DHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP28221PharosIPR0005055HT1D_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP282235-hydroxytryptamine receptor 2A308PROTEINGROUP MEMBERHTR2GENE_SYMBOL_OTHERHTR2AGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT8ZMGAPDBe7WC5APDBe7WC6APDBe7WC4APDBe7WC9APDBe8JT8APDBe7VODAPDBe7WC7APDBe7VOEAPDBe7WC8APDBe6WH4APDBe6WGTAPDBe6A93APDBe6A94APDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001618virus receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006096glycolytic processGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1935-hydroxytryptamine receptor 2APharmGKBB2RAC55-hydroxytryptamine receptor 2AUniProtB4DZ795-hydroxytryptamine receptor 2AUniProtF5GWE85-hydroxytryptamine receptor 2AUniProtQ5T8C05-hydroxytryptamine receptor 2AUniProtP282235-hydroxytryptamine receptor 2AUniProt6A93PDB6A94PDB6WGTPDB6WH4PDB6WHAPDB7RANPDB7VODPDB7VOEPDB7WC4PDB7WC5PDB7WC6PDB7WC7PDB7WC8PDB7WC9PDB8JT8PDB8UWLPDB8V6UPDB8ZMGPDB9ARXPDB9ARYPDB9ARZPDB9AS0PDB9AS1PDB9AS2PDB9AS3PDB9AS4PDB9AS5PDB9AS6PDB9AS7PDB9AS8PDB9AS9PDB9ASAPDBP28223AlphaFoldDBP28223IntActHGNC:5293HTR2AHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28223PharosP28223ExpressionAtlasIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamP283355-hydroxytryptamine receptor 2C309PROTEINGROUP MEMBERHTR1CGENE_SYMBOL_OTHERHTR2CGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROT8ZMFAPDBe6BQHAPDBe6BQGAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1945-hydroxytryptamine receptor 2CPharmGKBB1AMW45-hydroxytryptamine receptor 2CUniProtQ5VUF85-hydroxytryptamine receptor 2CUniProtQ9NP285-hydroxytryptamine receptor 2CUniProtP283355-hydroxytryptamine receptor 2CUniProt6BQGPDB6BQHPDB8DPFPDB8DPGPDB8DPHPDB8DPIPDB8ZMFPDBP28335AlphaFoldDBP28335IntActHGNC:5295HTR2CHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28335PharosIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamP285665-hydroxytryptamine receptor 1E523PROTEINGROUP MEMBERHTR1EGENE_SYMBOL5-hydroxytryptamine receptor 1EUNIPROTS31UNIPROTSerotonin receptor 1EUNIPROT5-HT-1EUNIPROT5-HT1EUNIPROTGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007193adenylate cyclase-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentPA295525-hydroxytryptamine receptor 1EPharmGKBE1P5035-hydroxytryptamine receptor 1EUniProtQ9P1Y15-hydroxytryptamine receptor 1EUniProtP285665-hydroxytryptamine receptor 1EUniProt7E33PDB8UGYPDB8UH3PDBP28566AlphaFoldDBP28566IntActHGNC:5291HTR1EHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP28566PharosIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1965-HYDROXYTRYPTAMINE RECEPTOR 1DPANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamP349695-hydroxytryptamine receptor 71480PROTEINGROUP MEMBERHTR7GENE_SYMBOL5-hydroxytryptamine receptor 7UNIPROT5-HT-XUNIPROTSerotonin receptor 7UNIPROT5-HT-7UNIPROT5-HT7UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007623circadian rhythmGoProcessGO:0008015blood circulationGoProcessGO:0042310vasoconstrictionGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0016020membraneGoComponentGO:0032588trans-Golgi network membraneGoComponentGO:0045202synapseGoComponentPA295615-hydroxytryptamine receptor 7PharmGKBB5BUP65-hydroxytryptamine receptor 7UniProtP783365-hydroxytryptamine receptor 7UniProtP783725-hydroxytryptamine receptor 7UniProtP785165-hydroxytryptamine receptor 7UniProtQ5VX015-hydroxytryptamine receptor 7UniProtQ5VX025-hydroxytryptamine receptor 7UniProtQ5VX035-hydroxytryptamine receptor 7UniProtP349695-hydroxytryptamine receptor 7UniProt7XTCPDBP34969AlphaFoldDBP34969IntActHGNC:5302HTR7HGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418555G alpha (s) signalling eventsReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP34969PharosIPR0010695HT_7_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF199IP13425P-RELATEDPANTHERPF000017tm_1PfamP504065-hydroxytryptamine receptor 61693PROTEINGROUP MEMBERHTR6GENE_SYMBOL5-hydroxytryptamine receptor 6UNIPROTSerotonin receptor 6UNIPROT5-HT-6UNIPROT5-HT6UNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004969histamine receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007188adenylate cyclase-modulating G protein-coupled receptor signaling pathwayGoProcessGO:0007192adenylate cyclase-activating serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0021795cerebral cortex cell migrationGoProcessGO:0032008positive regulation of TOR signalingGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005929ciliumGoComponentGO:0016020membraneGoComponentGO:0045202synapseGoComponentPA295605-hydroxytryptamine receptor 6PharmGKBQ136405-hydroxytryptamine receptor 6UniProtQ5TGZ15-hydroxytryptamine receptor 6UniProtP504065-hydroxytryptamine receptor 6UniProt7XTBPDB7YS6PDB8JLZPDBP50406AlphaFoldDBP50406IntActHGNC:5301HTR6HGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418555G alpha (s) signalling eventsReactomeP50406PharosIPR0022325HT6_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF2365-HYDROXYTRYPTAMINE RECEPTOR 6PANTHERPF000017tm_1PfamP478985-hydroxytryptamine receptor 5A1748PROTEINGROUP MEMBERHTR5AGENE_SYMBOL5-hydroxytryptamine receptor 5AUNIPROTSerotonin receptor 5AUNIPROT5-HT-5UNIPROT5-HT-5AUNIPROT5-HT5AUNIPROT7UM4APDBeGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0021766hippocampus developmentGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0043204perikaryonGoComponentGO:0099634postsynaptic specialization membraneGoComponentPA295585-hydroxytryptamine receptor 5APharmGKBQ2M2D25-hydroxytryptamine receptor 5AUniProtP478985-hydroxytryptamine receptor 5AUniProt7UM4PDB7UM5PDB7UM6PDB7UM7PDB7X5HPDBP47898AlphaFoldDBP47898IntActHGNC:5300HTR5AHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-418594G alpha (i) signalling eventsReactomeP47898PharosP47898ExpressionAtlasIPR0013975HT5A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF2025-HYDROXYTRYPTAMINE RECEPTOR 5APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamA5X5Y05-hydroxytryptamine receptor 3E2130PROTEINGROUP MEMBERHTR3EGENE_SYMBOL5-hydroxytryptamine receptor 3EUNIPROTSerotonin receptor 3EUNIPROT5-HT3-EUNIPROT5-HT3EUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1349002265-hydroxytryptamine receptor 3EPharmGKBA8IKD75-hydroxytryptamine receptor 3EUniProtE9PGF15-hydroxytryptamine receptor 3EUniProtQ495G15-hydroxytryptamine receptor 3EUniProtQ495G35-hydroxytryptamine receptor 3EUniProtQ6V7065-hydroxytryptamine receptor 3EUniProtQ6V7075-hydroxytryptamine receptor 3EUniProtQ7Z6B25-hydroxytryptamine receptor 3EUniProtA5X5Y05-hydroxytryptamine receptor 3EUniProtA5X5Y0AlphaFoldDBA5X5Y0IntActHGNC:24005HTR3EHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeA5X5Y0PharosA5X5Y0ExpressionAtlasIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamO952645-hydroxytryptamine receptor 3B2215PROTEINGROUP MEMBERHTR3BGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0009986cell surfaceGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295565-hydroxytryptamine receptor 3BPharmGKBB0YJ235-hydroxytryptamine receptor 3BUniProtQ0VJC35-hydroxytryptamine receptor 3BUniProtO952645-hydroxytryptamine receptor 3BUniProtO95264AlphaFoldDBO95264IntActHGNC:5298HTR3BHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeO95264PharosO95264ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamQ70Z445-hydroxytryptamine receptor 3D2991PROTEINGROUP MEMBERHTR3DGENE_SYMBOL5-hydroxytryptamine receptor 3DUNIPROTSerotonin receptor 3DUNIPROT5-HT3-DUNIPROT5-HT3DUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1348667555-hydroxytryptamine receptor 3DPharmGKBC9J2I65-hydroxytryptamine receptor 3DUniProtJ3QT785-hydroxytryptamine receptor 3DUniProtQ495N55-hydroxytryptamine receptor 3DUniProtQ495N65-hydroxytryptamine receptor 3DUniProtQ7Z6B35-hydroxytryptamine receptor 3DUniProtQ70Z445-hydroxytryptamine receptor 3DUniProtQ70Z44AlphaFoldDBQ70Z44IntActHGNC:24004HTR3DHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeQ70Z44PharosQ70Z44ExpressionAtlasIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamQ8WXA85-hydroxytryptamine receptor 3C3112PROTEINGROUP MEMBERHTR3CGENE_SYMBOL5-hydroxytryptamine receptor 3CUNIPROTSerotonin receptor 3CUNIPROT5-HT3-CUNIPROT5-HT3CUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0016020membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA1349257415-hydroxytryptamine receptor 3CPharmGKBA2RRR55-hydroxytryptamine receptor 3CUniProtQ8WXA85-hydroxytryptamine receptor 3CUniProtQ8WXA8AlphaFoldDBQ8WXA8IntActHGNC:24003HTR3CHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeQ8WXA8PharosIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPROTEIN FAMILY9606Rattus norvegicusSerotonin 1a (5-HT1a) receptor/Adrenergic receptor alpha-1CHEMBL2097171P15823Alpha-1B adrenergic receptor25PROTEINCOMPARATIVE PROTEINAdra1bGENE_SYMBOLAlpha-1B adrenergic receptorUNIPROTAlpha-1B adrenoreceptorUNIPROTAlpha-1B adrenoceptorUNIPROTGO:0005980glycogen catabolic processGoProcessGO:0001974blood vessel