20/chembl/api/data/target?limit=20&offset=20&pref_name__contains=kinase1347Homo sapiensTyrosine-protein kinase ABL1CHEMBL1862P00519Tyrosine-protein kinase ABL1173PROTEINSINGLE PROTEIN2.7.10.2EC_NUMBERAbelson murine leukemia viral oncogene homolog 1UNIPROTAbelson tyrosine-protein kinase 1UNIPROTABLGENE_SYMBOL_OTHERABL1GENE_SYMBOLJTK7GENE_SYMBOL_OTHERp150UNIPROTProto-oncogene c-AblUNIPROTTyrosine-protein kinase ABL1UNIPROTP00519AlphaFoldDBP00519ExpressionAtlasGO:0001726ruffleGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0015629actin cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0016604nuclear bodyGoComponentGO:0030425dendriteGoComponentGO:0030426growth coneGoComponentGO:0031252cell leading edgeGoComponentGO:0031965nuclear membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0043025neuronal cell bodyGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0098794postsynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0000287magnesium ion bindingGoFunctionGO:0000400four-way junction DNA bindingGoFunctionGO:0000405bubble DNA bindingGoFunctionGO:0001784phosphotyrosine residue bindingGoFunctionGO:0003677DNA bindingGoFunctionGO:0003713transcription coactivator activityGoFunctionGO:0003785actin monomer bindingGoFunctionGO:0004515nicotinate-nucleotide adenylyltransferase activityGoFunctionGO:0005080protein kinase C bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0017124SH3 domain bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0019905syntaxin bindingGoFunctionGO:0030145manganese ion bindingGoFunctionGO:0038191neuropilin bindingGoFunctionGO:0042169SH2 domain bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046875ephrin receptor bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0051019mitogen-activated protein kinase bindingGoFunctionGO:0070064proline-rich region bindingGoFunctionGO:0070097delta-catenin bindingGoFunctionGO:0097100supercoiled DNA bindingGoFunctionGO:1990837sequence-specific double-stranded DNA bindingGoFunctionGO:0000278mitotic cell cycleGoProcessGO:0001843neural tube closureGoProcessGO:0001922B-1 B cell homeostasisGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0002322B cell proliferation involved in immune responseGoProcessGO:0002333transitional one stage B cell differentiationGoProcessGO:0006281DNA repairGoProcessGO:0006298mismatch repairGoProcessGO:0006897endocytosisGoProcessGO:0006909phagocytosisGoProcessGO:0006914autophagyGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0006979response to oxidative stressGoProcessGO:0007155cell adhesionGoProcessGO:0007173epidermal growth factor receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0007249canonical NF-kappaB signal transductionGoProcessGO:0007611learning or memoryGoProcessGO:0008306associative learningGoProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageGoProcessGO:0010595positive regulation of endothelial cell migrationGoProcessGO:0018108peptidyl-tyrosine phosphorylationGoProcessGO:0021587cerebellum morphogenesisGoProcessGO:0022408negative regulation of cell-cell adhesionGoProcessGO:0030035microspike assemblyGoProcessGO:0030036actin cytoskeleton organizationGoProcessGO:0030041actin filament polymerizationGoProcessGO:0030100regulation of endocytosisGoProcessGO:0030155regulation of cell adhesionGoProcessGO:0030182neuron differentiationGoProcessGO:0030509BMP signaling pathwayGoProcessGO:0030514negative regulation of BMP signaling pathwayGoProcessGO:0030516regulation of axon extensionGoProcessGO:0030845phospholipase C-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0031113regulation of microtubule polymerizationGoProcessGO:0032489regulation of Cdc42 protein signal transductionGoProcessGO:0032729positive regulation of type II interferon productionGoProcessGO:0032743positive regulation of interleukin-2 productionGoProcessGO:0032956regulation of actin cytoskeleton organizationGoProcessGO:0033690positive regulation of osteoblast proliferationGoProcessGO:0034446substrate adhesion-dependent cell spreadingGoProcessGO:0034599cellular response to oxidative stressGoProcessGO:0034976response to endoplasmic reticulum stressGoProcessGO:0035791platelet-derived growth factor receptor-beta signaling pathwayGoProcessGO:0038083peptidyl-tyrosine autophosphorylationGoProcessGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisGoProcessGO:0038189neuropilin signaling pathwayGoProcessGO:0042100B cell proliferationGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0042770signal transduction in response to DNA damageGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0043542endothelial cell migrationGoProcessGO:0045580regulation of T cell differentiationGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045930negative regulation of mitotic cell cycleGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046632alpha-beta T cell differentiationGoProcessGO:0046777protein autophosphorylationGoProcessGO:0048008platelet-derived growth factor receptor signaling pathwayGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0048536spleen developmentGoProcessGO:0048538thymus developmentGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050798activated T cell proliferationGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0050853B cell receptor signaling pathwayGoProcessGO:0050885neuromuscular process controlling balanceGoProcessGO:0051128regulation of cellular component organizationGoProcessGO:0051281positive regulation of release of sequestered calcium ion into cytosolGoProcessGO:0051353positive regulation of oxidoreductase activityGoProcessGO:0051402neuron apoptotic processGoProcessGO:0051444negative regulation of ubiquitin-protein transferase activityGoProcessGO:0051450myoblast proliferationGoProcessGO:0051496positive regulation of stress fiber assemblyGoProcessGO:0051726regulation of cell cycleGoProcessGO:0051882mitochondrial depolarizationGoProcessGO:0051894positive regulation of focal adhesion assemblyGoProcessGO:0060020Bergmann glial cell differentiationGoProcessGO:0060038cardiac muscle cell proliferationGoProcessGO:0060563neuroepithelial cell differentiationGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070373negative regulation of ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071103DNA conformation changeGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:0071901negative regulation of protein serine/threonine kinase activityGoProcessGO:0072359circulatory system developmentGoProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisGoProcessGO:0090398cellular senescenceGoProcessGO:0098609cell-cell adhesionGoProcessGO:0099150regulation of postsynaptic specialization assemblyGoProcessGO:1900006positive regulation of dendrite developmentGoProcessGO:1900026positive regulation of substrate adhesion-dependent cell spreadingGoProcessGO:1900272negative regulation of long-term synaptic potentiationGoProcessGO:1902036regulation of hematopoietic stem cell differentiationGoProcessGO:1903053regulation of extracellular matrix organizationGoProcessGO:1903055positive regulation of extracellular matrix organizationGoProcessGO:1903210podocyte apoptotic processGoProcessGO:1903351cellular response to dopamineGoProcessGO:1903905positive regulation of establishment of T cell polarityGoProcessGO:1904157DN4 thymocyte differentiationGoProcessGO:1904518protein localization to cytoplasmic microtubule plus-endGoProcessGO:1905244regulation of modification of synaptic structureGoProcessGO:1905555positive regulation of blood vessel branchingGoProcessGO:1990051activation of protein kinase C activityGoProcessGO:2000042negative regulation of double-strand break repair via homologous recombinationGoProcessGO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathwayGoProcessGO:2000145regulation of cell motilityGoProcessGO:2000352negative regulation of endothelial cell apoptotic processGoProcessGO:2000406positive regulation of T cell migrationGoProcessGO:2000773negative regulation of cellular senescenceGoProcessHGNC:76ABL1HGNCP00519IntActIPR000719Prot_kinase_domInterProIPR000980SH2InterProIPR001245Ser-Thr/Tyr_kinase_cat_domInterProIPR001452SH3_domainInterProIPR008266Tyr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR015015F-actin-bindingInterProIPR017441Protein_kinase_ATP_BSInterProIPR020635Tyr_kinase_cat_domInterProIPR035837ABL_SH2InterProIPR036028SH3-like_dom_sfInterProIPR036860SH2_dom_sfInterProIPR050198Non-receptor_tyrosine_kinasesInterProPTHR24418TYROSINE-PROTEIN 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_1PfamPF07714PK_Tyr_Ser-ThrPfamPF08919F_actin_bindPfamPA24413ABL proto-oncogene 1, non-receptor tyrosine kinasePharmGKBP00519PharosR-HSA-2029482Regulation of actin dynamics for phagocytic cup formationReactomeR-HSA-428890Role of ABL in ROBO-SLIT signalingReactomeR-HSA-525793MyogenesisReactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEsReactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)ReactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsReactomeR-HSA-8940973RUNX2 