20/chembl/api/data/target?limit=20&offset=2017803Homo sapiensMaltase-glucoamylaseCHEMBL2074O43451Maltase-glucoamylase434PROTEINSINGLE PROTEIN3.2.1.20EC_NUMBERAlpha-1,4-glucosidaseUNIPROTMaltase-glucoamylaseUNIPROTMGAGENE_SYMBOL_OTHERMGAMGENE_SYMBOLMGAMLGENE_SYMBOL_OTHERSynonyms=MGAGENE_SYMBOL_OTHERO43451AlphaFoldDBO43451ExpressionAtlasGO:0005886plasma membraneGoComponentGO:0016324apical plasma membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0070821tertiary granule membraneGoComponentGO:0101003ficolin-1-rich granule membraneGoComponentGO:0003824catalytic activityGoFunctionGO:0004339glucan 1,4-alpha-glucosidase activityGoFunctionGO:0004553hydrolase activity, hydrolyzing O-glycosyl compoundsGoFunctionGO:0004558alpha-1,4-glucosidase activityGoFunctionGO:0004574oligo-1,6-glucosidase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016160amylase activityGoFunctionGO:0016798hydrolase activity, acting on glycosyl bondsGoFunctionGO:0030246carbohydrate bindingGoFunctionGO:0090599alpha-glucosidase activityGoFunctionGO:0000025maltose catabolic processGoProcessGO:0005975carbohydrate metabolic processGoProcessGO:0005983starch catabolic processGoProcessGO:1901027dextrin catabolic processGoProcessHGNC:7043MGAMHGNCO43451IntActIPR000322Glyco_hydro_31_TIMInterProIPR000519P_trefoil_domInterProIPR011013Gal_mutarotase_sf_domInterProIPR013780Glyco_hydro_bInterProIPR017853Glycoside_hydrolase_SFInterProIPR017957P_trefoil_CSInterProIPR025887Glyco_hydro_31_N_domInterProIPR030458Glyco_hydro_31_ASInterProIPR030459Glyco_hydro_31_CSInterProIPR044913P_trefoil_dom_sfInterProIPR048395Glyco_hydro_31_CInterProPTHR22762ALPHA-GLUCOSIDASEPANTHERPTHR22762:SF133P-TYPE DOMAIN-CONTAINING PROTEINPANTHER2QLYPDB2QMJPDB3CTTPDB3L4TPDB3L4UPDB3L4VPDB3L4WPDB3L4XPDB3L4YPDB3L4ZPDB3TONPDB3TOPPDB2QLYAPDBe2QMJAPDBe3CTTAPDBe3L4TAPDBe3L4UAPDBe3L4VAPDBe3L4WAPDBe3L4XAPDBe3L4YAPDBe3L4ZAPDBe3TONAPDBe3TOPAPDBePF00088TrefoilPfamPF01055Glyco_hydro_31_2ndPfamPF13802Gal_mutarotas_2PfamPF21365Glyco_hydro_31_3rdPfamPA30778maltase-glucoamylasePharmGKBO43451PharosR-HSA-189085Digestion of dietary carbohydrateReactomeR-HSA-6798695Neutrophil degranulationReactomeE7ER45Maltase-glucoamylaseUniProtO43451Maltase-glucoamylaseUniProtQ0VAX6Maltase-glucoamylaseUniProtQ75ME7Maltase-glucoamylaseUniProtQ86UM5Maltase-glucoamylaseUniProtSINGLE PROTEIN9606Homo sapiensATP-binding cassette sub-family C member 9CHEMBL1971O60706ATP-binding cassette sub-family C member 9294PROTEINSINGLE PROTEINABCC9GENE_SYMBOLATP-binding cassette sub-family C member 9UNIPROTSulfonylurea receptor 2UNIPROTSUR2GENE_SYMBOL_OTHERO60706AlphaFoldDBO60706ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005886plasma membraneGoComponentGO:0008282inward rectifying potassium channelGoComponentGO:0016020membraneGoComponentGO:0030017sarcomereGoComponentGO:0031004potassium ion-transporting ATPase complexGoComponentGO:0032991protein-containing complexGoComponentGO:0042383sarcolemmaGoComponentGO:0005267potassium channel activityGoFunctionGO:0005524ATP bindingGoFunctionGO:0008281sulfonylurea receptor activityGoFunctionGO:0015272ATP-activated inward rectifier potassium channel activityGoFunctionGO:0016887ATP hydrolysis activityGoFunctionGO:0019829ATPase-coupled monoatomic cation transmembrane transporter activityGoFunctionGO:0042626ATPase-coupled transmembrane transporter activityGoFunctionGO:0043225ATPase-coupled inorganic anion transmembrane transporter activityGoFunctionGO:0044325transmembrane transporter bindingGoFunctionGO:0140359ABC-type transporter activityGoFunctionGO:0000165MAPK cascadeGoProcessGO:0001508action potentialGoProcessGO:0001568blood vessel developmentGoProcessGO:0001666response to hypoxiaGoProcessGO:0003007heart morphogenesisGoProcessGO:0003018vascular process in circulatory systemGoProcessGO:0006813potassium ion transportGoProcessGO:0006950response to stressGoProcessGO:0007005mitochondrion organizationGoProcessGO:0007507heart developmentGoProcessGO:0007519skeletal muscle tissue developmentGoProcessGO:0008015blood circulationGoProcessGO:0008217regulation of blood pressureGoProcessGO:0019395fatty acid oxidationGoProcessGO:0035865cellular response to potassium ionGoProcessGO:0042311vasodilationGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0042542response to hydrogen peroxideGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0045333cellular respirationGoProcessGO:0045776negative regulation of blood pressureGoProcessGO:0046034ATP metabolic processGoProcessGO:0048144fibroblast proliferationGoProcessGO:0055085transmembrane transportGoProcessGO:0060976coronary vasculature developmentGoProcessGO:0061337cardiac conductionGoProcessGO:0062197cellular response to chemical stressGoProcessGO:0071277cellular response to calcium ionGoProcessGO:0071318cellular response to ATPGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0071805potassium ion transmembrane transportGoProcessGO:0072359circulatory system developmentGoProcessGO:0072592oxygen metabolic processGoProcessGO:0086003cardiac muscle cell contractionGoProcessGO:0097746blood vessel diameter maintenanceGoProcessGO:0098655monoatomic cation transmembrane transportGoProcessGO:0098656monoatomic anion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0150104transport across blood-brain barrierGoProcessGO:1901379regulation of potassium ion transmembrane transportGoProcessGO:1903409reactive oxygen species biosynthetic processGoProcessGO:1990573potassium ion import across plasma membraneGoProcessHGNC:60ABCC9HGNCO60706IntActIPR000388ABCC8/9InterProIPR001475ABCC9InterProIPR003439ABC_transporter-like_ATP-bdInterProIPR003593AAA+_ATPaseInterProIPR011527ABC1_TM_domInterProIPR017871ABC_transporter-like_CSInterProIPR027417P-loop_NTPaseInterProIPR036640ABC1_TM_sfInterProIPR047080ABCC9_ATP-bd_dom1InterProIPR050173ABC_transporter_C-likeInterProPTHR24223ATP-BINDING CASSETTE SUB-FAMILY CPANTHERPTHR24223:SF173ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 9PANTHERPF00005ABC_tranPfamPF00664ABC_membranePfamPA396ATP binding cassette subfamily C member 9PharmGKBO60706PharosR-HSA-1296025ATP sensitive Potassium channelsReactomeR-HSA-382556ABC-family proteins mediated transportReactomeR-HSA-5578775Ion homeostasisReactomeR-HSA-5678420Defective ABCC9 causes CMD10, ATFB12 and Cantu syndromeReactomeO60706ATP-binding cassette sub-family C member 9UniProtO60707ATP-binding cassette sub-family C member 9UniProtSINGLE PROTEIN9606Homo sapienscGMP-specific 3',5'-cyclic phosphodiesteraseCHEMBL1827O76074cGMP-specific 3',5'-cyclic phosphodiesterase124PROTEINSINGLE PROTEIN3.1.4.35EC_NUMBERCGB-PDEUNIPROTcGMP-binding cGMP-specific phosphodiesteraseUNIPROTcGMP-specific 3',5'-cyclic phosphodiesteraseUNIPROTPDE5GENE_SYMBOL_OTHERPDE5AGENE_SYMBOLO76074AlphaFoldDBO76074ExpressionAtlasGO:0005829cytosolGoComponentGO:0004112cyclic-nucleotide phosphodiesterase activityGoFunctionGO:00041143',5'-cyclic-nucleotide phosphodiesterase activityGoFunctionGO:00041153',5'-cyclic-AMP phosphodiesterase activityGoFunctionGO:0004117calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016787hydrolase activityGoFunctionGO:0030553cGMP bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:00475553',5'-cyclic-GMP phosphodiesterase activityGoFunctionGO:0048101calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activityGoFunctionGO:0007165signal transductionGoProcessGO:0010613positive regulation of cardiac muscle hypertrophyGoProcessGO:0010749regulation of nitric oxide mediated signal transductionGoProcessGO:0019933cAMP-mediated signalingGoProcessGO:0042098T cell proliferationGoProcessGO:0042130negative regulation of T cell proliferationGoProcessGO:0046068cGMP metabolic processGoProcessGO:0046069cGMP catabolic processGoProcessGO:0048599oocyte developmentGoProcessGO:0055118negative regulation of cardiac muscle contractionGoProcessGO:0060282positive regulation of oocyte developmentGoProcessHGNC:8784PDE5AHGNCO76074IntActIPR002073PDEase_catalytic_domInterProIPR003018GAFInterProIPR003607HD/PDEase_domInterProIPR023088PDEaseInterProIPR023174PDEase_CSInterProIPR029016GAF-like_dom_sfInterProIPR036971PDEase_catalytic_dom_sfInterProPTHR11347CYCLIC NUCLEOTIDE 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_IPfamPF01590GAFPfamPA33132phosphodiesterase 5APharmGKBO76074PharosR-HSA-418457cGMP effectsReactomeR-HSA-445355Smooth Muscle ContractionReactomeR-HSA-9013422RHOBTB1 GTPase cycleReactomeA0AV69cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtA8K2C4cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtO75026cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtO75887cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtO76074cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtQ86UI0cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtQ86V66cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtQ9Y6Z6cGMP-specific 