20/chembl/api/data/target?limit=20&offset=20&pref_name__contains=cyclin35Homo sapiensProstacyclin receptorCHEMBL1995P43119Prostacyclin receptor325PROTEINSINGLE PROTEINPRIPRGENE_SYMBOL_OTHERPTGIRGENE_SYMBOLProstacyclin receptorUNIPROTProstaglandin I2 receptorUNIPROTProstanoid IP receptorUNIPROTPGI receptorUNIPROTPGI2 receptorUNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0005085guanyl-nucleotide exchange factor activityGoFunctionGO:0016501prostacyclin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007187G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messengerGoProcessGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007267cell-cell signalingGoProcessGO:0010642negative regulation of platelet-derived growth factor receptor signaling pathwayGoProcessGO:0048662negative regulation of smooth muscle cell proliferationGoProcessGO:0005886plasma membraneGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentP43119Prostacyclin receptorUniProt8X79PDB8X7APDBP43119AlphaFoldDBP43119IntActHGNC:9602PTGIRHGNCR-HSA-391908Prostanoid ligand receptorsReactomeR-HSA-392851Prostacyclin signalling through prostacyclin receptorReactomeR-HSA-418555G alpha (s) signalling eventsReactomeP43119PharosP43119ExpressionAtlasIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProIPR008365Prostanoid_rcptInterProIPR000370Prostglndn_IP_rcptInterProPTHR11866G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBERPANTHERPTHR11866:SF7PROSTACYCLIN RECEPTORPANTHERPF000017tm_1PfamPA291prostaglandin I2 receptorPharmGKBSINGLE PROTEIN9606Rattus norvegicusG2/mitotic-specific cyclin-B1CHEMBL2093P30277G2/mitotic-specific cyclin-B1430PROTEINSINGLE PROTEINCcnb1GENE_SYMBOLG2/mitotic-specific cyclin-B1UNIPROTGO:0001701in utero embryonic developmentGoProcessGO:0045787positive regulation of cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0005113patched bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0044389ubiquitin-like protein ligase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0001556oocyte maturationGoProcessGO:0007052mitotic spindle organizationGoProcessGO:0007080mitotic metaphase chromosome alignmentGoProcessGO:0007283spermatogenesisGoProcessGO:0009636response to toxic substanceGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0031442positive regulation of mRNA 3'-end processingGoProcessGO:0042246tissue regenerationGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0046680response to DDTGoProcessGO:0048565digestive tract developmentGoProcessGO:0051301cell divisionGoProcessGO:0051987positive regulation of attachment of spindle microtubules to kinetochoreGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0060623regulation of chromosome condensationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0071283cellular response to iron(III) ionGoProcessGO:0071398cellular response to fatty acidGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0090266regulation of mitotic cell cycle spindle assembly checkpointGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0000922spindle poleGoComponentGO:0005813centrosomeGoComponentGO:0005856cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0000940outer kinetochoreGoComponentP30277G2/mitotic-specific cyclin-B1UniProtP30277AlphaFoldDBP30277IntActR-RNO-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-RNO-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-RNO-176412Phosphorylation of the APC/CReactomeR-RNO-176417Phosphorylation of Emi1ReactomeR-RNO-2299718Condensation of Prophase ChromosomesReactomeR-RNO-2500257Resolution of Sister Chromatid CohesionReactomeR-RNO-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-RNO-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-RNO-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-RNO-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-RNO-4419969Depolymerization of the Nuclear LaminaReactomeR-RNO-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-RNO-68875Mitotic ProphaseReactomeR-RNO-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-RNO-69478G2/M DNA replication checkpointReactomeR-RNO-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-RNO-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeIPR048026CCNB1_first_cyclin-boxInterProIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamSINGLE PROTEIN10116Homo sapiensG2/mitotic-specific cyclin-B1CHEMBL2412P14635G2/mitotic-specific cyclin-B122PROTEINSINGLE PROTEINCCNBGENE_SYMBOL_OTHERCCNB1GENE_SYMBOLG2/mitotic-specific cyclin-B1UNIPROT5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe5HQ0APDBe2JGZAPDBe4YC3APDBe2B9RAPDBeGO:0005113patched bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0044389ubiquitin-like protein ligase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0007052mitotic spindle organizationGoProcessGO:0007080mitotic metaphase chromosome alignmentGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045787positive regulation of cell cycleGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051987positive regulation of attachment of spindle microtubules to kinetochoreGoProcessGO:0090266regulation of mitotic cell cycle spindle assembly checkpointGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0000922spindle poleGoComponentGO:0005654nucleoplasmGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0000940outer kinetochoreGoComponentA8K066G2/mitotic-specific cyclin-B1UniProtQ5TZP9G2/mitotic-specific cyclin-B1UniProtP14635G2/mitotic-specific cyclin-B1UniProt2B9RPDB2JGZPDB4Y72PDB4YC3PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB7NJ0PDB8TARPDB8TAUPDB9FH9PDBP14635AlphaFoldDBP14635IntActHGNC:1579CCNB1HGNCR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-156711Polo-like kinase mediated eventsReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9725371Nuclear events stimulated by ALK signaling in cancerReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP14635PharosP14635ExpressionAtlasIPR048026CCNB1_first_cyclin-boxInterProIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA95cyclin B1PharmGKBSINGLE PROTEIN9606Homo sapiensG2/mitotic-specific cyclin B2CHEMBL3723O95067G2/mitotic-specific cyclin-B22039PROTEINSINGLE PROTEINCCNB2GENE_SYMBOLG2/mitotic-specific cyclin-B2UNIPROTGO:0005515protein bindingGoFunctionGO:0045296cadherin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0007057spindle assembly involved in female meiosis IGoProcessGO:0008315G2/MI transition of meiotic cell cycleGoProcessGO:0040008regulation of growthGoProcessGO:0043029T cell homeostasisGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0048538thymus developmentGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0015630microtubule cytoskeletonGoComponentGO:0016020membraneGoComponentPF00134Cyclin_NPfamB3KM93G2/mitotic-specific cyclin-B2UniProtQ6FI99G2/mitotic-specific cyclin-B2UniProtO95067G2/mitotic-specific cyclin-B2UniProtO95067AlphaFoldDBO95067IntActHGNC:1580CCNB2HGNCR-HSA-156711Polo-like kinase mediated eventsReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeO95067PharosO95067ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPA26148cyclin B2PharmGKBSINGLE PROTEIN9606Homo sapiensG1/S-specific cyclin-D1CHEMBL3610P24385G1/S-specific cyclin-D134PROTEINSINGLE PROTEINBCL1GENE_SYMBOL_OTHERPRAD1GENE_SYMBOL_OTHERSynonyms=BCL1GENE_SYMBOL_OTHERPRAD1 GN GENE_SYMBOL_OTHERCCND1GENE_SYMBOLG1/S-specific cyclin-D1UNIPROTB-cell lymphoma 1 proteinUNIPROTBCL-1 oncogeneUNIPROTPRAD1 oncogeneUNIPROTBCL-1UNIPROT6P8GAPDBe6P8FAPDBe6P8HAPDBe5VZUAPDBe2W96APDBe2W9FAPDBe2W99APDBe2W9ZAPDBe6P8EAPDBeGO:0003714transcription corepressor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0042826histone deacetylase bindingGoFunctionGO:0070064proline-rich region bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000320re-entry into mitotic cell cycleGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006974DNA damage responseGoProcessGO:0007595lactationGoProcessGO:0008283cell population proliferationGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0030182neuron differentiationGoProcessGO:0030857negative regulation of epithelial cell differentiationGoProcessGO:0030968endoplasmic reticulum unfolded protein responseGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0033598mammary gland epithelial cell proliferationGoProcessGO:0033601positive regulation of mammary gland epithelial cell proliferationGoProcessGO:0043524negative regulation of neuron apoptotic processGoProcessGO:0045444fat cell differentiationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0060749mammary gland alveolus developmentGoProcessGO:0097421liver regenerationGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:2000045regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0017053transcription repressor complexGoComponentQ6LEF0G1/S-specific cyclin-D1UniProtP24385G1/S-specific cyclin-D1UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB5VZUPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDBP24385AlphaFoldDBP24385IntActHGNC:1582CCND1HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-1912408Pre-NOTCH Transcription and TranslationReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8853884Transcriptional Regulation by VENTXReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-8951430RUNX3 regulates WNT signalingReactomeR-HSA-8951936RUNX3 regulates p14-ARFReactomeR-HSA-9018519Estrogen-dependent gene expressionReactomeR-HSA-9634638Estrogen-dependent nuclear events downstream of ESR-membrane signalingReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP24385PharosP24385ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA75cyclin D1PharmGKBSINGLE PROTEIN9606Homo sapiensG1/S-specific cyclin-E1CHEMBL3617P24864G1/S-specific cyclin-E135PROTEINSINGLE PROTEINCCNEGENE_SYMBOL_OTHERCCNE1GENE_SYMBOLG1/S-specific cyclin-E1UNIPROT8H6PAPDBe7XQKAPDBe1W98APDBe8H4RAPDBe8H6TAPDBe5L2WAPDBe7KJSAPDBe8VQ3APDBe8VQ4APDBeGO:0006468protein phosphorylationGoProcessGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902462positive regulation of mesenchymal stem cell proliferationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K684G1/S-specific cyclin-E1UniProtQ14091G1/S-specific cyclin-E1UniProtQ8NFG1G1/S-specific cyclin-E1UniProtQ92501G1/S-specific cyclin-E1UniProtQ9UD21G1/S-specific cyclin-E1UniProtP24864G1/S-specific cyclin-E1UniProt1W98PDB5L2WPDB7KJSPDB7XQKPDB8H4RPDB8H6PPDB8H6TPDB8VQ3PDB8VQ4PDBP24864AlphaFoldDBP24864IntActHGNC:1589CCNE1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP24864PharosP24864ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA96cyclin E1PharmGKBSINGLE PROTEIN9606Homo sapiensG1/S-specific cyclin-D3CHEMBL2422P30281G1/S-specific cyclin-D3763PROTEINSINGLE PROTEINCCND3GENE_SYMBOLG1/S-specific cyclin-D3UNIPROT3G33APDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0042098T cell proliferationGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentB2RD63G1/S-specific cyclin-D3UniProtB3KQ22G1/S-specific cyclin-D3UniProtE9PAS4G1/S-specific cyclin-D3UniProtE9PB36G1/S-specific cyclin-D3UniProtQ5T8J0G1/S-specific cyclin-D3UniProtQ6FG62G1/S-specific cyclin-D3UniProtQ96F49G1/S-specific cyclin-D3UniProtP30281G1/S-specific cyclin-D3UniProt3G33PDB7SJ3PDBP30281AlphaFoldDBP30281IntActHGNC:1585CCND3HGNCR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30281PharosP30281ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26152cyclin D3PharmGKBSINGLE PROTEIN9606Homo sapiensProstacyclin synthaseCHEMBL4428Q16647Prostacyclin synthase2744PROTEINSINGLE PROTEINCYP8GENE_SYMBOL_OTHERCYP8A1GENE_SYMBOL_OTHERPTGISGENE_SYMBOLProstacyclin synthaseUNIPROTHydroperoxy icosatetraenoate dehydrataseUNIPROTProstaglandin I2 synthaseUNIPROT5.3.99.4EC_NUMBER4.2.1.152EC_NUMBER3B6HAPDBe2IAGAPDBeGO:0004497monooxygenase activityGoFunctionGO:0005506iron ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0008116prostaglandin-I synthase activityGoFunctionGO:0016705oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygenGoFunctionGO:0016829lyase activityGoFunctionGO:0016853isomerase activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0106256hydroperoxy icosatetraenoate dehydratase activityGoFunctionGO:0001516prostaglandin biosynthetic processGoProcessGO:0006690icosanoid metabolic processGoProcessGO:0019371cyclooxygenase pathwayGoProcessGO:0034356NAD biosynthesis via nicotinamide riboside salvage pathwayGoProcessGO:0035360positive regulation of peroxisome proliferator activated receptor signaling pathwayGoProcessGO:0045019negative regulation of nitric oxide biosynthetic processGoProcessGO:0045766positive regulation of angiogenesisGoProcessGO:0050728negative regulation of inflammatory responseGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0097190apoptotic signaling pathwayGoProcessGO:1900119positive regulation of execution phase of apoptosisGoProcessGO:0005615extracellular spaceGoComponentGO:0005634nucleusGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005901caveolaGoComponentGO:0016020membraneGoComponentQ3MII8Prostacyclin synthaseUniProtQ9HAX2Prostacyclin synthaseUniProtQ9HAX3Prostacyclin synthaseUniProtQ9HAX4Prostacyclin synthaseUniProtQ16647Prostacyclin synthaseUniProt2IAGPDB3B6HPDBQ16647AlphaFoldDBQ16647IntActHGNC:9603PTGISHGNCR-HSA-197264Nicotinamide salvagingReactomeR-HSA-211979EicosanoidsReactomeR-HSA-2162123Synthesis of Prostaglandins (PG) and Thromboxanes (TX)ReactomeQ16647PharosIPR001128Cyt_P450InterProIPR024204Cyt_P450_CYP7A1-typeInterProIPR002403Cyt_P450_E_grp-IVInterProIPR036396Cyt_P450_sfInterProIPR027286PTGISInterProPTHR24306-PANTHERPTHR24306:SF4PROSTACYCLIN SYNTHASEPANTHERPF00067p450PfamPA292prostaglandin I2 synthasePharmGKBSINGLE PROTEIN9606Rattus norvegicusProstacyclin receptorCHEMBL3322P43253Prostacyclin receptor1642PROTEINSINGLE PROTEINPtgirGENE_SYMBOLProstacyclin receptorUNIPROTProstaglandin I2 receptorUNIPROTProstanoid IP receptorUNIPROTPGI receptorUNIPROTPGI2 receptorUNIPROTGO:0004930G protein-coupled receptor activityGoFunctionGO:0004954prostanoid receptor activityGoFunctionGO:0016501prostacyclin receptor activityGoFunctionGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007189adenylate cyclase-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0010642negative regulation of platelet-derived growth factor receptor signaling pathwayGoProcessGO:0048662negative regulation of smooth muscle cell proliferationGoProcessGO:0005886plasma membraneGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentP43253Prostacyclin receptorUniProtP43253AlphaFoldDBR-RNO-391908Prostanoid ligand receptorsReactomeR-RNO-392851Prostacyclin signalling through prostacyclin receptorReactomeIPR000276GPCR_RhodpsnInterProIPR017452GPCR_Rhodpsn_7TMInterProIPR008365Prostanoid_rcptInterProIPR000370Prostglndn_IP_rcptInterProPTHR11866G-PROTEIN COUPLED RECEPTOR FAMILY 1 MEMBERPANTHERPTHR11866:SF7PROSTACYCLIN RECEPTORPANTHERPF000017tm_1PfamSINGLE PROTEIN10116Escherichia coliTetracycline resistance protein, class BCHEMBL5821P02980Tetracycline resistance protein, class B4265PROTEINSINGLE PROTEINtetAGENE_SYMBOLTetracycline resistance protein, class BUNIPROTMetal-tetracycline/H(+) antiporterUNIPROTTetA(B)UNIPROTGO:0022857transmembrane transporter activityGoFunctionGO:0046677response to antibioticGoProcessGO:0055085transmembrane transportGoProcessGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentP02980Tetracycline resistance protein, class BUniProtP02980AlphaFoldDBIPR011701MFSInterProIPR020846MFS_domInterProIPR036259MFS_trans_sfInterProIPR005829Sugar_transporter_CSInterProIPR001958Tet-R_TetA/multi-R_MdtG-likeInterProPTHR23504:SF15MAJOR FACILITATOR SUPERFAMILY (MFS) PROFILE DOMAIN-CONTAINING PROTEINPANTHERPTHR23504MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN 10PANTHERPF07690MFS_1PfamSINGLE PROTEIN562CPX-2010Cyclin D1-CDK4 complexComplexPortalHomo sapiensCyclin-dependent kinase 4/cyclin D1CHEMBL1907601P11802Cyclin-dependent kinase 417PROTEINPROTEIN SUBUNITCDK4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBER6P8GAPDBe6P8FAPDBe6P8HAPDBe2W96APDBe2W9FAPDBe3G33APDBe2W99APDBe2W9ZAPDBe6P8EAPDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDBP11802AlphaFoldDBP11802IntActHGNC:1773CDK4HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP11802PharosP11802ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBP24385G1/S-specific cyclin-D134PROTEINPROTEIN SUBUNITBCL1GENE_SYMBOL_OTHERPRAD1GENE_SYMBOL_OTHERSynonyms=BCL1GENE_SYMBOL_OTHERPRAD1 GN GENE_SYMBOL_OTHERCCND1GENE_SYMBOLG1/S-specific cyclin-D1UNIPROTB-cell lymphoma 1 proteinUNIPROTBCL-1 oncogeneUNIPROTPRAD1 oncogeneUNIPROTBCL-1UNIPROT6P8GAPDBe6P8FAPDBe6P8HAPDBe5VZUAPDBe2W96APDBe2W9FAPDBe2W99APDBe2W9ZAPDBe6P8EAPDBeGO:0003714transcription corepressor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0042826histone deacetylase bindingGoFunctionGO:0070064proline-rich region bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000320re-entry into mitotic cell cycleGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006974DNA damage