regulates osteoblast differentiationReactomeR-HSA-9664422FCGR3A-mediated phagocytosisReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeR-HSA-9841922MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisReactomeR-HSA-9860927Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cellsReactomeA3KFJ3Tyrosine-protein kinase ABL1UniProtP00519Tyrosine-protein kinase ABL1UniProtQ13869Tyrosine-protein kinase ABL1UniProtQ13870Tyrosine-protein kinase ABL1UniProtQ16133Tyrosine-protein kinase ABL1UniProtQ17R61Tyrosine-protein kinase ABL1UniProtQ45F09Tyrosine-protein kinase ABL1UniProtSINGLE PROTEIN9606Homo sapiensReceptor tyrosine-protein kinase erbB-2CHEMBL1824P04626Receptor tyrosine-protein kinase erbB-2120PROTEINSINGLE PROTEIN2.7.10.1EC_NUMBERCD_antigen=CD340UNIPROTERBB2GENE_SYMBOLHER2GENE_SYMBOL_OTHERMetastatic lymph node gene 19 proteinUNIPROTMLN 19UNIPROTMLN19GENE_SYMBOL_OTHERNEUGENE_SYMBOL_OTHERNGLGENE_SYMBOL_OTHERp185erbB2UNIPROTProto-oncogene c-ErbB-2UNIPROTProto-oncogene NeuUNIPROTReceptor tyrosine-protein kinase erbB-2UNIPROTTyrosine kinase-type cell surface receptor HER2UNIPROTP04626AlphaFoldDBP04626ExpressionAtlasGO:0002116semaphorin receptor complexGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0005769early endosomeGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0009925basal plasma membraneGoComponentGO:0010008endosome membraneGoComponentGO:0016020membraneGoComponentGO:0016323basolateral plasma membraneGoComponentGO:0016324apical plasma membraneGoComponentGO:0031594neuromuscular junctionGoComponentGO:0032587ruffle membraneGoComponentGO:0038143ERBB3:ERBB2 complexGoComponentGO:0042734presynaptic membraneGoComponentGO:0042995cell projectionGoComponentGO:0043209myelin sheathGoComponentGO:0043235receptor complexGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0001042RNA polymerase I core bindingGoFunctionGO:0004714transmembrane receptor protein tyrosine kinase activityGoFunctionGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005004GPI-linked ephrin receptor activityGoFunctionGO:0005005transmembrane-ephrin receptor activityGoFunctionGO:0005006epidermal growth factor receptor activityGoFunctionGO:0005007fibroblast growth factor receptor activityGoFunctionGO:0005008hepatocyte growth factor receptor activityGoFunctionGO:0005009insulin receptor activityGoFunctionGO:0005010insulin-like growth factor receptor activityGoFunctionGO:0005011macrophage colony-stimulating factor receptor activityGoFunctionGO:0005018platelet-derived growth factor alpha-receptor activityGoFunctionGO:0005019platelet-derived growth factor beta-receptor activityGoFunctionGO:0005020stem cell factor receptor activityGoFunctionGO:0005021vascular endothelial growth factor receptor activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008288boss receptor activityGoFunctionGO:0015026coreceptor activityGoFunctionGO:0019838growth factor bindingGoFunctionGO:0030971receptor tyrosine kinase bindingGoFunctionGO:0036332placental growth factor receptor activityGoFunctionGO:0038062protein tyrosine kinase collagen receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0043125ErbB-3 class receptor bindingGoFunctionGO:0046982protein heterodimerization activityGoFunctionGO:0060175brain-derived neurotrophic factor receptor activityGoFunctionGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0007166cell surface receptor signaling pathwayGoProcessGO:0007167enzyme-linked receptor protein signaling pathwayGoProcessGO:0007169cell surface receptor protein tyrosine kinase signaling pathwayGoProcessGO:0007399nervous system developmentGoProcessGO:0007422peripheral nervous system developmentGoProcessGO:0007507heart developmentGoProcessGO:0007528neuromuscular junction developmentGoProcessGO:0008283cell population proliferationGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0008286insulin receptor signaling pathwayGoProcessGO:0008543fibroblast growth factor receptor signaling pathwayGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010646regulation of cell communicationGoProcessGO:0014044Schwann cell developmentGoProcessGO:0018108peptidyl-tyrosine phosphorylationGoProcessGO:0022008neurogenesisGoProcessGO:0023051regulation of signalingGoProcessGO:0030182neuron differentiationGoProcessGO:0030307positive regulation of cell growthGoProcessGO:0031547brain-derived neurotrophic factor receptor signaling pathwayGoProcessGO:0032886regulation of microtubule-based processGoProcessGO:0033080immature T cell proliferation in thymusGoProcessGO:0033088negative regulation of immature T cell proliferation in thymusGoProcessGO:0035025positive regulation of Rho protein signal transductionGoProcessGO:0035556intracellular signal transductionGoProcessGO:0035790platelet-derived growth factor receptor-alpha signaling pathwayGoProcessGO:0035791platelet-derived growth factor receptor-beta signaling pathwayGoProcessGO:0036323vascular endothelial growth factor receptor-1 signaling pathwayGoProcessGO:0038063collagen-activated tyrosine kinase receptor signaling pathwayGoProcessGO:0038084vascular endothelial growth factor signaling pathwayGoProcessGO:0038109Kit signaling pathwayGoProcessGO:0038127ERBB signaling pathwayGoProcessGO:0038133ERBB2-ERBB3 signaling pathwayGoProcessGO:0038134ERBB2-EGFR signaling pathwayGoProcessGO:0038135ERBB2-ERBB4 signaling pathwayGoProcessGO:0038145macrophage colony-stimulating factor signaling pathwayGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0042552myelinationGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043406positive regulation of MAP kinase activityGoProcessGO:0043410positive regulation of MAPK cascadeGoProcessGO:0043491phosphatidylinositol 3-kinase/protein kinase B signal transductionGoProcessGO:0045727positive regulation of translationGoProcessGO:0045765regulation of angiogenesisGoProcessGO:0045785positive regulation of cell adhesionGoProcessGO:0045943positive regulation of transcription by RNA polymerase IGoProcessGO:0048009insulin-like growth factor receptor signaling pathwayGoProcessGO:0048012hepatocyte growth factor receptor signaling pathwayGoProcessGO:0048013ephrin receptor signaling pathwayGoProcessGO:0048709oligodendrocyte differentiationGoProcessGO:0050679positive regulation of epithelial cell proliferationGoProcessGO:0070372regulation of ERK1 and ERK2 cascadeGoProcessGO:0071526semaphorin-plexin signaling pathwayGoProcessGO:0090314positive regulation of protein targeting to membraneGoProcessGO:0099645neurotransmitter receptor localization to postsynaptic specialization membraneGoProcessHGNC:3430ERBB2HGNCP04626IntActIPR000494Rcpt_L-domInterProIPR000719Prot_kinase_domInterProIPR001245Ser-Thr/Tyr_kinase_cat_domInterProIPR006211Furin-like_Cys-rich_domInterProIPR006212Furin_repeatInterProIPR008266Tyr_kinase_ASInterProIPR009030Growth_fac_rcpt_cys_sfInterProIPR011009Kinase-like_dom_sfInterProIPR016245Tyr_kinase_EGF/ERB/XmrK_rcptInterProIPR017441Protein_kinase_ATP_BSInterProIPR020635Tyr_kinase_cat_domInterProIPR032778GF_recep_IVInterProIPR036941Rcpt_L-dom_sfInterProIPR049328TM_ErbB1InterProIPR050122RTKInterProPTHR24416TYROSINE-PROTEIN KINASE RECEPTORPANTHERPTHR24416:SF137RECEPTOR TYROSINE-PROTEIN KINASE ERBB-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-likePfamPF01030Recep_L_domainPfamPF07714PK_Tyr_Ser-ThrPfamPF14843GF_recep_IVPfamPF21314TM_ErbB1PfamPA27844erb-b2 receptor tyrosine kinase 2PharmGKBP04626PharosR-HSA-1227986Signaling by ERBB2ReactomeR-HSA-1250196SHC1 events in ERBB2 signalingReactomeR-HSA-1251932PLCG1 events in ERBB2 signalingReactomeR-HSA-1257604PIP3 activates AKT signalingReactomeR-HSA-1306955GRB7 events in ERBB2 signalingReactomeR-HSA-1358803Downregulation of ERBB2:ERBB3 signalingReactomeR-HSA-1963640GRB2 events in ERBB2 signalingReactomeR-HSA-1963642PI3K events in ERBB2 signalingReactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerReactomeR-HSA-416572Sema4D induced cell migration and growth-cone collapseReactomeR-HSA-5673001RAF/MAP kinase cascadeReactomeR-HSA-6785631ERBB2 Regulates Cell MotilityReactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingReactomeR-HSA-8847993ERBB2 Activates PTK6 SignalingReactomeR-HSA-8863795Downregulation of ERBB2 signalingReactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsReactomeR-HSA-9634285Constitutive Signaling by Overexpressed ERBB2ReactomeR-HSA-9652282Drug-mediated inhibition of ERBB2 signalingReactomeR-HSA-9664565Signaling by ERBB2 KD MutantsReactomeR-HSA-9665233Resistance of ERBB2 KD mutants to trastuzumabReactomeR-HSA-9665244Resistance of ERBB2 KD mutants to sapitinibReactomeR-HSA-9665245Resistance of ERBB2 KD mutants to tesevatinibReactomeR-HSA-9665246Resistance of ERBB2 KD mutants to neratinibReactomeR-HSA-9665247Resistance of ERBB2 KD mutants to osimertinibReactomeR-HSA-9665249Resistance of ERBB2 KD mutants to afatinibReactomeR-HSA-9665250Resistance of