3',5'-cyclic phosphodiesteraseUniProtSINGLE PROTEIN9606Homo sapiensVoltage-dependent T-type calcium channel subunit alpha-1HCHEMBL1859O95180Voltage-dependent T-type calcium channel subunit alpha-1H167PROTEINSINGLE PROTEINCACNA1HGENE_SYMBOLLow-voltage-activated calcium channel alpha1 3.2 subunitUNIPROTVoltage-dependent T-type calcium channel subunit alpha-1HUNIPROTVoltage-gated calcium channel subunit alpha Cav3.2UNIPROTO95180AlphaFoldDBO95180ExpressionAtlasGO:0005886plasma membraneGoComponentGO:0005891voltage-gated calcium channel complexGoComponentGO:0016020membraneGoComponentGO:0034702monoatomic ion channel complexGoComponentGO:0005244voltage-gated monoatomic ion channel activityGoFunctionGO:0005245voltage-gated calcium channel activityGoFunctionGO:0005261monoatomic cation channel activityGoFunctionGO:0005262calcium channel activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008331high voltage-gated calcium channel activityGoFunctionGO:0008332low voltage-gated calcium channel activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046873metal ion transmembrane transporter activityGoFunctionGO:0097110scaffold protein bindingGoFunctionGO:0007517muscle organ developmentGoProcessGO:0007520myoblast fusionGoProcessGO:0008016regulation of heart contractionGoProcessGO:0032342aldosterone biosynthetic processGoProcessGO:0032870cellular response to hormone stimulusGoProcessGO:0034651cortisol biosynthetic processGoProcessGO:0035865cellular response to potassium ionGoProcessGO:0042391regulation of membrane potentialGoProcessGO:0070509calcium ion importGoProcessGO:0070588calcium ion transmembrane transportGoProcessGO:0098662inorganic cation transmembrane transportGoProcessGO:0098703calcium ion import across plasma membraneGoProcessGO:2000344positive regulation of acrosome reactionGoProcessHGNC:1395CACNA1HHGNCO95180IntActIPR005445VDCC_T_a1InterProIPR005821Ion_trans_domInterProIPR027359Volt_channel_dom_sfInterProIPR050599VDCC_alpha-1_subunitInterProPTHR45628VOLTAGE-DEPENDENT CALCIUM CHANNEL TYPE A SUBUNIT ALPHA-1PANTHERPTHR45628:SF37VOLTAGE-DEPENDENT T-TYPE CALCIUM CHANNEL SUBUNIT ALPHA-1HPANTHER9AYGPDB9AYHPDB9AYJPDB9AYKPDB9AYLPDBPF00520Ion_transPfamPA380calcium voltage-gated channel subunit alpha1 HPharmGKBO95180PharosR-HSA-419037NCAM1 interactionsReactomeR-HSA-445355Smooth Muscle ContractionReactomeR-HSA-9856532Mechanical load activates signaling by PIEZO1 and integrins in osteocytesReactomeB5ME00Voltage-dependent T-type calcium channel subunit alpha-1HUniProtF8WFD1Voltage-dependent T-type calcium channel subunit alpha-1HUniProtO95180Voltage-dependent T-type calcium channel subunit alpha-1HUniProtO95802Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ8WWI6Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ96QI6Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ96RZ9Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ9NYY4Voltage-dependent T-type calcium channel subunit alpha-1HUniProtQ9NYY5Voltage-dependent T-type calcium channel subunit alpha-1HUniProtSINGLE PROTEIN9606Ascaris suumNicotinic acetylcholine receptor alpha subunitCHEMBL1884O96760Nicotinic acetylcholine receptor alpha subunit198PROTEINSINGLE PROTEINNicotinic acetylcholine receptor alpha subunitUNIPROTO96760AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0045202synapseGoComponentGO:0045211postsynaptic membraneGoComponentGO:0004888transmembrane signaling receptor activityGoFunctionGO:0022848acetylcholine-gated monoatomic cation-selective channel activityGoFunctionGO:0007268chemical synaptic transmissionGoProcessGO:0034220monoatomic ion transmembrane transportGoProcessGO:0060078regulation of postsynaptic membrane potentialGoProcessGO:0060079excitatory postsynaptic potentialGoProcessIPR002394Nicotinic_acetylcholine_rcptInterProIPR006029Neurotrans-gated_channel_TMInterProIPR006201Neur_channelInterProIPR006202Neur_chan_lig-bdInterProIPR018000Neurotransmitter_ion_chnl_CSInterProIPR036719Neuro-gated_channel_TM_sfInterProIPR036734Neur_chan_lig-bd_sfInterProIPR038050Neuro_actylchol_recInterProPTHR18945NEUROTRANSMITTER GATED ION CHANNELPANTHERPF02931Neur_chan_LBDPfamPF02932Neur_chan_membPfamO96760UniProtSINGLE PROTEIN6253Homo sapiensDihydrofolate reductaseCHEMBL202P00374Dihydrofolate reductase396PROTEINSINGLE PROTEIN1.5.1.3EC_NUMBERDHFRGENE_SYMBOLDihydrofolate reductaseUNIPROTP00374AlphaFoldDBP00374ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005829cytosolGoComponentGO:0000900mRNA regulatory element binding translation repressor activityGoFunctionGO:0003723RNA bindingGoFunctionGO:0003729mRNA bindingGoFunctionGO:0004146dihydrofolate reductase activityGoFunctionGO:0005542folic acid bindingGoFunctionGO:0016491oxidoreductase activityGoFunctionGO:0050661NADP bindingGoFunctionGO:0070402NADPH bindingGoFunctionGO:1990825sequence-specific mRNA bindingGoFunctionGO:0006729tetrahydrobiopterin biosynthetic processGoProcessGO:0006730one-carbon metabolic processGoProcessGO:0017148negative regulation of translationGoProcessGO:0031103axon regenerationGoProcessGO:0046452dihydrofolate metabolic processGoProcessGO:0046653tetrahydrofolate metabolic processGoProcessGO:0046654tetrahydrofolate biosynthetic processGoProcessGO:0046655folic acid metabolic processGoProcessGO:0051000positive regulation of nitric-oxide synthase activityGoProcessGO:2000121regulation of removal of superoxide radicalsGoProcessHGNC:2861DHFRHGNCP00374IntActIPR001796DHFR_domInterProIPR012259DHFRInterProIPR017925DHFR_CSInterProIPR024072DHFR-like_dom_sfInterProPTHR48069DIHYDROFOLATE REDUCTASEPANTHERPTHR48069:SF6DIHYDROFOLATE 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_1PfamPA143dihydrofolate reductasePharmGKBP00374PharosR-HSA-1474151Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulationReactomeR-HSA-196757Metabolism of folate and pterinesReactomeR-HSA-69205G1/S-Specific TranscriptionReactomeB4DDD2Dihydrofolate reductaseUniProtP00374Dihydrofolate reductaseUniProtQ14130Dihydrofolate reductaseUniProtQ6IRW8Dihydrofolate reductaseUniProtSINGLE PROTEIN9606Escherichia coliDihydrofolate reductaseCHEMBL1809P0ABQ4Dihydrofolate reductase103PROTEINSINGLE PROTEIN1.5.1.3EC_NUMBERDihydrofolate reductaseUNIPROTfolAGENE_SYMBOLtmrA GENE_SYMBOL_OTHERP0ABQ4AlphaFoldDBGO:0005829cytosolGoComponentGO:0004146dihydrofolate reductase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0005542folic acid bindingGoFunctionGO:0016491oxidoreductase activityGoFunctionGO:0050661NADP bindingGoFunctionGO:0051870methotrexate bindingGoFunctionGO:0051871dihydrofolic acid bindingGoFunctionGO:0070401NADP+ bindingGoFunctionGO:0070402NADPH bindingGoFunctionGO:0006730one-carbon metabolic processGoProcessGO:000925710-formyltetrahydrofolate biosynthetic processGoProcessGO:0046452dihydrofolate metabolic processGoProcessGO:0046654tetrahydrofolate biosynthetic processGoProcessGO:0046655folic acid metabolic processGoProcessGO:0046656folic acid biosynthetic processGoProcessGO:0046677response to antibioticGoProcessP0ABQ4IntActIPR001796DHFR_domInterProIPR012259DHFRInterProIPR017925DHFR_CSInterProIPR024072DHFR-like_dom_sfInterProPTHR48069DIHYDROFOLATE REDUCTASEPANTHERPTHR48069:SF3DIHYDROFOLATE 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_1PfamP00379Dihydrofolate reductaseUniProtP0ABQ4Dihydrofolate reductaseUniProtSINGLE PROTEIN562Homo sapiensTyrosine-protein kinase ABL1CHEMBL1862P00519Tyrosine-protein kinase ABL1173PROTEINSINGLE PROTEIN2.7.10.2EC_NUMBERAbelson murine leukemia viral oncogene homolog 1UNIPROTAbelson tyrosine-protein kinase 1UNIPROTABLGENE_SYMBOL_OTHERABL1GENE_SYMBOLJTK7GENE_SYMBOL_OTHERp150UNIPROTProto-oncogene c-AblUNIPROTTyrosine-protein kinase ABL1UNIPROTP00519AlphaFoldDBP00519ExpressionAtlasGO:0001726ruffleGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005730nucleolusGoComponentGO:0005737cytoplasmGoComponentGO:0005739mitochondrionGoComponentGO:0005829cytosolGoComponentGO:0005856cytoskeletonGoComponentGO:0005886plasma membraneGoComponentGO:0014069postsynaptic densityGoComponentGO:0015629actin cytoskeletonGoComponentGO:0016020membraneGoComponentGO:0016604nuclear bodyGoComponentGO:0030425dendriteGoComponentGO:0030426growth coneGoComponentGO:0031252cell leading edgeGoComponentGO:0031965nuclear membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0043025neuronal cell bodyGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0098794postsynapseGoComponentGO:0098978glutamatergic synapseGoComponentGO:0000287magnesium ion bindingGoFunctionGO:0000400four-way junction DNA bindingGoFunctionGO:0000405bubble DNA bindingGoFunctionGO:0001784phosphotyrosine residue bindingGoFunctionGO:0003677DNA bindingGoFunctionGO:0003713transcription coactivator activityGoFunctionGO:0003785actin monomer bindingGoFunctionGO:0004515nicotinate-nucleotide adenylyltransferase