responseGoProcessGO:0007595lactationGoProcessGO:0008283cell population proliferationGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0030182neuron differentiationGoProcessGO:0030857negative regulation of epithelial cell differentiationGoProcessGO:0030968endoplasmic reticulum unfolded protein responseGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0033598mammary gland epithelial cell proliferationGoProcessGO:0033601positive regulation of mammary gland epithelial cell proliferationGoProcessGO:0043524negative regulation of neuron apoptotic processGoProcessGO:0045444fat cell differentiationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0060749mammary gland alveolus developmentGoProcessGO:0097421liver regenerationGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:2000045regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0017053transcription repressor complexGoComponentQ6LEF0G1/S-specific cyclin-D1UniProtP24385G1/S-specific cyclin-D1UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB5VZUPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDBP24385AlphaFoldDBP24385IntActHGNC:1582CCND1HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-1912408Pre-NOTCH Transcription and TranslationReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8853884Transcriptional Regulation by VENTXReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-8951430RUNX3 regulates WNT signalingReactomeR-HSA-8951936RUNX3 regulates p14-ARFReactomeR-HSA-9018519Estrogen-dependent gene expressionReactomeR-HSA-9634638Estrogen-dependent nuclear events downstream of ESR-membrane signalingReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP24385PharosP24385ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA75cyclin D1PharmGKBPROTEIN COMPLEX9606CPX-2007Cyclin B1-CDK1 complexComplexPortalHomo sapiensCyclin-dependent kinase 1/cyclin B1CHEMBL1907602P06493Cyclin-dependent kinase 17PROTEINPROTEIN SUBUNITCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDKN1GENE_SYMBOL_OTHERP34CDC2GENE_SYMBOL_OTHERCDK1GENE_SYMBOLCyclin-dependent kinase 1UNIPROTCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTp34 protein kinaseUNIPROTCDK1UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER4YC6APDBe5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe6GU7APDBe5HQ0APDBe6GU6APDBe6TWNAPDBe4YC3APDBeGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProt4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDBP06493AlphaFoldDBP06493IntActHGNC:1722CDK1HGNCR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeP06493PharosP06493ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHERPF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP14635G2/mitotic-specific cyclin-B122PROTEINPROTEIN SUBUNITCCNBGENE_SYMBOL_OTHERCCNB1GENE_SYMBOLG2/mitotic-specific cyclin-B1UNIPROT5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe5HQ0APDBe2JGZAPDBe4YC3APDBe2B9RAPDBeGO:0005113patched bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0044389ubiquitin-like protein ligase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0007052mitotic spindle organizationGoProcessGO:0007080mitotic metaphase chromosome alignmentGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045787positive regulation of cell cycleGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051987positive regulation of attachment of spindle microtubules to kinetochoreGoProcessGO:0090266regulation of mitotic cell cycle spindle assembly checkpointGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0000922spindle poleGoComponentGO:0005654nucleoplasmGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0000940outer kinetochoreGoComponentA8K066G2/mitotic-specific cyclin-B1UniProtQ5TZP9G2/mitotic-specific cyclin-B1UniProtP14635G2/mitotic-specific cyclin-B1UniProt2B9RPDB2JGZPDB4Y72PDB4YC3PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB7NJ0PDB8TARPDB8TAUPDB9FH9PDBP14635AlphaFoldDBP14635IntActHGNC:1579CCNB1HGNCR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-156711Polo-like kinase mediated eventsReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9725371Nuclear events stimulated by ALK signaling in cancerReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP14635PharosP14635ExpressionAtlasIPR048026CCNB1_first_cyclin-boxInterProIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA95cyclin B1PharmGKBPROTEIN COMPLEX9606CPX-2015Cyclin E1-CDK2 complexComplexPortalHomo sapiensCyclin-dependent kinase 2/cyclin E1CHEMBL1907605P24864G1/S-specific cyclin-E135PROTEINPROTEIN SUBUNITCCNEGENE_SYMBOL_OTHERCCNE1GENE_SYMBOLG1/S-specific cyclin-E1UNIPROT8H6PAPDBe7XQKAPDBe1W98APDBe8H4RAPDBe8H6TAPDBe5L2WAPDBe7KJSAPDBe8VQ3APDBe8VQ4APDBeGO:0006468protein phosphorylationGoProcessGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902462positive regulation of mesenchymal stem cell proliferationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K684G1/S-specific cyclin-E1UniProtQ14091G1/S-specific cyclin-E1UniProtQ8NFG1G1/S-specific cyclin-E1UniProtQ92501G1/S-specific cyclin-E1UniProtQ9UD21G1/S-specific cyclin-E1UniProtP24864G1/S-specific cyclin-E1UniProt1W98PDB5L2WPDB7KJSPDB7XQKPDB8H4RPDB8H6PPDB8H6TPDB8VQ3PDB8VQ4PDBP24864AlphaFoldDBP24864IntActHGNC:1589CCNE1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP24864PharosP24864ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA96cyclin E1PharmGKBP24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 2UniProt1AQ1PDB1B38PDB1B39PDB1BUHPDB1CKPPDB1DI8PDB1DM2PDB1E1VPDB1E1XPDB1E9HPDB1F5QPDB1FINPDB1FQ1PDB1FVTPDB1FVVPDB1G5SPDB1GIHPDB1GIIPDB1GIJPDB1GY3PDB1GZ8PDB1H00PDB1H01PDB1H07PDB1H08PDB1H0VPDB1H0WPDB1H1PPDB1H1QPDB1H1RPDB1H1SPDB1H24PDB1H25PDB1H26PDB1H27PDB1H28PDB1HCKPDB1HCLPDB1JSTPDB1JSUPDB1JSVPDB1JVPPDB1KE5PDB1KE6PDB1KE7PDB1KE8PDB1KE9PDB1OGUPDB1OI9PDB1OIQPDB1OIRPDB1OITPDB1OIUPDB1OIYPDB1OKVPDB1OKWPDB1OL1PDB1OL2PDB1P2APDB1P5EPDB1PF8PDB1PKDPDB1PW2PDB1PXIPDB1PXJPDB1PXKPDB1PXLPDB1PXMPDB1PXNPDB1PXOPDB1PXPPDB1PYEPDB1QMZPDB1R78PDB1URCPDB1URWPDB1V1KPDB1VYWPDB1VYZPDB1W0XPDB1W8CPDB1W98PDB1WCCPDB1Y8YPDB1Y91PDB1YKRPDB2A0CPDB2A4LPDB2B52PDB2B53PDB2B54PDB2B55PDB2BHEPDB2BHHPDB2BKZPDB2BPMPDB2BTRPDB2BTSPDB2C4GPDB2C5NPDB2C5OPDB2C5VPDB2C5XPDB2C5YPDB2C68PDB2C69PDB2C6IPDB2C6KPDB2C6LPDB2C6MPDB2C6OPDB2C6TPDB2CCHPDB2CCIPDB2CJMPDB2CLXPDB2DS1PDB2DUVPDB2EXMPDB2FVDPDB2G9XPDB2I40PDB2IW6PDB2IW8PDB2IW9PDB2J9MPDB2JGZPDB2R3FPDB2R3GPDB2R3HPDB2R3IPDB2R3JPDB2R3KPDB2R3LPDB2R3MPDB2R3NPDB2R3OPDB2R3PPDB2R3QPDB2R3RPDB2R64PDB2UUEPDB2UZBPDB2UZDPDB2UZEPDB2UZLPDB2UZNPDB2UZOPDB2V0DPDB2V22PDB2VTAPDB2VTHPDB2VTIPDB2VTJPDB2VTLPDB2VTMPDB2VTNPDB2VTOPDB2VTPPDB2VTQPDB2VTRPDB2VTSPDB2VTTPDB2VU3PDB2VV9PDB2W05PDB2W06PDB2W17PDB2W1HPDB2WEVPDB2WFYPDB2WHBPDB2WIHPDB2WIPPDB2WMAPDB2WMBPDB2WPAPDB2WXVPDB2X1NPDB2XMYPDB2XNBPDB3BHTPDB3BHUPDB3BHVPDB3DDPPDB3DDQPDB3DOGPDB3EIDPDB3EJ1PDB3EOCPDB3EZRPDB3EZVPDB3F5XPDB3FZ1PDB3IG7PDB3IGGPDB3LE6PDB3LFNPDB3LFQPDB3LFSPDB3MY5PDB3NS9PDB3PJ8PDB3PXFPDB3PXQPDB3PXRPDB3PXYPDB3PXZPDB3PY0PDB3PY1PDB3QHRPDB3QHWPDB3QL8PDB3QQFPDB3QQGPDB3QQHPDB3QQJPDB3QQKPDB3QQLPDB3QRTPDB3QRUPDB3QTQPDB3QTRPDB3QTSPDB3QTUPDB3QTWPDB3QTXPDB3QTZPDB3QU0PDB3QWJPDB3QWKPDB3QX2PDB3QX4PDB3QXOPDB3QXPPDB3QZFPDB3QZGPDB3QZHPDB3QZIPDB3R1QPDB3R1SPDB3R1YPDB3R28PDB3R6XPDB3R71PDB3R73PDB3R7EPDB3R7IPDB3R7UPDB3R7VPDB3R7YPDB3R83PDB3R8LPDB3R8MPDB3R8PPDB3R8UPDB3R8VPDB3R8ZPDB3R9DPDB3R9HPDB3R9NPDB3R9OPDB3RAHPDB3RAIPDB3RAKPDB3RALPDB3RJCPDB3RK5PDB3RK7PDB3RK9PDB3RKBPDB3RM6PDB3RM7PDB3RMFPDB3RNIPDB3ROYPDB3RPOPDB3RPRPDB3RPVPDB3RPYPDB3RZBPDB3S00PDB3S0OPDB3S1HPDB3S2PPDB3SQQPDB3SW4PDB3SW7PDB3TI1PDB3TIYPDB3TIZPDB3TNWPDB3ULIPDB3UNJPDB3UNKPDB3WBLPDB4ACMPDB4BCKPDB4BCMPDB4BCNPDB4BCOPDB4BCPPDB4BCQPDB4BGHPDB4BZDPDB4CFMPDB4CFNPDB4CFUPDB4CFVPDB4CFWPDB4CFXPDB4D1XPDB4D1ZPDB4EK3PDB4EK4PDB4EK5PDB4EK6PDB4EK8PDB4EOIPDB4EOJPDB4EOKPDB4EOLPDB4EOMPDB4EONPDB4EOOPDB4EOPPDB4EOQPDB4EORPDB4EOSPDB4ERWPDB4EZ3PDB4EZ7PDB4FKGPDB4FKIPDB4FKJPDB4FKLPDB4FKOPDB4FKPPDB4FKQPDB4FKRPDB4FKSPDB4FKTPDB4FKUPDB4FKVPDB4FKWPDB4FX3PDB4GCJPDB4I3ZPDB4II5PDB4KD1PDB4LYNPDB4NJ3PDB4RJ3PDB5A14PDB5ANDPDB5ANEPDB5ANGPDB5ANIPDB5ANJPDB5ANKPDB5ANOPDB5CYIPDB5D1JPDB5FP5PDB5FP6PDB5IEVPDB5IEXPDB5IEYPDB5IF1PDB5JQ5PDB5JQ8PDB5K4JPDB5L2WPDB5LMKPDB5MHQPDB5NEVPDB5OO0PDB5OO1PDB5OO3PDB5OSJPDB5OSMPDB5UQ1PDB5UQ2PDB5UQ3PDB6ATHPDB6GUBPDB6GUCPDB6GUEPDB6GUFPDB6GUHPDB6GUKPDB6GVAPDB6INLPDB6JGMPDB6OQIPDB6P3WPDB6Q3BPDB6Q3CPDB6Q3FPDB6Q48PDB6Q49PDB6Q4APDB6Q4BPDB6Q4CPDB6Q4DPDB6Q4EPDB6Q4FPDB6Q4GPDB6Q4HPDB6Q4IPDB6Q4JPDB6Q4KPDB6RIJPDB6SG4PDB6YL1PDB6YL6PDB6YLKPDB7ACKPDB7B5LPDB7B5RPDB7B7SPDB7E34PDB7KJSPDB7M2FPDB7MKXPDB7NVQPDB7QHLPDB7RA5PDB7RWEPDB7RWFPDB7RXOPDB7S4TPDB7S7APDB7S84PDB7S85PDB7S9XPDB7SA0PDB7UG1PDB7UXIPDB7UXKPDB7VDUPDB7ZPCPDB8B54PDB8BYAPDB8BZOPDB8CURPDB8ERDPDB8ERNPDB8FOWPDB8FP0PDB8FP5PDB8H6PPDB8H6TPDB8OR0PDB8OR4PDB8OY2PDB8ROZPDB8RU8PDB8UV0PDB8VQ3PDB8VQ4PDB9FR2PDBP24941AlphaFoldDBP24941IntActHGNC:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBPROTEIN COMPLEX9606Homo sapiensCyclin-dependent kinase 2/cyclin ECHEMBL2094126P24864G1/S-specific cyclin-E135PROTEINPROTEIN SUBUNITCCNEGENE_SYMBOL_OTHERCCNE1GENE_SYMBOLG1/S-specific cyclin-E1UNIPROT8H6PAPDBe7XQKAPDBe1W98APDBe8H4RAPDBe8H6TAPDBe5L2WAPDBe7KJSAPDBe8VQ3APDBe8VQ4APDBeGO:0006468protein phosphorylationGoProcessGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902462positive regulation of mesenchymal stem cell proliferationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K684G1/S-specific cyclin-E1UniProtQ14091G1/S-specific cyclin-E1UniProtQ8NFG1G1/S-specific cyclin-E1UniProtQ92501G1/S-specific cyclin-E1UniProtQ9UD21G1/S-specific cyclin-E1UniProtP24864G1/S-specific cyclin-E1UniProt1W98PDB5L2WPDB7KJSPDB7XQKPDB8H4RPDB8H6PPDB8H6TPDB8VQ3PDB8VQ4PDBP24864AlphaFoldDBP24864IntActHGNC:1589CCNE1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP24864PharosP24864ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA96cyclin E1PharmGKBP24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBO96020G1/S-specific cyclin-E21213PROTEINPROTEIN SUBUNITCCNE2GENE_SYMBOLG1/S-specific cyclin-E2UNIPROT8HN9APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentO95439G1/S-specific cyclin-E2UniProtO96020G1/S-specific cyclin-E2UniProt8HN9PDBO96020AlphaFoldDBO96020IntActHGNC:1590CCNE2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeO96020PharosO96020ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26155cyclin E2PharmGKBPROTEIN COMPLEX9606Homo sapiensCyclin-dependent kinase 1/cyclin BCHEMBL2094127P06493Cyclin-dependent kinase 17PROTEINPROTEIN SUBUNITCDC2GENE_SYMBOL_OTHERCDC28AGENE_SYMBOL_OTHERCDKN1GENE_SYMBOL_OTHERP34CDC2GENE_SYMBOL_OTHERCDK1GENE_SYMBOLCyclin-dependent kinase 1UNIPROTCell division control protein 2 homologUNIPROTCell division protein kinase 1UNIPROTp34 protein kinaseUNIPROTCDK1UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER4YC6APDBe5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe6GU7APDBe5HQ0APDBe6GU6APDBe6TWNAPDBe4YC3APDBeGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0030544Hsp70 protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000226microtubule cytoskeleton organizationGoProcessGO:0006281DNA repairGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0007077mitotic nuclear membrane disassemblyGoProcessGO:0007095mitotic G2 DNA damage checkpoint signalingGoProcessGO:0007098centrosome cycleGoProcessGO:0009636response to toxic substanceGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0014038regulation of Schwann cell differentiationGoProcessGO:0016477cell migrationGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0018107peptidyl-threonine phosphorylationGoProcessGO:0030261chromosome condensationGoProcessGO:0030855epithelial cell differentiationGoProcessGO:0031100animal organ regenerationGoProcessGO:0034501protein localization to kinetochoreGoProcessGO:0042307positive regulation of protein import into nucleusGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0042752regulation of circadian rhythmGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045995regulation of embryonic developmentGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048511rhythmic processGoProcessGO:0048678response to axon injuryGoProcessGO:0051301cell divisionGoProcessGO:0055015ventricular cardiac muscle cell developmentGoProcessGO:0060045positive regulation of cardiac muscle cell proliferationGoProcessGO:0062033positive regulation of mitotic sister chromatid segregationGoProcessGO:0065003protein-containing complex assemblyGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1902423regulation of attachment of mitotic spindle microtubules to kinetochoreGoProcessGO:1902850microtubule cytoskeleton organization involved in mitosisGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0005654nucleoplasmGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005876spindle microtubuleGoComponentGO:0016020membraneGoComponentGO:0030496midbodyGoComponentGO:0070062extracellular exosomeGoComponentA8K7C4Cyclin-dependent kinase 1UniProtC9J497Cyclin-dependent kinase 1UniProtO60764Cyclin-dependent kinase 1UniProtP06493Cyclin-dependent kinase 1UniProt4Y72PDB4YC3PDB4YC6PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB6GU6PDB6GU7PDB6TWNPDB7NJ0PDBP06493AlphaFoldDBP06493IntActHGNC:1722CDK1HGNCR-HSA-110056MAPK3 (ERK1) activationReactomeR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-380259Loss of Nlp from mitotic centrosomesReactomeR-HSA-380270Recruitment of mitotic centrosome proteins and complexesReactomeR-HSA-380284Loss of proteins required for interphase microtubule organization from the centrosomeReactomeR-HSA-380320Recruitment of NuMA to mitotic centrosomesReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-5620912Anchoring of the basal body to the plasma membraneReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8854518AURKA Activation by TPX2ReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9833482PKR-mediated signalingReactomeP06493PharosP06493ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF334CYCLIN-DEPENDENT KINASE 1PANTHERPF00069PkinasePfamPA99cyclin dependent kinase 1PharmGKBP14635G2/mitotic-specific cyclin-B122PROTEINPROTEIN SUBUNITCCNBGENE_SYMBOL_OTHERCCNB1GENE_SYMBOLG2/mitotic-specific cyclin-B1UNIPROT5LQFAPDBe6GU3APDBe6GU2APDBe4Y72APDBe6GU4APDBe5HQ0APDBe2JGZAPDBe4YC3APDBe2B9RAPDBeGO:0005113patched bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0044389ubiquitin-like protein ligase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0007052mitotic spindle organizationGoProcessGO:0007080mitotic metaphase chromosome alignmentGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0045787positive regulation of cell cycleGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051987positive regulation of attachment of spindle microtubules to kinetochoreGoProcessGO:0090266regulation of mitotic cell cycle spindle assembly checkpointGoProcessGO:1905448positive regulation of mitochondrial ATP synthesis coupled electron transportGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0000922spindle poleGoComponentGO:0005654nucleoplasmGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0000940outer kinetochoreGoComponentA8K066G2/mitotic-specific cyclin-B1UniProtQ5TZP9G2/mitotic-specific cyclin-B1UniProtP14635G2/mitotic-specific cyclin-B1UniProt2B9RPDB2JGZPDB4Y72PDB4YC3PDB5HQ0PDB5LQFPDB6GU2PDB6GU3PDB6GU4PDB7NJ0PDB8TARPDB8TAUPDB9FH9PDBP14635AlphaFoldDBP14635IntActHGNC:1579CCNB1HGNCR-HSA-113507E2F-enabled inhibition of pre-replication complex formationReactomeR-HSA-156711Polo-like kinase mediated eventsReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-174048APC/C:Cdc20 mediated degradation of Cyclin BReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-176412Phosphorylation of the APC/CReactomeR-HSA-176417Phosphorylation of Emi1ReactomeR-HSA-2299718Condensation of Prophase ChromosomesReactomeR-HSA-2465910MASTL Facilitates Mitotic ProgressionReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-4419969Depolymerization of the Nuclear LaminaReactomeR-HSA-6804114TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle ArrestReactomeR-HSA-68875Mitotic ProphaseReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-75035Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complexReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-9725371Nuclear events stimulated by ALK signaling in cancerReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP14635PharosP14635ExpressionAtlasIPR048026CCNB1_first_cyclin-boxInterProIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA95cyclin B1PharmGKBQ8WWL7G2/mitotic-specific cyclin-B31925PROTEINPROTEIN SUBUNITCYCB3GENE_SYMBOL_OTHERCCNB3GENE_SYMBOLG2/mitotic-specific cyclin-B3UNIPROTGO:0005515protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0016607nuclear speckGoComponentB1AQI5G2/mitotic-specific cyclin-B3UniProtB1AQI6G2/mitotic-specific cyclin-B3UniProtQ96SB5G2/mitotic-specific cyclin-B3UniProtQ96SB6G2/mitotic-specific cyclin-B3UniProtQ96SB7G2/mitotic-specific cyclin-B3UniProtQ9NT38G2/mitotic-specific cyclin-B3UniProtQ8WWL7G2/mitotic-specific