remodelingGoProcessGO:0001987vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressureGoProcessGO:0001996positive regulation of heart rate by epinephrine-norepinephrineGoProcessGO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineGoProcessGO:0007512adult heart developmentGoProcessGO:0007626locomotory behaviorGoProcessGO:0008542visual learningGoProcessGO:0035024negative regulation of Rho protein signal transductionGoProcessGO:0035265organ growthGoProcessGO:0042593glucose homeostasisGoProcessGO:0045818negative regulation of glycogen catabolic processGoProcessGO:0045819positive regulation of glycogen catabolic processGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0061049cell growth involved in cardiac muscle cell developmentGoProcessGO:0004930G protein-coupled receptor activityGoFunctionGO:0004937alpha1-adrenergic receptor activityGoFunctionGO:0046982protein heterodimerization activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007267cell-cell signalingGoProcessGO:0008217regulation of blood pressureGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0043410positive regulation of MAPK cascadeGoProcessGO:0055117regulation of cardiac muscle contractionGoProcessGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathwayGoProcessGO:0150099neuron-glial cell signalingGoProcessGO:0005886plasma membraneGoComponentGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005901caveolaGoComponentGO:0014704intercalated discGoComponentGO:0016020membraneGoComponentGO:0030315T-tubuleGoComponentGO:0031965nuclear membraneGoComponentQ63215Alpha-1B adrenergic receptorUniProtP15823Alpha-1B adrenergic receptorUniProtP15823AlphaFoldDBP15823IntActR-RNO-390696AdrenoceptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeR-RNO-416482G alpha (12/13) signalling eventsReactomeIPR002233ADR_famInterProIPR001115ADRA1B_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF17ALPHA-1B ADRENERGIC RECEPTORPANTHERPF000017tm_1PfamP23944Alpha-1D adrenergic receptor33PROTEINCOMPARATIVE PROTEINAdra1aGENE_SYMBOL_OTHERAdra1dGENE_SYMBOLAlpha-1D adrenergic receptorUNIPROTAlpha-1A adrenergic receptorUNIPROTAlpha-1D adrenoreceptorUNIPROTRA42UNIPROTAlpha-1D adrenoceptorUNIPROTGO:0001986negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressureGoProcessGO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureGoProcessGO:0004930G protein-coupled receptor activityGoFunctionGO:0004937alpha1-adrenergic receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007267cell-cell signalingGoProcessGO:0008217regulation of blood pressureGoProcessGO:0043410positive regulation of MAPK cascadeGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathwayGoProcessGO:0150099neuron-glial cell signalingGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentQ71UM4Alpha-1D adrenergic receptorUniProtP23944Alpha-1D adrenergic receptorUniProtP23944AlphaFoldDBR-RNO-390696AdrenoceptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeR-RNO-416482G alpha (12/13) signalling eventsReactomeIPR002233ADR_famInterProIPR000363ADRA1D_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF14ALPHA-1D ADRENERGIC RECEPTORPANTHERPF000017tm_1PfamP43140Alpha-1A adrenergic receptor45PROTEINCOMPARATIVE PROTEINAdra1cGENE_SYMBOL_OTHERAdra1aGENE_SYMBOLAlpha-1A adrenergic receptorUNIPROTAlpha-1A adrenoreceptorUNIPROTAlpha-1C adrenergic receptorUNIPROTAlpha-1A adrenoceptorUNIPROTGO:0000165MAPK cascadeGoProcessGO:0001985negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressureGoProcessGO:0001994norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressureGoProcessGO:0001996positive regulation of heart rate by epinephrine-norepinephrineGoProcessGO:0001997positive regulation of the force of heart contraction by epinephrine-norepinephrineGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007512adult heart developmentGoProcessGO:0010507negative regulation of autophagyGoProcessGO:0010613positive regulation of cardiac muscle hypertrophyGoProcessGO:0035024negative regulation of Rho protein signal transductionGoProcessGO:0035265organ growthGoProcessGO:0043410positive regulation of MAPK cascadeGoProcessGO:0061049cell growth involved in cardiac muscle cell developmentGoProcessGO:0004930G protein-coupled receptor activityGoFunctionGO:0004937alpha1-adrenergic receptor activityGoFunctionGO:0046982protein heterodimerization activityGoFunctionGO:0003084positive regulation of systemic arterial blood pressureGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007267cell-cell