ERBB2 KD mutants to AEE788ReactomeR-HSA-9665251Resistance of ERBB2 KD mutants to lapatinibReactomeR-HSA-9665348Signaling by ERBB2 ECD mutantsReactomeR-HSA-9665686Signaling by ERBB2 TMD/JMD mutantsReactomeR-HSA-9665737Drug resistance in ERBB2 TMD/JMD mutantsReactomeR-HSA-9927432Developmental Lineage of Mammary Gland Myoepithelial CellsReactomeR-HSA-9938206Developmental Lineage of Mammary Stem CellsReactomeB2RZG3Receptor tyrosine-protein kinase erbB-2UniProtB4DHN3Receptor tyrosine-protein kinase erbB-2UniProtP04626Receptor tyrosine-protein kinase erbB-2UniProtQ14256Receptor tyrosine-protein kinase erbB-2UniProtQ6LDV1Receptor tyrosine-protein kinase erbB-2UniProtQ9UMK4Receptor tyrosine-protein kinase erbB-2UniProtX5D2V5Receptor tyrosine-protein kinase erbB-2UniProtSINGLE PROTEIN9606Human herpesvirus 1 (strain SC16) (HHV-1) (Human herpes simplex virus1)Thymidine kinaseCHEMBL1820P06479Thymidine kinase116PROTEINSINGLE PROTEIN2.7.1.21EC_NUMBERThymidine kinaseUNIPROTTKGENE_SYMBOLGO:0004797thymidine kinase activityGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0006230TMP biosynthetic processGoProcessGO:0009157deoxyribonucleoside monophosphate biosynthetic processGoProcessGO:0071897DNA biosynthetic processGoProcessIPR001889Herpes_TKInterProIPR027417P-loop_NTPaseInterProPF00693Herpes_TKPfamP06479Thymidine kinaseUniProtSINGLE PROTEIN10309Mus musculusCyclin-dependent kinase 4CHEMBL2134P30285Cyclin-dependent kinase 4476PROTEINSINGLE PROTEIN2.7.11.22EC_NUMBERCdk4GENE_SYMBOLCell division protein kinase 4UNIPROTCrk3GENE_SYMBOL_OTHERCRK3UNIPROTCyclin-dependent kinase 4UNIPROTPSK-J3UNIPROTP30285AlphaFoldDBP30285ExpressionAtlasGO:0000785chromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005667transcription regulator complexGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessP30285IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR050108CDKInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamR-MMU-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-MMU-2559580Oxidative Stress Induced SenescenceReactomeR-MMU-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-MMU-2559585Oncogene Induced SenescenceReactomeR-MMU-3214858RMTs methylate histone argininesReactomeR-MMU-69231Cyclin D associated events in G1ReactomeR-MMU-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-MMU-8849470PTK6 Regulates Cell CycleReactomeR-MMU-8878166Transcriptional regulation by RUNX2ReactomeR-MMU-9616222Transcriptional regulation of granulopoiesisReactomeR-MMU-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30285Cyclin-dependent kinase 4UniProtSINGLE PROTEIN10090Homo sapiensCasein kinase II subunit alphaCHEMBL3629P68400Casein kinase II subunit alpha1946PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBERCasein kinase II subunit alphaUNIPROTCK2A1GENE_SYMBOL_OTHERCK II alphaUNIPROTCSNK2A1GENE_SYMBOLP68400AlphaFoldDBP68400ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0005956protein kinase CK2 complexGoComponentGO:0016605PML bodyGoComponentGO:0031519PcG protein complexGoComponentGO:0070822Sin3-type complexGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0051879Hsp90 protein bindingGoFunctionGO:0006302double-strand break repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0017148negative regulation of translationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030177positive regulation of Wnt signaling pathwayGoProcessGO:0030307positive regulation of cell growthGoProcessGO:0032435negative regulation of proteasomal ubiquitin-dependent protein catabolic processGoProcessGO:0045732positive regulation of protein catabolic processGoProcessGO:0048511rhythmic processGoProcessGO:0050821protein stabilizationGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061077chaperone-mediated protein foldingGoProcessGO:1905337positive regulation of aggrephagyGoProcessGO:1905818regulation of chromosome separationGoProcessGO:2000042negative regulation of double-strand break repair via homologous recombinationGoProcessGO:2000117negative regulation of cysteine-type endopeptidase activityGoProcessGO:2001234negative regulation of apoptotic signaling pathwayGoProcessHGNC:2457CSNK2A1HGNCP68400IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR045216CK2_alphaInterProPTHR24054CASEIN KINASE II SUBUNIT ALPHAPANTHERPTHR24054:SF16CASEIN KINASE II SUBUNIT ALPHA-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 kinase 2 alpha 1PharmGKBP68400PharosR-HSA-1483191Synthesis of PCReactomeR-HSA-201688WNT mediated activation of DVLReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-445144Signal transduction by L1ReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6814122Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta foldingReactomeR-HSA-8934903Receptor Mediated MitophagyReactomeR-HSA-8939243RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not knownReactomeR-HSA-8948751Regulation of PTEN stability and activityReactomeR-HSA-9755511KEAP1-NFE2L2 pathwayReactomeR-HSA-9768727Regulation of CDH1 posttranslational processing and trafficking to plasma membraneReactomeR-HSA-9828806Maturation of hRSV A proteinsReactomeR-HSA-9931529Phosphorylation and nuclear translocation of BMAL1 (ARNTL) and CLOCKReactomeR-HSA-9931530Phosphorylation and nuclear translocation of the CRY:PER:kinase complexReactomeB4DYS6Casein kinase II subunit alphaUniProtD3DVV8Casein kinase II subunit alphaUniProtP19138Casein kinase II subunit alphaUniProtP20426Casein kinase II subunit alphaUniProtP68400Casein kinase II subunit alphaUniProtQ14013Casein kinase II subunit alphaUniProtQ5U065Casein kinase II subunit alphaUniProtSINGLE PROTEIN9606Homo sapiensNucleoside diphosphate kinase ACHEMBL2159P15531Nucleoside diphosphate kinase A501PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBER2.7.13.3EC_NUMBER2.7.4.18EC_NUMBER2.7.4.6EC_NUMBER3.1.11.-EC_NUMBER3.1.24.-EC_NUMBERFarnesyl diphosphate kinase NME1UNIPROTGAADUNIPROTHistidine protein kinase NME1UNIPROTMetastasis inhibition factor nm23UNIPROTNDK1UNIPROTNDPK AUNIPROTNDPKAGENE_SYMBOL_OTHERNDP kinase AUNIPROTNM23GENE_SYMBOL_OTHERNM23-H1UNIPROTNME1GENE_SYMBOLNon-specific serine/threonine protein kinase NME1UNIPROTNucleoside diphoshate kinase 1UNIPROTNucleoside diphosphate kinase AUNIPROTPutative 3'-5'-DNA exonuclease NDK1UNIPROTPutative granzyme A-activated DNA endonucleaseUNIPROTSynonyms=NDPKAGENE_SYMBOL_OTHERTumor metastatic process-associated proteinUNIPROTP15531AlphaFoldDBP15531ExpressionAtlasGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005769early endosomeGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0032587ruffle membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0000287magnesium ion bindingGoFunctionGO:0003723RNA bindingGoFunctionGO:0004536DNA nuclease activityGoFunctionGO:0004550nucleoside diphosphate kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0005525GTP bindingGoFunctionGO:00084083'-5' exonuclease activityGoFunctionGO:0016301kinase activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006183GTP biosynthetic processGoProcessGO:0006228UTP biosynthetic processGoProcessGO:0006241CTP biosynthetic processGoProcessGO:0006259DNA metabolic processGoProcessGO:0006897endocytosisGoProcessGO:0007399nervous system developmentGoProcessGO:0007595lactationGoProcessGO:0008285negative regulation of cell population proliferationGoProcessGO:0009117nucleotide metabolic processGoProcessGO:0030154cell differentiationGoProcessGO:0030879mammary gland developmentGoProcessGO:0042981regulation of apoptotic processGoProcessGO:0050679positive regulation of epithelial cell proliferationGoProcessHGNC:7849NME1HGNCP15531IntActIPR001564Nucleoside_diP_kinaseInterProIPR023005Nucleoside_diP_kinase_ASInterProIPR034907NDK-like_domInterProIPR036850NDK-like_dom_sfInterProPTHR11349NUCLEOSIDE DIPHOSPHATE KINASEPANTHER1JXVPDB1UCNPDB2HVDPDB2HVEPDB3L7UPDB4ENOPDB5UI4PDB8OOVPDB9GD6PDB9GD8PDB9GD9PDB1JXVAPDBe1UCNAPDBe2HVDAPDBe2HVEAPDBe3L7UAPDBe4ENOAPDBe5UI4APDBe8OOVAPDBePF00334NDKPfamPA249NME/NM23 nucleoside diphosphate kinase 1PharmGKBP15531PharosR-HSA-499943Interconversion of nucleotide di- and triphosphatesReactomeR-HSA-9748787Azathioprine ADMEReactomeR-HSA-9755088Ribavirin ADMEReactomeP15531Nucleoside diphosphate kinase AUniProtQ6FGK3Nucleoside diphosphate kinase AUniProtQ86XQ2Nucleoside diphosphate kinase AUniProtQ9UDJ6Nucleoside diphosphate kinase AUniProtSINGLE PROTEIN9606Homo sapiensNucleoside diphosphate kinase BCHEMBL2160P22392Nucleoside diphosphate kinase B502PROTEINSINGLE PROTEIN2.7.13.3EC_NUMBER2.7.4.6EC_NUMBERC-myc purine-binding transcription factor PUFUNIPROTHistidine protein kinase NDKBUNIPROTNDK2UNIPROTNDPK BUNIPROTNDP kinase BUNIPROTNM23BGENE_SYMBOL_OTHERnm23-H2UNIPROTNME2GENE_SYMBOLNucleoside diphoshate kinase 2UNIPROTNucleoside diphosphate kinase BUNIPROTSynonyms=NDK2GENE_SYMBOL_OTHERP22392AlphaFoldDBP22392ExpressionAtlasGO:0001726ruffleGoComponentGO:0005576extracellular regionGoComponentGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005925focal adhesionGoComponentGO:0030027lamellipodiumGoComponentGO:0034774secretory granule lumenGoComponentGO:0042995cell projectionGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0070062extracellular exosomeGoComponentGO:0071944cell peripheryGoComponentGO:1904813ficolin-1-rich granule lumenGoComponentGO:0000155phosphorelay sensor kinase activityGoFunctionGO:0003677DNA bindingGoFunctionGO:0003713transcription coactivator activityGoFunctionGO:0004550nucleoside diphosphate kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019003GDP bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051880G-quadruplex DNA bindingGoFunctionGO:0000160phosphorelay signal transduction systemGoProcessGO:0006183GTP biosynthetic processGoProcessGO:0006228UTP biosynthetic processGoProcessGO:0006241CTP biosynthetic processGoProcessGO:0007155cell adhesionGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0009117nucleotide metabolic processGoProcessGO:0009142nucleoside triphosphate biosynthetic processGoProcessGO:0042981regulation of apoptotic processGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0045618positive regulation of keratinocyte differentiationGoProcessGO:0045682regulation of epidermis developmentGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0050679positive regulation of epithelial cell proliferationGoProcessHGNC:7850NME2HGNCP22392IntActIPR001564Nucleoside_diP_kinaseInterProIPR023005Nucleoside_diP_kinase_ASInterProIPR034907NDK-like_domInterProIPR036850NDK-like_dom_sfInterProPTHR11349NUCLEOSIDE DIPHOSPHATE KINASEPANTHER1NSKPDB1NUEPDB3BBBPDB3BBCPDB3BBFPDB7KPFPDB8PIEPDB8PYWPDB1NSKAPDBe1NUEAPDBe3BBBAPDBe3BBCAPDBe3BBFAPDBe7KPFAPDBe8PIEAPDBe8PYWAPDBePF00334NDKPfamPA250NME/NM23 nucleoside diphosphate kinase 2PharmGKBP22392PharosR-HSA-499943Interconversion of nucleotide di- and triphosphatesReactomeR-HSA-6798695Neutrophil degranulationReactomeR-HSA-9748787Azathioprine ADMEReactomeR-HSA-9755088Ribavirin ADMEReactomeA8MWA3Nucleoside diphosphate kinase BUniProtP22392Nucleoside diphosphate kinase BUniProtQ1WM23Nucleoside diphosphate kinase BUniProtQ6LCT6Nucleoside diphosphate kinase BUniProtSINGLE PROTEIN9606Homo sapiensDeath-associated protein kinase 3CHEMBL2468O43293Death-associated protein kinase 3809PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBERDAPK3GENE_SYMBOLDAP kinase 3UNIPROTDAP-like kinaseUNIPROTDeath-associated protein kinase 3UNIPROTDlkUNIPROTMYPT1 kinaseUNIPROTZIPKGENE_SYMBOL_OTHERZIP-kinaseUNIPROTZipper-interacting protein kinaseUNIPROTO43293AlphaFoldDBO43293ExpressionAtlasGO:0000775chromosome, centromeric regionGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0016605PML bodyGoComponentGO:0030496midbodyGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008140cAMP response element binding protein bindingGoFunctionGO:0031267small GTPase bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0042803protein homodimerization activityGoFunctionGO:0043522leucine zipper domain bindingGoFunctionGO:0006468protein phosphorylationGoProcessGO:0006915apoptotic processGoProcessGO:0006940regulation of smooth muscle contractionGoProcessGO:0007088regulation of mitotic nuclear divisionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008360regulation of cell shapeGoProcessGO:0017148negative regulation of translationGoProcessGO:0030335positive regulation of cell migrationGoProcessGO:0032956regulation of actin cytoskeleton organizationGoProcessGO:0035556intracellular signal transductionGoProcessGO:0042981regulation of apoptotic processGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043519regulation of myosin II filament organizationGoProcessGO:0046777protein autophosphorylationGoProcessGO:0051893regulation of focal adhesion assemblyGoProcessGO:0090263positive regulation of canonical Wnt signaling pathwayGoProcessGO:0097190apoptotic signaling pathwayGoProcessGO:2000145regulation of cell motilityGoProcessHGNC:2676DAPK3HGNCO43293IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR042870DAPK3_STKcInterProPTHR24342SERINE/THREONINE-PROTEIN KINASE 17PANTHERPTHR24342:SF18DEATH-ASSOCIATED PROTEIN KINASE 3PANTHER1YRPPDB2J90PDB3BHYPDB3BQRPDB5A6NPDB5A6OPDB5VJAPDB1YRPAPDBe2J90APDBe3BHYAPDBe3BQRAPDBe5A6NAPDBe5A6OAPDBe5VJAAPDBePF00069PkinasePfamPA27144death associated protein kinase 3PharmGKBO43293PharosR-HSA-418889Caspase activation via Dependence Receptors in the absence of ligandReactomeA0AVN4Death-associated protein kinase 3UniProtB3KQE2Death-associated protein kinase 3UniProtO43293Death-associated protein kinase 3UniProtQ05JY4Death-associated protein kinase 3UniProtSINGLE PROTEIN9606Homo sapiensUridine-cytidine kinase 2CHEMBL2469Q9BZX2Uridine-cytidine kinase 2810PROTEINSINGLE PROTEIN2.7.1.48EC_NUMBERCytidine monophosphokinase 2UNIPROTTestis-specific protein TSA903UNIPROTUCK 2UNIPROTUCK2GENE_SYMBOLUMPKGENE_SYMBOL_OTHERUridine-cytidine kinase 2UNIPROTUridine monophosphokinase 2UNIPROTQ9BZX2AlphaFoldDBQ9BZX2ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0004849uridine kinase activityGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0043771cytidine kinase activityGoFunctionGO:0009224CMP biosynthetic processGoProcessGO:0044206UMP salvageGoProcessGO:0044211CTP salvageGoProcessHGNC:12562UCK2HGNCQ9BZX2IntActIPR000764Uridine_kinase-likeInterProIPR006083PRK/URKInterProIPR027417P-loop_NTPaseInterProPTHR10285URIDINE KINASEPANTHER1UDWPDB1UEIPDB1UEJPDB1UFQPDB1UJ2PDB1XRJPDB6N53PDB6N54PDB6N55PDB6PWZPDB7SQLPDB1UDWAPDBe1UEIAPDBe1UEJAPDBe1UFQAPDBe1UJ2APDBe1XRJAPDBe6N53APDBe6N54APDBe6N55APDBe6PWZAPDBe7SQLAPDBePF00485PRKPfamPA362uridine-cytidine kinase 2PharmGKBQ9BZX2PharosR-HSA-73614Pyrimidine salvageReactomeQ5VV91Uridine-cytidine kinase 2UniProtQ7KZV3Uridine-cytidine kinase 2UniProtQ92528Uridine-cytidine kinase 2UniProtQ96KG5Uridine-cytidine kinase 2UniProtQ9BU42Uridine-cytidine kinase 2UniProtQ9BZX2Uridine-cytidine kinase 2UniProtSINGLE PROTEIN9606Homo sapiensDNA-dependent protein kinase catalytic subunitCHEMBL3142P78527DNA-dependent protein kinase catalytic subunit1467PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBERDNA-dependent protein kinase catalytic subunitUNIPROTDNA-PK catalytic subunitUNIPROTDNA-PKcsUNIPROTDNPK1UNIPROTHYRCGENE_SYMBOL_OTHERHYRC1GENE_SYMBOL_OTHERp460UNIPROTPRKDCGENE_SYMBOLS473KUNIPROTSer-473 kinaseUNIPROTP78527ExpressionAtlasGO:0000781chromosome, telomeric regionGoComponentGO:0000785chromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005667transcription regulator complexGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005958DNA-dependent protein kinase-DNA ligase 4 complexGoComponentGO:0016020membraneGoComponentGO:0032040small-subunit processomeGoComponentGO:0032991protein-containing complexGoComponentGO:0032993protein-DNA complexGoComponentGO:0070418DNA-dependent protein kinase complexGoComponentGO:0070419nonhomologous end joining complexGoComponentGO:0003677DNA bindingGoFunctionGO:0003690double-stranded DNA bindingGoFunctionGO:0003723RNA bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0034511U3 snoRNA bindingGoFunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingGoFunctionGO:0000460maturation of 5.8S rRNAGoProcessGO:0000723telomere maintenanceGoProcessGO:0001756somitogenesisGoProcessGO:0001933negative regulation of protein phosphorylationGoProcessGO:0002218activation of innate immune responseGoProcessGO:0002326B cell lineage commitmentGoProcessGO:0002327immature B cell differentiationGoProcessGO:0002328pro-B cell differentiationGoProcessGO:0002360T cell lineage commitmentGoProcessGO:0006281DNA repairGoProcessGO:0006302double-strand break repairGoProcessGO:0006303double-strand break repair via nonhomologous end joiningGoProcessGO:0006310DNA recombinationGoProcessGO:0006468protein phosphorylationGoProcessGO:0006974DNA damage responseGoProcessGO:0007420brain developmentGoProcessGO:0007507heart developmentGoProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageGoProcessGO:0016233telomere cappingGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030098lymphocyte differentiationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0031648protein destabilizationGoProcessGO:0032869cellular response to insulin stimulusGoProcessGO:0033077T cell differentiation in thymusGoProcessGO:0033151V(D)J recombinationGoProcessGO:0033152immunoglobulin V(D)J recombinationGoProcessGO:0033153T cell receptor V(D)J recombinationGoProcessGO:0034462small-subunit processome assemblyGoProcessGO:0035234ectopic germ cell programmed cell deathGoProcessGO:0042254ribosome biogenesisGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0045087innate immune responseGoProcessGO:0045621positive regulation of lymphocyte differentiationGoProcessGO:0045648positive regulation of erythrocyte differentiationGoProcessGO:0045727positive regulation of translationGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0048511rhythmic processGoProcessGO:0048660regulation of