cyclin-B3UniProtQ8WWL7AlphaFoldDBQ8WWL7IntActHGNC:18709CCNB3HGNCQ8WWL7PharosIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA38653cyclin B3PharmGKBO95067G2/mitotic-specific cyclin-B22039PROTEINPROTEIN SUBUNITCCNB2GENE_SYMBOLG2/mitotic-specific cyclin-B2UNIPROTGO:0005515protein bindingGoFunctionGO:0045296cadherin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0007057spindle assembly involved in female meiosis IGoProcessGO:0008315G2/MI transition of meiotic cell cycleGoProcessGO:0040008regulation of growthGoProcessGO:0043029T cell homeostasisGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0048538thymus developmentGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0015630microtubule cytoskeletonGoComponentGO:0016020membraneGoComponentPF00134Cyclin_NPfamB3KM93G2/mitotic-specific cyclin-B2UniProtQ6FI99G2/mitotic-specific cyclin-B2UniProtO95067G2/mitotic-specific cyclin-B2UniProtO95067AlphaFoldDBO95067IntActHGNC:1580CCNB2HGNCR-HSA-156711Polo-like kinase mediated eventsReactomeR-HSA-162658Golgi Cisternae Pericentriolar Stack ReorganizationReactomeR-HSA-2500257Resolution of Sister Chromatid CohesionReactomeR-HSA-2514853Condensation of Prometaphase ChromosomesReactomeR-HSA-2565942Regulation of PLK1 Activity at G2/M TransitionReactomeR-HSA-2980767Activation of NIMA Kinases NEK9, NEK6, NEK7ReactomeR-HSA-2995383Initiation of Nuclear Envelope (NE) ReformationReactomeR-HSA-3301854Nuclear Pore Complex (NPC) DisassemblyReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69478G2/M DNA replication checkpointReactomeR-HSA-8852276The role of GTSE1 in G2/M progression after G2 checkpointReactomeO95067PharosO95067ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPA26148cyclin B2PharmGKBPROTEIN COMPLEX9606Homo sapiensCyclin-dependent kinase 2/cyclin ACHEMBL2094128P24941Cyclin-dependent kinase 236PROTEINPROTEIN SUBUNITCDKN2GENE_SYMBOL_OTHERCDK2GENE_SYMBOLCyclin-dependent kinase 2UNIPROTCell division protein kinase 2UNIPROTp33 protein kinaseUNIPROT2.7.11.22EC_NUMBER2DS1APDBe3RKBAPDBe3QHRAPDBe3DOGAPDBe3RK5APDBe7SA0APDBe3TNWAPDBe3RK7APDBe2FVDAPDBe3QHWAPDBe3RK9APDBe2VV9APDBe1AQ1APDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe7ZPCAPDBe4EOSAPDBe1VYZAPDBe1OL2APDBe4EOIAPDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe2WXVAPDBe1OKWAPDBe1OKVAPDBe1B39APDBe3RMFAPDBe1B38APDBe2G9XAPDBe8OY2APDBe5FP6APDBe5FP5APDBe3RM6APDBe3RM7APDBe7UG1APDBe7RA5APDBe1KE9APDBe1KE8APDBe2BPMAPDBe1KE7APDBe1KE6APDBe1KE5APDBe4RJ3APDBe3RNIAPDBe2DUVAPDBe3F5XAPDBe3QL8APDBe3PJ8APDBe6SG4APDBe1E9HAPDBe3S0OAPDBe4ERWAPDBe1BUHAPDBe3S00APDBe2EXMAPDBe3RPOAPDBe3S1HAPDBe3ROYAPDBe2C4GAPDBe2A0CAPDBe3SQQAPDBe2R3JAPDBe2UZOAPDBe2R3IAPDBe4D1ZAPDBe2C5YAPDBe2R3HAPDBe2C5XAPDBe2C69APDBe2R3GAPDBe2C68APDBe2R3FAPDBe2C5VAPDBe3S2PAPDBe1HCKAPDBe2R3RAPDBe2R3QAPDBe2R3PAPDBe2R3OAPDBe7ACKAPDBe2R3NAPDBe2R3MAPDBe2UZLAPDBe2R3LAPDBe2R3KAPDBe2UZNAPDBe4D1XAPDBe3RPYAPDBe3FZ1APDBe3LE6APDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe2BTSAPDBe5UQ2APDBe1P2AAPDBe2BTRAPDBe3RPRAPDBe5UQ1APDBe5UQ3APDBe2C5OAPDBe2C5NAPDBe3RPVAPDBe6RIJAPDBe2B55APDBe3R1QAPDBe2C6LAPDBe2C6KAPDBe2C6IAPDBe1R78APDBe4FX3APDBe1HCLAPDBe2B54APDBe2C6TAPDBe2B53APDBe2B52APDBe2C6OAPDBe2C6MAPDBe3QQKAPDBe3QQLAPDBe6GUCAPDBe6GUBAPDBe2R64APDBe3QQFAPDBe3QQGAPDBe3QQHAPDBe3QQJAPDBe3LFNAPDBe3R1SAPDBe3LFQAPDBe3R28APDBe3LFSAPDBe3R1YAPDBe3SW4APDBe6GVAAPDBe1PW2APDBe2A4LAPDBe1WCCAPDBe5D1JAPDBe3EZRAPDBe5NEVAPDBe3EZVAPDBe1P5EAPDBe6GUEAPDBe6GUFAPDBe6GUHAPDBe6GUKAPDBe3QRTAPDBe3SW7APDBe3QRUAPDBe4NJ3APDBe2JGZAPDBe4KD1APDBe1PXPAPDBe1PXOAPDBe3QU0APDBe1PXNAPDBe1PXMAPDBe3QTQAPDBe1PXLAPDBe3QTRAPDBe7QHLAPDBe1PXKAPDBe3QTSAPDBe1PXJAPDBe1PXIAPDBe3QTUAPDBe8FP5APDBe8FOWAPDBe5ANKAPDBe5ANJAPDBe4EZ3APDBe5ANOAPDBe8FP0APDBe4EZ7APDBe5ANEAPDBe5ANDAPDBe5ANGAPDBe5ANIAPDBe3R71APDBe3R73APDBe3QTWAPDBe3QTXAPDBe1PYEAPDBe3QTZAPDBe3R83APDBe3R7UAPDBe3R7VAPDBe3R7IAPDBe3R7EAPDBe1YKRAPDBe3R6XAPDBe8VQ3APDBe8VQ4APDBe1GIJAPDBe3QX2APDBe1GIIAPDBe1GIHAPDBe3QX4APDBe3R8UAPDBe3R8VAPDBe3QWJAPDBe3QWKAPDBe3R8LAPDBe3R8MAPDBe2WEVAPDBe3IGGAPDBe3R8PAPDBe7E34APDBe3WBLAPDBe5A14APDBe5MHQAPDBe3R7YAPDBe3IG7APDBe2WFYAPDBe5OO0APDBe5OO1APDBe8ERDAPDBe5OO3APDBe3R9NAPDBe3QXOAPDBe3R9OAPDBe3QXPAPDBe8H6PAPDBe3R9DAPDBe8H6TAPDBe3R9HAPDBe3R8ZAPDBe3RZBAPDBe2WHBAPDBe1FINAPDBe8ERNAPDBe9FR2APDBe3NS9APDBe4BZDAPDBe4GCJAPDBe3PXYAPDBe3PXZAPDBe5CYIAPDBe3PY0APDBe3PY1APDBe3PXQAPDBe3PXRAPDBe3QZFAPDBe3PXFAPDBe3QZGAPDBe3QZHAPDBe3QZIAPDBe5IF1APDBe1JSVAPDBe1JSUAPDBe1JSTAPDBe2WIPAPDBe2WIHAPDBe1H00APDBe2CCIAPDBe2CCHAPDBe6ATHAPDBe1H08APDBe1H07APDBe7UXKAPDBe8UV0APDBe1H01APDBe5IEYAPDBe7UXIAPDBe4II5APDBe5IEVAPDBe5IEXAPDBe2XNBAPDBe6Q48APDBe7S4TAPDBe5OSJAPDBe1H0WAPDBe1H0VAPDBe2XMYAPDBe5LMKAPDBe5OSMAPDBe6Q3CAPDBe6Q3BAPDBe1DI8APDBe6Q3FAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe2WMBAPDBe6JGMAPDBe1JVPAPDBe3DDPAPDBe3DDQAPDBe6OQIAPDBe6Q4JAPDBe6Q4IAPDBe1H28APDBe1H27APDBe6Q4KAPDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe6Q4BAPDBe6Q4AAPDBe6Q4DAPDBe6Q4CAPDBe6Q4FAPDBe6Q4EAPDBe6Q4HAPDBe6Q4GAPDBe6Q49APDBe6P3WAPDBe1FQ1APDBe7S84APDBe7S85APDBe3MY5APDBe1DM2APDBe3RAKAPDBe3RALAPDBe8CURAPDBe1W0XAPDBe7MKXAPDBe7S7AAPDBe3RAHAPDBe3RAIAPDBe1CKPAPDBe3EJ1APDBe2I40APDBe8RU8APDBe2WPAAPDBe7RWFAPDBe7RWEAPDBe3EIDAPDBe7S9XAPDBe1PF8APDBe7KJSAPDBe1V1KAPDBe7RXOAPDBe2W05APDBe2W06APDBe8B54APDBe2X1NAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe2W1HAPDBe5L2WAPDBe2BHHAPDBe2IW9APDBe2IW8APDBe3TI1APDBe2W17APDBe2BHEAPDBe2V0DAPDBe4BCMAPDBe4FKQAPDBe5JQ5APDBe4BCNAPDBe4FKRAPDBe1URCAPDBe4BCOAPDBe4FKSAPDBe1G5SAPDBe4BCPAPDBe4FKTAPDBe4BCQAPDBe4FKUAPDBe4FKVAPDBe5JQ8APDBe4FKWAPDBe3ULIAPDBe4FKIAPDBe3TIYAPDBe4FKJAPDBe3TIZAPDBe4FKLAPDBe1E1XAPDBe1E1VAPDBe4BCKAPDBe4FKOAPDBe4FKPAPDBe4FKGAPDBe1Y91APDBe1Y8YAPDBe4EK3APDBe4EK4APDBe4EK5APDBe4EK6APDBe4CFUAPDBe4EK8APDBe4CFVAPDBe2CLXAPDBe4CFMAPDBe4CFNAPDBe6YL1APDBe6YL6APDBe2J9MAPDBe1URWAPDBe1FVVAPDBe3BHTAPDBe1FVTAPDBe3BHUAPDBe3BHVAPDBe1F5QAPDBe3UNJAPDBe1GY3APDBe3UNKAPDBe2BKZAPDBe4ACMAPDBe4LYNAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe6YLKAPDBe2V22APDBe2VTHAPDBe2VTIAPDBe2VTJAPDBe1GZ8APDBe2VTLAPDBe4I3ZAPDBe2VTMAPDBe1W8CAPDBe2VTNAPDBe2VTOAPDBe6INLAPDBe2VTAAPDBe7VDUAPDBe1PKDAPDBe7M2FAPDBe5K4JAPDBe1OI9APDBe3EOCAPDBe3RJCAPDBe7NVQAPDBe1OIRAPDBe1OIQAPDBe1W98APDBe4BGHAPDBe2VTPAPDBe1OIYAPDBe2VTQAPDBe1QMZAPDBe2VTRAPDBe2VU3APDBe2VTSAPDBe2VTTAPDBe1OIUAPDBe1OITAPDBeGO:0000287magnesium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0006281DNA repairGoProcessGO:0006468protein phosphorylationGoProcessGO:0006813potassium ion transportGoProcessGO:0007099centriole replicationGoProcessGO:0007165signal transductionGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0007346regulation of mitotic cell cycleGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0018105peptidyl-serine phosphorylationGoProcessGO:0031453positive regulation of heterochromatin formationGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0032298positive regulation of DNA-templated DNA replication initiationGoProcessGO:0043247telomere maintenance in response to DNA damageGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0051298centrosome duplicationGoProcessGO:0051301cell divisionGoProcessGO:0051321meiotic cell cycleGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090398cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000781chromosome, telomeric regionGoComponentGO:0000793condensed chromosomeGoComponentGO:0000805X chromosomeGoComponentGO:0000806Y chromosomeGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005635nuclear envelopeGoComponentGO:0005654nucleoplasmGoComponentGO:0005768endosomeGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0015030Cajal bodyGoComponentGO:0005667transcription regulator complexGoComponentA8K7C6Cyclin-dependent kinase 2UniProtO75100Cyclin-dependent kinase 2UniProtP24941Cyclin-dependent kinase 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:1771CDK2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-176187Activation of ATR in response to replication stressReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-68962Activation of the pre-replicative complexReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeP24941PharosP24941ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF521CYCLIN-DEPENDENT KINASE 2PANTHERPF00069PkinasePfamPA101cyclin dependent kinase 2PharmGKBP20248Cyclin-A2918PROTEINPROTEIN SUBUNITCCNAGENE_SYMBOL_OTHERSynonyms=CCN1GENE_SYMBOL_OTHERCCNA GN GENE_SYMBOL_OTHERCCNA2GENE_SYMBOLCyclin-A2UNIPROTCyclin