signalingGoProcessGO:0008217regulation of blood pressureGoProcessGO:0010460positive regulation of heart rateGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0032230positive regulation of synaptic transmission, GABAergicGoProcessGO:0045760positive regulation of action potentialGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045987positive regulation of smooth muscle contractionGoProcessGO:0055117regulation of cardiac muscle contractionGoProcessGO:0060452positive regulation of cardiac muscle contractionGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071880adenylate cyclase-activating adrenergic receptor signaling pathwayGoProcessGO:0071882phospholipase C-activating adrenergic receptor signaling pathwayGoProcessGO:0090037positive regulation of protein kinase C signalingGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0150099neuron-glial cell signalingGoProcessGO:0005886plasma membraneGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098691dopaminergic synapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005901caveolaGoComponentGO:0016020membraneGoComponentGO:0030018Z discGoComponentGO:0030315T-tubuleGoComponentGO:0031965nuclear membraneGoComponentP43140Alpha-1A adrenergic receptorUniProtP43140AlphaFoldDBP43140IntActR-RNO-390696AdrenoceptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeR-RNO-416482G alpha (12/13) signalling eventsReactomeIPR002233ADR_famInterProIPR001004ADRA1A_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPTHR24248:SF16ALPHA-1A ADRENERGIC RECEPTORPANTHERPF000017tm_1PfamP193275-hydroxytryptamine receptor 1A3093PROTEINCOMPARATIVE PROTEIN5ht1aGENE_SYMBOL_OTHERHtr1aGENE_SYMBOL5-hydroxytryptamine receptor 1AUNIPROTSerotonin receptor 1AUNIPROT5-HT-1AUNIPROT5-HT1AUNIPROTGO:0007214gamma-aminobutyric acid signaling pathwayGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0001586Gi/o-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0090722receptor-receptor interactionGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007198adenylate cyclase-inhibiting serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0014053negative regulation of gamma-aminobutyric acid secretionGoProcessGO:0014062regulation of serotonin secretionGoProcessGO:0019229regulation of vasoconstrictionGoProcessGO:0031117positive regulation of microtubule depolymerizationGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0035640exploration behaviorGoProcessGO:0042428serotonin metabolic processGoProcessGO:0046883regulation of hormone secretionGoProcessGO:0050795regulation of behaviorGoProcessGO:0060259regulation of feeding behaviorGoProcessGO:0097114NMDA glutamate receptor clusteringGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0098982GABA-ergic synapseGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043203axon hillockGoComponentP193275-hydroxytryptamine receptor 1AUniProtP19327AlphaFoldDBP19327IntActR-RNO-390666Serotonin receptorsReactomeIPR0006105HT1A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR24248:SF1915-HYDROXYTRYPTAMINE RECEPTOR 1APANTHERPTHR24248ADRENERGIC RECEPTOR-RELATED G-PROTEIN COUPLED RECEPTORPANTHERPF000017tm_1PfamSELECTIVITY GROUP10116Homo sapiensSerotonin receptor (2b and 2c)CHEMBL2111466P415955-hydroxytryptamine receptor 2B133PROTEINCOMPARATIVE PROTEINHTR2BGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROTSerotonin receptor 2BUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROT4NC3APDBe6DS0APDBe5TUDAPDBe6DRYAPDBe6DRXAPDBe5TVNAPDBe4IB4APDBe6DRZAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007507heart developmentGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA295545-hydroxytryptamine receptor 2BPharmGKBB2R9D55-hydroxytryptamine receptor 2BUniProtQ53TI15-hydroxytryptamine receptor 2BUniProtQ622215-hydroxytryptamine receptor 2BUniProtQ6P5235-hydroxytryptamine receptor 2BUniProtP415955-hydroxytryptamine receptor 2BUniProt4IB4PDB4NC3PDB5TUDPDB5TVNPDB6DRXPDB6DRYPDB6DRZPDB6DS0PDB7SRQPDB7SRRPDB7SRSPDB9JGKPDBP41595AlphaFoldDBP41595IntActHGNC:5294HTR2BHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP41595PharosIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamP283355-hydroxytryptamine receptor 2C309PROTEINCOMPARATIVE PROTEINHTR1CGENE_SYMBOL_OTHERHTR2CGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROT8ZMFAPDBe6BQHAPDBe6BQGAPDBeGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentPA1945-hydroxytryptamine receptor 2CPharmGKBB1AMW45-hydroxytryptamine receptor 