smooth muscle cell proliferationGoProcessGO:0050678regulation of epithelial cell proliferationGoProcessGO:0080135regulation of cellular response to stressGoProcessGO:0097681double-strand break repair via alternative nonhomologous end joiningGoProcessGO:0160049negative regulation of cGAS/STING signaling pathwayGoProcessGO:1902036regulation of hematopoietic stem cell differentiationGoProcessGO:1905221positive regulation of platelet formationGoProcessGO:2001034positive regulation of double-strand break repair via nonhomologous end joiningGoProcessHGNC:9413PRKDCHGNCP78527IntActIPR000403PI3/4_kinase_cat_domInterProIPR003151PIK-rel_kinase_FATInterProIPR003152FATC_domInterProIPR011009Kinase-like_dom_sfInterProIPR011989ARM-likeInterProIPR012582DNAPKcs_CC3InterProIPR014009PIK_FATInterProIPR016024ARM-type_foldInterProIPR018936PI3/4_kinase_CSInterProIPR036940PI3/4_kinase_cat_sfInterProIPR037706DNA-PK_domInterProIPR045581DNAPKcs_CC5InterProIPR046803DNAPKcs_CC1-2InterProIPR046804DNA-PKcs_NInterProIPR050517DDR_Repair_KinaseInterProPTHR11139ATAXIA TELANGIECTASIA MUTATED ATM -RELATEDPANTHERPTHR11139:SF68DNA-DEPENDENT PROTEIN KINASE CATALYTIC SUBUNITPANTHER5LUQPDB5W1RPDB5Y3RPDB6ZFPPDB6ZH2PDB6ZH4PDB6ZH6PDB6ZH8PDB6ZHAPDB6ZHEPDB7K0YPDB7K10PDB7K11PDB7K19PDB7K1BPDB7K1JPDB7K1KPDB7K1NPDB7LT3PDB7NFCPDB7NFEPDB7OTMPDB7OTPPDB7OTVPDB7OTWPDB7OTYPDB7SGLPDB7SU3PDB7SUDPDB7TYRPDB7Z87PDB7Z88PDB8BH3PDB8BHVPDB8BHYPDB8BOTPDB8EZ9PDB8EZAPDB8EZBPDB8RD4PDB9G9LPDB9GD7PDB5LUQAPDBePF00454PI3_PI4_kinasePfamPF02259FATPfamPF02260FATCPfamPF08163DNAPKcs_CC3PfamPF19704DNAPKcs_CC5PfamPF20500DNA-PKcs_NPfamPF20502DNAPKcs_CC1-2PfamPA33776protein kinase, DNA-activated, catalytic subunitPharmGKBP78527PharosR-HSA-1834949Cytosolic sensors of pathogen-associated DNAReactomeR-HSA-3270619IRF3-mediated induction of type I IFNReactomeR-HSA-5693571Nonhomologous End-Joining (NHEJ)ReactomeR-HSA-8866654E3 ubiquitin ligases ubiquitinate target proteinsReactomeP78527DNA-dependent protein kinase catalytic subunitUniProtP78528DNA-dependent protein kinase catalytic subunitUniProtQ13327DNA-dependent protein kinase catalytic subunitUniProtQ13337DNA-dependent protein kinase catalytic subunitUniProtQ14175DNA-dependent protein kinase catalytic subunitUniProtQ59H99DNA-dependent protein kinase catalytic subunitUniProtQ7Z611DNA-dependent protein kinase catalytic subunitUniProtQ96SE6DNA-dependent protein kinase catalytic subunitUniProtQ9UME3DNA-dependent protein kinase catalytic subunitUniProtSINGLE PROTEIN9606Homo sapiensDeoxycytidine kinaseCHEMBL2447P27707Deoxycytidine kinase788PROTEINSINGLE PROTEIN2.7.1.113EC_NUMBER2.7.1.74EC_NUMBER2.7.1.76EC_NUMBERdCKUNIPROTDCKGENE_SYMBOLDeoxyadenosine kinaseUNIPROTDeoxycytidine kinaseUNIPROTDeoxyguanosine kinaseUNIPROTP27707AlphaFoldDBP27707ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005829cytosolGoComponentGO:0004136deoxyadenosine kinase activityGoFunctionGO:0004137deoxycytidine kinase activityGoFunctionGO:0004138deoxyguanosine kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019136deoxynucleoside kinase activityGoFunctionGO:0042803protein homodimerization activityGoFunctionGO:0043771cytidine kinase activityGoFunctionGO:0006220pyrimidine nucleotide metabolic processGoProcessGO:0009224CMP biosynthetic processGoProcessGO:0106383dAMP salvageGoProcessGO:1901293nucleoside phosphate biosynthetic processGoProcessHGNC:2704DCKHGNCP27707IntActIPR002624DCK/DGKInterProIPR027417P-loop_NTPaseInterProIPR031314DNK_domInterProIPR050566Deoxyribonucleoside_kinaseInterProPTHR10513DEOXYNUCLEOSIDE KINASEPANTHERPTHR10513:SF19DEOXYCYTIDINE 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 kinasePharmGKBP27707PharosR-HSA-73614Pyrimidine salvageReactomeR-HSA-74217Purine salvageReactomeB2R8V6Deoxycytidine kinaseUniProtP27707Deoxycytidine kinaseUniProtQ5TZY7Deoxycytidine kinaseUniProtQ6FI11Deoxycytidine kinaseUniProtSINGLE PROTEIN9606Homo sapiensMitogen-activated protein kinase 11CHEMBL3961Q15759Mitogen-activated protein kinase 112280PROTEINSINGLE PROTEIN2.7.11.24EC_NUMBERMAPK 11UNIPROTMAPK11GENE_SYMBOLMAP kinase 11UNIPROTMAP kinase p38 betaUNIPROTMitogen-activated protein kinase 11UNIPROTMitogen-activated protein kinase p38 betaUNIPROTp38-2UNIPROTp38bUNIPROTPRKM11GENE_SYMBOL_OTHERSAPK2GENE_SYMBOL_OTHERSAPK2bUNIPROTSAPK2BGENE_SYMBOL_OTHERStress-activated protein kinase 2bUNIPROTQ15759AlphaFoldDBQ15759ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0000165MAPK cascadeGoProcessGO:0001649osteoblast differentiationGoProcessGO:0007254JNK cascadeGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0031098stress-activated protein kinase signaling cascadeGoProcessGO:0032735positive regulation of interleukin-12 productionGoProcessGO:0033554cellular response to stressGoProcessGO:0035556intracellular signal transductionGoProcessGO:0038066p38MAPK cascadeGoProcessGO:0045648positive regulation of erythrocyte differentiationGoProcessGO:0051149positive regulation of muscle cell differentiationGoProcessGO:0051403stress-activated MAPK cascadeGoProcessGO:0060038cardiac muscle cell proliferationGoProcessGO:0060043regulation of cardiac muscle cell proliferationGoProcessGO:0060044negative regulation of cardiac muscle cell proliferationGoProcessGO:0060348bone developmentGoProcessGO:0071493cellular response to UV-BGoProcessGO:0090398cellular senescenceGoProcessHGNC:6873MAPK11HGNCQ15759IntActIPR000719Prot_kinase_domInterProIPR003527MAP_kinase_CSInterProIPR008352MAPK_HOG-likeInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR050117MAPKInterProPTHR24055MITOGEN-ACTIVATED PROTEIN KINASEPANTHER3GC8PDB3GC9PDB3GP0PDB8YGWPDB3GC8APDBe3GC9APDBe3GP0APDBe8YGWAPDBePF00069PkinasePfamPA30618mitogen-activated protein kinase 11PharmGKBQ15759PharosR-HSA-168638NOD1/2 Signaling PathwayReactomeR-HSA-171007p38MAPK eventsReactomeR-HSA-198753ERK/MAPK targetsReactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-4420097VEGFA-VEGFR2 PathwayReactomeR-HSA-450302activated TAK1 mediates p38 MAPK activationReactomeR-HSA-450341Activation of the AP-1 family of transcription factorsReactomeR-HSA-450604KSRP (KHSRP) binds and destabilizes mRNAReactomeR-HSA-525793MyogenesisReactomeR-HSA-5668599RHO GTPases Activate NADPH OxidasesReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeA8K730Mitogen-activated protein kinase 11UniProtB0LPG1Mitogen-activated protein kinase 11UniProtB7Z630Mitogen-activated protein kinase 11UniProtE7ETQ1Mitogen-activated protein kinase 11UniProtL7RT27Mitogen-activated protein kinase 11UniProtO00284Mitogen-activated protein kinase 11UniProtO15472Mitogen-activated protein kinase 11UniProtQ15759Mitogen-activated protein kinase 11UniProtQ2XNF2Mitogen-activated protein kinase 11UniProtSINGLE PROTEIN9606Homo sapiensThymidine kinase, cytosolicCHEMBL2883P04183Thymidine kinase, cytosolic1212PROTEINSINGLE PROTEIN2.7.1.21EC_NUMBERThymidine kinase, cytosolicUNIPROTTK1GENE_SYMBOLP04183AlphaFoldDBP04183ExpressionAtlasGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0004797thymidine kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008270zinc ion bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0009157deoxyribonucleoside monophosphate biosynthetic processGoProcessGO:0046104thymidine metabolic processGoProcessGO:0046105thymidine biosynthetic processGoProcessGO:0051289protein homotetramerizationGoProcessGO:0071897DNA biosynthetic processGoProcessGO:1904860DNA synthesis involved in mitotic DNA replicationGoProcessHGNC:11830TK1HGNCP04183IntActIPR001267Thymidine_kinaseInterProIPR020633Thymidine_kinase_CSInterProIPR027417P-loop_NTPaseInterProPTHR11441THYMIDINE KINASEPANTHERPTHR11441:SF0THYMIDINE KINASE, CYTOSOLICPANTHER1W4RPDB1XBTPDB2ORVPDB2WVJPDB1W4RAPDBe1XBTAPDBe2ORVAPDBe2WVJAPDBePF00265TKPfamPA352thymidine kinase 1PharmGKBP04183PharosR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-73614Pyrimidine salvageReactomeB2RC58Thymidine kinase, cytosolicUniProtP04183Thymidine kinase, cytosolicUniProtQ969V0Thymidine kinase, cytosolicUniProtQ9UMG9Thymidine kinase, cytosolicUniProtSINGLE PROTEIN9606Homo sapiensTyrosine-protein kinase LckCHEMBL258P06239Tyrosine-protein kinase Lck382PROTEINSINGLE PROTEIN2.7.10.2EC_NUMBERLCKGENE_SYMBOLLeukocyte C-terminal Src kinaseUNIPROTLSKUNIPROTLymphocyte cell-specific protein-tyrosine kinaseUNIPROTp56-LCKUNIPROTProtein YT16UNIPROTProto-oncogene LckUNIPROTT cell-specific protein-tyrosine kinaseUNIPROTTyrosine-protein kinase LckUNIPROTP06239AlphaFoldDBP06239ExpressionAtlasGO:0000242pericentriolar materialGoComponentGO:0001772immunological synapseGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0045121membrane raftGoComponentGO:0070062extracellular exosomeGoComponentGO:0001784phosphotyrosine residue bindingGoFunctionGO:0004722protein serine/threonine phosphatase activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016004phospholipase activator activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019903protein phosphatase bindingGoFunctionGO:0042169SH2 