activityGoFunctionGO:0005080protein kinase C bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0016301kinase activityGoFunctionGO:0017124SH3 domain bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0019905syntaxin bindingGoFunctionGO:0030145manganese ion bindingGoFunctionGO:0038191neuropilin bindingGoFunctionGO:0042169SH2 domain bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0046875ephrin receptor bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0051019mitogen-activated protein kinase bindingGoFunctionGO:0070064proline-rich region bindingGoFunctionGO:0070097delta-catenin bindingGoFunctionGO:0097100supercoiled DNA bindingGoFunctionGO:1990837sequence-specific double-stranded DNA bindingGoFunctionGO:0000278mitotic cell cycleGoProcessGO:0001843neural tube closureGoProcessGO:0001922B-1 B cell homeostasisGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0002322B cell proliferation involved in immune responseGoProcessGO:0002333transitional one stage B cell differentiationGoProcessGO:0006281DNA repairGoProcessGO:0006298mismatch repairGoProcessGO:0006897endocytosisGoProcessGO:0006909phagocytosisGoProcessGO:0006914autophagyGoProcessGO:0006915apoptotic processGoProcessGO:0006974DNA damage responseGoProcessGO:0006979response to oxidative stressGoProcessGO:0007155cell adhesionGoProcessGO:0007173epidermal growth factor receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0007229integrin-mediated signaling pathwayGoProcessGO:0007249canonical NF-kappaB signal transductionGoProcessGO:0007611learning or memoryGoProcessGO:0008306associative learningGoProcessGO:0008630intrinsic apoptotic signaling pathway in response to DNA damageGoProcessGO:0010595positive regulation of endothelial cell migrationGoProcessGO:0018108peptidyl-tyrosine phosphorylationGoProcessGO:0021587cerebellum morphogenesisGoProcessGO:0022408negative regulation of cell-cell adhesionGoProcessGO:0030035microspike assemblyGoProcessGO:0030036actin cytoskeleton organizationGoProcessGO:0030041actin filament polymerizationGoProcessGO:0030100regulation of endocytosisGoProcessGO:0030155regulation of cell adhesionGoProcessGO:0030182neuron differentiationGoProcessGO:0030509BMP signaling pathwayGoProcessGO:0030514negative regulation of BMP signaling pathwayGoProcessGO:0030516regulation of axon extensionGoProcessGO:0030845phospholipase C-inhibiting G protein-coupled receptor signaling pathwayGoProcessGO:0031113regulation of microtubule polymerizationGoProcessGO:0032489regulation of Cdc42 protein signal transductionGoProcessGO:0032729positive regulation of type II interferon productionGoProcessGO:0032743positive regulation of interleukin-2 productionGoProcessGO:0032956regulation of actin cytoskeleton organizationGoProcessGO:0033690positive regulation of osteoblast proliferationGoProcessGO:0034446substrate adhesion-dependent cell spreadingGoProcessGO:0034599cellular response to oxidative stressGoProcessGO:0034976response to endoplasmic reticulum stressGoProcessGO:0035791platelet-derived growth factor receptor-beta signaling pathwayGoProcessGO:0038083peptidyl-tyrosine autophosphorylationGoProcessGO:0038096Fc-gamma receptor signaling pathway involved in phagocytosisGoProcessGO:0038189neuropilin signaling pathwayGoProcessGO:0042100B cell proliferationGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0042770signal transduction in response to DNA damageGoProcessGO:0043065positive regulation of apoptotic processGoProcessGO:0043123positive regulation of canonical NF-kappaB signal transductionGoProcessGO:0043525positive regulation of neuron apoptotic processGoProcessGO:0043542endothelial cell migrationGoProcessGO:0045580regulation of T cell differentiationGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045930negative regulation of mitotic cell cycleGoProcessGO:0045931positive regulation of mitotic cell cycleGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046632alpha-beta T cell differentiationGoProcessGO:0046777protein autophosphorylationGoProcessGO:0048008platelet-derived growth factor receptor signaling pathwayGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0048536spleen developmentGoProcessGO:0048538thymus developmentGoProcessGO:0050731positive regulation of peptidyl-tyrosine phosphorylationGoProcessGO:0050798activated T cell proliferationGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0050853B cell receptor signaling pathwayGoProcessGO:0050885neuromuscular process controlling balanceGoProcessGO:0051128regulation of cellular component organizationGoProcessGO:0051281positive regulation of release of sequestered calcium ion into cytosolGoProcessGO:0051353positive regulation of oxidoreductase activityGoProcessGO:0051402neuron apoptotic processGoProcessGO:0051444negative regulation of ubiquitin-protein transferase activityGoProcessGO:0051450myoblast proliferationGoProcessGO:0051496positive regulation of stress fiber assemblyGoProcessGO:0051726regulation of cell cycleGoProcessGO:0051882mitochondrial depolarizationGoProcessGO:0051894positive regulation of focal adhesion assemblyGoProcessGO:0060020Bergmann glial cell differentiationGoProcessGO:0060038cardiac muscle cell proliferationGoProcessGO:0060563neuroepithelial cell differentiationGoProcessGO:0070301cellular response to hydrogen peroxideGoProcessGO:0070371ERK1 and ERK2 cascadeGoProcessGO:0070373negative regulation of ERK1 and ERK2 cascadeGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071103DNA conformation changeGoProcessGO:0071222cellular response to lipopolysaccharideGoProcessGO:0071901negative regulation of protein serine/threonine kinase activityGoProcessGO:0072359circulatory system developmentGoProcessGO:0090050positive regulation of cell migration involved in sprouting angiogenesisGoProcessGO:0090398cellular senescenceGoProcessGO:0098609cell-cell adhesionGoProcessGO:0099150regulation of postsynaptic specialization assemblyGoProcessGO:1900006positive regulation of dendrite developmentGoProcessGO:1900026positive regulation of substrate adhesion-dependent cell spreadingGoProcessGO:1900272negative regulation of long-term synaptic potentiationGoProcessGO:1902036regulation of hematopoietic stem cell differentiationGoProcessGO:1903053regulation of extracellular matrix organizationGoProcessGO:1903055positive regulation of extracellular matrix organizationGoProcessGO:1903210podocyte apoptotic processGoProcessGO:1903351cellular response to dopamineGoProcessGO:1903905positive regulation of establishment of T cell polarityGoProcessGO:1904157DN4 thymocyte differentiationGoProcessGO:1904518protein localization to cytoplasmic microtubule plus-endGoProcessGO:1905244regulation of modification of synaptic structureGoProcessGO:1905555positive regulation of blood vessel branchingGoProcessGO:1990051activation of protein kinase C activityGoProcessGO:2000042negative regulation of double-strand break repair via homologous recombinationGoProcessGO:2000096positive regulation of Wnt signaling pathway, planar cell polarity pathwayGoProcessGO:2000145regulation of cell motilityGoProcessGO:2000352negative regulation of endothelial cell apoptotic processGoProcessGO:2000406positive regulation of T cell migrationGoProcessGO:2000773negative regulation of cellular senescenceGoProcessHGNC:76ABL1HGNCP00519IntActIPR000719Prot_kinase_domInterProIPR000980SH2InterProIPR001245Ser-Thr/Tyr_kinase_cat_domInterProIPR001452SH3_domainInterProIPR008266Tyr_kinase_ASInterProIPR011009Kinase-like_dom_sfInterProIPR015015F-actin-bindingInterProIPR017441Protein_kinase_ATP_BSInterProIPR020635Tyr_kinase_cat_domInterProIPR035837ABL_SH2InterProIPR036028SH3-like_dom_sfInterProIPR036860SH2_dom_sfInterProIPR050198Non-receptor_tyrosine_kinasesInterProPTHR24418TYROSINE-PROTEIN 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_1PfamPF07714PK_Tyr_Ser-ThrPfamPF08919F_actin_bindPfamPA24413ABL proto-oncogene 1, non-receptor tyrosine kinasePharmGKBP00519PharosR-HSA-2029482Regulation of actin dynamics for phagocytic cup formationReactomeR-HSA-428890Role of ABL in ROBO-SLIT signalingReactomeR-HSA-525793MyogenesisReactomeR-HSA-5663213RHO GTPases Activate WASPs and WAVEsReactomeR-HSA-5685938HDR through Single Strand Annealing (SSA)ReactomeR-HSA-5693565Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaksReactomeR-HSA-69231Cyclin D associated events in G1ReactomeR-HSA-8939236RUNX1 regulates transcription of genes involved in differentiation of HSCsReactomeR-HSA-8940973RUNX2 regulates osteoblast differentiationReactomeR-HSA-9664422FCGR3A-mediated phagocytosisReactomeR-HSA-983231Factors involved in megakaryocyte development and platelet productionReactomeR-HSA-9841922MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosisReactomeR-HSA-9860927Turbulent (oscillatory, disturbed) flow shear stress activates signaling