AUNIPROTCyclin-AUNIPROT3EJ1APDBe2I40APDBe2WHBAPDBe1FINAPDBe2WPAAPDBe3EIDAPDBe6GVAAPDBe5CYIAPDBe4EONAPDBe4EOOAPDBe4EOPAPDBe2UUEAPDBe4EOQAPDBe4EORAPDBe4EOSAPDBe1OL2APDBe4EOIAPDBe5NEVAPDBe8B54APDBe1OL1APDBe1VYWAPDBe4EOJAPDBe4EOKAPDBe4EOLAPDBe4EOMAPDBe1P5EAPDBe2WXVAPDBe2X1NAPDBe1OKWAPDBe1OKVAPDBe7B7SAPDBe2IW6APDBe2CJMAPDBe5IF1APDBe1JSUAPDBe1JSTAPDBe2IW9APDBe2IW8APDBe2WIPAPDBe7LUOAPDBe2BPMAPDBe2WIHAPDBe2CCIAPDBe4BCMAPDBe2CCHAPDBe4BCNAPDBe1URCAPDBe4BCPAPDBe7QHLAPDBe6ATHAPDBe3F5XAPDBe4BCKAPDBe6SG4APDBe1E9HAPDBe4CFUAPDBe4CFVAPDBe5LMKAPDBe4CFMAPDBe4CFNAPDBe1H1QAPDBe1H1PAPDBe2WMAAPDBe1FVVAPDBe2WMBAPDBe1GY3APDBe2BKZAPDBe1H28APDBe1H27APDBe1H26APDBe1H25APDBe1H1SAPDBe1H24APDBe1H1RAPDBe2C4GAPDBe4CFWAPDBe4CFXAPDBe1OGUAPDBe2V22APDBe2C5XAPDBe2C5VAPDBe6P3WAPDBe7ACKAPDBe2UZLAPDBe2WEVAPDBe1PKDAPDBe2UZBAPDBe2UZDAPDBe2UZEAPDBe1OI9APDBe2C5OAPDBe2C5NAPDBe3EOCAPDBe2WFYAPDBe6RIJAPDBe4FX3APDBe2C6TAPDBe1OIYAPDBe7MKXAPDBe1QMZAPDBe1OIUAPDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000086G2/M transition of mitotic cell cycleGoProcessGO:0007265Ras protein signal transductionGoProcessGO:0031100animal organ regenerationGoProcessGO:0044320cellular response to leptin stimulusGoProcessGO:0044772mitotic cell cycle phase transitionGoProcessGO:0044843cell cycle G1/S phase transitionGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0071314cellular response to cocaineGoProcessGO:0071373cellular response to luteinizing hormone stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:0071407cellular response to organic cyclic compoundGoProcessGO:0071456cellular response to hypoxiaGoProcessGO:0071732cellular response to nitric oxideGoProcessGO:0090102cochlea developmentGoProcessGO:1990314cellular response to insulin-like growth factor stimulusGoProcessGO:2000573positive regulation of DNA biosynthetic processGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0001939female pronucleusGoComponentGO:0001940male pronucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K7B6Cyclin-A2UniProtQ2M3U6Cyclin-A2UniProtQ4W5P4Cyclin-A2UniProtQ6LER8Cyclin-A2UniProtP20248Cyclin-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:1578CCNA2HGNCR-HSA-1362300Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1ReactomeR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP20248PharosIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR046965Cyclin_A/B-likeInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA94cyclin A2PharmGKBP78396Cyclin-A11927PROTEINPROTEIN SUBUNITCCNA1GENE_SYMBOLCyclin-A1UNIPROTGO:0005515protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0007141male meiosis IGoProcessGO:0007283spermatogenesisGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0015630microtubule cytoskeletonGoComponentB7Z7E3Cyclin-A1UniProtQ5T3V0Cyclin-A1UniProtQ5U0G2Cyclin-A1UniProtQ8IY91Cyclin-A1UniProtP78396Cyclin-A1UniProtP78396AlphaFoldDBP78396IntActHGNC:1577CCNA1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-170145Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexesReactomeR-HSA-171319Telomere Extension By TelomeraseReactomeR-HSA-174184Cdc20:Phospho-APC/C mediated degradation of Cyclin AReactomeR-HSA-176408Regulation of APC/C activators between G1/S and early anaphaseReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-5689880Ub-specific processing proteasesReactomeR-HSA-5693607Processing of DNA double-strand break endsReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-6804756Regulation of TP53 Activity through PhosphorylationReactomeR-HSA-6804757Regulation of TP53 DegradationReactomeR-HSA-68911G2 PhaseReactomeR-HSA-68949Orc1 removal from chromatinReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeP78396PharosP78396ExpressionAtlasIPR039361CyclinInterProIPR032447Cyclin-A_NInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPF16500Cyclin_N2PfamPA26147cyclin A1PharmGKBPROTEIN COMPLEX9606Homo sapiensCyclin-dependent kinase 4/cyclin DCHEMBL2095942P11802Cyclin-dependent kinase 417PROTEINPROTEIN SUBUNITCDK4GENE_SYMBOLCyclin-dependent kinase 4UNIPROTCell division protein kinase 4UNIPROTPSK-J3UNIPROT2.7.11.22EC_NUMBER6P8GAPDBe6P8FAPDBe6P8HAPDBe2W96APDBe2W9FAPDBe3G33APDBe2W99APDBe2W9ZAPDBe6P8EAPDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0061469regulation of type B pancreatic cell proliferationGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:1904628cellular response to phorbol 13-acetate 12-myristateGoProcessGO:1904637cellular response to ionomycinGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0005667transcription regulator complexGoComponentB2R9A0Cyclin-dependent kinase 4UniProtB4DNF9Cyclin-dependent kinase 4UniProtO00576Cyclin-dependent kinase 4UniProtQ6FG61Cyclin-dependent kinase 4UniProtP11802Cyclin-dependent kinase 4UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB3G33PDB5FWKPDB5FWLPDB5FWMPDB5FWPPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDB7SJ3PDBP11802AlphaFoldDBP11802IntActHGNC:1773CDK4HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-912446Meiotic recombinationReactomeR-HSA-9616222Transcriptional regulation of granulopoiesisReactomeR-HSA-9630791Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632697Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP11802PharosP11802ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF129CYCLIN-DEPENDENT KINASE 4PANTHERPF00069PkinasePfamPA102cyclin dependent kinase 4PharmGKBP24385G1/S-specific cyclin-D134PROTEINPROTEIN SUBUNITBCL1GENE_SYMBOL_OTHERPRAD1GENE_SYMBOL_OTHERSynonyms=BCL1GENE_SYMBOL_OTHERPRAD1 GN GENE_SYMBOL_OTHERCCND1GENE_SYMBOLG1/S-specific cyclin-D1UNIPROTB-cell lymphoma 1 proteinUNIPROTBCL-1 oncogeneUNIPROTPRAD1 oncogeneUNIPROTBCL-1UNIPROT6P8GAPDBe6P8FAPDBe6P8HAPDBe5VZUAPDBe2W96APDBe2W9FAPDBe2W99APDBe2W9ZAPDBe6P8EAPDBeGO:0003714transcription corepressor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0042826histone deacetylase bindingGoFunctionGO:0070064proline-rich region bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000320re-entry into mitotic cell cycleGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006974DNA damage responseGoProcessGO:0007595lactationGoProcessGO:0008283cell population proliferationGoProcessGO:0010971positive regulation of G2/M transition of mitotic cell cycleGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0030182neuron differentiationGoProcessGO:0030857negative regulation of epithelial cell differentiationGoProcessGO:0030968endoplasmic reticulum unfolded protein responseGoProcessGO:0031571mitotic G1 DNA damage checkpoint signalingGoProcessGO:0033598mammary gland epithelial cell proliferationGoProcessGO:0033601positive regulation of mammary gland epithelial cell proliferationGoProcessGO:0043524negative regulation of neuron apoptotic processGoProcessGO:0045444fat cell differentiationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0060749mammary gland alveolus developmentGoProcessGO:0097421liver regenerationGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:2000045regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0005923bicellular tight junctionGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0017053transcription repressor complexGoComponentQ6LEF0G1/S-specific cyclin-D1UniProtP24385G1/S-specific cyclin-D1UniProt2W96PDB2W99PDB2W9FPDB2W9ZPDB5VZUPDB6P8EPDB6P8FPDB6P8GPDB6P8HPDBP24385AlphaFoldDBP24385IntActHGNC:1582CCND1HGNCR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-1912408Pre-NOTCH Transcription and TranslationReactomeR-HSA-3214858RMTs methylate histone argininesReactomeR-HSA-6785807Interleukin-4 and Interleukin-13 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-75815Ubiquitin-dependent degradation of Cyclin DReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-8853884Transcriptional Regulation by VENTXReactomeR-HSA-8878166Transcriptional regulation by RUNX2ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-8951430RUNX3 regulates WNT signalingReactomeR-HSA-8951936RUNX3 regulates p14-ARFReactomeR-HSA-9018519Estrogen-dependent gene expressionReactomeR-HSA-9634638Estrogen-dependent nuclear events downstream of ESR-membrane signalingReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeR-HSA-9825892Regulation of MITF-M-dependent genes involved in cell cycle and proliferationReactomeP24385PharosP24385ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA75cyclin D1PharmGKBP30281G1/S-specific cyclin-D3763PROTEINPROTEIN SUBUNITCCND3GENE_SYMBOLG1/S-specific cyclin-D3UNIPROT3G33APDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0042098T cell proliferationGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentB2RD63G1/S-specific cyclin-D3UniProtB3KQ22G1/S-specific cyclin-D3UniProtE9PAS4G1/S-specific