domain bindingGoFunctionGO:0042608T cell receptor bindingGoFunctionGO:0042609CD4 receptor bindingGoFunctionGO:0042610CD8 receptor bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0043274phospholipase bindingGoFunctionGO:0043548phosphatidylinositol 3-kinase bindingGoFunctionGO:0051117ATPase bindingGoFunctionGO:0006468protein phosphorylationGoProcessGO:0006882intracellular zinc ion homeostasisGoProcessGO:0007169cell surface receptor protein tyrosine kinase signaling pathwayGoProcessGO:0018108peptidyl-tyrosine phosphorylationGoProcessGO:0030097hemopoiesisGoProcessGO:0030168platelet activationGoProcessGO:0030217T cell differentiationGoProcessGO:0031295T cell costimulationGoProcessGO:0034116positive regulation of heterotypic cell-cell adhesionGoProcessGO:0035556intracellular signal transductionGoProcessGO:0038083peptidyl-tyrosine autophosphorylationGoProcessGO:0038094Fc-gamma receptor signaling pathwayGoProcessGO:0042110T cell activationGoProcessGO:0045087innate immune responseGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0050853B cell receptor signaling pathwayGoProcessGO:0050862positive regulation of T cell receptor signaling pathwayGoProcessGO:0050870positive regulation of T cell activationGoProcessGO:0050900leukocyte migrationGoProcessGO:0051209release of sequestered calcium ion into cytosolGoProcessGO:0051249regulation of lymphocyte activationGoProcessGO:0160162CD27 signaling pathwayGoProcessGO:1903039positive regulation of leukocyte cell-cell adhesionGoProcessGO:2001056positive regulation of cysteine-type endopeptidase activityGoProcessGO:2001244positive regulation of intrinsic apoptotic signaling pathwayGoProcessHGNC:6524LCKHGNCP06239IntActIPR000719Prot_kinase_domInterProIPR000980SH2InterProIPR001245Ser-Thr/Tyr_kinase_cat_domInterProIPR001452SH3_domainInterProIPR008266Tyr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR020635Tyr_kinase_cat_domInterProIPR035749Lck_SH3InterProIPR035850Lck_SH2InterProIPR036028SH3-like_dom_sfInterProIPR036860SH2_dom_sfInterProIPR050198Non-receptor_tyrosine_kinasesInterProPTHR24418TYROSINE-PROTEIN 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_1PfamPF07714PK_Tyr_Ser-ThrPfamPA30307LCK proto-oncogene, Src family tyrosine kinasePharmGKBP06239PharosR-HSA-114604GPVI-mediated activation cascadeReactomeR-HSA-1257604PIP3 activates AKT signalingReactomeR-HSA-1433557Signaling by SCF-KITReactomeR-HSA-1433559Regulation of KIT signalingReactomeR-HSA-164944Nef and signal transductionReactomeR-HSA-167590Nef Mediated CD4 Down-regulationReactomeR-HSA-202424Downstream TCR signalingReactomeR-HSA-202427Phosphorylation of CD3 and TCR zeta chainsReactomeR-HSA-202430Translocation of ZAP-70 to Immunological synapseReactomeR-HSA-202433Generation of second messenger moleculesReactomeR-HSA-210990PECAM1 interactionsReactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerReactomeR-HSA-2424491DAP12 signalingReactomeR-HSA-389356Co-stimulation by CD28ReactomeR-HSA-389357CD28 dependent PI3K/Akt signalingReactomeR-HSA-389359CD28 dependent Vav1 pathwayReactomeR-HSA-389513Co-inhibition by CTLA4ReactomeR-HSA-389948Co-inhibition by PD-1ReactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingReactomeR-HSA-9013407RHOH GTPase cycleReactomeR-HSA-9020558Interleukin-2 signalingReactomeR-HSA-9670439Signaling by phosphorylated juxtamembrane, extracellular and kinase domain KIT mutantsReactomeR-HSA-9706374FLT3 signaling through SRC family kinasesReactomeD3DPP8Tyrosine-protein kinase LckUniProtP06239Tyrosine-protein kinase LckUniProtP07100Tyrosine-protein kinase LckUniProtQ12850Tyrosine-protein kinase LckUniProtQ13152Tyrosine-protein kinase LckUniProtQ5TDH8Tyrosine-protein kinase LckUniProtQ5TDH9Tyrosine-protein kinase LckUniProtQ7RTZ3Tyrosine-protein kinase LckUniProtQ96DW4Tyrosine-protein kinase LckUniProtQ9NYT8Tyrosine-protein kinase LckUniProtSINGLE PROTEIN9606Homo sapiensPhosphoglycerate kinase 1CHEMBL2886P00558Phosphoglycerate kinase 11216PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBER2.7.2.3EC_NUMBERCell migration-inducing gene 10 proteinUNIPROTPGK1GENE_SYMBOLPGKAGENE_SYMBOL_OTHERPhosphoglycerate kinase 1UNIPROTPrimer recognition protein 2UNIPROTPRP 2UNIPROTP00558AlphaFoldDBP00558ExpressionAtlasGO:0005615extracellular spaceGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0045121membrane raftGoComponentGO:0070062extracellular exosomeGoComponentGO:0004618phosphoglycerate kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0043531ADP bindingGoFunctionGO:0047134protein-disulfide reductase (NAD(P)H) activityGoFunctionGO:0006094gluconeogenesisGoProcessGO:0006096glycolytic processGoProcessGO:0016525negative regulation of angiogenesisGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031639plasminogen activationGoProcessGO:0061621canonical glycolysisGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0160218negative regulation of acetyl-CoA biosynthetic process from pyruvateGoProcessHGNC:8896PGK1HGNCP00558IntActIPR001576Phosphoglycerate_kinaseInterProIPR015824Phosphoglycerate_kinase_NInterProIPR015911Phosphoglycerate_kinase_CSInterProIPR036043Phosphoglycerate_kinase_sfInterProPTHR11406PHOSPHOGLYCERATE KINASEPANTHERPTHR11406:SF14PHOSPHOGLYCERATE KINASE 1PANTHER2WZBPDB2WZCPDB2WZDPDB2X13PDB2X14PDB2X15PDB2XE6PDB2XE7PDB2XE8PDB2Y3IPDB2YBEPDB2ZGVPDB3C39PDB3C3APDB3C3BPDB3C3CPDB3ZOZPDB4AXXPDB4O33PDB5M1RPDB5M3UPDB5M6ZPDB5MXMPDB5NP8PDB5O7DPDB8YHPPDB9FDHPDB9FDNPDB2WZBAPDBe2WZCAPDBe2WZDAPDBe2X13APDBe2X14APDBe2X15APDBe2XE6APDBe2XE7APDBe2XE8APDBe2Y3IAPDBe2YBEAPDBe2ZGVAPDBe3C39APDBe3C3AAPDBe3C3BAPDBe3C3CAPDBe3ZOZAPDBe4AXXAPDBe4O33APDBe5M1RAPDBe5M3UAPDBe5M6ZAPDBe5MXMAPDBe5NP8APDBe5O7DAPDBe8YHPAPDBe9FDHAPDBe9FDNAPDBePF00162PGKPfamPA33234phosphoglycerate kinase 1PharmGKBP00558PharosR-HSA-70171GlycolysisReactomeR-HSA-70263GluconeogenesisReactomeR-HSA-9636667Manipulation of host energy metabolismReactomeA8K4W6Phosphoglycerate kinase 1UniProtB7Z7A9Phosphoglycerate kinase 1UniProtP00558Phosphoglycerate kinase 1UniProtQ5J7W1Phosphoglycerate kinase 1UniProtQ6IBT6Phosphoglycerate kinase 1UniProtQ8NI87Phosphoglycerate kinase 1UniProtSINGLE PROTEIN9606Homo sapiensUrokinase plasminogen activator surface receptorCHEMBL4883Q03405Urokinase plasminogen activator surface receptor3199PROTEINSINGLE PROTEINCD_antigen=CD87UNIPROTMO3GENE_SYMBOL_OTHERMonocyte activation antigen Mo3UNIPROTPLAURGENE_SYMBOLuPARUNIPROTU-PARUNIPROTUPARGENE_SYMBOL_OTHERUrokinase plasminogen activator surface receptorUNIPROTQ03405AlphaFoldDBQ03405ExpressionAtlasGO:0005576extracellular regionGoComponentGO:0005788endoplasmic reticulum lumenGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005886plasma membraneGoComponentGO:0005925focal adhesionGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0019898extrinsic component of membraneGoComponentGO:0035579specific granule membraneGoComponentGO:0042995cell projectionGoComponentGO:0070161anchoring junctionGoComponentGO:0098552side of membraneGoComponentGO:0098637protein complex involved in cell-matrix adhesionGoComponentGO:1905370serine-type endopeptidase complexGoComponentGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030377urokinase plasminogen activator receptor activityGoFunctionGO:0038023signaling receptor activityGoFunctionGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006935chemotaxisGoProcessGO:0007165signal transductionGoProcessGO:0007596blood coagulationGoProcessGO:0030155regulation of cell adhesionGoProcessGO:0034112positive regulation of homotypic cell-cell adhesionGoProcessGO:0038195urokinase plasminogen activator signaling pathwayGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0045742positive regulation of epidermal growth factor receptor signaling pathwayGoProcessGO:0051917regulation of fibrinolysisGoProcessGO:0090200positive regulation of release of cytochrome c from mitochondriaGoProcessGO:2000117negative regulation of cysteine-type endopeptidase activityGoProcessGO:2001243negative regulation of intrinsic apoptotic signaling pathwayGoProcessHGNC:9053PLAURHGNCQ03405IntActIPR016054LY6_UPA_recep-likeInterProIPR018363CD59_antigen_CSInterProIPR045860Snake_toxin-like_sfInterProPTHR10624UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTOR-RELATEDPANTHERPTHR10624:SF6UROKINASE PLASMINOGEN ACTIVATOR SURFACE RECEPTORPANTHER1YWHPDB2FD6PDB2I9BPDB3BT1PDB3BT2PDB3U73PDB3U74PDB4K24PDB4QTIPDB7E17PDB7V63PDB1YWHAPDBe2FD6APDBe2I9BAPDBe3BT1APDBe3BT2APDBe3U73APDBe3U74APDBe4K24APDBe4QTIAPDBe7E17APDBe7V63APDBePF00021UPAR_LY6PfamPA33383plasminogen activator, urokinase receptorPharmGKBQ03405PharosR-HSA-162791Attachment of GPI anchor to uPARReactomeR-HSA-6798695Neutrophil degranulationReactomeR-HSA-75205Dissolution of Fibrin ClotReactomeA8K409Urokinase plasminogen activator surface receptorUniProtQ03405Urokinase plasminogen activator surface receptorUniProtQ12876Urokinase plasminogen activator surface receptorUniProtQ15845Urokinase plasminogen activator surface receptorUniProtQ16887Urokinase plasminogen activator surface receptorUniProtQ6IB52Urokinase plasminogen activator surface receptorUniProtQ9BWT0Urokinase plasminogen activator surface receptorUniProtQ9NYC8Urokinase plasminogen activator surface receptorUniProtQ9UD69Urokinase plasminogen activator surface receptorUniProtQ9UEA6Urokinase plasminogen activator surface receptorUniProtQ9UM92Urokinase plasminogen activator surface receptorUniProtQ9UMV0Urokinase plasminogen activator surface receptorUniProtSINGLE PROTEIN9606Homo sapiensAdenosine kinaseCHEMBL3589P55263Adenosine kinase1909PROTEINSINGLE PROTEIN2.7.1.