by PIEZO1 and integrins in endothelial cellsReactomeA3KFJ3Tyrosine-protein kinase ABL1UniProtP00519Tyrosine-protein kinase ABL1UniProtQ13869Tyrosine-protein kinase ABL1UniProtQ13870Tyrosine-protein kinase ABL1UniProtQ16133Tyrosine-protein kinase ABL1UniProtQ17R61Tyrosine-protein kinase ABL1UniProtQ45F09Tyrosine-protein kinase ABL1UniProtSINGLE PROTEIN9606Homo sapiensEpidermal growth factor receptorCHEMBL203P00533Epidermal growth factor receptor147PROTEINSINGLE PROTEIN2.7.10.1EC_NUMBEREGFRGENE_SYMBOLEpidermal growth factor receptorUNIPROTERBBGENE_SYMBOL_OTHERERBB1GENE_SYMBOL_OTHERHER1GENE_SYMBOL_OTHERProto-oncogene c-ErbB-1UNIPROTReceptor tyrosine-protein kinase erbB-1UNIPROTP00533AlphaFoldDBP00533ExpressionAtlasGO:0000139Golgi membraneGoComponentGO:0005576extracellular regionGoComponentGO:0005615extracellular spaceGoComponentGO:0005634nucleusGoComponentGO:0005737cytoplasmGoComponentGO:0005768endosomeGoComponentGO:0005783endoplasmic reticulumGoComponentGO:0005789endoplasmic reticulum membraneGoComponentGO:0005794Golgi apparatusGoComponentGO:0005886plasma membraneGoComponentGO:0005925focal adhesionGoComponentGO:0009925basal plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0010008endosome membraneGoComponentGO:0016020membraneGoComponentGO:0016323basolateral plasma membraneGoComponentGO:0016324apical plasma membraneGoComponentGO:0030054cell junctionGoComponentGO:0030669clathrin-coated endocytic vesicle membraneGoComponentGO:0031901early endosome membraneGoComponentGO:0031965nuclear membraneGoComponentGO:0032587ruffle membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0043235receptor complexGoComponentGO:0045121membrane raftGoComponentGO:0048471perinuclear region of cytoplasmGoComponentGO:0070435Shc-EGFR complexGoComponentGO:0097060synaptic membraneGoComponentGO:0097489multivesicular body, internal vesicle lumenGoComponentGO:0098978glutamatergic synapseGoComponentGO:0001618virus receptor activityGoFunctionGO:0003682chromatin bindingGoFunctionGO:0003690double-stranded DNA bindingGoFunctionGO:0004714transmembrane receptor protein tyrosine kinase activityGoFunctionGO:0004888transmembrane signaling receptor activityGoFunctionGO:0005004GPI-linked ephrin receptor activityGoFunctionGO:0005005transmembrane-ephrin receptor activityGoFunctionGO:0005006epidermal growth factor receptor activityGoFunctionGO:0005007fibroblast growth factor receptor activityGoFunctionGO:0005008hepatocyte growth factor receptor activityGoFunctionGO:0005009insulin receptor activityGoFunctionGO:0005010insulin-like growth factor receptor activityGoFunctionGO:0005011macrophage colony-stimulating factor receptor activityGoFunctionGO:0005018platelet-derived growth factor alpha-receptor activityGoFunctionGO:0005019platelet-derived growth factor beta-receptor activityGoFunctionGO:0005020stem cell factor receptor activityGoFunctionGO:0005021vascular endothelial growth factor receptor activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005178integrin bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0005524ATP bindingGoFunctionGO:0008288boss receptor activityGoFunctionGO:0016301kinase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019900kinase bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0019903protein phosphatase bindingGoFunctionGO:0031625ubiquitin protein ligase bindingGoFunctionGO:0036332placental growth factor receptor activityGoFunctionGO:0038062protein tyrosine kinase collagen receptor activityGoFunctionGO:0042802identical protein bindingGoFunctionGO:0045296cadherin bindingGoFunctionGO:0048408epidermal growth factor bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0051117ATPase bindingGoFunctionGO:0060175brain-derived neurotrophic factor receptor activityGoFunctionGO:0000165MAPK cascadeGoProcessGO:0000902cell morphogenesisGoProcessGO:0001503ossificationGoProcessGO:0001889liver developmentGoProcessGO:0001892embryonic placenta developmentGoProcessGO:0001934positive regulation of protein phosphorylationGoProcessGO:0001942hair follicle developmentGoProcessGO:0006412translationGoProcessGO:0006979response to oxidative stressGoProcessGO:0007165signal transductionGoProcessGO:0007166cell surface receptor signaling pathwayGoProcessGO:0007169cell surface receptor protein tyrosine kinase signaling pathwayGoProcessGO:0007173epidermal growth factor receptor signaling pathwayGoProcessGO:0007435salivary gland morphogenesisGoProcessGO:0007494midgut developmentGoProcessGO:0007611learning or memoryGoProcessGO:0007623circadian rhythmGoProcessGO:0008283cell population proliferationGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0008286insulin receptor signaling pathwayGoProcessGO:0008543fibroblast growth factor receptor signaling pathwayGoProcessGO:0008544epidermis developmentGoProcessGO:0010646regulation of cell communicationGoProcessGO:0016101diterpenoid metabolic processGoProcessGO:0018108peptidyl-tyrosine phosphorylationGoProcessGO:0021795cerebral cortex cell migrationGoProcessGO:0022008neurogenesisGoProcessGO:0023051regulation of signalingGoProcessGO:0030307positive regulation of cell growthGoProcessGO:0030324lung developmentGoProcessGO:0030335positive regulation of cell migrationGoProcessGO:0031547brain-derived neurotrophic factor receptor signaling pathwayGoProcessGO:0032930positive regulation of superoxide anion generationGoProcessGO:0033138positive regulation of peptidyl-serine phosphorylationGoProcessGO:0035556intracellular signal transductionGoProcessGO:0035790platelet-derived growth factor receptor-alpha signaling pathwayGoProcessGO:0035791platelet-derived growth factor receptor-beta signaling pathwayGoProcessGO:0036323vascular endothelial growth factor receptor-1 signaling pathwayGoProcessGO:0038063collagen-activated tyrosine kinase receptor signaling pathwayGoProcessGO:0038083peptidyl-tyrosine autophosphorylationGoProcessGO:0038084vascular endothelial growth factor signaling pathwayGoProcessGO:0038109Kit signaling pathwayGoProcessGO:0038127ERBB signaling pathwayGoProcessGO:0038134ERBB2-EGFR signaling pathwayGoProcessGO:0038145macrophage colony-stimulating factor signaling pathwayGoProcessGO:0042059negative regulation of epidermal growth factor receptor signaling pathwayGoProcessGO:0042127regulation of cell population proliferationGoProcessGO:0042177negative regulation of protein catabolic processGoProcessGO:0042311vasodilationGoProcessGO:0042327positive regulation of phosphorylationGoProcessGO:0042698ovulation cycleGoProcessGO:0042743hydrogen peroxide metabolic processGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043410positive regulation of MAPK cascadeGoProcessGO:0043586tongue developmentGoProcessGO:0045737positive regulation of cyclin-dependent protein serine/threonine kinase activityGoProcessGO:0045739positive regulation of DNA repairGoProcessGO:0045740positive regulation of DNA replicationGoProcessGO:0045780positive regulation of bone resorptionGoProcessGO:0045907positive regulation of vasoconstrictionGoProcessGO:0045930negative regulation of mitotic cell cycleGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0046718symbiont entry into host cellGoProcessGO:0048009insulin-like growth factor receptor signaling pathwayGoProcessGO:0048012hepatocyte growth factor receptor signaling pathwayGoProcessGO:0048013ephrin receptor signaling pathwayGoProcessGO:0048143astrocyte activationGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0048546digestive tract morphogenesisGoProcessGO:0048661positive regulation of smooth muscle cell proliferationGoProcessGO:0048812neuron projection morphogenesisGoProcessGO:0050673epithelial cell proliferationGoProcessGO:0050679positive regulation of epithelial cell proliferationGoProcessGO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionGoProcessGO:0051968positive regulation of synaptic transmission, glutamatergicGoProcessGO:0060252positive regulation of glial cell proliferationGoProcessGO:0060571morphogenesis of an epithelial foldGoProcessGO:0061029eyelid development in camera-type eyeGoProcessGO:0070257positive regulation of mucus secretionGoProcessGO:0070374positive regulation of ERK1 and ERK2 cascadeGoProcessGO:0071230cellular response to amino acid stimulusGoProcessGO:0071260cellular response to mechanical stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:0071466cellular response to xenobiotic stimulusGoProcessGO:0071549cellular response to dexamethasone stimulusGoProcessGO:0090263positive regulation of canonical Wnt signaling pathwayGoProcessGO:0097421liver regenerationGoProcessGO:0098609cell-cell adhesionGoProcessGO:1900020positive regulation of protein kinase C activityGoProcessGO:1900087positive regulation of G1/S transition of mitotic cell cycleGoProcessGO:1902722positive regulation of prolactin secretionGoProcessGO:1902895positive