cyclin-D3UniProtE9PB36G1/S-specific cyclin-D3UniProtQ5T8J0G1/S-specific cyclin-D3UniProtQ6FG62G1/S-specific cyclin-D3UniProtQ96F49G1/S-specific cyclin-D3UniProtP30281G1/S-specific cyclin-D3UniProt3G33PDB7SJ3PDBP30281AlphaFoldDBP30281IntActHGNC:1585CCND3HGNCR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30281PharosP30281ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26152cyclin D3PharmGKBP30279G1/S-specific cyclin-D21930PROTEINPROTEIN SUBUNITCCND2GENE_SYMBOLG1/S-specific cyclin-D2UNIPROT6EI2APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0007616long-term memoryGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0008344adult locomotory behaviorGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0071481cellular response to X-rayGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0000785chromatinGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005829cytosolGoComponentGO:0016020membraneGoComponentGO:0031965nuclear membraneGoComponentA8K531G1/S-specific cyclin-D2UniProtQ13955G1/S-specific cyclin-D2UniProtQ5U035G1/S-specific cyclin-D2UniProtP30279G1/S-specific cyclin-D2UniProt6EI2PDBP30279AlphaFoldDBP30279IntActHGNC:1583CCND2HGNCR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30279PharosP30279ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26150cyclin D2PharmGKBPROTEIN COMPLEX GROUP9606Homo sapiensCyclin-dependent kinase 7/ cyclin HCHEMBL2111288P51946Cyclin-H506PROTEINPROTEIN SUBUNITCCNHGENE_SYMBOLCyclin-HUNIPROTMO15-associated proteinUNIPROTp34UNIPROTp37UNIPROT1KXUAPDBe1JKWAPDBe8PYRAPDBeGO:0016251RNA polymerase II general transcription initiation factor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0050821protein stabilizationGoProcessGO:2000045regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0000439transcription factor TFIIH core complexGoComponentGO:0005675transcription factor TFIIH holo complexGoComponentGO:0070516CAK-ERCC2 complexGoComponentGO:0070985transcription factor TFIIK complexGoComponentQ53X72Cyclin-HUniProtQ8TBL9Cyclin-HUniProtP51946Cyclin-HUniProt1JKWPDB1KXUPDB6O9LPDB6XBZPDB6XD3PDB7B5OPDB7B5QPDB7EGBPDB7EGCPDB7ENAPDB7ENCPDB7LBMPDB7NVRPDB8BVWPDB8BYQPDB8GXQPDB8GXSPDB8ORMPDB8P6VPDB8P6WPDB8P6XPDB8P6YPDB8P6ZPDB8P70PDB8P71PDB8P72PDB8P73PDB8P74PDB8P75PDB8P76PDB8P77PDB8P78PDB8P79PDB8PLZPDB8PYRPDB8S0RPDB8S0TPDBP51946AlphaFoldDBP51946IntActHGNC:1594CCNHHGNCR-HSA-112382Formation of RNA Pol II elongation complexReactomeR-HSA-113418Formation of the Early Elongation ComplexReactomeR-HSA-167152Formation of HIV elongation complex in the absence of HIV TatReactomeR-HSA-167158Formation of the HIV-1 Early Elongation ComplexReactomeR-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionReactomeR-HSA-167161HIV Transcription InitiationReactomeR-HSA-167162RNA Polymerase II HIV Promoter EscapeReactomeR-HSA-167172Transcription of the HIV genomeReactomeR-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatReactomeR-HSA-167246Tat-mediated elongation of the HIV-1 transcriptReactomeR-HSA-427413NoRC negatively regulates rRNA expressionReactomeR-HSA-5696395Formation of Incision Complex in GG-NERReactomeR-HSA-674695RNA Polymerase II Pre-transcription EventsReactomeR-HSA-6781823Formation of TC-NER Pre-Incision ComplexReactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)ReactomeR-HSA-6782135Dual incision in TC-NERReactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERReactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-72086mRNA CappingReactomeR-HSA-73762RNA Polymerase I Transcription InitiationReactomeR-HSA-73772RNA Polymerase I Promoter EscapeReactomeR-HSA-73776RNA Polymerase II Promoter EscapeReactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningReactomeR-HSA-73863RNA Polymerase I Transcription TerminationReactomeR-HSA-75953RNA Polymerase II Transcription InitiationReactomeR-HSA-75955RNA Polymerase II Transcription ElongationReactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceReactomeR-HSA-77075RNA Pol II CTD phosphorylation and interaction with CEReactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsReactomeP51946PharosP51946ExpressionAtlasIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR043198Cyclin/Ssn8InterProIPR031658Cyclin_C_2InterProIPR006671Cyclin_NInterProIPR027081CyclinH/Ccl1InterProPTHR10026CYCLINPANTHERPF16899Cyclin_C_2PfamPF00134Cyclin_NPfamPA26159cyclin HPharmGKBP50613Cyclin-dependent kinase 71382PROTEINPROTEIN SUBUNITCAKGENE_SYMBOL_OTHERCAK1GENE_SYMBOL_OTHERCDKN7GENE_SYMBOL_OTHERMO15GENE_SYMBOL_OTHERSTK1GENE_SYMBOL_OTHERCDK7GENE_SYMBOLCyclin-dependent kinase 7UNIPROT39 kDa protein kinaseUNIPROTCDK-activating kinase 1UNIPROTCell division protein kinase 7UNIPROTSerine/threonine-protein kinase 1UNIPROTTFIIH basal transcription factor complex kinase subunitUNIPROTp39 Mo15UNIPROT2.7.11.22EC_NUMBER2.7.11.23EC_NUMBER8R99APDBe1UA2APDBe8P4ZAPDBe8R9AAPDBe8R9BAPDBe8R9OAPDBe8PYRAPDBe8R9UAPDBe8R9SAPDBeGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0006281DNA repairGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0050821protein stabilizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:2000045regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0001650fibrillar centerGoComponentGO:0001673male germ cell nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0000439transcription factor TFIIH core complexGoComponentGO:0005675transcription factor TFIIH holo complexGoComponentGO:0070516CAK-ERCC2 complexGoComponentGO:0070985transcription factor TFIIK complexGoComponentQ9BS60Cyclin-dependent kinase 7UniProtQ9UE19Cyclin-dependent kinase 7UniProtP50613Cyclin-dependent kinase 7UniProt1UA2PDB6O9LPDB6XBZPDB6XD3PDB7B5OPDB7B5QPDB7EGBPDB7EGCPDB7ENAPDB7ENCPDB7LBMPDB7NVRPDB8BVWPDB8BYQPDB8GXQPDB8GXSPDB8ORMPDB8P4ZPDB8P6VPDB8P6WPDB8P6XPDB8P6YPDB8P6ZPDB8P70PDB8P71PDB8P72PDB8P73PDB8P74PDB8P75PDB8P76PDB8P77PDB8P78PDB8P79PDB8P7LPDB8PLZPDB8PYRPDB8R99PDB8R9APDB8R9BPDB8R9OPDB8R9SPDB8R9UPDB8S0RPDB8S0TPDBP50613AlphaFoldDBP50613IntActHGNC:1778CDK7HGNCR-HSA-112382Formation of RNA Pol II elongation complexReactomeR-HSA-113418Formation of the Early Elongation ComplexReactomeR-HSA-167152Formation of HIV elongation complex in the absence of HIV TatReactomeR-HSA-167158Formation of the HIV-1 Early Elongation ComplexReactomeR-HSA-167160RNA Pol II CTD phosphorylation and interaction with CE during HIV infectionReactomeR-HSA-167161HIV Transcription InitiationReactomeR-HSA-167162RNA Polymerase II HIV Promoter EscapeReactomeR-HSA-167172Transcription of the HIV genomeReactomeR-HSA-167200Formation of HIV-1 elongation complex containing HIV-1 TatReactomeR-HSA-167246Tat-mediated elongation of the HIV-1 transcriptReactomeR-HSA-427413NoRC negatively regulates rRNA expressionReactomeR-HSA-5696395Formation of Incision Complex in GG-NERReactomeR-HSA-674695RNA Polymerase II Pre-transcription EventsReactomeR-HSA-6781823Formation of TC-NER Pre-Incision ComplexReactomeR-HSA-6781827Transcription-Coupled Nucleotide Excision Repair (TC-NER)ReactomeR-HSA-6782135Dual incision in TC-NERReactomeR-HSA-6782210Gap-filling DNA repair synthesis and ligation in TC-NERReactomeR-HSA-6796648TP53 Regulates Transcription of DNA Repair GenesReactomeR-HSA-6807505RNA polymerase II transcribes snRNA genesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69273Cyclin A/B1/B2 associated events during G2/M transitionReactomeR-HSA-69656Cyclin A:Cdk2-associated events at S phase entryReactomeR-HSA-72086mRNA CappingReactomeR-HSA-73762RNA Polymerase I Transcription InitiationReactomeR-HSA-73772RNA Polymerase I Promoter EscapeReactomeR-HSA-73776RNA Polymerase II Promoter EscapeReactomeR-HSA-73779RNA Polymerase II Transcription Pre-Initiation And Promoter OpeningReactomeR-HSA-73863RNA Polymerase I Transcription TerminationReactomeR-HSA-75953RNA Polymerase II Transcription InitiationReactomeR-HSA-75955RNA Polymerase II Transcription ElongationReactomeR-HSA-76042RNA Polymerase II Transcription Initiation And Promoter ClearanceReactomeR-HSA-77075RNA Pol II CTD phosphorylation and interaction with CEReactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsReactomeP50613PharosP50613ExpressionAtlasIPR050108CDKInterProIPR037770CDK7InterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF0CYCLIN-DEPENDENT KINASE 7PANTHERPF00069PkinasePfamPA26314cyclin dependent kinase 7PharmGKBPROTEIN COMPLEX9606Homo sapiensCDK3/cyclin ECHEMBL2111444P24864G1/S-specific cyclin-E135PROTEINGROUP MEMBERCCNEGENE_SYMBOL_OTHERCCNE1GENE_SYMBOLG1/S-specific