-EC_NUMBER2.7.1.20EC_NUMBERAdenosine 5'-phosphotransferaseUNIPROTAdenosine kinaseUNIPROTADKGENE_SYMBOLN6-isopentenyladenosine kinaseUNIPROTN6-methyladenosine kinaseUNIPROTN6,N6-dimethyladenosine kinaseUNIPROTP55263AlphaFoldDBP55263ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0003723RNA bindingGoFunctionGO:0004001adenosine kinase activityGoFunctionGO:0004136deoxyadenosine kinase activityGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0006144purine nucleobase metabolic processGoProcessGO:0006166purine ribonucleoside salvageGoProcessGO:0006175dATP biosynthetic processGoProcessGO:0006753nucleoside phosphate metabolic processGoProcessGO:0009156ribonucleoside monophosphate biosynthetic processGoProcessGO:0032263GMP salvageGoProcessGO:0034654nucleobase-containing compound biosynthetic processGoProcessGO:0044209AMP salvageGoProcessGO:0106383dAMP salvageGoProcessHGNC:257ADKHGNCP55263IntActIPR001805AdenokinaseInterProIPR002173Carboh/pur_kinase_PfkB_CSInterProIPR011611PfkB_domInterProIPR029056Ribokinase-likeInterProPTHR45769ADENOSINE KINASEPANTHERPTHR45769:SF3ADENOSINE KINASEPANTHER1BX4PDB2I6APDB2I6BPDB4O1LPDB1BX4APDBe2I6AAPDBe2I6BAPDBe4O1LAPDBePF00294PfkBPfamPA24579adenosine kinasePharmGKBP55263PharosR-HSA-74217Purine salvageReactomeR-HSA-9755088Ribavirin ADMEReactomeB7Z783Adenosine kinaseUniProtB7Z800Adenosine kinaseUniProtO00741Adenosine kinaseUniProtO00742Adenosine kinaseUniProtP55263Adenosine kinaseUniProtQ16710Adenosine kinaseUniProtQ5JQ10Adenosine kinaseUniProtQ5JQ11Adenosine kinaseUniProtQ9BTN2Adenosine kinaseUniProtSINGLE PROTEIN9606Homo sapiensMitogen-activated protein kinase 14CHEMBL260Q16539Mitogen-activated protein kinase 142937PROTEINSINGLE PROTEIN2.7.11.24EC_NUMBERCSAID-binding proteinUNIPROTCSBPGENE_SYMBOL_OTHERCSBPUNIPROTCSBP1GENE_SYMBOL_OTHERCSBP2GENE_SYMBOL_OTHERCSPB1GENE_SYMBOL_OTHERCytokine suppressive anti-inflammatory drug-binding proteinUNIPROTMAPK 14UNIPROTMAPK14GENE_SYMBOLMAP kinase 14UNIPROTMAP kinase MXI2UNIPROTMAP kinase p38 alphaUNIPROTMAX-interacting protein 2UNIPROTMitogen-activated protein kinase 14UNIPROTMitogen-activated protein kinase p38 alphaUNIPROTMXI2GENE_SYMBOL_OTHERSAPK2aUNIPROTSAPK2AGENE_SYMBOL_OTHERStress-activated protein kinase 2aUNIPROTSynonyms=CSBPGENE_SYMBOL_OTHERQ16539AlphaFoldDBQ16539ExpressionAtlasGO:0000922spindle poleGoComponentGO:0005576extracellular regionGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005829cytosolGoComponentGO:0016607nuclear speckGoComponentGO:0034774secretory granule lumenGoComponentGO:0098978glutamatergic synapseGoComponentGO:1904813ficolin-1-rich granule lumenGoComponentGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019903protein phosphatase bindingGoFunctionGO:0048273mitogen-activated protein kinase p38 bindingGoFunctionGO:0051525NFAT protein bindingGoFunctionGO:0000077DNA damage checkpoint signalingGoProcessGO:0000165MAPK cascadeGoProcessGO:0000902cell morphogenesisGoProcessGO:0001502cartilage condensationGoProcessGO:0001525angiogenesisGoProcessGO:0001649osteoblast differentiationGoProcessGO:0001890placenta developmentGoProcessGO:0002021response to dietary excessGoProcessGO:0002062chondrocyte differentiationGoProcessGO:0002862negative regulation of inflammatory response to antigenic stimulusGoProcessGO:0006006glucose metabolic processGoProcessGO:0006915apoptotic processGoProcessGO:0006935chemotaxisGoProcessGO:0006974DNA damage responseGoProcessGO:0007165signal transductionGoProcessGO:0007166cell surface receptor signaling pathwayGoProcessGO:0007178cell surface receptor protein serine/threonine kinase signaling pathwayGoProcessGO:0007254JNK cascadeGoProcessGO:0007519skeletal muscle tissue developmentGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010831positive regulation of myotube differentiationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0019395fatty acid oxidationGoProcessGO:0030168platelet activationGoProcessGO:0030278regulation of ossificationGoProcessGO:0030316osteoclast differentiationGoProcessGO:0031098stress-activated protein kinase signaling cascadeGoProcessGO:0031281positive regulation of cyclase activityGoProcessGO:0031663lipopolysaccharide-mediated signaling pathwayGoProcessGO:0032735positive regulation of interleukin-12 productionGoProcessGO:0033554cellular response to stressGoProcessGO:0035331negative regulation of hippo signalingGoProcessGO:0035556intracellular signal transductionGoProcessGO:0038066p38MAPK cascadeGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042770signal transduction in response to DNA damageGoProcessGO:0043536positive regulation of blood vessel endothelial cell migrationGoProcessGO:0045648positive regulation of erythrocyte differentiationGoProcessGO:0045663positive regulation of myoblast differentiationGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046323D-glucose importGoProcessGO:0046326positive regulation of D-glucose importGoProcessGO:0048010vascular endothelial growth factor receptor signaling pathwayGoProcessGO:0048863stem cell differentiationGoProcessGO:0051146striated muscle cell differentiationGoProcessGO:0051149positive regulation of muscle cell differentiationGoProcessGO:0051403stress-activated MAPK cascadeGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0060348bone developmentGoProcessGO:00709353'-UTR-mediated mRNA stabilizationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:0071223cellular response to lipoteichoic acidGoProcessGO:0071479cellular response to ionizing radiationGoProcessGO:0071493cellular response to UV-BGoProcessGO:0090090negative regulation of canonical Wnt signaling pathwayGoProcessGO:0090336positive regulation of brown fat cell differentiationGoProcessGO:0090398cellular senescenceGoProcessGO:0090400stress-induced premature senescenceGoProcessGO:0099179regulation of synaptic membrane adhesionGoProcessGO:1900015regulation of cytokine production involved in inflammatory responseGoProcessGO:1901741positive regulation of myoblast fusionGoProcessGO:2000379positive regulation of reactive oxygen species metabolic processGoProcessHGNC:6876MAPK14HGNCQ16539IntActIPR000719Prot_kinase_domInterProIPR003527MAP_kinase_CSInterProIPR008352MAPK_HOG-likeInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR038784MAPK14InterProIPR050117MAPKInterProPTHR24055MITOGEN-ACTIVATED PROTEIN 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-activated protein kinase 14PharmGKBQ16539PharosR-HSA-168638NOD1/2 Signaling PathwayReactomeR-HSA-171007p38MAPK eventsReactomeR-HSA-198753ERK/MAPK targetsReactomeR-HSA-2151209Activation of PPARGC1A (PGC-1alpha) by phosphorylationReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-418592ADP signalling through P2Y purinoceptor 1ReactomeR-HSA-432142Platelet sensitization by LDLReactomeR-HSA-4420097VEGFA-VEGFR2 PathwayReactomeR-HSA-450302activated TAK1 mediates p38 MAPK activationReactomeR-HSA-450341Activation of the AP-1 family of transcription factorsReactomeR-HSA-450604KSRP (KHSRP) binds and destabilizes mRNAReactomeR-HSA-525793MyogenesisReactomeR-HSA-5668599RHO GTPases Activate NADPH OxidasesReactomeR-HSA-6798695Neutrophil degranulationReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-9662834CD163 mediating an anti-inflammatory responseReactomeR-HSA-9824585Regulation of MITF-M-dependent genes involved in pigmentationReactomeA6ZJ92Mitogen-activated protein kinase 14UniProtA8K6P4Mitogen-activated protein kinase 14UniProtB0LPH0Mitogen-activated protein kinase 14UniProtB5TY32Mitogen-activated protein kinase 14UniProtO60776Mitogen-activated protein kinase 14UniProtQ13083Mitogen-activated protein kinase 14UniProtQ14084Mitogen-activated protein kinase 14UniProtQ16539Mitogen-activated protein kinase 14UniProtQ8TDX0Mitogen-activated protein kinase 14UniProtSINGLE PROTEIN9606Homo sapiensAdenylate kinase 2, mitochondrialCHEMBL4938P54819Adenylate kinase 2, mitochondrial3251PROTEINSINGLE PROTEIN2.7.4.3EC_NUMBERAdenylate kinase 2, mitochondrialUNIPROTAdenylate kinase 2, mitochondrial, N-terminally processedUNIPROTAdenylate monophosphate kinaseUNIPROTADK2GENE_SYMBOL_OTHERAK 2UNIPROTAK2GENE_SYMBOLATP:AMP phosphotransferaseUNIPROTATP-AMP transphosphorylase 2UNIPROTP54819AlphaFoldDBP54819ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005758mitochondrial intermembrane spaceGoComponentGO:0036126sperm flagellumGoComponentGO:0070062extracellular