regulation of miRNA transcriptionGoProcessGO:1903078positive regulation of protein localization to plasma membraneGoProcessGO:1905208negative regulation of cardiocyte differentiationGoProcessHGNC:3236EGFRHGNCP00533IntActIPR000494Rcpt_L-domInterProIPR000719Prot_kinase_domInterProIPR001245Ser-Thr/Tyr_kinase_cat_domInterProIPR006211Furin-like_Cys-rich_domInterProIPR006212Furin_repeatInterProIPR008266Tyr_kinase_ASInterProIPR009030Growth_fac_rcpt_cys_sfInterProIPR011009Kinase-like_dom_sfInterProIPR016245Tyr_kinase_EGF/ERB/XmrK_rcptInterProIPR017441Protein_kinase_ATP_BSInterProIPR020635Tyr_kinase_cat_domInterProIPR032778GF_recep_IVInterProIPR036941Rcpt_L-dom_sfInterProIPR049328TM_ErbB1InterProIPR050122RTKInterProPTHR24416TYROSINE-PROTEIN KINASE RECEPTORPANTHERPTHR24416:SF91EPIDERMAL GROWTH FACTOR 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-likePfamPF01030Recep_L_domainPfamPF07714PK_Tyr_Ser-ThrPfamPF14843GF_recep_IVPfamPF21314TM_ErbB1PfamPA7360epidermal growth factor receptorPharmGKBP00533PharosR-HSA-1227986Signaling by ERBB2ReactomeR-HSA-1236382Constitutive Signaling by Ligand-Responsive EGFR Cancer VariantsReactomeR-HSA-1236394Signaling by ERBB4ReactomeR-HSA-1250196SHC1 events in ERBB2 signalingReactomeR-HSA-1251932PLCG1 events in ERBB2 signalingReactomeR-HSA-1257604PIP3 activates AKT signalingReactomeR-HSA-177929Signaling by EGFRReactomeR-HSA-179812GRB2 events in EGFR signalingReactomeR-HSA-180292GAB1 signalosomeReactomeR-HSA-180336SHC1 events in EGFR signalingReactomeR-HSA-182971EGFR downregulationReactomeR-HSA-1963640GRB2 events in ERBB2 signalingReactomeR-HSA-1963642PI3K events in ERBB2 signalingReactomeR-HSA-212718EGFR interacts with phospholipase C-gammaReactomeR-HSA-2179392EGFR Transactivation by GastrinReactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerReactomeR-HSA-445144Signal transduction by L1ReactomeR-HSA-5637810Constitutive Signaling by EGFRvIIIReactomeR-HSA-5638303Inhibition of Signaling by Overexpressed EGFRReactomeR-HSA-5673001RAF/MAP kinase cascadeReactomeR-HSA-6785631ERBB2 Regulates Cell MotilityReactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingReactomeR-HSA-8847993ERBB2 Activates PTK6 SignalingReactomeR-HSA-8856825Cargo recognition for clathrin-mediated endocytosisReactomeR-HSA-8856828Clathrin-mediated endocytosisReactomeR-HSA-8857538PTK6 promotes HIF1A stabilizationReactomeR-HSA-8863795Downregulation of ERBB2 signalingReactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsReactomeR-HSA-9009391Extra-nuclear estrogen signalingReactomeR-HSA-9013507NOTCH3 Activation and Transmission of Signal to the NucleusReactomeR-HSA-9609690HCMV Early EventsReactomeR-HSA-9634638Estrogen-dependent nuclear events downstream of ESR-membrane signalingReactomeR-HSA-9664565Signaling by ERBB2 KD MutantsReactomeR-HSA-9665348Signaling by ERBB2 ECD mutantsReactomeR-HSA-9665686Signaling by ERBB2 TMD/JMD mutantsReactomeR-HSA-9820960Respiratory syncytial virus (RSV) attachment and entryReactomeO00688Epidermal growth factor receptorUniProtO00732Epidermal growth factor receptorUniProtP00533Epidermal growth factor receptorUniProtP06268Epidermal growth factor receptorUniProtQ14225Epidermal growth factor receptorUniProtQ68GS5Epidermal growth factor receptorUniProtQ92795Epidermal growth factor receptorUniProtQ9BZS2Epidermal growth factor receptorUniProtQ9GZX1Epidermal growth factor receptorUniProtQ9H2C9Epidermal growth factor receptorUniProtQ9H3C9Epidermal growth factor receptorUniProtQ9UMD7Epidermal growth factor receptorUniProtQ9UMD8Epidermal growth factor receptorUniProtQ9UMG5Epidermal growth factor receptorUniProtSINGLE PROTEIN9606Escherichia coli K-12DNA-directed RNA polymerase subunit betaCHEMBL1852P0A8V2DNA-directed RNA polymerase subunit beta158PROTEINSINGLE PROTEIN2.7.7.6EC_NUMBERDNA-directed RNA polymerase subunit betaUNIPROTgroNGENE_SYMBOL_OTHERnitBGENE_SYMBOL_OTHERrifGENE_SYMBOL_OTHERRNA polymerase subunit betaUNIPROTRNAP subunit betaUNIPROTronGENE_SYMBOL_OTHERrpoBGENE_SYMBOLstlGENE_SYMBOL_OTHERstvGENE_SYMBOL_OTHERtabDGENE_SYMBOL_OTHERTranscriptase subunit betaUNIPROTP0A8V2AlphaFoldDBGO:0000345cytosolic DNA-directed RNA polymerase complexGoComponentGO:0000428DNA-directed RNA polymerase complexGoComponentGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0008023transcription elongation factor complexGoComponentGO:0016020membraneGoComponentGO:0001054RNA polymerase I activityGoFunctionGO:0001055RNA polymerase II activityGoFunctionGO:0001056RNA polymerase III activityGoFunctionGO:0001057RNA polymerase IV activityGoFunctionGO:0001058RNA polymerase V activityGoFunctionGO:0001066plastid single subunit type RNA polymerase activityGoFunctionGO:0003677DNA bindingGoFunctionGO:0003899DNA-directed 5'-3' RNA polymerase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0016779nucleotidyltransferase activityGoFunctionGO:00340625'-3' RNA polymerase activityGoFunctionGO:0006879intracellular iron ion homeostasisGoProcessGO:0009408response to heatGoProcessGO:0031564transcription antiterminationGoProcessGO:0036460cellular response to cell envelope stressGoProcessGO:0042128nitrate assimilationGoProcessGO:0044780bacterial-type flagellum assemblyGoProcessGO:0046677response to antibioticGoProcessGO:0048870cell motilityGoProcessGO:0071973bacterial-type flagellum-dependent cell motilityGoProcessGO:0090605submerged biofilm formationGoProcessP0A8V2IntActIPR007120DNA-dir_RNAP_su2_domInterProIPR007121RNA_pol_bsu_CSInterProIPR007641RNA_pol_Rpb2_7InterProIPR007642RNA_pol_Rpb2_2InterProIPR007644RNA_pol_bsu_protrusionInterProIPR007645RNA_pol_Rpb2_3InterProIPR010243RNA_pol_bsu_bacInterProIPR014724RNA_pol_RPB2_OB-foldInterProIPR015712DNA-dir_RNA_pol_su2InterProIPR019462DNA-dir_RNA_pol_bsu_external_1InterProIPR037033DNA-dir_RNAP_su2_hyb_sfInterProIPR037034RNA_pol_Rpb2_2_sfInterProIPR042107DNA-dir_RNA_pol_bsu_ext_1_sfInterProPTHR20856DNA-DIRECTED RNA POLYMERASE I SUBUNIT 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_pol_Rpb2_6PfamPF04560RNA_pol_Rpb2_7PfamPF04561RNA_pol_Rpb2_2PfamPF04563RNA_pol_Rpb2_1PfamPF04565RNA_pol_Rpb2_3PfamPF10385RNA_pol_Rpb2_45PfamP00575DNA-directed RNA polymerase subunit betaUniProtP00576DNA-directed RNA polymerase subunit betaUniProtP0A8V2DNA-directed RNA polymerase subunit betaUniProtP78242DNA-directed RNA polymerase subunit betaUniProtQ2M8S3DNA-directed RNA polymerase subunit betaUniProtSINGLE PROTEIN83333Homo sapiensProthrombinCHEMBL204P00734Prothrombin92PROTEINSINGLE PROTEIN3.4.21.5EC_NUMBERActivation peptide fragment 1UNIPROTActivation peptide fragment 2UNIPROTCoagulation factor IIUNIPROTF2GENE_SYMBOLProthrombinUNIPROTThrombin heavy chainUNIPROTThrombin light chainUNIPROTP00734AlphaFoldDBP00734ExpressionAtlasGO:0005576extracellular regionGoComponentGO:0005615extracellular spaceGoComponentGO:0005788endoplasmic reticulum lumenGoComponentGO:0005796Golgi lumenGoComponentGO:0005886plasma membraneGoComponentGO:0009897external side of plasma membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0072562blood microparticleGoComponentGO:0001530lipopolysaccharide bindingGoFunctionGO:0004175endopeptidase activityGoFunctionGO:0004252serine-type endopeptidase activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005509calcium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0008083growth factor activityGoFunctionGO:0008201heparin bindingGoFunctionGO:0008233peptidase activityGoFunctionGO:0008236serine-type peptidase activityGoFunctionGO:0048018receptor ligand activityGoFunctionGO:0070053thrombospondin receptor activityGoFunctionGO:0001934positive regulation of protein phosphorylationGoProcessGO:0006508proteolysisGoProcessGO:0007166cell surface receptor signaling pathwayGoProcessGO:0007186G protein-coupled receptor signaling pathwayGoProcessGO:0007596blood coagulationGoProcessGO:0008284positive regulation of cell population proliferationGoProcessGO:0008360regulation of cell shapeGoProcessGO:0009611response to woundingGoProcessGO:0010544negative regulation of platelet activationGoProcessGO:0030168platelet activationGoProcessGO:0030193regulation of blood coagulationGoProcessGO:0030194positive regulation of blood coagulationGoProcessGO:0030195negative regulation of blood coagulationGoProcessGO:0030307positive regulation of cell growthGoProcessGO:0032024positive regulation of insulin secretionGoProcessGO:0032967positive regulation of collagen biosynthetic processGoProcessGO:0042730fibrinolysisGoProcessGO:0045861negative regulation of proteolysisGoProcessGO:0046427positive regulation of receptor signaling pathway via JAK-STATGoProcessGO:0048712negative regulation of astrocyte differentiationGoProcessGO:0051281positive regulation of release of sequestered calcium ion into cytosolGoProcessGO:0051480regulation of cytosolic calcium ion concentrationGoProcessGO:0051838cytolysis