2CUniProtQ5VUF85-hydroxytryptamine receptor 2CUniProtQ9NP285-hydroxytryptamine receptor 2CUniProtP283355-hydroxytryptamine receptor 2CUniProt6BQGPDB6BQHPDB8DPFPDB8DPGPDB8DPHPDB8DPIPDB8ZMFPDBP28335AlphaFoldDBP28335IntActHGNC:5295HTR2CHGNCR-HSA-390666Serotonin receptorsReactomeR-HSA-416476G alpha (q) signalling eventsReactomeP28335PharosIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamSELECTIVITY GROUP9606CPX-2715-hydroxytryptamine-3A/B receptor complexComplexPortalHomo sapiensSerotonin 3 (5-HT3) receptorCHEMBL2111332P460985-hydroxytryptamine receptor 3A214PROTEINPROTEIN SUBUNIT5HT3RGENE_SYMBOL_OTHERHTR3GENE_SYMBOL_OTHERHTR3AGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0032154cleavage furrowGoComponentGO:0045211postsynaptic membraneGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295555-hydroxytryptamine receptor 3APharmGKBB4DSY65-hydroxytryptamine receptor 3AUniProtG5E9865-hydroxytryptamine receptor 3AUniProtO608545-hydroxytryptamine receptor 3AUniProtQ7KZM75-hydroxytryptamine receptor 3AUniProtQ999185-hydroxytryptamine receptor 3AUniProtQ9BSZ95-hydroxytryptamine receptor 3AUniProtP460985-hydroxytryptamine receptor 3AUniProt8AXDPDB8BL8PDB8BLAPDB8BLBPDBP46098AlphaFoldDBP46098IntActHGNC:5297HTR3AHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeP46098PharosP46098ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamO952645-hydroxytryptamine receptor 3B2215PROTEINPROTEIN SUBUNITHTR3BGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0005231excitatory extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:1904315transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potentialGoFunctionGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0009986cell surfaceGoComponentGO:1902495transmembrane transporter complexGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentPA295565-hydroxytryptamine receptor 3BPharmGKBB0YJ235-hydroxytryptamine receptor 3BUniProtQ0VJC35-hydroxytryptamine receptor 3BUniProtO952645-hydroxytryptamine receptor 3BUniProtO95264AlphaFoldDBO95264IntActHGNC:5298HTR3BHGNCR-HSA-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeO95264PharosO95264ExpressionAtlasIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPROTEIN COMPLEX9606Mus musculusSerotonin 3 receptor (5HT3)CHEMBL2111333Q9JHJ55-hydroxytryptamine receptor 3B2099PROTEINGROUP MEMBERHtr3bGENE_SYMBOL5-hydroxytryptamine receptor 3BUNIPROTSerotonin receptor 3BUNIPROT5-HT3-BUNIPROT5-HT3BUNIPROTGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentQ9JHJ55-hydroxytryptamine receptor 3BUniProtQ9JHJ5AlphaFoldDBQ9JHJ5IntActR-MMU-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081345HT3_rcpt_BInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamP239795-hydroxytryptamine receptor 3A3284PROTEINGROUP MEMBER5ht3GENE_SYMBOL_OTHERHtr3GENE_SYMBOL_OTHERHtr3aGENE_SYMBOL5-hydroxytryptamine receptor 3AUNIPROT5-hydroxytryptamine receptor 3UNIPROTSerotonin receptor 3AUNIPROTSerotonin-gated ion channel receptorUNIPROT5-HT3-AUNIPROT5-HT3AUNIPROT5-HT-3UNIPROT5-HT3RUNIPROT4PIRAPDBeGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005230extracellular ligand-gated monoatomic ion channel activityGoFunctionGO:0022850serotonin-gated monoatomic cation channel activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099507ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potentialGoFunctionGO:0006811monoatomic ion transportGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0099505regulation of presynaptic membrane potentialGoProcessGO:0140227serotonin-gated cation-selective signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0032154cleavage furrowGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:1904602serotonin-activated cation-selective channel complexGoComponentE9QLC05-hydroxytryptamine receptor 3AUniProtQ612255-hydroxytryptamine receptor 3AUniProtQ612265-hydroxytryptamine receptor 3AUniProtP239795-hydroxytryptamine receptor 3AUniProt4PIRPDB6BE1PDB6DG7PDB6DG8PDB6HINPDB6HIOPDB6HIQPDB6HISPDB6NP0PDB6W1JPDB6W1MPDB6W1YPDB6Y1ZPDB6Y59PDB6Y5APDB6Y5BPDB8AW2PDB8C1WPDB8C1ZPDB8C20PDB8C21PDB8CC6PDB8CC7PDB8FRWPDB8FRXPDB8FRZPDB8FSBPDB8FSPPDB8FSZPDBP23979AlphaFoldDBR-MMU-112314Neurotransmitter receptors and postsynaptic signal transmissionReactomeIPR0081325HT3_rcptInterProIPR0081335HT3_rcpt_AInterProIPR049944LGIC_TM_5-HT3InterProIPR006202Neur_chan_lig-bdInterProIPR036734Neur_chan_lig-bd_sfInterProIPR006201Neur_channelInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR038050Neuro_actylchol_recInterProIPR006029Neurotrans-gated_channel_TMInterProIPR018000Neurotransmitter_ion_chnl_CSInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamPROTEIN FAMILY10090Homo sapiensSerotonin and norepinephrine transporters (SERT/NET)CHEMBL2111346P31645Sodium-dependent serotonin transporter226PROTEINCOMPARATIVE PROTEINHTTGENE_SYMBOL_OTHERSERTGENE_SYMBOL_OTHERSLC6A4GENE_SYMBOLSodium-dependent serotonin transporterUNIPROT5HT transporterUNIPROTSolute carrier family 6 member 4UNIPROTSERTUNIPROT5HTTUNIPROT5I6ZAPDBe5I71APDBe5I74APDBe6W2BAPDBe5I73APDBe6AWOAPDBe5I75APDBe6AWNAPDBe6W2CAPDBe6AWQAPDBe6AWPAPDBe5I6XAPDBeGO:0005178integrin bindingGoFunctionGO:0005261monoatomic cation channel activityGoFunctionGO:0005326neurotransmitter transmembrane transporter activityGoFunctionGO:0005335serotonin:sodium:chloride symporter activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008504monoamine transmembrane transporter activityGoFunctionGO:0017075syntaxin-1 bindingGoFunctionGO:0019811cocaine bindingGoFunctionGO:0031402sodium ion bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0050998nitric-oxide synthase bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0001666response to hypoxiaGoProcessGO:0006836neurotransmitter transportGoProcessGO:0006837serotonin transportGoProcessGO:0006865amino acid transportGoProcessGO:0007613memoryGoProcessGO:0007623circadian rhythmGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0014064positive regulation of serotonin secretionGoProcessGO:0021941negative regulation of cerebellar granule cell precursor proliferationGoProcessGO:0032227negative regulation of synaptic transmission, dopaminergicGoProcessGO:0035725sodium ion transmembrane transportGoProcessGO:0042310vasoconstrictionGoProcessGO:0042713sperm ejaculationGoProcessGO:0045665negative regulation of neuron differentiationGoProcessGO:0045787positive regulation of cell cycleGoProcessGO:0046621negative regulation of organ growthGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0048484enteric nervous system developmentGoProcessGO:0048854brain morphogenesisGoProcessGO:0051610serotonin uptakeGoProcessGO:0051899membrane depolarizationGoProcessGO:0070527platelet aggregationGoProcessGO:0071300cellular response to retinoic acidGoProcessGO:0071321cellular response to cGMPGoProcessGO:0090067regulation of thalamus sizeGoProcessGO:0098810neurotransmitter reuptakeGoProcessGO:1990708conditioned place preferenceGoProcessGO:0005886plasma membraneGoComponentGO:0043005neuron projectionGoComponentGO:0045202synapseGoComponentGO:0005768endosomeGoComponentGO:0005925focal adhesionGoComponentGO:0010008endosome membraneGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0045121membrane raftGoComponentGO:0045211postsynaptic membraneGoComponentGO:0070161anchoring junctionGoComponentGO:0099154serotonergic synapseGoComponentPA312solute carrier family 6 member 4PharmGKBQ5EE02Sodium-dependent serotonin transporterUniProtP31645Sodium-dependent serotonin transporterUniProt5I6XPDB5I6ZPDB5I71PDB5I73PDB5I74PDB5I75PDB6AWNPDB6AWOPDB6AWPPDB6AWQPDB6DZVPDB6DZWPDB6DZYPDB6DZZPDB6VRHPDB6VRKPDB6VRLPDB6W2BPDB6W2CPDB7LI6PDB7LI7PDB7LI8PDB7LI9PDB7LIAPDB7LWDPDB7MGWPDB7TXTPDBP31645AlphaFoldDBP31645IntActHGNC:11050SLC6A4HGNCR-HSA-380615Serotonin clearance from the synaptic cleftReactomeP31645PharosP31645ExpressionAtlasIPR000175Na/ntran_symportInterProIPR013086Na/ntran_symport_serotonin_NInterProIPR037272SNS_sfInterProPTHR11616:SF105SODIUM-DEPENDENT SEROTONIN TRANSPORTERPANTHERPTHR11616SODIUM/CHLORIDE DEPENDENT TRANSPORTERPANTHERPF034915HT_transport_NPfamPF00209SNFPfamP23975Sodium-dependent noradrenaline transporter436PROTEINCOMPARATIVE PROTEINNAT1GENE_SYMBOL_OTHERNET1GENE_SYMBOL_OTHERSLC6A5GENE_SYMBOL_OTHERSynonyms=NAT1GENE_SYMBOL_OTHERSLC6A2GENE_SYMBOLSodium-dependent noradrenaline transporterUNIPROTNorepinephrine transporterUNIPROTSolute carrier family 6 member 2UNIPROTNETUNIPROTGO:0003779actin bindingGoFunctionGO:0005326neurotransmitter transmembrane transporter activityGoFunctionGO:0005328neurotransmitter:sodium symporter activityGoFunctionGO:0005330dopamine:sodium symporter activityGoFunctionGO:0005334norepinephrine:sodium symporter activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008504monoamine transmembrane transporter activityGoFunctionGO:0022857transmembrane transporter activityGoFunctionGO:0043014alpha-tubulin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0048487beta-tubulin bindingGoFunctionGO:0006836neurotransmitter