exosomeGoComponentGO:0097226sperm mitochondrial sheathGoComponentGO:0004017adenylate kinase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0016776phosphotransferase activity, phosphate group as acceptorGoFunctionGO:0019205nucleobase-containing compound kinase activityGoFunctionGO:0006172ADP biosynthetic processGoProcessGO:0009117nucleotide metabolic processGoProcessGO:0009123nucleoside monophosphate metabolic processGoProcessGO:0046033AMP metabolic processGoProcessGO:0046034ATP metabolic processGoProcessGO:0046940nucleoside monophosphate phosphorylationGoProcessHGNC:362AK2HGNCP54819IntActIPR000850Adenylat/UMP-CMP_kinInterProIPR006259Adenyl_kin_subInterProIPR007862Adenylate_kinase_lid-domInterProIPR027417P-loop_NTPaseInterProIPR028587AK2InterProIPR033690Adenylat_kinase_CSInterProPTHR23359NUCLEOTIDE KINASEPANTHER2C9YPDB9FL7PDB2C9YAPDBePF00406ADKPfamPF05191ADK_lidPfamPA24656adenylate kinase 2PharmGKBP54819PharosR-HSA-499943Interconversion of nucleotide di- and triphosphatesReactomeA8K6L1Adenylate kinase 2, mitochondrialUniProtB4DHH7Adenylate kinase 2, mitochondrialUniProtB4DL64Adenylate kinase 2, mitochondrialUniProtP54819Adenylate kinase 2, mitochondrialUniProtQ16856Adenylate kinase 2, mitochondrialUniProtQ5EB54Adenylate kinase 2, mitochondrialUniProtQ5TIF7Adenylate kinase 2, mitochondrialUniProtQ8TCY2Adenylate kinase 2, mitochondrialUniProtQ8TCY3Adenylate kinase 2, mitochondrialUniProtSINGLE PROTEIN9606Homo sapiensGlycogen synthase kinase-3 betaCHEMBL262P49841Glycogen synthase kinase-3 beta3114PROTEINSINGLE PROTEIN2.7.11.1EC_NUMBER2.7.11.26EC_NUMBERGlycogen synthase kinase-3 betaUNIPROTGSK3BGENE_SYMBOLGSK-3 betaUNIPROTSerine/threonine-protein kinase GSK3BUNIPROTP49841AlphaFoldDBP49841ExpressionAtlasGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0030424axonGoComponentGO:0030425dendriteGoComponentGO:0030877beta-catenin destruction complexGoComponentGO:0098793presynapseGoComponentGO:0098794postsynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:1990909Wnt signalosomeGoComponentGO:0002020protease bindingGoFunctionGO:0002039p53 bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008013beta-catenin bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0031625ubiquitin protein ligase bindingGoFunctionGO:0034236protein kinase A catalytic subunit bindingGoFunctionGO:0034452dynactin bindingGoFunctionGO:0048156tau protein bindingGoFunctionGO:0051059NF-kappaB bindingGoFunctionGO:0061629RNA polymerase II-specific DNA-binding transcription factor bindingGoFunctionGO:0097110scaffold protein bindingGoFunctionGO:0001837epithelial to mesenchymal transitionGoProcessGO:0001954positive regulation of cell-matrix adhesionGoProcessGO:0005977glycogen metabolic processGoProcessGO:0006468protein phosphorylationGoProcessGO:0006983ER overload responseGoProcessGO:0007005mitochondrion organizationGoProcessGO:0007212G protein-coupled dopamine receptor signaling pathwayGoProcessGO:0007399nervous system developmentGoProcessGO:0007623circadian rhythmGoProcessGO:0008286insulin receptor signaling pathwayGoProcessGO:0009968negative regulation of signal transductionGoProcessGO:0010508positive regulation of autophagyGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010719negative regulation of epithelial to mesenchymal transitionGoProcessGO:0010975regulation of neuron projection developmentGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0019082viral protein processingGoProcessGO:0021766hippocampus developmentGoProcessGO:0030154cell differentiationGoProcessGO:0030336negative regulation of cell migrationGoProcessGO:0030516regulation of axon extensionGoProcessGO:0031333negative regulation of protein-containing complex assemblyGoProcessGO:0031334positive regulation of protein-containing complex assemblyGoProcessGO:0031398positive regulation of protein ubiquitinationGoProcessGO:0032007negative regulation of TOR signalingGoProcessGO:0032436positive regulation of proteasomal ubiquitin-dependent protein catabolic processGoProcessGO:0032886regulation of microtubule-based processGoProcessGO:0035556intracellular signal transductionGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043161proteasome-mediated ubiquitin-dependent protein catabolic processGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0043547positive regulation of GTPase activityGoProcessGO:0045597positive regulation of cell differentiationGoProcessGO:0045668negative regulation of osteoblast differentiationGoProcessGO:0045719negative regulation of glycogen biosynthetic processGoProcessGO:0045724positive regulation of cilium assemblyGoProcessGO:0045732positive regulation of protein catabolic processGoProcessGO:0046777protein autophosphorylationGoProcessGO:0046825regulation of protein export from nucleusGoProcessGO:0046827positive regulation of protein export from nucleusGoProcessGO:0048511rhythmic processGoProcessGO:0048814regulation of dendrite morphogenesisGoProcessGO:0050770regulation of axonogenesisGoProcessGO:0051093negative regulation of developmental processGoProcessGO:0060070canonical Wnt signaling pathwayGoProcessGO:0060079excitatory postsynaptic potentialGoProcessGO:0070507regulation of microtubule cytoskeleton organizationGoProcessGO:0070885negative regulation of calcineurin-NFAT signaling cascadeGoProcessGO:0071109superior temporal gyrus developmentGoProcessGO:0071300cellular response to retinoic acidGoProcessGO:0090090negative regulation of canonical Wnt signaling pathwayGoProcessGO:0097191extrinsic apoptotic signaling pathwayGoProcessGO:0097192extrinsic apoptotic signaling pathway in absence of ligandGoProcessGO:0099171presynaptic modulation of chemical synaptic transmissionGoProcessGO:0150101regulation of microtubule anchoring at centrosomeGoProcessGO:1900034regulation of cellular response to heatGoProcessGO:1900181negative regulation of protein localization to nucleusGoProcessGO:1900271regulation of long-term synaptic potentiationGoProcessGO:1901030positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathwayGoProcessGO:1901984negative regulation of protein acetylationGoProcessGO:1902042negative regulation of extrinsic apoptotic signaling pathway via death domain receptorsGoProcessGO:1903566positive regulation of protein localization to ciliumGoProcessGO:1903940negative regulation of TORC2 signalingGoProcessGO:1904339negative regulation of dopaminergic neuron differentiationGoProcessGO:1904646cellular response to amyloid-betaGoProcessGO:1904781positive regulation of protein localization to centrosomeGoProcessGO:2000077negative regulation of type B pancreatic cell developmentGoProcessGO:2000466negative regulation of glycogen (starch) synthase activityGoProcessGO:2000740negative regulation of mesenchymal stem cell differentiationGoProcessHGNC:4617GSK3BHGNCP49841IntActIPR000719Prot_kinase_domInterProIPR008271Ser/Thr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR017441Protein_kinase_ATP_BSInterProIPR039192STKc_GSK3InterProIPR050591GSK-3InterProPTHR24057GLYCOGEN SYNTHASE KINASE-3 ALPHAPANTHERPTHR24057:SF8GLYCOGEN SYNTHASE KINASE-3 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 synthase kinase 3 betaPharmGKBP49841PharosR-HSA-195253Degradation of beta-catenin by the destruction complexReactomeR-HSA-196299Beta-catenin phosphorylation cascadeReactomeR-HSA-198323AKT phosphorylates targets in the cytosolReactomeR-HSA-3371453Regulation of HSF1-mediated heat shock responseReactomeR-HSA-399956CRMPs in Sema3A signalingReactomeR-HSA-4641262Disassembly of the destruction complex and recruitment of AXIN to the membraneReactomeR-HSA-5250924B-WICH complex positively regulates rRNA expressionReactomeR-HSA-5339716Signaling by GSK3beta mutantsReactomeR-HSA-5358747CTNNB1 S33 mutants aren't phosphorylatedReactomeR-HSA-5358749CTNNB1 S37 mutants aren't phosphorylatedReactomeR-HSA-5358751CTNNB1 S45 mutants aren't phosphorylatedReactomeR-HSA-5358752CTNNB1 T41 mutants aren't phosphorylatedReactomeR-HSA-5467337APC truncation mutants have impaired AXIN bindingReactomeR-HSA-5467340AXIN missense mutants destabilize the destruction complexReactomeR-HSA-5467348Truncations of AMER1 destabilize the destruction complexReactomeR-HSA-5610783Degradation of GLI2 by the proteasomeReactomeR-HSA-5610785GLI3 is processed to GLI3R by the proteasomeReactomeR-HSA-5674400Constitutive Signaling by AKT1 E17K in CancerReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8939902Regulation of RUNX2 expression and activityReactomeR-HSA-9683610Maturation of nucleoproteinReactomeR-HSA-9694631Maturation of nucleoproteinReactomeR-HSA-9762114GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2ReactomeR-HSA-9856649Transcriptional and post-translational regulation of MITF-M expression and activityReactomeD3DN89Glycogen synthase kinase-3 betaUniProtP49841Glycogen synthase kinase-3 betaUniProtQ9BWH3Glycogen synthase kinase-3 betaUniProtQ9UL47Glycogen synthase kinase-3 betaUniProtSINGLE PROTEIN9606