by host of symbiont cellsGoProcessGO:0051897positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transductionGoProcessGO:0051918negative regulation of fibrinolysisGoProcessGO:0061844antimicrobial humoral immune response mediated by antimicrobial peptideGoProcessGO:0070493thrombin-activated receptor signaling pathwayGoProcessGO:0070945neutrophil-mediated killing of gram-negative bacteriumGoProcessGO:1900016negative regulation of cytokine production involved in inflammatory responseGoProcessGO:1900182positive regulation of protein localization to nucleusGoProcessGO:1900738positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:1990806ligand-gated ion channel signaling pathwayGoProcessGO:2000379positive regulation of reactive oxygen species metabolic processGoProcessHGNC:3535F2HGNCP00734IntActIPR000001KringleInterProIPR000294GLA_domainInterProIPR001254Trypsin_domInterProIPR001314Peptidase_S1AInterProIPR003966Prothrombin/thrombinInterProIPR009003Peptidase_S1_PAInterProIPR013806Kringle-likeInterProIPR018056Kringle_CSInterProIPR018114TRYPSIN_HISInterProIPR018992Thrombin_light_chainInterProIPR033116TRYPSIN_SERInterProIPR035972GLA-like_dom_SFInterProIPR037111Thrombin_light_chain_sfInterProIPR038178Kringle_sfInterProIPR043504Peptidase_S1_PA_chymotrypsinInterProIPR051659Serine_Protease_S1-DomainInterProPTHR24254PROTHROMBINPANTHERPTHR24254: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_lightPfamPA157coagulation factor II, thrombinPharmGKBP00734PharosR-HSA-140837Intrinsic Pathway of Fibrin Clot FormationReactomeR-HSA-140875Common Pathway of Fibrin Clot FormationReactomeR-HSA-159740Gamma-carboxylation of protein precursorsReactomeR-HSA-159763Transport of gamma-carboxylated protein precursors from the endoplasmic reticulum to the Golgi apparatusReactomeR-HSA-159782Removal of aminoterminal propeptides from gamma-carboxylated proteinsReactomeR-HSA-202733Cell surface interactions at the vascular wallReactomeR-HSA-375276Peptide ligand-binding receptorsReactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)ReactomeR-HSA-416476G alpha (q) signalling eventsReactomeR-HSA-456926Thrombin signalling through proteinase activated receptors (PARs)ReactomeR-HSA-76009Platelet Aggregation (Plug Formation)ReactomeR-HSA-9657688Defective factor XII causes hereditary angioedemaReactomeR-HSA-9672391Defective F8 cleavage by thrombinReactomeR-HSA-977606Regulation of Complement cascadeReactomeB2R7F7ProthrombinUniProtB4E1A7ProthrombinUniProtP00734ProthrombinUniProtQ4QZ40ProthrombinUniProtQ53H04ProthrombinUniProtQ53H06ProthrombinUniProtQ69EZ7ProthrombinUniProtQ7Z7P3ProthrombinUniProtQ9UCA1ProthrombinUniProtSINGLE PROTEIN9606Homo sapiensPlasminogenCHEMBL1801P00747Plasminogen93PROTEINSINGLE PROTEIN3.4.21.7EC_NUMBERActivation peptideUNIPROTAngiostatinUNIPROTPlasmin heavy chain AUNIPROTPlasmin heavy chain A, short formUNIPROTPlasmin light chain BUNIPROTPlasminogenUNIPROTPLGGENE_SYMBOLP00747AlphaFoldDBP00747ExpressionAtlasGO:0005576extracellular regionGoComponentGO:0005615extracellular spaceGoComponentGO:0005886plasma membraneGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0031093platelet alpha granule lumenGoComponentGO:0070062extracellular exosomeGoComponentGO:0072562blood microparticleGoComponentGO:0002020protease bindingGoFunctionGO:0004175endopeptidase activityGoFunctionGO:0004252serine-type endopeptidase activityGoFunctionGO:0005102signaling receptor bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0008236serine-type peptidase activityGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019900kinase bindingGoFunctionGO:0019904protein domain specific bindingGoFunctionGO:0034185apolipoprotein bindingGoFunctionGO:0051087protein-folding chaperone bindingGoFunctionGO:1990405protein antigen bindingGoFunctionGO:0006508proteolysisGoProcessGO:0007596blood coagulationGoProcessGO:0008285negative regulation of cell population proliferationGoProcessGO:0010812negative regulation of cell-substrate adhesionGoProcessGO:0022617extracellular matrix disassemblyGoProcessGO:0042730fibrinolysisGoProcessGO:0043536positive regulation of blood vessel endothelial cell migrationGoProcessGO:0048771tissue remodelingGoProcessGO:0051702biological process involved in interaction with symbiontGoProcessGO:0051918negative regulation of fibrinolysisGoProcessGO:0051919positive regulation of fibrinolysisGoProcessGO:2000048negative regulation of cell-cell adhesion mediated by cadherinGoProcessHGNC:9071PLGHGNCP00747IntActIPR000001KringleInterProIPR001254Trypsin_domInterProIPR001314Peptidase_S1AInterProIPR003609Pan_appInterProIPR009003Peptidase_S1_PAInterProIPR013806Kringle-likeInterProIPR018056Kringle_CSInterProIPR018114TRYPSIN_HISInterProIPR023317Pept_S1A_plasminInterProIPR033116TRYPSIN_SERInterProIPR038178Kringle_sfInterProIPR043504Peptidase_S1_PA_chymotrypsinInterProIPR050759Serine_protease_kringleInterProPTHR24261PLASMINOGEN-RELATEDPANTHERPTHR24261:SF2LIPOPROTEIN(A)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_1PfamPF00051KringlePfamPF00089TrypsinPfamPA33405plasminogenPharmGKBP00747PharosR-HSA-114608Platelet degranulationReactomeR-HSA-1474228Degradation of the extracellular matrixReactomeR-HSA-1592389Activation of Matrix MetalloproteinasesReactomeR-HSA-186797Signaling by PDGFReactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)ReactomeR-HSA-75205Dissolution of Fibrin ClotReactomeP00747PlasminogenUniProtQ15146PlasminogenUniProtQ5TEH4PlasminogenUniProtQ6PA00PlasminogenUniProtSINGLE PROTEIN9606Escherichia coliBeta-lactamase TEMCHEMBL2065P62593Beta-lactamase TEM405PROTEINSINGLE PROTEIN3.5.2.6EC_NUMBERBeta-lactamase TEMUNIPROTblaGENE_SYMBOLblaT-3GENE_SYMBOLblaT-4GENE_SYMBOLblaT-5GENE_SYMBOLblaT-6GENE_SYMBOLIRT-4UNIPROTPenicillinaseUNIPROTTEM-1UNIPROTTEM-16/CAZ-7UNIPROTTEM-2UNIPROTTEM-24/CAZ-6UNIPROTTEM-3UNIPROTTEM-4UNIPROTTEM-5UNIPROTTEM-6UNIPROTTEM-8/CAZ-2UNIPROTP62593AlphaFoldDBGO:0005515protein bindingGoFunctionGO:0008800beta-lactamase activityGoFunctionGO:0016787hydrolase activityGoFunctionGO:0030655beta-lactam antibiotic catabolic processGoProcessGO:0046677response to antibioticGoProcessP62593IntActIPR000871Beta-lactam_class-AInterProIPR012338Beta-lactam/transpept-likeInterProIPR023650Beta-lactam_class-A_ASInterProIPR045155Beta-lactam_catInterProPTHR35333BETA-LACTAMASEPANTHERPTHR35333:SF3BETA-LACTAMASE-TYPE TRANSPEPTIDASE FOLD CONTAINING 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-lactamase2PfamP00810Beta-lactamase TEMUniProtP62593Beta-lactamase TEMUniProtQ47313Beta-lactamase TEMUniProtSINGLE PROTEIN562Homo sapiensAdenosine deaminaseCHEMBL1910P00813Adenosine deaminase223PROTEINSINGLE PROTEIN3.5.4.4EC_NUMBERADAGENE_SYMBOLADA1GENE_SYMBOL_OTHERAdenosine aminohydrolaseUNIPROTAdenosine deaminaseUNIPROTP00813AlphaFoldDBP00813ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005764lysosomeGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0009897external side of plasma membraneGoComponentGO:0009986cell surfaceGoComponentGO:0016020membraneGoComponentGO:0060205cytoplasmic vesicle lumenGoComponentGO:0070161anchoring junctionGoComponentGO:0004000adenosine deaminase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008270zinc ion bindingGoFunctionGO:0016787hydrolase activityGoFunctionGO:0019239deaminase activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:00469362'-deoxyadenosine deaminase activityGoFunctionGO:0000255allantoin metabolic processGoProcessGO:0001666response to hypoxiaGoProcessGO:0001701in utero embryonic developmentGoProcessGO:0001829trophectodermal cell differentiationGoProcessGO:0001889liver developmentGoProcessGO:0001890placenta developmentGoProcessGO:0002314germinal center B cell differentiationGoProcessGO:0002467germinal center formationGoProcessGO:0002636positive regulation of germinal center formationGoProcessGO:0002686negative regulation of leukocyte migrationGoProcessGO:0002901mature B cell apoptotic processGoProcessGO:0002906negative regulation of mature B cell apoptotic processGoProcessGO:0006154adenosine catabolic processGoProcessGO:0006157deoxyadenosine catabolic processGoProcessGO:0006196AMP catabolic processGoProcessGO:0006805xenobiotic metabolic processGoProcessGO:0006915apoptotic processGoProcessGO:0007155cell adhesionGoProcessGO:0009117nucleotide metabolic processGoProcessGO:0009168purine ribonucleoside monophosphate biosynthetic processGoProcessGO:0010460positive regulation of heart rateGoProcessGO:0019722calcium-mediated signalingGoProcessGO:0030217T cell differentiationGoProcessGO:0030324lung developmentGoProcessGO:0030890positive regulation of B cell proliferationGoProcessGO:0032261purine nucleotide salvageGoProcessGO:0032263GMP salvageGoProcessGO:0033077T cell differentiation in thymusGoProcessGO:0033089positive regulation of T cell differentiation in thymusGoProcessGO:0033632regulation