cyclin-E1UNIPROT8H6PAPDBe7XQKAPDBe1W98APDBe8H4RAPDBe8H6TAPDBe5L2WAPDBe7KJSAPDBe8VQ3APDBe8VQ4APDBeGO:0006468protein phosphorylationGoProcessGO:0005515protein bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0016055Wnt signaling pathwayGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902462positive regulation of mesenchymal stem cell proliferationGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentA8K684G1/S-specific cyclin-E1UniProtQ14091G1/S-specific cyclin-E1UniProtQ8NFG1G1/S-specific cyclin-E1UniProtQ92501G1/S-specific cyclin-E1UniProtQ9UD21G1/S-specific cyclin-E1UniProtP24864G1/S-specific cyclin-E1UniProt1W98PDB5L2WPDB7KJSPDB7XQKPDB8H4RPDB8H6PPDB8H6TPDB8VQ3PDB8VQ4PDBP24864AlphaFoldDBP24864IntActHGNC:1589CCNE1HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-8849470PTK6 Regulates Cell CycleReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9706019RHOBTB3 ATPase cycleReactomeP24864PharosP24864ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA96cyclin E1PharmGKBO96020G1/S-specific cyclin-E21213PROTEINGROUP MEMBERCCNE2GENE_SYMBOLG1/S-specific cyclin-E2UNIPROT8HN9APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000079regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000723telomere maintenanceGoProcessGO:0006270DNA replication initiationGoProcessGO:0007129homologous chromosome pairing at meiosisGoProcessGO:0032880regulation of protein localizationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0070192chromosome organization involved in meiotic cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentO95439G1/S-specific cyclin-E2UniProtO96020G1/S-specific cyclin-E2UniProt8HN9PDBO96020AlphaFoldDBO96020IntActHGNC:1590CCNE2HGNCR-HSA-1538133G0 and Early G1ReactomeR-HSA-187577SCF(Skp2)-mediated degradation of p27/p21ReactomeR-HSA-2559586DNA Damage/Telomere Stress Induced SenescenceReactomeR-HSA-390471Association of TriC/CCT with target proteins during biosynthesisReactomeR-HSA-6804116TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestReactomeR-HSA-69017CDK-mediated phosphorylation and removal of Cdc6ReactomeR-HSA-69200Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexesReactomeR-HSA-69202Cyclin E associated events during G1/S transitionReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-69563p53-Dependent G1 DNA Damage ResponseReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeO96020PharosO96020ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26155cyclin E2PharmGKBQ00526Cyclin-dependent kinase 32759PROTEINGROUP MEMBERCDKN3GENE_SYMBOL_OTHERCDK3GENE_SYMBOLCyclin-dependent kinase 3UNIPROTCell division protein kinase 3UNIPROT2.7.11.22EC_NUMBER7XQKAPDBe8H4RAPDBeGO:0006974DNA damage responseGoProcessGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0030332cyclin bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0007165signal transductionGoProcessGO:0008283cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0045023G0 to G1 transitionGoProcessGO:0045746negative regulation of Notch signaling pathwayGoProcessGO:0051301cell divisionGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentQ00526Cyclin-dependent kinase 3UniProt7XQKPDB8H4RPDBQ00526AlphaFoldDBQ00526IntActHGNC:1772CDK3HGNCQ00526PharosQ00526ExpressionAtlasIPR050108CDKInterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF462CYCLIN-DEPENDENT KINASE 3PANTHERPF00069PkinasePfamPA26309cyclin dependent kinase 3PharmGKBPROTEIN COMPLEX GROUP9606CPX-2013Cyclin D3-CDK6 complexComplexPortalHomo sapiensCDK6/cyclin D3CHEMBL2111448P30281G1/S-specific cyclin-D3763PROTEINPROTEIN SUBUNITCCND3GENE_SYMBOLG1/S-specific cyclin-D3UNIPROT3G33APDBe7SJ3APDBeGO:0005515protein bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0042098T cell proliferationGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005815microtubule organizing centerGoComponentGO:0005654nucleoplasmGoComponentGO:0005829cytosolGoComponentB2RD63G1/S-specific cyclin-D3UniProtB3KQ22G1/S-specific cyclin-D3UniProtE9PAS4G1/S-specific cyclin-D3UniProtE9PB36G1/S-specific cyclin-D3UniProtQ5T8J0G1/S-specific cyclin-D3UniProtQ6FG62G1/S-specific cyclin-D3UniProtQ96F49G1/S-specific cyclin-D3UniProtP30281G1/S-specific cyclin-D3UniProt3G33PDB7SJ3PDBP30281AlphaFoldDBP30281IntActHGNC:1585CCND3HGNCR-HSA-381340Transcriptional regulation of white adipocyte differentiationReactomeR-HSA-5687128MAPK6/MAPK4 signalingReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeP30281PharosP30281ExpressionAtlasIPR039361CyclinInterProIPR013763Cyclin-like_domInterProIPR036915Cyclin-like_sfInterProIPR004367Cyclin_C-domInterProIPR006671Cyclin_NInterProIPR048258Cyclins_cyclin-boxInterProPTHR10177CYCLINSPANTHERPF02984Cyclin_CPfamPF00134Cyclin_NPfamPA26152cyclin D3PharmGKBQ00534Cyclin-dependent kinase 6847PROTEINPROTEIN SUBUNITCDKN6GENE_SYMBOL_OTHERCDK6GENE_SYMBOLCyclin-dependent kinase 6UNIPROTCell division protein kinase 6UNIPROTSerine/threonine-protein kinase PLSTIREUNIPROT2.7.11.22EC_NUMBER5L2TAPDBe4AUAAPDBe5L2SAPDBe1G3NAPDBe3NUXAPDBe1BI7APDBe1BLXAPDBe4TTHAPDBe6OQLAPDBe3NUPAPDBe6OQOAPDBe2F2CAPDBe2EUFAPDBe4EZ5APDBe8I0MAPDBe1JOWAPDBe1BI8APDBe5L2IAPDBe1XO2APDBeGO:0048699generation of neuronsGoProcessGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0030332cyclin bindingGoFunctionGO:0098770FBXO family protein bindingGoFunctionGO:0000082G1/S transition of mitotic cell cycleGoProcessGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0001954positive regulation of cell-matrix adhesionGoProcessGO:0002244hematopoietic progenitor cell differentiationGoProcessGO:0003323type B pancreatic cell developmentGoProcessGO:0006468protein phosphorylationGoProcessGO:0007165signal transductionGoProcessGO:0007219Notch signaling pathwayGoProcessGO:0008285negative regulation of cell population proliferationGoProcessGO:0010389regulation of G2/M transition of mitotic cell cycleGoProcessGO:0010628positive regulation of gene expressionGoProcessGO:0014002astrocyte developmentGoProcessGO:0021542dentate gyrus developmentGoProcessGO:0021670lateral ventricle developmentGoProcessGO:0030097hemopoiesisGoProcessGO:0030154cell differentiationGoProcessGO:0033077T cell differentiation in thymusGoProcessGO:0042063gliogenesisGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0043697cell dedifferentiationGoProcessGO:0045596negative regulation of cell differentiationGoProcessGO:0045638negative regulation of myeloid cell differentiationGoProcessGO:0045646regulation of erythrocyte differentiationGoProcessGO:0045656negative regulation of monocyte differentiationGoProcessGO:0045668negative regulation of osteoblast differentiationGoProcessGO:0045786negative regulation of cell cycleGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0050680negative regulation of epithelial cell proliferationGoProcessGO:0051301cell divisionGoProcessGO:0051726regulation of cell cycleGoProcessGO:0060218hematopoietic stem cell differentiationGoProcessGO:1902036regulation of hematopoietic stem cell differentiationGoProcessGO:2000145regulation of cell motilityGoProcessGO:2000773negative regulation of cellular senescenceGoProcessGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0001726ruffleGoComponentGO:0005654nucleoplasmGoComponentGO:0005813centrosomeGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0042995cell projectionGoComponentA4D1G0Cyclin-dependent kinase 6UniProtQ00534Cyclin-dependent kinase 6UniProt1BI7PDB1BI8PDB1BLXPDB1G3NPDB1JOWPDB1XO2PDB2EUFPDB2F2CPDB3NUPPDB3NUXPDB4AUAPDB4EZ5PDB4TTHPDB5L2IPDB5L2SPDB5L2TPDB6OQLPDB6OQOPDB8I0MPDBQ00534AlphaFoldDBQ00534IntActHGNC:1777CDK6HGNCR-HSA-2559580Oxidative Stress Induced SenescenceReactomeR-HSA-2559582Senescence-Associated Secretory Phenotype (SASP)ReactomeR-HSA-2559585Oncogene Induced SenescenceReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8934593Regulation of RUNX1 Expression and ActivityReactomeR-HSA-9630794Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9632700Evasion of Oxidative Stress Induced Senescence Due to Defective p16INK4A binding to CDK4 and CDK6ReactomeR-HSA-9661069Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)ReactomeR-HSA-9754119Drug-mediated inhibition of CDK4/CDK6 activityReactomeQ00534PharosIPR050108CDKInterProIPR028788CDK6InterProIPR011009Kinase-like_dom_sfInterProIPR000719Prot_kinase_domInterProIPR017441Protein_kinase_ATP_BSInterProIPR008271Ser/Thr_kinase_ASInterProPTHR24056CELL DIVISION PROTEIN KINASEPANTHERPTHR24056:SF130CYCLIN-DEPENDENT KINASE 6PANTHERPF00069PkinasePfamPA103cyclin dependent kinase 6PharmGKBPROTEIN COMPLEX9606