transportGoProcessGO:0006865amino acid transportGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0015874norepinephrine transportGoProcessGO:0035725sodium ion transmembrane transportGoProcessGO:0048265response to painGoProcessGO:0051583dopamine uptake involved in synaptic transmissionGoProcessGO:0051620norepinephrine uptakeGoProcessGO:0098810neurotransmitter reuptakeGoProcessGO:0005886plasma membraneGoComponentGO:0030424axonGoComponentGO:0032809neuronal cell body membraneGoComponentGO:0042734presynaptic membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0030672synaptic vesicle membraneGoComponentPA310solute carrier family 6 member 2PharmGKBB2R707Sodium-dependent noradrenaline transporterUniProtB4DX48Sodium-dependent noradrenaline transporterUniProtQ96KH8Sodium-dependent noradrenaline transporterUniProtP23975Sodium-dependent noradrenaline transporterUniProt8HFEPDB8HFFPDB8HFGPDB8HFIPDB8HFLPDB8I3VPDB8WGRPDB8WGXPDB8WTUPDB8WTVPDB8WTWPDB8WTXPDB8WTYPDB8XB2PDB8XB3PDB8XB4PDB8Y8ZPDB8Y90PDB8Y91PDB8Y92PDB8Y93PDB8Y94PDB8Y95PDB8YR2PDB8Z1LPDB8ZOYPDB8ZP1PDB8ZP2PDB8ZPBPDBP23975AlphaFoldDBP23975IntActHGNC:11048SLC6A2HGNCR-HSA-442660Na+/Cl- dependent neurotransmitter transportersReactomeR-HSA-5619109Defective SLC6A2 causes orthostatic intolerance (OI)ReactomeP23975PharosP23975ExpressionAtlasIPR000175Na/ntran_symportInterProIPR002435Na/ntran_symport_noradrenalineInterProIPR037272SNS_sfInterProPTHR11616:SF320SODIUM-DEPENDENT NORADRENALINE TRANSPORTERPANTHERPTHR11616SODIUM/CHLORIDE DEPENDENT TRANSPORTERPANTHERPF00209SNFPfamSELECTIVITY GROUP9606Rattus norvegicusSerotonin receptor 2a and 2c (5HT2A and 5HT2C)CHEMBL2111383P089095-hydroxytryptamine receptor 2C2748PROTEINCOMPARATIVE PROTEIN5ht1cGENE_SYMBOL_OTHERHtr1cGENE_SYMBOL_OTHERHtr2cGENE_SYMBOL5-hydroxytryptamine receptor 2CUNIPROT5-hydroxytryptamine receptor 1CUNIPROTSerotonin receptor 2CUNIPROT5-HT-2CUNIPROT5-HT2CUNIPROT5-HTR2CUNIPROT5-HT-1CUNIPROT5-HT1CUNIPROTGO:0045600positive regulation of fat cell differentiationGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001662behavioral fear responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007626locomotory behaviorGoProcessGO:0007631feeding behaviorGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014054positive regulation of gamma-aminobutyric acid secretionGoProcessGO:0014057positive regulation of acetylcholine secretion, neurotransmissionGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0031100animal organ regenerationGoProcessGO:0031583phospholipase D-activating G protein-coupled receptor signaling pathwayGoProcessGO:0031644regulation of nervous system processGoProcessGO:0032098regulation of appetiteGoProcessGO:0035095behavioral response to nicotineGoProcessGO:0043397regulation of corticotropin-releasing hormone secretionGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045963negative regulation of dopamine metabolic processGoProcessGO:0046960sensitizationGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP089095-hydroxytryptamine receptor 2CUniProt2MHOPDBP08909AlphaFoldDBP08909IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0003775HT2C_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF325-HYDROXYTRYPTAMINE RECEPTOR 2CPANTHERPF000017tm_1PfamP148425-hydroxytryptamine receptor 2A2961PROTEINCOMPARATIVE PROTEINHtr2GENE_SYMBOL_OTHERHtr2aGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT4OAJAPDBeGO:0006096glycolytic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP148425-hydroxytryptamine receptor 2AUniProt4OAJPDBP14842AlphaFoldDBP14842IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamSELECTIVITY GROUP10116Rattus norvegicusSerotonin receptor 2a and 2b (5HT2A and 5HT2B)CHEMBL2111398P309945-hydroxytryptamine receptor 2B2194PROTEINCOMPARATIVE PROTEINSrlGENE_SYMBOL_OTHERHtr2bGENE_SYMBOL5-hydroxytryptamine receptor 2BUNIPROT5-HT-2FUNIPROTSerotonin receptor 2BUNIPROTStomach fundus serotonin receptorUNIPROT5-HT-2BUNIPROT5-HT2BUNIPROTGO:0007507heart developmentGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0001965G-protein alpha-subunit bindingGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005096GTPase activator activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001755neural crest cell migrationGoProcessGO:0001819positive regulation of cytokine productionGoProcessGO:0001938positive regulation of endothelial cell proliferationGoProcessGO:0002031G protein-coupled receptor internalizationGoProcessGO:0003007heart morphogenesisGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014033neural crest cell differentiationGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0019934cGMP-mediated signalingGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0035733hepatic stellate cell activationGoProcessGO:0042310vasoconstrictionGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0043647inositol phosphate metabolic processGoProcessGO:0048598embryonic morphogenesisGoProcessGO:0050795regulation of behaviorGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051781positive regulation of cell divisionGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071418cellular response to amine stimulusGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:1904015cellular response to serotoninGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0005737cytoplasmGoComponentGO:0043005neuron projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0045202synapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentQ9QW445-hydroxytryptamine receptor 2BUniProtP309945-hydroxytryptamine receptor 2BUniProtP30994AlphaFoldDBP30994IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004825HT2B_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF315-HYDROXYTRYPTAMINE RECEPTOR 2BPANTHERPF000017tm_1PfamP148425-hydroxytryptamine receptor 2A2961PROTEINCOMPARATIVE PROTEINHtr2GENE_SYMBOL_OTHERHtr2aGENE_SYMBOL5-hydroxytryptamine receptor 2AUNIPROTSerotonin receptor 2AUNIPROT5-HT-2UNIPROT5-HT-2AUNIPROT4OAJAPDBeGO:0006096glycolytic processGoProcessGO:0044380protein localization to cytoskeletonGoProcessGO:0045600positive regulation of fat cell differentiationGoProcessGO:0045821positive regulation of glycolytic processGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0001587Gq/11-coupled serotonin receptor activityGoFunctionGO:0004930G protein-coupled receptor activityGoFunctionGO:0004993G protein-coupled serotonin receptor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0030594neurotransmitter receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051378serotonin bindingGoFunctionGO:0099589serotonin receptor activityGoFunctionGO:0001659temperature homeostasisGoProcessGO:0002720positive regulation of cytokine production involved in immune responseGoProcessGO:0006874intracellular calcium ion homeostasisGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007208phospholipase C-activating serotonin receptor signaling pathwayGoProcessGO:0007210serotonin receptor signaling pathwayGoProcessGO:0007268chemical synaptic transmissionGoProcessGO:0007613memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010513positive regulation of phosphatidylinositol biosynthetic processGoProcessGO:0014059regulation of dopamine secretionGoProcessGO:0014824artery smooth muscle contractionGoProcessGO:0031652positive regulation of heat generationGoProcessGO:0043267negative regulation of potassium ion transportGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0046960sensitizationGoProcessGO:0048148behavioral response to cocaineGoProcessGO:0050729positive regulation of inflammatory responseGoProcessGO:0050951sensory perception of temperature stimulusGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051967negative regulation of synaptic transmission, glutamatergicGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0098664G protein-coupled serotonin receptor signaling pathwayGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:1901731positive regulation of platelet aggregationGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005886plasma membraneGoComponentGO:0030425dendriteGoComponentGO:0042734presynaptic membraneGoComponentGO:0045211postsynaptic membraneGoComponentGO:0098978glutamatergic synapseGoComponentGO:0005883neurofilamentGoComponentGO:0005901caveolaGoComponentGO:0030424axonGoComponentGO:0042995cell projectionGoComponentGO:0043025neuronal cell bodyGoComponentGO:0043198dendritic shaftGoComponentGO:0045202synapseGoComponentGO:0070852cell body fiberGoComponentGO:0098793presynapseGoComponentGO:0098666G protein-coupled serotonin receptor complexGoComponentP148425-hydroxytryptamine receptor 2AUniProt4OAJPDBP14842AlphaFoldDBP14842IntActR-RNO-390666Serotonin receptorsReactomeR-RNO-416476G alpha (q) signalling eventsReactomeIPR0004555HT2A_rcptInterProIPR0022315HT_rcptInterProIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProPTHR242475-HYDROXYTRYPTAMINE RECEPTORPANTHERPTHR24247:SF305-HYDROXYTRYPTAMINE RECEPTOR 2APANTHERPF000017tm_1PfamSELECTIVITY GROUP10116