of cell-cell adhesion mediated by integrinGoProcessGO:0042100B cell proliferationGoProcessGO:0042110T cell activationGoProcessGO:0043066negative regulation of apoptotic processGoProcessGO:0043084penile erectionGoProcessGO:0043101purine-containing compound salvageGoProcessGO:0043103hypoxanthine salvageGoProcessGO:0043605amide catabolic processGoProcessGO:0044209AMP salvageGoProcessGO:0045580regulation of T cell differentiationGoProcessGO:0045582positive regulation of T cell differentiationGoProcessGO:0045987positive regulation of smooth muscle contractionGoProcessGO:0046059dAMP catabolic processGoProcessGO:0046061dATP catabolic processGoProcessGO:0046085adenosine metabolic processGoProcessGO:0046101hypoxanthine biosynthetic processGoProcessGO:0046103inosine biosynthetic processGoProcessGO:0046111xanthine biosynthetic processGoProcessGO:0046632alpha-beta T cell differentiationGoProcessGO:0046638positive regulation of alpha-beta T cell differentiationGoProcessGO:0048286lung alveolus developmentGoProcessGO:0048541Peyer's patch developmentGoProcessGO:0048566embryonic digestive tract developmentGoProcessGO:0050728negative regulation of inflammatory responseGoProcessGO:0050850positive regulation of calcium-mediated signalingGoProcessGO:0050852T cell receptor signaling pathwayGoProcessGO:0050862positive regulation of T cell receptor signaling pathwayGoProcessGO:0050870positive regulation of T cell activationGoProcessGO:0050900leukocyte migrationGoProcessGO:0060169negative regulation of adenosine receptor signaling pathwayGoProcessGO:0060407negative regulation of penile erectionGoProcessGO:0070242thymocyte apoptotic processGoProcessGO:0070244negative regulation of thymocyte apoptotic processGoProcessGO:0070254mucus secretionGoProcessGO:0070256negative regulation of mucus secretionGoProcessHGNC:186ADAHGNCP00813IntActIPR001365A_deaminase_domInterProIPR006330Ado/ade_deaminaseInterProIPR006650A/AMP_deam_ASInterProIPR028893A_deaminaseInterProIPR032466Metal_HydrolaseInterProPTHR11409ADENOSINE DEAMINASEPANTHERPTHR11409:SF43ADENOSINE DEAMINASEPANTHER3IARPDB7RTGPDB3IARAPDBe7RTGAPDBePF00962A_deaminasePfamPA24503adenosine deaminasePharmGKBP00813PharosR-HSA-74217Purine salvageReactomeR-HSA-9734735Defective ADA disrupts (deoxy)adenosine deaminationReactomeR-HSA-9755088Ribavirin ADMEReactomeP00813Adenosine deaminaseUniProtQ53F92Adenosine deaminaseUniProtQ6LA59Adenosine deaminaseUniProtSINGLE PROTEIN9606Homo sapiensCarbonic anhydrase 2CHEMBL205P00918Carbonic anhydrase 294PROTEINSINGLE PROTEIN4.2.1.1EC_NUMBER4.2.1.69EC_NUMBERCA2GENE_SYMBOLCACUNIPROTCA-IIUNIPROTCarbonate dehydratase IIUNIPROTCarbonic anhydrase 2UNIPROTCarbonic anhydrase CUNIPROTCarbonic anhydrase IIUNIPROTCyanamide hydratase CA2UNIPROTP00918AlphaFoldDBP00918ExpressionAtlasGO:0005737cytoplasmGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0043209myelin sheathGoComponentGO:0045177apical part of cellGoComponentGO:0070062extracellular exosomeGoComponentGO:0004064arylesterase activityGoFunctionGO:0004089carbonate dehydratase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008270zinc ion bindingGoFunctionGO:0016829lyase activityGoFunctionGO:0018820cyanamide hydratase activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0002009morphogenesis of an epitheliumGoProcessGO:0006730one-carbon metabolic processGoProcessGO:0015670carbon dioxide transportGoProcessGO:0032230positive regulation of synaptic transmission, GABAergicGoProcessGO:0032849positive regulation of cellular pH reductionGoProcessGO:0038166angiotensin-activated signaling pathwayGoProcessGO:0044070regulation of monoatomic anion transportGoProcessGO:0046903secretionGoProcessGO:0051453regulation of intracellular pHGoProcessGO:2001150positive regulation of dipeptide transmembrane transportGoProcessGO:2001225regulation of chloride transportGoProcessHGNC:1373CA2HGNCP00918IntActIPR001148CA_domInterProIPR018338Carbonic_anhydrase_a-class_CSInterProIPR023561Carbonic_anhydrase_a-classInterProIPR036398CA_dom_sfInterProPTHR18952CARBONIC ANHYDRASEPANTHERPTHR18952:SF120CARBONIC ANHYDRASE 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 anhydrase 2PharmGKBP00918PharosR-HSA-1237044Erythrocytes take up carbon dioxide and release oxygenReactomeR-HSA-1247673Erythrocytes take up oxygen and release carbon dioxideReactomeR-HSA-1475029Reversible hydration of carbon dioxideReactomeB2R7G8Carbonic anhydrase 2UniProtP00918Carbonic anhydrase 2UniProtQ6FI12Carbonic anhydrase 2UniProtQ96ET9Carbonic anhydrase 2UniProtSINGLE PROTEIN9606Homo sapiensAntithrombin-IIICHEMBL1950P01008Antithrombin-III273PROTEINSINGLE PROTEINAntithrombin-IIIUNIPROTAT3 GENE_SYMBOL_OTHERATIIIUNIPROTSerpin C1UNIPROTSERPINC1GENE_SYMBOLP01008AlphaFoldDBP01008ExpressionAtlasGO:0005576extracellular regionGoComponentGO:0005615extracellular spaceGoComponentGO:0005788endoplasmic reticulum lumenGoComponentGO:0005886plasma membraneGoComponentGO:0070062extracellular exosomeGoComponentGO:0072562blood microparticleGoComponentGO:0002020protease bindingGoFunctionGO:0004867serine-type endopeptidase inhibitor activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008201heparin bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0007596blood coagulationGoProcessGO:0030193regulation of blood coagulationGoProcessHGNC:775SERPINC1HGNCP01008IntActIPR000215Serpin_famInterProIPR023795Serpin_CSInterProIPR023796Serpin_domInterProIPR033829Antithrombin_3_serpin_domainInterProIPR036186Serpin_sfInterProIPR042178Serpin_sf_1InterProIPR042185Serpin_sf_2InterProPTHR11461SERINE PROTEASE INHIBITOR, SERPINPANTHERPTHR11461:SF53ANTITHROMBIN-IIIPANTHER1ANTPDB1ATHPDB1AZXPDB1BR8PDB1DZGPDB1DZHPDB1E03PDB1E04PDB1E05PDB1JVQPDB1LK6PDB1NQ9PDB1OYHPDB1R1LPDB1SR5PDB1T1FPDB1TB6PDB2ANTPDB2B4XPDB2B5TPDB2BEHPDB2GD4PDB2HIJPDB2ZNHPDB3EVJPDB3KCGPDB4EB1PDB1ANTAPDBe1ATHAPDBe1AZXAPDBe1BR8APDBe1DZGAPDBe1DZHAPDBe1E03APDBe1E04APDBe1E05APDBe1JVQAPDBe1LK6APDBe1NQ9APDBe1OYHAPDBe1R1LAPDBe1SR5APDBe1T1FAPDBe1TB6APDBe2ANTAPDBe2B4XAPDBe2B5TAPDBe2BEHAPDBe2GD4APDBe2HIJAPDBe2ZNHAPDBe3EVJAPDBe3KCGAPDBe4EB1APDBePF00079SerpinPfamPA35026serpin family C member 1PharmGKBP01008PharosR-HSA-140837Intrinsic Pathway of Fibrin Clot FormationReactomeR-HSA-140875Common Pathway of Fibrin Clot FormationReactomeR-HSA-381426Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)ReactomeR-HSA-8957275Post-translational protein phosphorylationReactomeB2R6P0Antithrombin-IIIUniProtP01008Antithrombin-IIIUniProtP78439Antithrombin-IIIUniProtP78447Antithrombin-IIIUniProtQ13815Antithrombin-IIIUniProtQ5TC78Antithrombin-IIIUniProtQ7KZ43Antithrombin-IIIUniProtQ7KZ97Antithrombin-IIIUniProtQ9UC78Antithrombin-IIIUniProtSINGLE PROTEIN9606Homo sapiensTroponin C, slow skeletal and cardiac musclesCHEMBL2066P63316Troponin C, slow skeletal and cardiac muscles406PROTEINSINGLE PROTEINTN-CUNIPROTTNNCGENE_SYMBOL_OTHERTNNC1GENE_SYMBOLTroponin C, slow skeletal and cardiac musclesUNIPROTP63316AlphaFoldDBP63316ExpressionAtlasGO:0005829cytosolGoComponentGO:0005861troponin complexGoComponentGO:0043292contractile muscle fiberGoComponentGO:1990584cardiac Troponin complexGoComponentGO:0005509calcium ion bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0031013troponin I bindingGoFunctionGO:0031014troponin T bindingGoFunctionGO:0042803protein homodimerization activityGoFunctionGO:0046872metal ion bindingGoFunctionGO:0048306calcium-dependent protein bindingGoFunctionGO:0051015actin filament bindingGoFunctionGO:0006937regulation of muscle contractionGoProcessGO:0014883transition between fast and slow fiberGoProcessGO:0032972regulation of muscle filament sliding speedGoProcessGO:0055010ventricular cardiac muscle tissue morphogenesisGoProcessHGNC:11943TNNC1HGNCP63316IntActIPR002048EF_hand_domInterProIPR011992EF-hand-dom_pairInterProIPR018247EF_Hand_1_Ca_BSInterProIPR050230CALM/Myosin/TropC-likeInterProPTHR23048MYOSIN LIGHT CHAIN 1, 3PANTHERPTHR23048:SF47TROPONIN C1, SLOW SKELETAL AND CARDIAC 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-hand_7PfamPF13833EF-hand_8PfamPA36632troponin C1, slow skeletal and cardiac typePharmGKBP63316PharosR-HSA-390522Striated Muscle ContractionReactomeO14800Troponin C, slow skeletal and cardiac musclesUniProtP02590Troponin C, slow skeletal and cardiac musclesUniProtP04463Troponin C, slow skeletal and cardiac musclesUniProtP63316Troponin C, slow skeletal and cardiac musclesUniProtSINGLE PROTEIN9606Escherichia coli K-12Penicillin-binding protein 1ACHEMBL1813P02918Penicillin-binding protein 1A110PROTEINSINGLE PROTEIN2.4.99.28EC_NUMBER3.4.16.4EC_NUMBERDD-transpeptidaseUNIPROTmrcAGENE_SYMBOLPBP-1aUNIPROTPBP1aUNIPROTPenicillin-binding protein 1AUNIPROTPenicillin-insensitive transglycosylaseUNIPROTPenicillin-sensitive transpeptidaseUNIPROTPeptidoglycan TGaseUNIPROTponA GENE_SYMBOL_OTHERP02918AlphaFoldDBGO:0005886plasma membraneGoComponentGO:0030288outer membrane-bounded periplasmic spaceGoComponentGO:0004180carboxypeptidase activityGoFunctionGO:0004185serine-type carboxypeptidase activityGoFunctionGO:0005515protein bindingGoFunctionGO:0008658penicillin bindingGoFunctionGO:0008955peptidoglycan glycosyltransferase activityGoFunctionGO:0009002serine-type D-Ala-D-Ala carboxypeptidase activityGoFunctionGO:0016757glycosyltransferase activityGoFunctionGO:0006508proteolysisGoProcessGO:0008360regulation of cell shapeGoProcessGO:0009252peptidoglycan biosynthetic processGoProcessGO:0046677response to antibioticGoProcessGO:0071555cell wall organizationGoProcessP02918IntActIPR001264Glyco_trans_51InterProIPR001460PCN-bd_TpeptInterProIPR012338Beta-lactam/transpept-likeInterProIPR023346Lysozyme-like_dom_sfInterProIPR031376PCB_OBInterProIPR036950PBP_transglycosylaseInterProIPR050396Glycosyltr_51/TranspeptidaseInterProPTHR32282BINDING PROTEIN TRANSPEPTIDASE, PUTATIVE-RELATEDPANTHERPTHR32282:SF27PENICILLIN-BINDING PROTEIN 1APANTHERPF00905TranspeptidasePfamPF00912TransglyPfamPF17092PCB_OBPfamP02918Penicillin-binding protein 1AUniProtP76688Penicillin-binding protein 1AUniProtQ2M761Penicillin-binding protein 1AUniProtSINGLE PROTEIN83333Homo sapiensEstrogen receptorCHEMBL206P03372Estrogen receptor410PROTEINSINGLE PROTEINER-alphaUNIPROTESRGENE_SYMBOL_OTHERESR1GENE_SYMBOLEstradiol receptorUNIPROTEstrogen receptorUNIPROTNR3A1GENE_SYMBOL_OTHERNuclear receptor subfamily 3 group A member 1UNIPROTP03372AlphaFoldDBP03372ExpressionAtlasGO:0000785chromatinGoComponentGO:0000791euchromatinGoComponentGO:0005634nucleusGoComponentGO:0005654nucleoplasmGoComponentGO:0005667transcription regulator complexGoComponentGO:0005737cytoplasmGoComponentGO:0005794Golgi apparatusGoComponentGO:0005829cytosolGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0032991protein-containing complexGoComponentGO:0000978RNA polymerase II cis-regulatory region sequence-specific DNA bindingGoFunctionGO:0001093TFIIB-class transcription factor bindingGoFunctionGO:0001221transcription coregulator bindingGoFunctionGO:0001222transcription corepressor bindingGoFunctionGO:0001223transcription coactivator bindingGoFunctionGO:0003677DNA bindingGoFunctionGO:0003682chromatin bindingGoFunctionGO:0004879nuclear receptor activityGoFunctionGO:0005496steroid bindingGoFunctionGO:0005515protein bindingGoFunctionGO:0005516calmodulin bindingGoFunctionGO:0008013beta-catenin bindingGoFunctionGO:0008270zinc ion bindingGoFunctionGO:0017025TBP-class protein bindingGoFunctionGO:0019899enzyme bindingGoFunctionGO:0019901protein kinase bindingGoFunctionGO:0030235nitric-oxide synthase regulator activityGoFunctionGO:0030284nuclear estrogen receptor activityGoFunctionGO:0030331nuclear estrogen receptor bindingGoFunctionGO:0034056estrogen response element bindingGoFunctionGO:0042802identical protein bindingGoFunctionGO:0043565sequence-specific DNA bindingGoFunctionGO:0046872metal ion bindingGoFunctionGO:0051117ATPase bindingGoFunctionGO:007188914-3-3 protein bindingGoFunctionGO:1990837sequence-specific double-stranded DNA bindingGoFunctionGO:0000122negative regulation of transcription by RNA polymerase IIGoProcessGO:0001547antral ovarian follicle growthGoProcessGO:0002064epithelial cell developmentGoProcessGO:0007165signal transductionGoProcessGO:0007200phospholipase C-activating G protein-coupled receptor signaling pathwayGoProcessGO:0007204positive regulation of cytosolic calcium ion concentrationGoProcessGO:0008209androgen metabolic processGoProcessGO:0008584male gonad developmentGoProcessGO:0010629negative regulation of gene expressionGoProcessGO:0030518nuclear receptor-mediated steroid hormone signaling pathwayGoProcessGO:0030520estrogen receptor signaling pathwayGoProcessGO:0034121regulation of toll-like receptor signaling pathwayGoProcessGO:0034392negative regulation of smooth muscle cell apoptotic processGoProcessGO:0043124negative regulation of canonical NF-kappaB signal transductionGoProcessGO:0043401steroid hormone receptor signaling pathwayGoProcessGO:0045893positive regulation of DNA-templated transcriptionGoProcessGO:0045944positive regulation of transcription by RNA polymerase IIGoProcessGO:0048144fibroblast proliferationGoProcessGO:0048146positive regulation of fibroblast proliferationGoProcessGO:0048863stem cell differentiationGoProcessGO:0050727regulation of inflammatory responseGoProcessGO:0051123RNA polymerase II preinitiation complex assemblyGoProcessGO:0060065uterus developmentGoProcessGO:0060068vagina developmentGoProcessGO:0060523prostate epithelial cord elongationGoProcessGO:0060527prostate epithelial cord arborization involved in prostate glandular acinus morphogenesisGoProcessGO:0060687regulation of branching involved in prostate gland morphogenesisGoProcessGO:0060745mammary gland branching involved in pregnancyGoProcessGO:0060749mammary gland alveolus developmentGoProcessGO:0060750epithelial cell proliferation involved in mammary gland duct elongationGoProcessGO:0071168protein localization to chromatinGoProcessGO:0071391cellular response to estrogen stimulusGoProcessGO:0071392cellular response to estradiol stimulusGoProcessGO:1902894negative regulation of miRNA transcriptionGoProcessGO:1904035regulation of epithelial cell apoptotic processGoProcessHGNC:3467ESR1HGNCP03372IntActIPR000536Nucl_hrmn_rcpt_lig-bdInterProIPR001292Estr_rcptInterProIPR001628Znf_hrmn_rcptInterProIPR001723Nuclear_hrmn_rcptInterProIPR013088Znf_NHR/GATAInterProIPR024178Est_rcpt/est-rel_rcpInterProIPR024736Oestrogen-typ_rcpt_final_C_domInterProIPR035500NHR-like_dom_sfInterProIPR046944Estr_rcpt_NInterProIPR050200Nuclear_hormone_rcpt_NR3InterProPTHR48092KNIRPS-RELATED PROTEIN-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_recepPfamPF00105zf-C4PfamPF02159Oest_recepPfamPF12743ESR1_CPfamPA156estrogen receptor 1PharmGKBP03372PharosR-HSA-1251985Nuclear signaling by ERBB4ReactomeR-HSA-1257604PIP3 activates AKT signalingReactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in CancerReactomeR-HSA-383280Nuclear Receptor transcription pathwayReactomeR-HSA-4090294SUMOylation of intracellular receptorsReactomeR-HSA-5689896Ovarian tumor domain proteasesReactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT SignalingReactomeR-HSA-8866910TFAP2 (AP-2) family regulates transcription of growth factors and their receptorsReactomeR-HSA-8931987RUNX1 regulates estrogen receptor mediated transcriptionReactomeR-HSA-8939211ESR-mediated signalingReactomeR-HSA-8939256RUNX1 regulates transcription of genes involved in WNT signalingReactomeR-HSA-8939902Regulation of RUNX2 expression and activityReactomeR-HSA-9009391Extra-nuclear estrogen signalingReactomeR-HSA-9018519Estrogen-dependent gene expressionReactomeR-HSA-9841251Mitochondrial unfolded protein response (UPRmt)ReactomeP03372Estrogen receptorUniProtQ13511Estrogen receptorUniProtQ14276Estrogen receptorUniProtQ5T5H7Estrogen receptorUniProtQ6MZQ9Estrogen receptorUniProtQ9NU51Estrogen receptorUniProtQ9UDZ7Estrogen receptorUniProtQ9UIS7Estrogen receptorUniProtSINGLE PROTEIN9606Influenza A virus (A/Puerto Rico/8/1934(H1N1))NeuraminidaseCHEMBL2051P03468Neuraminidase391PROTEINSINGLE PROTEIN3.2.1.18EC_NUMBERNAGENE_SYMBOLNeuraminidaseUNIPROTGO:0005576extracellular regionGoComponentGO:0005886plasma membraneGoComponentGO:0016020membraneGoComponentGO:0020002host cell plasma membraneGoComponentGO:0033644host cell membraneGoComponentGO:0044423virion componentGoComponentGO:0055036virion membraneGoComponentGO:0004308exo-alpha-sialidase activityGoFunctionGO:0016504peptidase activator activityGoFunctionGO:0016798hydrolase activity, acting on glycosyl bondsGoFunctionGO:0046872metal ion bindingGoFunctionGO:0005975carbohydrate metabolic processGoProcessGO:0019076viral release from host cellGoProcessGO:0046761viral budding from plasma membraneGoProcessP03468IntActIPR001860Glyco_hydro_34InterProIPR033654Sialidase_Influenza_A/BInterProIPR036278Sialidase_sfInterPro6WZYPDB6X00PDB6WZYAPDBe6X00APDBePF00064NeurPfamR-HSA-168255Influenza InfectionReactomeR-HSA-168275Entry of Influenza Virion into Host Cell via EndocytosisReactomeR-HSA-168277Influenza Virus Induced ApoptosisReactomeR-HSA-168288Fusion of the Influenza Virion to the Host Cell EndosomeReactomeR-HSA-168298ReleaseReactomeR-HSA-168302BuddingReactomeR-HSA-168303Packaging of Eight RNA SegmentsReactomeR-HSA-168316Assembly of Viral Components at the Budding SiteReactomeR-HSA-168336Uncoating of the Influenza VirionReactomeR-HSA-168874Transport of HA trimer, NA tetramer and M2 tetramer from the endoplasmic reticulum to the Golgi ApparatusReactomeR-HSA-192823Viral mRNA TranslationReactomeA4GXH6NeuraminidaseUniProtP03468NeuraminidaseUniProtQ20N35NeuraminidaseUniProtQ84043NeuraminidaseUniProtQ8JUU4NeuraminidaseUniProtSINGLE PROTEIN211044